Rattus norvegicus

47 known processes

Hmgcl

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

Hmgcl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
lipid modificationGO:0030258520.346
lipid oxidationGO:0034440300.311
oxoacid metabolic processGO:00434362900.232
fatty acid beta oxidationGO:0006635220.160
monocarboxylic acid metabolic processGO:00327871520.154
single organism biosynthetic processGO:00447113420.133
carboxylic acid metabolic processGO:00197522890.133
organic acid metabolic processGO:00060822920.122
cofactor metabolic processGO:0051186950.116
small molecule catabolic processGO:0044282590.116
catabolic processGO:00090563510.112
single organism catabolic processGO:00447122830.100
monocarboxylic acid catabolic processGO:0072329280.096
cellular lipid catabolic processGO:0044242370.092
lipid metabolic processGO:00066292830.082
cellular lipid metabolic processGO:00442552080.080
lipid catabolic processGO:0016042460.079
oxidation reduction processGO:00551143040.077
cellular catabolic processGO:00442482950.073
coenzyme metabolic processGO:0006732860.071
regulation of molecular functionGO:00650093980.067
organophosphate metabolic processGO:00196373700.065
fatty acid oxidationGO:0019395290.064
fatty acid metabolic processGO:0006631990.052
organic substance catabolic processGO:19015753160.049
organic acid catabolic processGO:0016054490.047
response to oxygen levelsGO:00704822650.042
cellular ketone metabolic processGO:0042180510.041
regulation of cellular ketone metabolic processGO:0010565270.040
programmed cell deathGO:00125013920.038
cellular amino acid metabolic processGO:00065201070.038
regulation of cell projection organizationGO:00313441750.037
organelle organizationGO:00069962660.036
carboxylic acid catabolic processGO:0046395490.036
nucleoside phosphate metabolic processGO:00067532830.036
fatty acid catabolic processGO:0009062260.035
response to nutrientGO:00075842480.035
positive regulation of multicellular organismal processGO:00512403870.035
neuron differentiationGO:00301823680.034
response to nutrient levelsGO:00316673700.033
regulation of multicellular organismal developmentGO:20000263760.032
cellular response to oxygen containing compoundGO:19017013860.032
gland developmentGO:00487321550.032
regulation of catalytic activityGO:00507903040.031
reproductive processGO:00224143720.031
neuron projection developmentGO:00311752730.030
response to peptideGO:19016522920.029
cell projection organizationGO:00300303020.029
regulation of programmed cell deathGO:00430673410.029
regulation of nervous system developmentGO:00519602640.028
cellular response to nitrogen compoundGO:19016992100.028
nucleobase containing small molecule metabolic processGO:00550863160.027
cellular response to hormone stimulusGO:00328702470.027
positive regulation of developmental processGO:00510942830.027
response to glucocorticoidGO:00513842230.026
steroid metabolic processGO:0008202730.026
transcription dna templatedGO:00063513770.026
cellular response to organonitrogen compoundGO:00714171970.025
regulation of cell differentiationGO:00455953200.025
regulation of phosphorus metabolic processGO:00511743490.025
cellular component assemblyGO:00226073600.025
Human
lipid biosynthetic processGO:00086101280.025
organic acid biosynthetic processGO:0016053830.025
brain developmentGO:00074202470.024
regulation of cellular amino acid metabolic processGO:000652120.023
positive regulation of molecular functionGO:00440932300.023
cellular response to endogenous stimulusGO:00714953770.023
cation homeostasisGO:00550801950.023
regulation of neurogenesisGO:00507672470.023
carboxylic acid biosynthetic processGO:0046394830.023
neuron developmentGO:00486662860.023
cellular amine metabolic processGO:0044106380.023
regulation of cell developmentGO:00602842630.023
carbohydrate derivative metabolic processGO:19011353460.023
ion homeostasisGO:00508012120.023
cellular response to stressGO:00335542690.022
multi organism reproductive processGO:00447032620.022
regulation of apoptotic processGO:00429813350.022
response to extracellular stimulusGO:00099913800.022
negative regulation of protein metabolic processGO:00512481140.022
response to peptide hormoneGO:00434342780.022
metal ion homeostasisGO:00550651860.022
chemical homeostasisGO:00488782920.021
regulation of neuron differentiationGO:00456642080.021
positive regulation of cellular biosynthetic processGO:00313282950.021
response to decreased oxygen levelsGO:00362932370.021
response to cytokineGO:00340972150.021
regulation of protein metabolic processGO:00512462890.021
regulation of phosphorylationGO:00423252480.021
developmental process involved in reproductionGO:00030061590.021
immune system processGO:00023762040.020
regulation of nucleic acid templated transcriptionGO:19035063800.020
positive regulation of transportGO:00510502450.020
