IMP: Integrative Multi-species Prediction

Rattus norvegicus

14 known processes

Serpina10

serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

(Aliases: Rasp1,MGC108600)

Entrez: 171154
Ensembl: ENSRNOG00000028888
RGD: 621220
UniProtKB: Q62975

Process Predictions
Disease Predictions

Serpina10 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
coagulation	GO:0050817	28	0.847
hemostasis	GO:0007599	26	0.471
blood coagulation	GO:0007596	26	0.329
fibrinolysis	GO:0042730	2	0.194
wound healing	GO:0042060	122	0.183
macromolecular complex assembly	GO:0065003	273	0.168
regulation of intracellular signal transduction	GO:1902531	218	0.154
regeneration	GO:0031099	163	0.147
positive regulation of blood coagulation	GO:0030194	4	0.145
regulation of fibrinolysis	GO:0051917	2	0.141
extracellular matrix constituent secretion	GO:0070278	4	0.134
positive regulation of response to stimulus	GO:0048584	285	0.133
response to extracellular stimulus	GO:0009991	380	0.133	Rat
biological adhesion	GO:0022610	110	0.120	Rat
regulation of protein metabolic process	GO:0051246	289	0.115	Rat Fly
defense response	GO:0006952	194	0.113	Rat Fly
negative regulation of protein metabolic process	GO:0051248	114	0.111	Rat Fly
cellular component biogenesis	GO:0044085	368	0.111
protein maturation	GO:0051604	68	0.110	Fly
protein complex assembly	GO:0006461	263	0.110
cellular amino acid metabolic process	GO:0006520	107	0.107
positive regulation of coagulation	GO:0050820	5	0.104
organic acid metabolic process	GO:0006082	292	0.097
apoptotic process	GO:0006915	381	0.095
proteolysis	GO:0006508	175	0.094	Rat Fly
immune response	GO:0006955	104	0.094	Fly
macromolecule localization	GO:0033036	252	0.093
cellular component assembly	GO:0022607	360	0.088
cell activation	GO:0001775	97	0.085
negative regulation of gene expression	GO:0010629	199	0.085	Rat Fly
negative regulation of macromolecule metabolic process	GO:0010605	260	0.084	Rat Fly
regulation of cellular localization	GO:0060341	263	0.082
immune system process	GO:0002376	204	0.082	Fly
response to camp	GO:0051591	91	0.079
protein complex subunit organization	GO:0071822	302	0.077
macromolecular complex subunit organization	GO:0043933	339	0.074
negative regulation of peptidase activity	GO:0010466	38	0.072	Rat Fly
regulation of phosphorus metabolic process	GO:0051174	349	0.069
mapk cascade	GO:0000165	140	0.068
b cell mediated immunity	GO:0019724	4	0.068
protein activation cascade	GO:0072376	12	0.066
positive regulation of signal transduction	GO:0009967	175	0.065
cell substrate adhesion	GO:0031589	29	0.064
regulation of programmed cell death	GO:0043067	341	0.063
response to inorganic substance	GO:0010035	377	0.061
inflammatory response	GO:0006954	150	0.059	Rat
immunoglobulin mediated immune response	GO:0016064	4	0.058
protein processing	GO:0016485	68	0.058	Fly
protein oligomerization	GO:0051259	191	0.057
cell adhesion	GO:0007155	110	0.057	Rat
single organism reproductive process	GO:0044702	297	0.056
negative regulation of molecular function	GO:0044092	133	0.055	Rat Fly
single organism cell adhesion	GO:0098602	46	0.055
gland development	GO:0048732	155	0.055
positive regulation of intracellular signal transduction	GO:1902533	138	0.054
organ regeneration	GO:0031100	101	0.054
response to peptide	GO:1901652	292	0.053
plasminogen activation	GO:0031639	2	0.053
regulation of apoptotic process	GO:0042981	335	0.053
organic substance catabolic process	GO:1901575	316	0.052
positive regulation of heterotypic cell cell adhesion	GO:0034116	1	0.051
regulation of system process	GO:0044057	208	0.051
