Rattus norvegicus

0 known processes

Pcdh18

protocadherin 18

(Aliases: MGC188762)

Pcdh18 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of multicellular organismal developmentGO:20000263760.145
regulation of molecular functionGO:00650093980.114
regulation of phosphorus metabolic processGO:00511743490.109
response to nutrient levelsGO:00316673700.108
regulation of phosphate metabolic processGO:00192203490.103
response to woundingGO:00096112540.097
cellular response to oxygen containing compoundGO:19017013860.094
single organism biosynthetic processGO:00447113420.092
protein phosphorylationGO:00064683450.089
locomotionGO:00400112370.087
regulation of phosphorylationGO:00423252480.082
regulation of cellular component organizationGO:00511283680.080
response to extracellular stimulusGO:00099913800.080
single organism reproductive processGO:00447022970.079
reproductive processGO:00224143720.079
positive regulation of developmental processGO:00510942830.076
regulation of cell proliferationGO:00421273590.076
organic acid metabolic processGO:00060822920.075
positive regulation of nucleobase containing compound metabolic processGO:00459353190.075
regulation of apoptotic processGO:00429813350.075
cellular response to endogenous stimulusGO:00714953770.074
negative regulation of cell deathGO:00605482290.070
positive regulation of phosphorus metabolic processGO:00105622620.070
cation transportGO:00068123820.070
regulation of cell differentiationGO:00455953200.069
oxoacid metabolic processGO:00434362900.068
regulation of signal transductionGO:00099663180.067
wound healingGO:00420601220.067
regulation of protein phosphorylationGO:00019321830.067
response to estrogenGO:00436272320.066
regulation of cellular protein metabolic processGO:00322682670.065
positive regulation of cell differentiationGO:00455972170.064
positive regulation of nitrogen compound metabolic processGO:00511733340.063
cardiovascular system developmentGO:00723581340.063
tissue developmentGO:00098882520.063
positive regulation of gene expressionGO:00106282440.062
carbohydrate derivative metabolic processGO:19011353460.061
cellular component movementGO:00069282480.060
positive regulation of biosynthetic processGO:00098913190.060
carboxylic acid metabolic processGO:00197522890.060
gland developmentGO:00487321550.060
response to nutrientGO:00075842480.059
rna metabolic processGO:00160704060.058
positive regulation of response to stimulusGO:00485842850.058
positive regulation of phosphate metabolic processGO:00459372620.057
cellular response to lipidGO:00713962010.057
positive regulation of rna metabolic processGO:00512542030.057
anatomical structure morphogenesisGO:00096532980.057
organophosphate metabolic processGO:00196373700.057
nucleotide metabolic processGO:00091172790.057
regulation of cellular amine metabolic processGO:003323880.056
regulation of catalytic activityGO:00507903040.055
cell migrationGO:00164771970.054
positive regulation of cell proliferationGO:00082842490.054
multicellular organism reproductionGO:00325042330.054
regulation of programmed cell deathGO:00430673410.053
regulation of protein metabolic processGO:00512462890.053
regulation of transcription from rna polymerase ii promoterGO:00063572340.052
regulation of rna metabolic processGO:00512523910.052
regulation of cell developmentGO:00602842630.051
positive regulation of multicellular organismal processGO:00512403870.051
response to cytokineGO:00340972150.050
programmed cell deathGO:00125013920.050
regulation of nucleic acid templated transcriptionGO:19035063800.050
transmembrane transportGO:00550854120.050
positive regulation of cellular biosynthetic processGO:00313282950.049
neuron projection developmentGO:00311752730.049
chemical homeostasisGO:00488782920.049
enzyme linked receptor protein signaling pathwayGO:00071671160.049
response to peptide hormoneGO:00434342780.049
neuron developmentGO:00486662860.049
calcium ion homeostasisGO:00550741620.048
transcription dna templatedGO:00063513770.047
neuron differentiationGO:00301823680.045
positive regulation of neurogenesisGO:00507691650.045
divalent inorganic cation homeostasisGO:00725071650.045
cellular component biogenesisGO:00440853680.045
regulation of nervous system developmentGO:00519602640.044
