Rattus norvegicus

254 known processes

Hmgcr

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

(Aliases: 3H3M)

Hmgcr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cholesterol metabolic processGO:0008203170.781
lipid biosynthetic processGO:00086101280.776
alcohol biosynthetic processGO:0046165380.773
steroid metabolic processGO:0008202730.571
lipid metabolic processGO:00066292830.538
single organism biosynthetic processGO:00447113420.490
cellular response to oxygen containing compoundGO:19017013860.454
steroid biosynthetic processGO:0006694480.406
sterol metabolic processGO:0016125180.394
cellular response to fatty acidGO:0071398290.319
cellular lipid metabolic processGO:00442552080.313
cellular response to nitrogen compoundGO:19016992100.301
hepaticobiliary system developmentGO:0061008900.299
cellular response to peptideGO:19016531330.297
cellular response to alcoholGO:0097306870.294
response to triglycerideGO:003401430.235
response to molecule of bacterial originGO:00022371940.229
cellular response to gonadotropin stimulusGO:0071371170.228
response to temperature stimulusGO:0009266940.226
gonad developmentGO:00084061040.200
response to fatty acidGO:0070542650.192
regulation of cholesterol metabolic processGO:009018150.180
response to metal ionGO:00100382530.179
cellular response to lipidGO:00713962010.165
cellular response to organic cyclic compoundGO:00714072020.159
tube developmentGO:0035295890.154
growthGO:00400071650.135
response to extracellular stimulusGO:00099913800.134
cellular ketone body metabolic processGO:004695040.133
cellular response to insulin stimulusGO:0032869810.128
response to organophosphorusGO:00466831020.126
cellular response to organonitrogen compoundGO:00714171970.121
response to ketoneGO:19016541820.114
cellular response to molecule of bacterial originGO:0071219560.110
liver developmentGO:0001889900.102
response to acid chemicalGO:00011012220.101
response to peptideGO:19016522920.095
organic hydroxy compound metabolic processGO:19016151150.092
response to nutrientGO:00075842480.092
cellular response to cholesterolGO:007139790.090
cellular response to peptide hormone stimulusGO:00713751200.089
intracellular signal transductionGO:00355563140.084
head developmentGO:00603222470.084
cellular response to follicle stimulating hormone stimulusGO:0071372130.083
brain developmentGO:00074202470.078
urogenital system developmentGO:0001655780.077
protein complex subunit organizationGO:00718223020.069
coenzyme metabolic processGO:0006732860.065
response to linoleic acidGO:007054330.065
cellular response to hormone stimulusGO:00328702470.061
demethylationGO:007098870.060
cholesterol biosynthetic processGO:0006695100.059
response to starvationGO:0042594590.059
cellular response to stressGO:00335542690.059
small molecule biosynthetic processGO:00442831240.059
secretionGO:00469033070.058
response to monosaccharideGO:00342841590.058
regulation of fatty acid transportGO:2000191100.055
positive regulation of transcription from rna polymerase ii promoter in response to stressGO:003600330.054
regulation of apoptotic processGO:00429813350.054
central nervous system developmentGO:00074173110.054
anatomical structure morphogenesisGO:00096532980.053
response to cholesterolGO:0070723130.053
response to nutrient levelsGO:00316673700.051
response to oxygen levelsGO:00704822650.051
cellular response to lipopolysaccharideGO:0071222550.051
protein complex biogenesisGO:00702712630.051
positive regulation of cell growthGO:0030307440.051
response to inorganic substanceGO:00100353770.050
monocarboxylic acid metabolic processGO:00327871520.050
tissue developmentGO:00098882520.049
response to cytokineGO:00340972150.048
regulation of multicellular organismal developmentGO:20000263760.048
response to insulinGO:00328681330.047
positive regulation of programmed cell deathGO:00430681570.046
metanephric epithelium developmentGO:007220740.045
positive regulation of multicellular organismal processGO:00512403870.044
single organism reproductive processGO:00447022970.041
regulation of developmental growthGO:0048638450.040
macromolecular complex assemblyGO:00650032730.040
sterol homeostasisGO:005509230.039
organic acid metabolic processGO:00060822920.039
cellular response to endogenous stimulusGO:00714953770.039
nucleic acid templated transcriptionGO:00976593790.039
regulation of phosphate metabolic processGO:00192203490.039
neuron differentiationGO:00301823680.039
alcohol metabolic processGO:0006066770.038
midgut developmentGO:0007494130.036
amine metabolic processGO:0009308380.036
response to biotic stimulusGO:00096072260.036