regulation of cellular amino acid metabolic process	GO:0006521	2	0.049
regulation of mapk cascade	GO:0043408	116	0.048
regulation of protein processing	GO:0070613	50	0.047	Rat Fly
positive regulation of extracellular matrix organization	GO:1903055	4	0.047
regulation of protein maturation	GO:1903317	50	0.047	Rat Fly
cellular ketone metabolic process	GO:0042180	51	0.046
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.045
intracellular signal transduction	GO:0035556	314	0.045
programmed cell death	GO:0012501	392	0.044
anatomical structure morphogenesis	GO:0009653	298	0.044
multi organism reproductive process	GO:0044703	262	0.044
regulation of endothelial cell apoptotic process	GO:2000351	3	0.043
negative regulation of programmed cell death	GO:0043069	183	0.042
oxoacid metabolic process	GO:0043436	290	0.042
response to wounding	GO:0009611	254	0.041
multicellular organism reproduction	GO:0032504	233	0.041	Fly
regulation of hemostasis	GO:1900046	9	0.041
protein complex biogenesis	GO:0070271	263	0.040
regulation of cellular amine metabolic process	GO:0033238	8	0.040
regulation of immunoglobulin mediated immune response	GO:0002889	2	0.038
regulation of response to external stimulus	GO:0032101	106	0.038	Rat Fly
regulation of response to stress	GO:0080134	126	0.038	Rat
positive regulation of cellular amine metabolic process	GO:0033240	3	0.038
cellular homeostasis	GO:0019725	252	0.038
response to glucocorticoid	GO:0051384	223	0.038
protein transport	GO:0015031	132	0.038
regulation of phosphate metabolic process	GO:0019220	349	0.038
positive regulation of mapk cascade	GO:0043410	92	0.037
cellular amide metabolic process	GO:0043603	44	0.037	Fly
regulation of molecular function	GO:0065009	398	0.037	Rat Fly
regulation of blood coagulation	GO:0030193	9	0.037
regulation of phosphorylation	GO:0042325	248	0.037
amine metabolic process	GO:0009308	38	0.036
positive regulation of transport	GO:0051050	245	0.036
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.036
homeostatic process	GO:0042592	331	0.035
anion transport	GO:0006820	178	0.035
response to oxygen levels	GO:0070482	265	0.035
negative regulation of endopeptidase activity	GO:0010951	36	0.035	Rat Fly
platelet activation	GO:0030168	8	0.035
response to monosaccharide	GO:0034284	159	0.035
cellular amine metabolic process	GO:0044106	38	0.035
cell matrix adhesion	GO:0007160	19	0.034
regulation of signal transduction	GO:0009966	318	0.034	Fly
multicellular organismal reproductive process	GO:0048609	233	0.034
hepatocyte proliferation	GO:0072574	3	0.034
negative regulation of protein processing	GO:0010955	47	0.034	Rat Fly
regulation of anatomical structure morphogenesis	GO:0022603	141	0.033
regulation of b cell mediated immunity	GO:0002712	2	0.033
regulation of cellular component organization	GO:0051128	368	0.033
negative regulation of cell death	GO:0060548	229	0.032
regulation of cellular protein metabolic process	GO:0032268	267	0.032	Rat Fly
positive regulation of phosphorus metabolic process	GO:0010562	262	0.032
response to hexose	GO:0009746	144	0.031
nitrogen compound transport	GO:0071705	229	0.031
platelet aggregation	GO:0070527	4	0.031
cation transport	GO:0006812	382	0.030
brain development	GO:0007420	247	0.030
positive regulation of protein transport	GO:0051222	41	0.030
positive regulation of phosphorylation	GO:0042327	177	0.030
regulation of cellular ketone metabolic process	GO:0010565	27	0.030
single organism biosynthetic process	GO:0044711	342	0.029
anterior posterior pattern specification	GO:0009952	1	0.029
cellular chemical homeostasis	GO:0055082	247	0.029
protein phosphorylation	GO:0006468	345	0.029
