Rattus norvegicus

186 known processes

Parp1

poly (ADP-ribose) polymerase 1

(Aliases: MGC93658,Parp-1,Adprt)

Parp1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of transcription dna templatedGO:00063553740.476
rna metabolic processGO:00160704060.426
rna biosynthetic processGO:00327743800.335
transcription dna templatedGO:00063513770.284
oxoacid metabolic processGO:00434362900.282
regulation of nucleic acid templated transcriptionGO:19035063800.280
regulation of rna biosynthetic processGO:20011413810.261
regulation of rna metabolic processGO:00512523910.256
macromolecular complex subunit organizationGO:00439333390.247
nucleic acid templated transcriptionGO:00976593790.246
transcription from rna polymerase ii promoterGO:00063662520.220
regulation of multicellular organismal developmentGO:20000263760.171
regulation of cellular component organizationGO:00511283680.162
organelle organizationGO:00069962660.153
Mouse
cellular amino acid metabolic processGO:00065201070.142
organic acid metabolic processGO:00060822920.137
macromolecular complex assemblyGO:00650032730.135
carboxylic acid metabolic processGO:00197522890.119
negative regulation of rna biosynthetic processGO:19026791180.112
chromosome organizationGO:0051276360.112
Mouse
regulation of programmed cell deathGO:00430673410.111
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.110
negative regulation of metabolic processGO:00098923310.110
cellular response to stressGO:00335542690.106
regulation of transcription from rna polymerase ii promoterGO:00063572340.103
positive regulation of rna biosynthetic processGO:19026801970.100
cellular component biogenesisGO:00440853680.100
negative regulation of transcription dna templatedGO:00458921160.100
negative regulation of cellular metabolic processGO:00313242810.098
regulation of protein metabolic processGO:00512462890.096
negative regulation of cellular biosynthetic processGO:00313271610.096
positive regulation of nitrogen compound metabolic processGO:00511733340.094
dna metabolic processGO:0006259960.094
Human Mouse
negative regulation of macromolecule metabolic processGO:00106052600.092
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.091
folic acid containing compound metabolic processGO:0006760100.091
regulation of cell differentiationGO:00455953200.089
central nervous system developmentGO:00074173110.088
negative regulation of gene expressionGO:00106291990.088
positive regulation of rna metabolic processGO:00512542030.087
programmed cell deathGO:00125013920.083
regulation of apoptotic processGO:00429813350.082
negative regulation of macromolecule biosynthetic processGO:00105581480.079
regulation of cell developmentGO:00602842630.078
negative regulation of nucleobase containing compound metabolic processGO:00459341530.077
apoptotic processGO:00069153810.077
cellular response to organic cyclic compoundGO:00714072020.077
negative regulation of nucleic acid templated transcriptionGO:19035071170.075
negative regulation of rna metabolic processGO:00512531230.075
positive regulation of nucleobase containing compound metabolic processGO:00459353190.074
cellular component assemblyGO:00226073600.074
chromatin assembly or disassemblyGO:000633310.073
histone h3 acetylationGO:004396620.071
negative regulation of nitrogen compound metabolic processGO:00511721610.069
cellular response to nitrogen compoundGO:19016992100.069
Human
regulation of cellular amine metabolic processGO:003323880.067
positive regulation of nucleic acid templated transcriptionGO:19035081970.067
regulation of protein modification processGO:00313991940.066
regulation of cellular ketone metabolic processGO:0010565270.066
chromatin organizationGO:0006325340.065
positive regulation of transcription dna templatedGO:00458931970.065
positive regulation of cellular biosynthetic processGO:00313282950.064
cellular response to organonitrogen compoundGO:00714171970.063
Human
positive regulation of gene expressionGO:00106282440.062
amine metabolic processGO:0009308380.062
positive regulation of cellular component organizationGO:00511302000.061
positive regulation of macromolecule biosynthetic processGO:00105572470.061
cellular response to hormone stimulusGO:00328702470.061
Human
positive regulation of cellular amino acid metabolic processGO:004576410.061
response to hypoxiaGO:00016662310.061
peptidyl amino acid modificationGO:00181931260.060
negative regulation of biosynthetic processGO:00098901680.060
protein phosphorylationGO:00064683450.059
intracellular signal transductionGO:00355563140.058
single organism reproductive processGO:00447022970.058
cellular response to oxygen containing compoundGO:19017013860.058
Human Mouse
positive regulation of multicellular organismal processGO:00512403870.057
rhythmic processGO:00485111560.057
response to nutrient levelsGO:00316673700.057
positive regulation of nervous system developmentGO:00519621780.056
positive regulation of biosynthetic processGO:00098913190.056