positive regulation of cell communicationGO:00106472710.044
cellular cation homeostasisGO:00300031800.044
apoptotic processGO:00069153810.043
positive regulation of intracellular signal transductionGO:19025331380.043
response to oxygen levelsGO:00704822650.043
circulatory system developmentGO:00723591340.043
cellular metal ion homeostasisGO:00068751720.042
signal transduction by phosphorylationGO:00230141440.042
positive regulation of phosphorylationGO:00423271770.042
positive regulation of rna biosynthetic processGO:19026801970.042
regulation of rna biosynthetic processGO:20011413810.042
growthGO:00400071650.042
ion transmembrane transportGO:00342203650.041
cellular ion homeostasisGO:00068731840.041
intracellular signal transductionGO:00355563140.041
transcription from rna polymerase ii promoterGO:00063662520.041
reproductionGO:00000032450.041
regulation of system processGO:00440572080.041
positive regulation of nucleic acid templated transcriptionGO:19035081970.041
response to decreased oxygen levelsGO:00362932370.041
positive regulation of protein phosphorylationGO:00019341350.040
regulation of neuron differentiationGO:00456642080.040
negative regulation of cell proliferationGO:00082851190.040
cell motilityGO:00488702020.040
regulation of neurogenesisGO:00507672470.039
amine metabolic processGO:0009308380.039
positive regulation of protein metabolic processGO:00512471780.039
regulation of growthGO:00400081050.039
negative regulation of cellular metabolic processGO:00313242810.039
positive regulation of signal transductionGO:00099671750.038
regulation of intracellular signal transductionGO:19025312180.038
cellular response to growth factor stimulusGO:00713631620.038
positive regulation of transcription dna templatedGO:00458931970.038
response to inorganic substanceGO:00100353770.038
negative regulation of cell differentiationGO:0045596990.037
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.037
regulation of cellular ketone metabolic processGO:0010565270.037
ribonucleotide metabolic processGO:00092592310.037
cellular chemical homeostasisGO:00550822470.037
nucleobase containing small molecule metabolic processGO:00550863160.037
cellular response to hormone stimulusGO:00328702470.037
positive regulation of cellular component organizationGO:00511302000.036
nucleoside phosphate metabolic processGO:00067532830.036
purine nucleotide metabolic processGO:00061632290.036
cell cell signalingGO:00072673350.036
cellular component assemblyGO:00226073600.036
positive regulation of cell migrationGO:0030335960.036
response to lipopolysaccharideGO:00324961910.036
nucleic acid templated transcriptionGO:00976593790.035
response to molecule of bacterial originGO:00022371940.035
localization of cellGO:00516742020.035
response to growth factorGO:00708481890.035
rna biosynthetic processGO:00327743800.035
cellular homeostasisGO:00197252520.035
negative regulation of response to stimulusGO:00485851550.035
lipid metabolic processGO:00066292830.034
regulation of protein modification processGO:00313991940.034
positive regulation of nervous system developmentGO:00519621780.034
brain developmentGO:00074202470.034
response to corticosteroidGO:00319602350.034
purine ribonucleotide metabolic processGO:00091502270.034
negative regulation of programmed cell deathGO:00430691830.033
cellular ketone metabolic processGO:0042180510.033
metal ion homeostasisGO:00550651860.033
positive regulation of catalytic activityGO:00430851840.033
negative regulation of gene expressionGO:00106291990.032
metal ion transportGO:00300012890.032
cellular amine metabolic processGO:0044106380.032
nitrogen compound transportGO:00717052290.032
developmental process involved in reproductionGO:00030061590.032
regulation of ion transportGO:00432692450.032
cellular response to stressGO:00335542690.032
mapk cascadeGO:00001651400.032
negative regulation of developmental processGO:00510931250.031
negative regulation of cell communicationGO:00106481580.031
regulation of cell projection organizationGO:00313441750.031
positive regulation of protein modification processGO:00314011420.031
response to hypoxiaGO:00016662310.031
inorganic cation transmembrane transportGO:00986622020.031
renal system developmentGO:0072001670.031