cellular response to oxygen containing compound	GO:1901701	386	0.029
complement activation	GO:0006956	11	0.029
rna biosynthetic process	GO:0032774	380	0.028
gamete generation	GO:0007276	124	0.028
peptidyl amino acid modification	GO:0018193	126	0.028
regulation of plasminogen activation	GO:0010755	2	0.028
transcription from rna polymerase ii promoter	GO:0006366	252	0.028
cellular response to insulin stimulus	GO:0032869	81	0.028
response to peptide hormone	GO:0043434	278	0.027
positive regulation of secretion by cell	GO:1903532	128	0.027
positive regulation of erk1 and erk2 cascade	GO:0070374	29	0.027
response to nutrient	GO:0007584	248	0.027	Rat
regulation of cell proliferation	GO:0042127	359	0.027
regulation of response to wounding	GO:1903034	69	0.027	Rat
response to carbohydrate	GO:0009743	183	0.027
regulation of body fluid levels	GO:0050878	90	0.026
nucleic acid templated transcription	GO:0097659	379	0.026
negative regulation of metabolic process	GO:0009892	331	0.026	Rat Fly
negative regulation of apoptotic process	GO:0043066	181	0.026
response to corticosteroid	GO:0031960	235	0.026
positive regulation of signaling	GO:0023056	270	0.026
positive regulation of secretion	GO:0051047	140	0.025
regulation of heterotypic cell cell adhesion	GO:0034114	2	0.025
response to platinum ion	GO:0070541	4	0.025
regulation of multicellular organismal development	GO:2000026	376	0.024
single organismal cell cell adhesion	GO:0016337	42	0.024
carboxylic acid metabolic process	GO:0019752	289	0.024
regulation of immune system process	GO:0002682	123	0.024	Fly
negative regulation of cell communication	GO:0010648	158	0.024	Fly
negative regulation of protein maturation	GO:1903318	47	0.024	Rat Fly
catabolic process	GO:0009056	351	0.024
positive regulation of phosphate metabolic process	GO:0045937	262	0.023
regulation of protein transport	GO:0051223	68	0.023
erk1 and erk2 cascade	GO:0070371	48	0.023
regulation of protein phosphorylation	GO:0001932	183	0.023
signal transduction by phosphorylation	GO:0023014	144	0.023
cell projection organization	GO:0030030	302	0.023
metal ion transport	GO:0030001	289	0.022
regulation of inflammatory response	GO:0050727	48	0.022	Rat
cofactor metabolic process	GO:0051186	95	0.022
establishment of protein localization	GO:0045184	141	0.022
exocytosis	GO:0006887	60	0.022
single organism catabolic process	GO:0044712	283	0.022
cellular response to nitrogen compound	GO:1901699	210	0.022
cellular carbohydrate metabolic process	GO:0044262	72	0.022
blood circulation	GO:0008015	183	0.022
positive regulation of cell death	GO:0010942	184	0.022
negative regulation of cellular metabolic process	GO:0031324	281	0.022	Rat Fly
secretion	GO:0046903	307	0.022
developmental growth	GO:0048589	100	0.022
response to biotic stimulus	GO:0009607	226	0.022	Fly
single fertilization	GO:0007338	3	0.021
tonic smooth muscle contraction	GO:0014820	4	0.021
regulation of secretion by cell	GO:1903530	208	0.021
positive regulation of cell communication	GO:0010647	271	0.021
regulation of proteolysis	GO:0030162	66	0.021	Rat Fly
liver morphogenesis	GO:0072576	3	0.021
response to metal ion	GO:0010038	253	0.021
chemical homeostasis	GO:0048878	292	0.021
fertilization	GO:0009566	3	0.021
metal ion homeostasis	GO:0055065	186	0.020
response to decreased oxygen levels	GO:0036293	237	0.020
reproduction	GO:0000003	245	0.020	Fly
cellular response to endogenous stimulus	GO:0071495	377	0.020
regulation of serine type peptidase activity	GO:1902571	1	0.020
positive regulation of immune system process	GO:0002684	90	0.020