regulation of cellular amino acid metabolic processGO:000652120.056
positive regulation of protein metabolic processGO:00512471780.056
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.055
positive regulation of cell differentiationGO:00455972170.054
regulation of nervous system developmentGO:00519602640.053
neuron differentiationGO:00301823680.053
response to extracellular stimulusGO:00099913800.053
response to peptideGO:19016522920.053
Human
positive regulation of molecular functionGO:00440932300.053
regulation of molecular functionGO:00650093980.051
cellular response to oxidative stressGO:0034599760.051
Mouse
neuron projection developmentGO:00311752730.051
regulation of cellular localizationGO:00603412630.051
carbohydrate derivative metabolic processGO:19011353460.050
protein complex subunit organizationGO:00718223020.049
single organism biosynthetic processGO:00447113420.048
positive regulation of cell proliferationGO:00082842490.048
anatomical structure morphogenesisGO:00096532980.047
positive regulation of cell communicationGO:00106472710.047
positive regulation of cell developmentGO:00107201760.047
chromatin modificationGO:0016568330.046
organic substance catabolic processGO:19015753160.046
neurological system processGO:00508772190.046
response to decreased oxygen levelsGO:00362932370.046
cellular response to endogenous stimulusGO:00714953770.046
response to estrogenGO:00436272320.045
cell cycleGO:00070491010.045
head developmentGO:00603222470.045
positive regulation of phosphate metabolic processGO:00459372620.045
positive regulation of cellular amine metabolic processGO:003324030.045
protein complex biogenesisGO:00702712630.044
cellular amine metabolic processGO:0044106380.044
dna packagingGO:000632340.044
cell projection morphogenesisGO:00488581230.044
positive regulation of developmental processGO:00510942830.043
regulation of cell cycleGO:0051726730.043
response to acid chemicalGO:00011012220.042
positive regulation of response to stimulusGO:00485842850.041
cellular response to lipidGO:00713962010.041
negative regulation of cell deathGO:00605482290.041
protein complex assemblyGO:00064612630.041
catabolic processGO:00090563510.041
regulation of cell proliferationGO:00421273590.041
positive regulation of cellular protein metabolic processGO:00322701670.041
positive regulation of cell deathGO:00109421840.040
positive regulation of neurogenesisGO:00507691650.040
reproductive processGO:00224143720.040
alpha amino acid metabolic processGO:1901605710.040
cognitionGO:0050890920.040
single organism organelle organizationGO:19025891800.039
Mouse
cell projection organizationGO:00300303020.039
cellular ketone metabolic processGO:0042180510.038
glial cell differentiationGO:0010001650.038
gland developmentGO:00487321550.038
cell cycle checkpointGO:000007520.037
tissue developmentGO:00098882520.037
cellular component movementGO:00069282480.037
regulation of neurogenesisGO:00507672470.037
brain developmentGO:00074202470.036
single organism catabolic processGO:00447122830.036
response to corticosteroidGO:00319602350.036
regulation of cellular protein metabolic processGO:00322682670.036
response to nutrientGO:00075842480.035
response to ketoneGO:19016541820.035
behaviorGO:00076102050.034
neuron developmentGO:00486662860.034
regulation of neuron differentiationGO:00456642080.034
single organism behaviorGO:00447081300.034
positive regulation of transportGO:00510502450.033
regulation of organelle organizationGO:0033043800.033
response to oxygen levelsGO:00704822650.033
organophosphate metabolic processGO:00196373700.032
cell growthGO:00160491040.031
agingGO:00075682410.031
cell cycle processGO:0022402570.031
cell part morphogenesisGO:00329901230.031
nucleobase containing small molecule metabolic processGO:00550863160.030
negative regulation of apoptotic processGO:00430661810.030
nucleotide metabolic processGO:00091172790.030
cellular response to growth factor stimulusGO:00713631620.030
positive regulation of protein modification processGO:00314011420.030
response to inorganic substanceGO:00100353770.030
Mouse
nucleosome organizationGO:003472810.030
negative regulation of response to stimulusGO:00485851550.030
response to glucocorticoidGO:00513842230.030
homeostatic processGO:00425923310.030
Mouse
response to reactive oxygen speciesGO:00003021200.030
Mouse
regulation of phosphate metabolic processGO:00192203490.029
regulation of phosphorylationGO:00423252480.029
gliogenesisGO:0042063930.029
locomotionGO:00400112370.029
growthGO:00400071650.029
Mouse
negative regulation of cell differentiationGO:0045596990.029
regulation of phosphorus metabolic processGO:00511743490.028
response to toxic substanceGO:00096361330.028
response to metal ionGO:00100382530.027
regulation of signal transductionGO:00099663180.027
response to estradiolGO:00323551640.027
response to ethanolGO:00454711620.027
response to peptide hormoneGO:00434342780.026
Human