negative regulation of nitrogen compound metabolic processGO:00511721610.020
central nervous system developmentGO:00074173110.020
negative regulation of metabolic processGO:00098923310.020
nucleotide metabolic processGO:00091172790.019
reactive nitrogen species metabolic processGO:200105710.019
rna biosynthetic processGO:00327743800.019
negative regulation of programmed cell deathGO:00430691830.019
rna metabolic processGO:00160704060.019
regulation of phosphate metabolic processGO:00192203490.019
head developmentGO:00603222470.019
homeostatic processGO:00425923310.019
anion transportGO:00068201780.019
macromolecular complex subunit organizationGO:00439333390.019
Human
positive regulation of cell differentiationGO:00455972170.019
cellular component biogenesisGO:00440853680.019
Human
cellular chemical homeostasisGO:00550822470.019
negative regulation of signalingGO:00230571570.018
apoptotic processGO:00069153810.018
ion transmembrane transportGO:00342203650.018
reproductionGO:00000032450.018
intracellular signal transductionGO:00355563140.018
regulation of neuron projection developmentGO:00109751610.018
single organism organelle organizationGO:19025891800.018
organonitrogen compound biosynthetic processGO:19015661670.018
response to ketoneGO:19016541820.018
regulation of cellular amine metabolic processGO:003323880.018
regulation of cellular protein metabolic processGO:00322682670.017
thioester metabolic processGO:0035383280.017
negative regulation of cellular protein metabolic processGO:00322691060.017
cellular response to organic cyclic compoundGO:00714072020.017
protein phosphorylationGO:00064683450.017
positive regulation of biosynthetic processGO:00098913190.017
positive regulation of cellular amine metabolic processGO:003324030.017
negative regulation of biosynthetic processGO:00098901680.017
amine metabolic processGO:0009308380.017
regulation of rna biosynthetic processGO:20011413810.017
response to external biotic stimulusGO:00432072210.017
regulation of hormone levelsGO:00108171870.017
positive regulation of catalytic activityGO:00430851840.016
response to glucoseGO:00097491360.016
positive regulation of response to stimulusGO:00485842850.016
hematopoietic progenitor cell differentiationGO:000224420.016
intracellular transportGO:00469071850.016
multicellular organism reproductionGO:00325042330.016
response to inorganic substanceGO:00100353770.016
positive regulation of neurogenesisGO:00507691650.016
response to vitaminGO:00332731310.016
negative regulation of apoptotic processGO:00430661810.016
purine containing compound metabolic processGO:00725212530.016
transmembrane transportGO:00550854120.016
cation transportGO:00068123820.016
metal ion transportGO:00300012890.016
negative regulation of cellular metabolic processGO:00313242810.016
cellular metal ion homeostasisGO:00068751720.015
steroid biosynthetic processGO:0006694480.015
response to hypoxiaGO:00016662310.015
regulation of catabolic processGO:00098941130.015
multicellular organismal reproductive processGO:00486092330.015
positive regulation of cell motilityGO:2000147970.015
cellular cation homeostasisGO:00300031800.015
regulation of cellular localizationGO:00603412630.015
cellular response to peptide hormone stimulusGO:00713751200.015
organophosphate biosynthetic processGO:00904071430.015
gamete generationGO:00072761240.015
negative regulation of cell communicationGO:00106481580.015
positive regulation of phosphorus metabolic processGO:00105622620.015
regulation of intracellular signal transductionGO:19025312180.015
response to hexoseGO:00097461440.015
positive regulation of neuron projection developmentGO:0010976990.015
sexual reproductionGO:00199531480.014
positive regulation of phosphate metabolic processGO:00459372620.014
regenerationGO:00310991630.014
negative regulation of gene expressionGO:00106291990.014
response to radiationGO:00093141370.014
cellular homeostasisGO:00197252520.014
organic acid transportGO:00158491160.014
carbohydrate metabolic processGO:00059751300.014
negative regulation of macromolecule biosynthetic processGO:00105581480.014
regulation of transcription dna templatedGO:00063553740.014
purine nucleotide metabolic processGO:00061632290.014
negative regulation of macromolecule metabolic processGO:00106052600.014
protein localizationGO:00081041910.014
regulation of hydrolase activityGO:00513361430.014
protein complex assemblyGO:00064612630.014
Human
protein oligomerizationGO:00512591910.014
Human
nucleic acid templated transcriptionGO:00976593790.014
negative regulation of neurogenesisGO:0050768780.014
small molecule biosynthetic processGO:00442831240.014
regulation of cellular component organizationGO:00511283680.014
positive regulation of cell communicationGO:00106472710.014