positive regulation of cellular biosynthetic process	GO:0031328	295	0.020
regulation of ion transport	GO:0043269	245	0.020
cellular response to organonitrogen compound	GO:0071417	197	0.020
small molecule biosynthetic process	GO:0044283	124	0.020
regulation of catalytic activity	GO:0050790	304	0.019	Rat Fly
ion transmembrane transport	GO:0034220	365	0.019
positive regulation of cellular component organization	GO:0051130	200	0.019
sexual reproduction	GO:0019953	148	0.019
negative regulation of catalytic activity	GO:0043086	103	0.019	Rat Fly
negative regulation of fibrinolysis	GO:0051918	2	0.019
single organism carbohydrate metabolic process	GO:0044723	118	0.019
regulation of blood circulation	GO:1903522	110	0.019
spermatogenesis	GO:0007283	99	0.019
organophosphate metabolic process	GO:0019637	370	0.019
negative regulation of multicellular organismal process	GO:0051241	203	0.019
tetrapyrrole metabolic process	GO:0033013	11	0.019
divalent inorganic cation transport	GO:0072511	134	0.019
cellular metal ion homeostasis	GO:0006875	172	0.019
macromolecule catabolic process	GO:0009057	58	0.018
transcription dna templated	GO:0006351	377	0.018
response to hypoxia	GO:0001666	231	0.018
g protein coupled receptor signaling pathway	GO:0007186	242	0.018
calcium ion homeostasis	GO:0055074	162	0.018
heterotypic cell cell adhesion	GO:0034113	2	0.018
regulation of protein modification process	GO:0031399	194	0.018
immune effector process	GO:0002252	53	0.018	Fly
response to vitamin	GO:0033273	131	0.018
oxidation reduction process	GO:0055114	304	0.018
cellular protein complex assembly	GO:0043623	44	0.018
regulation of establishment of protein localization	GO:0070201	69	0.018
positive regulation of apoptotic process	GO:0043065	154	0.018
positive regulation of programmed cell death	GO:0043068	157	0.018
regulation of rna biosynthetic process	GO:2001141	381	0.018
central nervous system development	GO:0007417	311	0.017
secretion by cell	GO:0032940	248	0.017
cell type specific apoptotic process	GO:0097285	134	0.017
response to purine containing compound	GO:0014074	126	0.017
negative regulation of immune system process	GO:0002683	39	0.017
regulation of nucleic acid templated transcription	GO:1903506	380	0.017
ion homeostasis	GO:0050801	212	0.017
response to temperature stimulus	GO:0009266	94	0.017
activation of immune response	GO:0002253	26	0.017
response to organophosphorus	GO:0046683	102	0.017
regulation of protein localization	GO:0032880	81	0.017
cellular response to growth factor stimulus	GO:0071363	162	0.017
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.017
cellular component morphogenesis	GO:0032989	155	0.017
regulation of catabolic process	GO:0009894	113	0.016
protein localization	GO:0008104	191	0.016
circulatory system development	GO:0072359	134	0.016
cellular response to stress	GO:0033554	269	0.016
glycogen metabolic process	GO:0005977	23	0.016
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.016
lipid biosynthetic process	GO:0008610	128	0.016
carbohydrate homeostasis	GO:0033500	75	0.016
positive regulation of gene expression	GO:0010628	244	0.016
response to glucose	GO:0009749	136	0.016
cellular macromolecular complex assembly	GO:0034622	58	0.016
regulation of angiogenesis	GO:0045765	39	0.016
response to external biotic stimulus	GO:0043207	221	0.016	Fly
cellular response to external stimulus	GO:0071496	118	0.016
gonad development	GO:0008406	104	0.015
transmembrane transport	GO:0055085	412	0.015
regulation of cell differentiation	GO:0045595	320	0.015
regulation of transcription dna templated	GO:0006355	374	0.015
lipid localization	GO:0010876	62	0.015