negative regulation of programmed cell deathGO:00430691830.026
regenerationGO:00310991630.026
positive regulation of phosphorus metabolic processGO:00105622620.026
regulation of protein phosphorylationGO:00019321830.026
carbohydrate metabolic processGO:00059751300.026
single organism intracellular transportGO:19025821660.025
axon developmentGO:0061564960.025
cell morphogenesis involved in differentiationGO:00009041190.025
cellular response to ketoneGO:1901655510.025
response to amino acidGO:0043200750.025
positive regulation of phosphorylationGO:00423271770.025
positive regulation of signal transductionGO:00099671750.024
cellular response to external stimulusGO:00714961180.024
developmental growthGO:00485891000.024
cell migrationGO:00164771970.024
regulation of cell projection organizationGO:00313441750.024
response to cytokineGO:00340972150.024
reproductive structure developmentGO:00486081280.023
regulation of anatomical structure morphogenesisGO:00226031410.023
multi multicellular organism processGO:00447061380.023
intracellular transportGO:00469071850.023
cation transportGO:00068123820.023
regulation of secretionGO:00510462240.023
regulation of cell morphogenesis involved in differentiationGO:0010769720.022
glycosyl compound metabolic processGO:19016571820.022
blood vessel developmentGO:0001568690.022
chromosome segregationGO:000705920.022
response to heatGO:0009408600.022
regulation of neuron deathGO:19012141150.022
regulation of cell cycle g1 s phase transitionGO:190280670.022
response to radiationGO:00093141370.022
regulation of cell migrationGO:00303341280.022
regulation of intracellular signal transductionGO:19025312180.022
cell motilityGO:00488702020.022
regulation of cell growthGO:0001558850.022
negative regulation of protein metabolic processGO:00512481140.022
reproductionGO:00000032450.021
regulation of growthGO:00400081050.021
Mouse
cellular homeostasisGO:00197252520.021
cell type specific apoptotic processGO:00972851340.021
response to vitaminGO:00332731310.021
negative regulation of signalingGO:00230571570.021
protein processingGO:0016485680.021
organ morphogenesisGO:0009887750.021
defense responseGO:00069521940.021
negative regulation of multicellular organismal processGO:00512412030.021
regulation of cellular component movementGO:00512701500.021
regulation of cell motilityGO:20001451310.021
multicellular organismal reproductive processGO:00486092330.020
regulation of anatomical structure sizeGO:00900661350.020
regulation of immune system processGO:00026821230.020
positive regulation of signalingGO:00230562700.020
positive regulation of cell projection organizationGO:00313461110.020
cellular component morphogenesisGO:00329891550.020
cellular lipid metabolic processGO:00442552080.020
regulation of neuron projection developmentGO:00109751610.020
response to biotic stimulusGO:00096072260.020
immune system processGO:00023762040.020
purine containing compound metabolic processGO:00725212530.020
nucleoside phosphate metabolic processGO:00067532830.020
multicellular organism reproductionGO:00325042330.020
organonitrogen compound biosynthetic processGO:19015661670.019
cellular chemical homeostasisGO:00550822470.019
positive regulation of apoptotic processGO:00430651540.019
learning or memoryGO:0007611900.019
response to growth factorGO:00708481890.019
female gonad developmentGO:0008585530.019
positive regulation of programmed cell deathGO:00430681570.019
signal transduction by phosphorylationGO:00230141440.019
nucleocytoplasmic transportGO:0006913480.019
response to ionizing radiationGO:0010212590.019
proteolysisGO:00065081750.019
response to bacteriumGO:00096172000.019
cytoskeleton organizationGO:00070101110.019
regulation of catalytic activityGO:00507903040.019
cellular nitrogen compound catabolic processGO:00442701630.019
response to lipopolysaccharideGO:00324961910.019
anatomical structure formation involved in morphogenesisGO:0048646830.019
positive regulation of protein phosphorylationGO:00019341350.019
positive regulation of neuron differentiationGO:00456661260.019
regulation of locomotionGO:00400121480.019
cellular response to steroid hormone stimulusGO:0071383930.018
epithelium developmentGO:0060429960.018
urogenital system developmentGO:0001655780.018
cellular response to corticosteroid stimulusGO:0071384690.018
memoryGO:0007613540.018
multi organism reproductive processGO:00447032620.018
dna integrity checkpointGO:003157020.018
cellular catabolic processGO:00442482950.018
lipid metabolic processGO:00066292830.018
regulation of system processGO:00440572080.018
response to woundingGO:00096112540.018
female pregnancyGO:00075651220.018
positive regulation of cell motilityGO:2000147970.018
maintenance of locationGO:0051235170.018
forebrain developmentGO:0030900980.018
cell cycle phase transitionGO:0044770210.018
positive regulation of neuron projection developmentGO:0010976990.018
response to mechanical stimulusGO:00096121340.018