cell projection organizationGO:00300303020.031
positive regulation of macromolecule biosynthetic processGO:00105572470.031
g protein coupled receptor signaling pathwayGO:00071862420.031
heart morphogenesisGO:000300730.030
blood vessel developmentGO:0001568690.030
positive regulation of signalingGO:00230562700.030
anterior posterior pattern specificationGO:000995210.030
carbohydrate derivative biosynthetic processGO:19011371240.030
positive regulation of cell developmentGO:00107201760.030
immune system processGO:00023762040.030
positive regulation of cellular component movementGO:00512721020.030
inorganic ion transmembrane transportGO:00986602290.029
ossificationGO:0001503700.029
ribose phosphate metabolic processGO:00196932350.029
regulation of locomotionGO:00400121480.029
response to acid chemicalGO:00011012220.029
neurological system processGO:00508772190.029
purine containing compound metabolic processGO:00725212530.029
regulation of response to stressGO:00801341260.029
urogenital system developmentGO:0001655780.029
response to other organismGO:00517072200.029
multi organism reproductive processGO:00447032620.029
cytosolic calcium ion homeostasisGO:00514801400.028
cellular calcium ion homeostasisGO:00068741600.028
response to vitaminGO:00332731310.028
response to peptideGO:19016522920.028
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.028
protein complex biogenesisGO:00702712630.028
negative regulation of metabolic processGO:00098923310.028
ion homeostasisGO:00508012120.028
glycosaminoglycan biosynthetic processGO:000602440.028
behaviorGO:00076102050.027
catabolic processGO:00090563510.027
negative regulation of signal transductionGO:0009968830.027
positive regulation of mapk cascadeGO:0043410920.027
negative regulation of multicellular organismal processGO:00512412030.027
regenerationGO:00310991630.027
cellular divalent inorganic cation homeostasisGO:00725031620.027
positive regulation of molecular functionGO:00440932300.027
gonad developmentGO:00084061040.027
homeostatic processGO:00425923310.027
organonitrogen compound biosynthetic processGO:19015661670.027
ras protein signal transductionGO:0007265290.027
positive regulation of transportGO:00510502450.027
negative regulation of macromolecule metabolic processGO:00106052600.026
multicellular organismal reproductive processGO:00486092330.026
divalent metal ion transportGO:00708381320.026
negative regulation of apoptotic processGO:00430661810.026
regulation of stem cell differentiationGO:200073620.026
synaptic transmissionGO:00072682350.026
regulation of cellular amino acid metabolic processGO:000652120.026
angiogenesisGO:0001525530.026
regulation of mapk cascadeGO:00434081160.026
regulation of cellular localizationGO:00603412630.026
regulation of transcription dna templatedGO:00063553740.026
positive regulation of cellular protein metabolic processGO:00322701670.025
cellular response to abiotic stimulusGO:0071214850.025
response to estradiolGO:00323551640.025
cellular response to external stimulusGO:00714961180.025
cellular amino acid metabolic processGO:00065201070.025
response to bacteriumGO:00096172000.025
single organism catabolic processGO:00447122830.025
organic substance catabolic processGO:19015753160.025
head developmentGO:00603222470.025
organelle organizationGO:00069962660.025
regulation of anatomical structure morphogenesisGO:00226031410.025
cation homeostasisGO:00550801950.024
negative regulation of signalingGO:00230571570.024
regulation of cell growthGO:0001558850.024
reproductive structure developmentGO:00486081280.024
regulation of anatomical structure sizeGO:00900661350.023
multi multicellular organism processGO:00447061380.023
positive regulation of cell projection organizationGO:00313461110.023
development of primary sexual characteristicsGO:00451371070.023
negative regulation of nitrogen compound metabolic processGO:00511721610.023
negative regulation of macromolecule biosynthetic processGO:00105581480.023
macromolecular complex subunit organizationGO:00439333390.023
inflammatory responseGO:00069541500.023
muscle system processGO:00030121150.023
regulation of neuron projection developmentGO:00109751610.023
cellular response to organic cyclic compoundGO:00714072020.023
cellular response to organonitrogen compoundGO:00714171970.023