cellular component assemblyGO:00226073600.036
response to corticosteroidGO:00319602350.034
cellular amine metabolic processGO:0044106380.034
regulation of secretionGO:00510462240.033
neuron developmentGO:00486662860.033
organic anion transportGO:00157111320.033
positive regulation of biosynthetic processGO:00098913190.033
regulation of cell differentiationGO:00455953200.033
regulation of cell developmentGO:00602842630.033
response to testosteroneGO:0033574550.032
regulation of molecular functionGO:00650093980.032
response to carbohydrateGO:00097431830.031
isoprenoid metabolic processGO:0006720450.030
reproductive structure developmentGO:00486081280.030
rna biosynthetic processGO:00327743800.030
lipid localizationGO:0010876620.030
positive regulation of signalingGO:00230562700.029
protein autophosphorylationGO:0046777660.028
cellular response to steroid hormone stimulusGO:0071383930.028
regulation of cellular amine metabolic processGO:003323880.028
regulation of rna biosynthetic processGO:20011413810.028
signal transduction by phosphorylationGO:00230141440.028
cellular response to biotic stimulusGO:0071216590.028
negative regulation of molecular functionGO:00440921330.028
respiratory system developmentGO:0060541450.028
response to purine containing compoundGO:00140741260.027
response to peptide hormoneGO:00434342780.027
regulation of cellular component organizationGO:00511283680.027
reproductionGO:00000032450.026
cellular component biogenesisGO:00440853680.026
cation transmembrane transportGO:00986552630.026
response to interleukin 15GO:007067240.026
regulation of signal transductionGO:00099663180.026
macromolecular complex subunit organizationGO:00439333390.025
metal ion transportGO:00300012890.025
cellular response to acid chemicalGO:0071229750.025
reproductive processGO:00224143720.025
positive regulation of cell developmentGO:00107201760.024
erythrocyte differentiationGO:003021810.024
cell morphogenesisGO:00009021420.024
ras protein signal transductionGO:0007265290.024
single organism organelle organizationGO:19025891800.024
response to other organismGO:00517072200.024
protein phosphorylationGO:00064683450.023
regulation of response to stressGO:00801341260.023
nucleobase containing small molecule metabolic processGO:00550863160.023
regulation of hormone secretionGO:00468831060.023
response to hypoxiaGO:00016662310.023
positive regulation of transportGO:00510502450.023
response to estrogenGO:00436272320.023
organophosphate catabolic processGO:00464341480.023
positive regulation of cell deathGO:00109421840.022
cation transportGO:00068123820.022
fatty acid metabolic processGO:0006631990.022
isoprenoid biosynthetic processGO:0008299120.022
regulation of synaptic transmissionGO:00508041410.022
icosanoid metabolic processGO:0006690380.022
regulation of neuron projection developmentGO:00109751610.022
catabolic processGO:00090563510.022
response to amino acidGO:0043200750.022
positive regulation of secretionGO:00510471400.022
rna metabolic processGO:00160704060.021
organic acid biosynthetic processGO:0016053830.021
cell projection organizationGO:00300303020.021
programmed cell deathGO:00125013920.021
inorganic ion transmembrane transportGO:00986602290.021
neuron projection developmentGO:00311752730.021
apoptotic processGO:00069153810.021
transcription dna templatedGO:00063513770.021
organelle organizationGO:00069962660.020
organic substance catabolic processGO:19015753160.020
response to woundingGO:00096112540.020
single organism catabolic processGO:00447122830.020
multicellular organismal reproductive processGO:00486092330.020
circulatory system developmentGO:00723591340.020
carbohydrate homeostasisGO:0033500750.020
response to interleukin 1GO:0070555550.020
reproductive system developmentGO:00614581280.020
cellular catabolic processGO:00442482950.020
positive regulation of cellular component organizationGO:00511302000.019
regulation of cellular ketone metabolic processGO:0010565270.019
positive regulation of apoptotic processGO:00430651540.019
regulation of system processGO:00440572080.019
anion transportGO:00068201780.019
regulation of bmp signaling pathwayGO:003051020.019
regulation of programmed cell deathGO:00430673410.019
positive regulation of cell differentiationGO:00455972170.019
regulation of intracellular signal transductionGO:19025312180.019
lipid transportGO:0006869610.019
positive regulation of developmental processGO:00510942830.019
response to campGO:0051591910.019
negative regulation of cell deathGO:00605482290.018
cellular amino acid metabolic processGO:00065201070.018
cellular response to cytokine stimulusGO:00713451270.018