positive regulation of cellular component organizationGO:00511302000.014
response to reactive oxygen speciesGO:00003021200.013
regulation of homeostatic processGO:00328441010.013
positive regulation of cell developmentGO:00107201760.013
tissue developmentGO:00098882520.013
secretionGO:00469033070.013
regulation of signal transductionGO:00099663180.013
nucleoside phosphate biosynthetic processGO:19012931020.013
negative regulation of cell proliferationGO:00082851190.013
coenzyme biosynthetic processGO:0009108220.013
divalent inorganic cation homeostasisGO:00725071650.013
hepaticobiliary system developmentGO:0061008900.013
response to mechanical stimulusGO:00096121340.013
cellular response to peptideGO:19016531330.013
cellular protein localizationGO:00346131220.013
single organism reproductive processGO:00447022970.013
regulation of kinase activityGO:00435491170.013
response to biotic stimulusGO:00096072260.013
regulation of rna metabolic processGO:00512523910.013
regulation of cell proliferationGO:00421273590.013
negative regulation of nervous system developmentGO:0051961790.013
positive regulation of cell proliferationGO:00082842490.013
carbohydrate derivative biosynthetic processGO:19011371240.013
peptidyl amino acid modificationGO:00181931260.012
response to bacteriumGO:00096172000.012
cellular ion homeostasisGO:00068731840.012
positive regulation of phosphorylationGO:00423271770.012
blood circulationGO:00080151830.012
cellular component movementGO:00069282480.012
alpha amino acid metabolic processGO:1901605710.012
regulation of protein phosphorylationGO:00019321830.012
response to corticosteroidGO:00319602350.012
growthGO:00400071650.012
response to estrogenGO:00436272320.012
regulation of cellular catabolic processGO:00313291010.012
cellular response to cytokine stimulusGO:00713451270.012
organic anion transportGO:00157111320.012
nitrogen compound transportGO:00717052290.012
defense responseGO:00069521940.012
regulation of protein kinase activityGO:00458591050.012
response to metal ionGO:00100382530.012
carboxylic acid transportGO:00469421150.012
development of primary sexual characteristicsGO:00451371070.012
purine ribonucleotide metabolic processGO:00091502270.012
reactive oxygen species metabolic processGO:0072593370.012
female pregnancyGO:00075651220.012
response to molecule of bacterial originGO:00022371940.012
regulation of protein modification processGO:00313991940.012
macromolecule localizationGO:00330362520.012
negative regulation of catalytic activityGO:00430861030.012
protein complex biogenesisGO:00702712630.012
Human
lymphoid progenitor cell differentiationGO:000232020.012
neurological system processGO:00508772190.012
negative regulation of molecular functionGO:00440921330.011
response to transition metal nanoparticleGO:19902671220.011
agingGO:00075682410.011
nucleotide biosynthetic processGO:0009165980.011
positive regulation of nitrogen compound metabolic processGO:00511733340.011
negative regulation of cell developmentGO:0010721820.011
positive regulation of cellular amino acid metabolic processGO:004576410.011
ribonucleoside metabolic processGO:00091191740.011
regulation of blood pressureGO:0008217830.011
axon developmentGO:0061564960.011
divalent inorganic cation transportGO:00725111340.011
positive regulation of nervous system developmentGO:00519621780.011
negative regulation of phosphorus metabolic processGO:0010563800.011
acetyl coa metabolic processGO:0006084170.011
negative regulation of secretionGO:0051048820.011
pteridine containing compound metabolic processGO:0042558140.011
mitochondrion organizationGO:0007005350.011
pyridine containing compound metabolic processGO:0072524320.011
response to monosaccharideGO:00342841590.011
positive regulation of cellular protein metabolic processGO:00322701670.011
purine nucleotide biosynthetic processGO:0006164830.011
carbohydrate derivative catabolic processGO:19011361470.011
protein complex subunit organizationGO:00718223020.011
Human
response to insulinGO:00328681330.011
calcium ion homeostasisGO:00550741620.011
carbohydrate catabolic processGO:0016052400.011
cellular response to alcoholGO:0097306870.010
nicotinamide nucleotide metabolic processGO:0046496280.010
heterocycle catabolic processGO:00467001670.010
chromosome segregationGO:000705920.010
negative regulation of signal transductionGO:0009968830.010
localization of cellGO:00516742020.010
kidney developmentGO:0001822670.010
g protein coupled receptor signaling pathwayGO:00071862420.010
spermatogenesisGO:0007283990.010
cofactor biosynthetic processGO:0051188280.010

Hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.026
inherited metabolic disorderDOID:65500.026
nervous system diseaseDOID:86300.018
disease of anatomical entityDOID:700.018
disease of cellular proliferationDOID:1456600.012
sensory system diseaseDOID:005015500.010