anion transportGO:00068201780.023
cellular component morphogenesisGO:00329891550.023
cell growthGO:00160491040.023
regulation of protein kinase activityGO:00458591050.023
oxidation reduction processGO:00551143040.023
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.022
response to mechanical stimulusGO:00096121340.022
cellular response to cytokine stimulusGO:00713451270.022
organophosphate biosynthetic processGO:00904071430.022
cellular lipid metabolic processGO:00442552080.022
response to glucocorticoidGO:00513842230.022
single organism intracellular transportGO:19025821660.022
positive regulation of cell deathGO:00109421840.021
positive regulation of ion transportGO:0043270940.021
positive regulation of cellular amine metabolic processGO:003324030.021
circulatory system processGO:00030131830.021
organ morphogenesisGO:0009887750.021
agingGO:00075682410.021
bmp signaling pathwayGO:003050940.020
regulation of response to external stimulusGO:00321011060.020
developmental growthGO:00485891000.020
blood circulationGO:00080151830.020
regulation of immune system processGO:00026821230.020
positive regulation of secretionGO:00510471400.020
response to external biotic stimulusGO:00432072210.020
sex differentiationGO:00075481130.020
small gtpase mediated signal transductionGO:0007264360.020
secretionGO:00469033070.020
response to metal ionGO:00100382530.020
regulation of cell motilityGO:20001451310.020
regulation of cellular component movementGO:00512701500.020
muscle structure developmentGO:0061061870.019
cation transmembrane transportGO:00986552630.019
axis specificationGO:000979840.019
regulation of nucleotide metabolic processGO:00061401170.019
eye morphogenesisGO:004859240.019
regulation of fat cell differentiationGO:004559830.019
cellular response to nitrogen compoundGO:19016992100.019
lipid biosynthetic processGO:00086101280.019
cell morphogenesis involved in differentiationGO:00009041190.019
positive regulation of cell motilityGO:2000147970.019
cellular response to glucocorticoid stimulusGO:0071385680.019
cellular catabolic processGO:00442482950.019
response to oxidative stressGO:00069791860.019
sexual reproductionGO:00199531480.019
vasculature developmentGO:0001944700.018
neuronal action potentialGO:0019228350.018
regulation of metal ion transportGO:00109591180.018
macromolecular complex assemblyGO:00650032730.018
proteolysisGO:00065081750.018
response to radiationGO:00093141370.018
regulation of transferase activityGO:00513381230.018
negative regulation of transcription dna templatedGO:00458921160.018
regulation of muscle system processGO:0090257790.018
positive regulation of neuron differentiationGO:00456661260.018
negative regulation of cell developmentGO:0010721820.018
response to carbohydrateGO:00097431830.018
organ regenerationGO:00311001010.017
regulation of blood circulationGO:19035221100.017
regulation of secretion by cellGO:19035302080.017
intracellular transportGO:00469071850.017
cellular protein localizationGO:00346131220.017
negative regulation of phosphate metabolic processGO:0045936800.017
embryonic pattern specificationGO:000988010.017
regulation of catabolic processGO:00098941130.017
positive regulation of kinase activityGO:0033674770.017
positive regulation of neuron projection developmentGO:0010976990.017
macromolecule localizationGO:00330362520.017
negative regulation of nucleobase containing compound metabolic processGO:00459341530.017
positive regulation of cellular amino acid metabolic processGO:004576410.017
negative regulation of molecular functionGO:00440921330.017
negative regulation of transportGO:00510511360.017
response to ketoneGO:19016541820.017
female pregnancyGO:00075651220.017
positive regulation of cytosolic calcium ion concentrationGO:00072041220.016
regulation of cell migrationGO:00303341280.016
ribonucleotide catabolic processGO:00092611360.016
heterocycle catabolic processGO:00467001670.016
negative regulation of rna biosynthetic processGO:19026791180.016
response to hydrogen peroxideGO:0042542890.016
regulation of hormone levelsGO:00108171870.016
nucleoside metabolic processGO:00091161790.016
embryo developmentGO:0009790490.016
peptidyl tyrosine phosphorylationGO:0018108720.016
small molecule biosynthetic processGO:00442831240.016