regulation of rna metabolic processGO:00512523910.018
cellular response to external stimulusGO:00714961180.018
protein complex assemblyGO:00064612630.018
response to vitaminGO:00332731310.018
monovalent inorganic cation transportGO:00156721720.018
hormone secretionGO:00468791150.018
positive regulation of nitrogen compound metabolic processGO:00511733340.017
transmembrane transportGO:00550854120.017
positive regulation of cellular amine metabolic processGO:003324030.017
endocytosisGO:0006897840.017
carboxylic acid metabolic processGO:00197522890.017
negative regulation of developmental processGO:00510931250.017
multicellular organism reproductionGO:00325042330.017
cellular amino acid biosynthetic processGO:0008652320.017
reactive oxygen species biosynthetic processGO:190340980.017
response to external biotic stimulusGO:00432072210.017
response to lipopolysaccharideGO:00324961910.016
response to estradiolGO:00323551640.016
response to sterolGO:0036314130.016
macromolecule localizationGO:00330362520.016
negative regulation of multicellular organismal processGO:00512412030.016
nucleoside triphosphate metabolic processGO:00091411440.016
immune system processGO:00023762040.016
circulatory system processGO:00030131830.016
cellular chemical homeostasisGO:00550822470.016
cytoskeleton organizationGO:00070101110.016
cellular homeostasisGO:00197252520.016
regulation of transferase activityGO:00513381230.016
regulation of cellular localizationGO:00603412630.016
bmp signaling pathwayGO:003050940.016
organophosphate metabolic processGO:00196373700.015
regulation of nucleic acid templated transcriptionGO:19035063800.015
transcription from rna polymerase ii promoterGO:00063662520.015
response to follicle stimulating hormoneGO:0032354180.015
regulation of ion transportGO:00432692450.015
cellular response to extracellular stimulusGO:0031668730.015
embryonic pattern specificationGO:000988010.015
multicellular organism growthGO:003526410.015
g protein coupled receptor signaling pathwayGO:00071862420.015
inorganic cation transmembrane transportGO:00986622020.015
regulation of cellular amino acid metabolic processGO:000652120.015
negative regulation of metabolic processGO:00098923310.015
regulation of transcription dna templatedGO:00063553740.015
short chain fatty acid biosynthetic processGO:005179020.014
signal releaseGO:00230611450.014
acetate metabolic processGO:000608320.014
gland developmentGO:00487321550.014
purine nucleotide metabolic processGO:00061632290.014
monocarboxylic acid transportGO:0015718520.014
digestive tract developmentGO:0048565390.014
regulation of anatomical structure morphogenesisGO:00226031410.014
regulation of cell projection organizationGO:00313441750.014
negative regulation of apoptotic processGO:00430661810.014
regulation of lipid biosynthetic processGO:0046890380.014
positive regulation of cellular biosynthetic processGO:00313282950.014
response to radiationGO:00093141370.014
negative regulation of cell proliferationGO:00082851190.014
synaptic transmissionGO:00072682350.014
homeostatic processGO:00425923310.014
nucleotide metabolic processGO:00091172790.014
acid secretionGO:0046717480.014
regulation of hormone levelsGO:00108171870.014
positive regulation of hydrolase activityGO:0051345860.013
locomotionGO:00400112370.013
response to decreased oxygen levelsGO:00362932370.013
enzyme linked receptor protein signaling pathwayGO:00071671160.013
actin filament based processGO:0030029860.013
peptide hormone secretionGO:0030072840.013
response to bacteriumGO:00096172000.013
dendrite developmentGO:0016358720.013
carbohydrate derivative metabolic processGO:19011353460.013
organic acid transportGO:00158491160.013
positive regulation of macromolecule biosynthetic processGO:00105572470.013
regulation of lipid metabolic processGO:0019216680.013
oxidation reduction processGO:00551143040.013
developmental process involved in reproductionGO:00030061590.013
muscle system processGO:00030121150.013
regulation of arp2 3 complex mediated actin nucleationGO:003431520.013
striated muscle tissue developmentGO:0014706580.013
regulation of homeostatic processGO:00328441010.013
positive regulation of molecular functionGO:00440932300.013
ribose phosphate metabolic processGO:00196932350.013
cellular response to ketoneGO:1901655510.013
small gtpase mediated signal transductionGO:0007264360.013
cellular ketone metabolic processGO:0042180510.013
mammary gland epithelium developmentGO:006118010.013
peptide secretionGO:0002790860.013
membrane organizationGO:0061024940.012
lung developmentGO:0030324430.012