positive regulation of hemostasis	GO:1900048	4	0.015
positive regulation of rna metabolic process	GO:0051254	203	0.015
sulfur compound metabolic process	GO:0006790	70	0.015
coenzyme metabolic process	GO:0006732	86	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.015
response to other organism	GO:0051707	220	0.015	Fly
regulation of cell morphogenesis	GO:0022604	77	0.015
negative regulation of humoral immune response	GO:0002921	4	0.015
negative regulation of developmental process	GO:0051093	125	0.015
tissue development	GO:0009888	252	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.015
peptidyl tyrosine phosphorylation	GO:0018108	72	0.015
extracellular matrix organization	GO:0030198	13	0.015
regulation of coagulation	GO:0050818	11	0.014
regulation of transmembrane transport	GO:0034762	122	0.014
response to lead ion	GO:0010288	33	0.014
glucose homeostasis	GO:0042593	75	0.014
cellular cation homeostasis	GO:0030003	180	0.014
hormone secretion	GO:0046879	115	0.014
cellular response to peptide hormone stimulus	GO:0071375	120	0.014
regulation of erk1 and erk2 cascade	GO:0070372	41	0.014
regulation of anatomical structure size	GO:0090066	135	0.014
cellular response to gonadotropin stimulus	GO:0071371	17	0.014
positive regulation of rna biosynthetic process	GO:1902680	197	0.014
heart morphogenesis	GO:0003007	3	0.014
locomotion	GO:0040011	237	0.014
protein polymerization	GO:0051258	22	0.014
regulation of exocytosis	GO:0017157	37	0.014
cellular response to glucose stimulus	GO:0071333	65	0.014
reproductive process	GO:0022414	372	0.013
intracellular transport	GO:0046907	185	0.013
nucleobase containing small molecule metabolic process	GO:0055086	316	0.013
response to growth factor	GO:0070848	189	0.013
regulation of hydrolase activity	GO:0051336	143	0.013	Rat Fly
male gonad development	GO:0008584	59	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.013
negative regulation of signaling	GO:0023057	157	0.013	Fly
monovalent inorganic cation transport	GO:0015672	172	0.013
positive regulation of blood circulation	GO:1903524	65	0.013
regulation of cell adhesion	GO:0030155	52	0.013	Rat
regulation of defense response	GO:0031347	68	0.013	Rat
hormone transport	GO:0009914	121	0.013
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.013
cellular modified amino acid metabolic process	GO:0006575	61	0.013
vesicle mediated transport	GO:0016192	181	0.012
glycerolipid metabolic process	GO:0046486	67	0.012
single organism cellular localization	GO:1902580	102	0.012
regulation of wound healing	GO:0061041	14	0.012
embryonic axis specification	GO:0000578	1	0.012
regulation of acute inflammatory response	GO:0002673	23	0.012
response to heat	GO:0009408	60	0.012
lipid metabolic process	GO:0006629	283	0.012
hepaticobiliary system development	GO:0061008	90	0.012
acute inflammatory response	GO:0002526	58	0.012
response to toxic substance	GO:0009636	133	0.012
negative regulation of cellular component organization	GO:0051129	83	0.012
detection of visible light	GO:0009584	3	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.012
regulation of membrane potential	GO:0042391	110	0.012
regulation of cell projection organization	GO:0031344	175	0.012
vasoconstriction	GO:0042310	54	0.012
positive regulation of cellular protein metabolic process	GO:0032270	167	0.012
regulation of blood vessel size	GO:0050880	89	0.012
vasculature development	GO:0001944	70	0.012
regulation of cell cell adhesion	GO:0022407	14	0.012
positive regulation of cell development	GO:0010720	176	0.012
response to nutrient levels	GO:0031667	370	0.012	Rat