regulation of purine nucleotide metabolic processGO:19005421150.016
muscle contractionGO:0006936880.016
gliogenesisGO:0042063930.016
regulation of canonical wnt signaling pathwayGO:006082840.016
response to alkaloidGO:00432791320.016
vascular process in circulatory systemGO:0003018960.016
positive regulation of secretion by cellGO:19035321280.016
regulation of cell morphogenesis involved in differentiationGO:0010769720.015
salivary gland developmentGO:000743130.015
cellular response to alcoholGO:0097306870.015
negative regulation of neurogenesisGO:0050768780.015
glycosyl compound metabolic processGO:19016571820.015
protein complex subunit organizationGO:00718223020.015
positive regulation of locomotionGO:00400171020.015
single organism organelle organizationGO:19025891800.015
response to hexoseGO:00097461440.015
striated muscle cell developmentGO:0055002260.015
tube developmentGO:0035295890.015
response to monosaccharideGO:00342841590.015
heart developmentGO:0007507720.015
response to reactive oxygen speciesGO:00003021200.015
ribose phosphate biosynthetic processGO:0046390870.015
negative regulation of protein metabolic processGO:00512481140.015
organic cyclic compound catabolic processGO:19013611750.015
cell part morphogenesisGO:00329901230.015
aminoglycan biosynthetic processGO:000602340.015
regulation of kinase activityGO:00435491170.015
purine ribonucleoside triphosphate catabolic processGO:00092071220.015
nucleoside phosphate biosynthetic processGO:19012931020.015
anatomical structure formation involved in morphogenesisGO:0048646830.015
positive regulation of nucleotide metabolic processGO:0045981910.015
negative regulation of rna metabolic processGO:00512531230.015
respiratory system developmentGO:0060541450.015
kidney developmentGO:0001822670.015
divalent inorganic cation transportGO:00725111340.015
regulation of hydrolase activityGO:00513361430.015
sensory perceptionGO:00076001010.015
regulation of body fluid levelsGO:0050878900.015
action potentialGO:0001508540.014
central nervous system developmentGO:00074173110.014
negative regulation of biosynthetic processGO:00098901680.014
endocrine system developmentGO:0035270300.014
male gonad developmentGO:0008584590.014
positive regulation of transferase activityGO:0051347810.014
secretion by cellGO:00329402480.014
cytoplasmic transportGO:00164821150.014
response to organophosphorusGO:00466831020.014
positive regulation of purine nucleotide metabolic processGO:1900544910.014
regulation of secretionGO:00510462240.014
positive regulation of programmed cell deathGO:00430681570.014
regulation of membrane potentialGO:00423911100.014
motor neuron axon guidanceGO:000804510.014
carbohydrate metabolic processGO:00059751300.014
intracellular protein transportGO:0006886790.014
cellular response to ketoneGO:1901655510.014
salivary gland morphogenesisGO:000743510.014
purine nucleoside catabolic processGO:00061521240.014
protein localizationGO:00081041910.014
gastrulationGO:000736920.014
peptidyl tyrosine modificationGO:0018212720.014
purine nucleoside triphosphate metabolic processGO:00091441410.014
axonogenesisGO:0007409710.014
regulation of ossificationGO:0030278320.014
response to glucoseGO:00097491360.014
maintenance of locationGO:0051235170.014
cellular response to steroid hormone stimulusGO:0071383930.014
regulation of ion transmembrane transportGO:00347651210.014
response to fatty acidGO:0070542650.013
transmission of nerve impulseGO:0019226420.013
reproductive system developmentGO:00614581280.013
protein complex assemblyGO:00064612630.013
response to dexamethasoneGO:0071548490.013
regulation of blood vessel sizeGO:0050880890.013
muscle organ developmentGO:0007517500.013
cellular response to corticosteroid stimulusGO:0071384690.013
chemotaxisGO:0006935660.013
cellular response to mechanical stimulusGO:0071260480.013
nucleoside triphosphate metabolic processGO:00091411440.013
cellular response to peptide hormone stimulusGO:00713751200.013
non canonical wnt signaling pathwayGO:003556730.013
cell morphogenesisGO:00009021420.013
monocarboxylic acid metabolic processGO:00327871520.013
purine nucleoside metabolic processGO:00422781690.013
response to insulinGO:00328681330.013
carbohydrate derivative catabolic processGO:19011361470.013