cellular component morphogenesisGO:00329891550.012
hemopoiesisGO:0030097340.012
regulation of phosphorylationGO:00423252480.012
positive regulation of protein metabolic processGO:00512471780.012
nitrogen compound transportGO:00717052290.012
negative regulation of cell communicationGO:00106481580.012
positive regulation of phosphate metabolic processGO:00459372620.012
nucleoside phosphate metabolic processGO:00067532830.012
organophosphate biosynthetic processGO:00904071430.012
metanephric nephron tubule developmentGO:007223430.012
muscle contractionGO:0006936880.012
oxoacid metabolic processGO:00434362900.012
adipose tissue developmentGO:006061260.012
hormone transportGO:00099141210.012
neuron deathGO:00709971270.012
chemical homeostasisGO:00488782920.012
carbohydrate derivative biosynthetic processGO:19011371240.012
heart morphogenesisGO:000300730.012
regulation of cell morphogenesisGO:0022604770.012
negative regulation of ion transportGO:0043271510.012
cell cycleGO:00070491010.012
regulation of cholesterol biosynthetic processGO:004554040.012
regulation of cytokine productionGO:0001817560.012
response to ethanolGO:00454711620.012
regulation of protein metabolic processGO:00512462890.012
response to hexoseGO:00097461440.011
cellular metal ion homeostasisGO:00068751720.011
purine containing compound metabolic processGO:00725212530.011
positive regulation of protein phosphorylationGO:00019341350.011
respiratory tube developmentGO:0030323430.011
b cell differentiationGO:003018320.011
regulation of phosphorus metabolic processGO:00511743490.011
regulation of cellular protein metabolic processGO:00322682670.011
regulation of synaptic plasticityGO:0048167700.011
regulation of reactive oxygen species biosynthetic processGO:190342650.011
ion transmembrane transportGO:00342203650.011
regulation of nervous system developmentGO:00519602640.011
microtubule based processGO:0007017360.011
organic hydroxy compound biosynthetic processGO:1901617510.011
response to alkaloidGO:00432791320.011
positive regulation of cellular amino acid metabolic processGO:004576410.011
negative regulation of rna metabolic processGO:00512531230.011
regulation of cell growthGO:0001558850.011
wound healingGO:00420601220.011
response to lipoprotein particleGO:005509480.011
axis specificationGO:000979840.011
purine nucleoside metabolic processGO:00422781690.011
cell cell signalingGO:00072673350.011
response to glucocorticoidGO:00513842230.011
glucose homeostasisGO:0042593750.011
regulation of organic acid transportGO:0032890350.011
regulation of cell proliferationGO:00421273590.011
regulation of vesicle mediated transportGO:0060627810.011
chromosome segregationGO:000705920.011
regulation of insulin secretionGO:0050796650.011
potassium ion transmembrane transportGO:0071805710.011
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.011
protein oligomerizationGO:00512591910.011
gliogenesisGO:0042063930.011
female pregnancyGO:00075651220.011
regulation of protein serine threonine kinase activityGO:0071900640.010
prostaglandin transportGO:001573280.010
regulation of neuron differentiationGO:00456642080.010
glycerolipid metabolic processGO:0046486670.010
protein homooligomerizationGO:0051260910.010
negative regulation of mitotic cell cycle phase transitionGO:190199130.010
centrosome cycleGO:000709810.010
response to stilbenoidGO:003563410.010
response to hydrogen peroxideGO:0042542890.010
single organism behaviorGO:00447081300.010
mechanoreceptor differentiationGO:004249020.010
regulation of reactive oxygen species metabolic processGO:2000377260.010
reactive nitrogen species metabolic processGO:200105710.010
thioester metabolic processGO:0035383280.010
positive regulation of catalytic activityGO:00430851840.010
positive regulation of ion transportGO:0043270940.010
multi organism reproductive processGO:00447032620.010
regulation of hydrolase activityGO:00513361430.010
mitotic spindle organizationGO:000705220.010
regulation of cell motilityGO:20001451310.010
protein heterooligomerizationGO:0051291890.010
negative regulation of catalytic activityGO:00430861030.010

Hmgcr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
intellectual disabilityDOID:105900.046
specific developmental disorderDOID:006003800.046
non specific x linked mental retardationDOID:005077600.046
developmental disorder of mental healthDOID:006003700.046
disease of mental healthDOID:15000.046
non syndromic intellectual disabilityDOID:005088900.046
nervous system diseaseDOID:86300.012
disease of anatomical entityDOID:700.012
disease of metabolismDOID:001466700.011
disease of cellular proliferationDOID:1456600.010