behavior	GO:0007610	205	0.012
neuron projection development	GO:0031175	273	0.012
response to triglyceride	GO:0034014	3	0.012
lipid transport	GO:0006869	61	0.011
chemosensory behavior	GO:0007635	2	0.011
protein heterooligomerization	GO:0051291	89	0.011
response to activity	GO:0014823	73	0.011
regulation of secretion	GO:0051046	224	0.011
small molecule catabolic process	GO:0044282	59	0.011
lymphocyte mediated immunity	GO:0002449	14	0.011
sodium ion transport	GO:0006814	82	0.011
carbohydrate derivative metabolic process	GO:1901135	346	0.011
cell morphogenesis involved in differentiation	GO:0000904	119	0.011
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.011
positive regulation of protein modification process	GO:0031401	142	0.011
regulation of nervous system development	GO:0051960	264	0.011
negative regulation of response to stimulus	GO:0048585	155	0.011	Rat Fly
regulation of metal ion transport	GO:0010959	118	0.011
regulation of calcium ion transport	GO:0051924	77	0.011
cellular response to peptide	GO:1901653	133	0.011
cytolysis	GO:0019835	4	0.011
endothelial cell apoptotic process	GO:0072577	3	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011
urea cycle	GO:0000050	5	0.011
gastrulation	GO:0007369	2	0.011
neurological system process	GO:0050877	219	0.011
vascular process in circulatory system	GO:0003018	96	0.011
regulation of neuron projection development	GO:0010975	161	0.011
respiratory tube development	GO:0030323	43	0.011
cellular sodium ion homeostasis	GO:0006883	4	0.011
regulation of smooth muscle cell proliferation	GO:0048660	75	0.011
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.011
response to mineralocorticoid	GO:0051385	49	0.011
positive regulation of extracellular matrix constituent secretion	GO:0003331	2	0.010
response to oxidative stress	GO:0006979	186	0.010
single organism intracellular transport	GO:1902582	166	0.010
peptidyl tyrosine modification	GO:0018212	72	0.010
organelle organization	GO:0006996	266	0.010
cgmp biosynthetic process	GO:0006182	15	0.010
embryonic pattern specification	GO:0009880	1	0.010
male gamete generation	GO:0048232	99	0.010
glial cell differentiation	GO:0010001	65	0.010
innate immune response	GO:0045087	35	0.010
alcohol metabolic process	GO:0006066	77	0.010
cellular macromolecule localization	GO:0070727	122	0.010
amide biosynthetic process	GO:0043604	10	0.010
response to transition metal nanoparticle	GO:1990267	122	0.010
regulation of behavior	GO:0050795	61	0.010
cellular calcium ion homeostasis	GO:0006874	160	0.010
regulation of cell development	GO:0060284	263	0.010
gliogenesis	GO:0042063	93	0.010
positive regulation of transcription factor import into nucleus	GO:0042993	4	0.010
regulation of neurogenesis	GO:0050767	247	0.010
positive regulation of biosynthetic process	GO:0009891	319	0.010
cellular response to carbohydrate stimulus	GO:0071322	72	0.010

Serpina10 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
immune system disease	DOID:2914	0.162
hematopoietic system disease	DOID:74	0.162
disease of anatomical entity	DOID:7	0.162
inherited blood coagulation disease	DOID:2214	0.162
blood coagulation disease	DOID:1247	0.162
inherited metabolic disorder	DOID:655	0.044
disease of metabolism	DOID:0014667	0.044
disease of cellular proliferation	DOID:14566	0.017
organ system cancer	DOID:0050686	0.015
cancer	DOID:162	0.015
musculoskeletal system disease	DOID:17	0.013
cardiovascular system disease	DOID:1287	0.011
acquired metabolic disease	DOID:0060158	0.011
gastrointestinal system cancer	DOID:3119	0.010

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