erk1 and erk2 cascadeGO:0070371480.013
response to retinoic acidGO:0032526630.013
dendrite developmentGO:0016358720.013
epithelial cell differentiationGO:0030855710.013
nucleoside triphosphate catabolic processGO:00091431230.013
regulation of synaptic transmissionGO:00508041410.013
regulation of calcium ion transportGO:0051924770.013
lipid storageGO:001991510.013
ribonucleotide biosynthetic processGO:0009260850.013
calcium ion transportGO:00068161310.013
response to purine containing compoundGO:00140741260.013
calcium ion transmembrane transportGO:0070588700.012
camera type eye developmentGO:0043010480.012
taxisGO:0042330670.012
guanosine containing compound catabolic processGO:1901069710.012
single organism carbohydrate metabolic processGO:00447231180.012
multicellular organismal signalingGO:0035637440.012
regulation of dna metabolic processGO:0051052600.012
positive regulation of apoptotic processGO:00430651540.012
sequestering of metal ionGO:005123890.012
glial cell differentiationGO:0010001650.012
epithelium developmentGO:0060429960.012
membrane organizationGO:0061024940.012
protein oligomerizationGO:00512591910.012
purine ribonucleoside metabolic processGO:00461281680.012
organonitrogen compound catabolic processGO:19015651790.012
nucleobase containing compound catabolic processGO:00346551520.012
rho protein signal transductionGO:0007266110.012
male sex differentiationGO:0046661640.012
blood vessel morphogenesisGO:0048514580.012
lipid localizationGO:0010876620.012
positive regulation of catabolic processGO:0009896780.012
alcohol metabolic processGO:0006066770.012
response to calcium ionGO:0051592590.012
peptidyl amino acid modificationGO:00181931260.012
positive regulation of blood circulationGO:1903524650.012
regulation of embryonic developmentGO:004599520.012
regulation of cellular catabolic processGO:00313291010.012
phospholipid metabolic processGO:0006644610.012
smooth muscle cell proliferationGO:0048659770.011
nucleoside phosphate catabolic processGO:19012921400.011
muscle cell proliferationGO:0033002840.011
regulation of response to woundingGO:1903034690.011
sensory perception of painGO:0019233730.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
liver developmentGO:0001889900.011
negative regulation of nervous system developmentGO:0051961790.011
cardiac chamber developmentGO:000320510.011
cellular carbohydrate metabolic processGO:0044262720.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.011
lung developmentGO:0030324430.011
positive regulation of endothelial cell migrationGO:001059540.011
hematopoietic progenitor cell differentiationGO:000224420.011
cellular nitrogen compound catabolic processGO:00442701630.011
cell cycleGO:00070491010.011
gtp metabolic processGO:0046039720.011
negative regulation of cellular protein metabolic processGO:00322691060.011
cell projection morphogenesisGO:00488581230.011
regulation of lipid metabolic processGO:0019216680.011
purine nucleoside triphosphate catabolic processGO:00091461220.011
sensory organ developmentGO:0007423740.011
regulation of neuron deathGO:19012141150.011
purine ribonucleotide biosynthetic processGO:0009152810.011
negative regulation of phosphorus metabolic processGO:0010563800.011
regulation of homeostatic processGO:00328441010.011
gamete generationGO:00072761240.011
ribonucleoside triphosphate metabolic processGO:00091991410.011
regulation of epithelial cell proliferationGO:0050678490.011
muscle tissue developmentGO:0060537580.011
eye developmentGO:0001654500.011
organic anion transportGO:00157111320.011
positive regulation of biomineral tissue developmentGO:007016940.011
cellular macromolecule localizationGO:00707271220.011
negative regulation of cellular component organizationGO:0051129830.011

Pcdh18 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.044
nervous system diseaseDOID:86300.044
central nervous system diseaseDOID:33100.018
disease of cellular proliferationDOID:1456600.017
disease of metabolismDOID:001466700.015
inherited metabolic disorderDOID:65500.015
cardiovascular system diseaseDOID:128700.015
cancerDOID:16200.011
sensory system diseaseDOID:005015500.011
eye and adnexa diseaseDOID:149200.011
eye diseaseDOID:561400.011
musculoskeletal system diseaseDOID:1700.011