cellular response to alcoholGO:0097306870.018
single organism carbohydrate metabolic processGO:00447231180.017
double strand break repairGO:000630210.017
Human Mouse
ribonucleoside monophosphate metabolic processGO:0009161880.017
cytoplasmic transportGO:00164821150.017
purine nucleotide metabolic processGO:00061632290.017
negative regulation of cell cycle phase transitionGO:190198840.017
positive regulation of catalytic activityGO:00430851840.017
cardiovascular system developmentGO:00723581340.017
response to dexamethasoneGO:0071548490.017
regulation of protein localizationGO:0032880810.017
oxidation reduction processGO:00551143040.017
positive regulation of immune system processGO:0002684900.017
cellular macromolecule localizationGO:00707271220.017
female sex differentiationGO:0046660590.017
response to temperature stimulusGO:0009266940.017
vasculature developmentGO:0001944700.017
regulation of protein transportGO:0051223680.017
negative regulation of developmental processGO:00510931250.017
ribose phosphate metabolic processGO:00196932350.016
positive regulation of secretionGO:00510471400.016
cellular response to drugGO:0035690300.016
cell morphogenesisGO:00009021420.016
establishment of protein localizationGO:00451841410.016
response to oxidative stressGO:00069791860.016
Mouse
mitotic spindle organizationGO:000705220.016
embryonic pattern specificationGO:000988010.016
negative regulation of cell developmentGO:0010721820.016
ion homeostasisGO:00508012120.016
regulation of dna metabolic processGO:0051052600.016
organic cyclic compound catabolic processGO:19013611750.016
chemical homeostasisGO:00488782920.016
cellular modified amino acid metabolic processGO:0006575610.016
protein oligomerizationGO:00512591910.016
ras protein signal transductionGO:0007265290.016
cofactor metabolic processGO:0051186950.016
positive regulation of intracellular signal transductionGO:19025331380.016
regulation of cell morphogenesisGO:0022604770.016
muscle system processGO:00030121150.015
negative regulation of cellular protein metabolic processGO:00322691060.015
gastrulationGO:000736920.015
eye morphogenesisGO:004859240.015
response to molecule of bacterial originGO:00022371940.015
mitotic cell cycle phase transitionGO:0044772200.015
fatty acid metabolic processGO:0006631990.015
response to carbohydrateGO:00097431830.015
secretionGO:00469033070.015
macromolecule localizationGO:00330362520.015
secretion by cellGO:00329402480.015
mapk cascadeGO:00001651400.015
neuron deathGO:00709971270.015
sex differentiationGO:00075481130.014
cellular macromolecular complex assemblyGO:0034622580.014
neuron projection morphogenesisGO:00488121220.014
aromatic compound catabolic processGO:00194391680.014
localization of cellGO:00516742020.014
regulation of response to stressGO:00801341260.014
negative regulation of molecular functionGO:00440921330.014
positive regulation of secretion by cellGO:19035321280.014
positive regulation of mapk cascadeGO:0043410920.014
ribonucleotide metabolic processGO:00092592310.014
negative regulation of mitotic cell cycle phase transitionGO:190199130.014
regulation of ion transportGO:00432692450.014
purine nucleoside metabolic processGO:00422781690.014
response to hexoseGO:00097461440.014
nuclear transportGO:0051169490.014
divalent metal ion transportGO:00708381320.014
regulation of immune responseGO:0050776550.014
cellular response to cytokine stimulusGO:00713451270.014
circadian rhythmGO:0007623880.013
metal ion transportGO:00300012890.013
purine ribonucleoside monophosphate metabolic processGO:0009167840.013
reproductive system developmentGO:00614581280.013
negative regulation of cell proliferationGO:00082851190.013
positive regulation of locomotionGO:00400171020.013
monocarboxylic acid metabolic processGO:00327871520.013
nucleobase containing compound catabolic processGO:00346551520.013
response to other organismGO:00517072200.013
positive regulation of intracellular protein transportGO:0090316200.013
embryonic appendage morphogenesisGO:003511340.013
negative regulation of cell communicationGO:00106481580.013
response to monosaccharideGO:00342841590.013
response to hydrogen peroxideGO:0042542890.013
macromolecule catabolic processGO:0009057580.013
chromatin remodelingGO:000633830.013
nucleoside metabolic processGO:00091161790.013
development of primary sexual characteristicsGO:00451371070.013
tube developmentGO:0035295890.013
cell cell signalingGO:00072673350.013
heterocycle catabolic processGO:00467001670.013
response to antibioticGO:0046677390.013
cell cycle g1 s phase transitionGO:0044843130.013
ribonucleotide catabolic processGO:00092611360.013
spindle organizationGO:000705120.013
covalent chromatin modificationGO:0016569300.013
developmental process involved in reproductionGO:00030061590.013
negative regulation of signal transductionGO:0009968830.013
axis specificationGO:000979840.013
organophosphate biosynthetic processGO:00904071430.013
regulation of intracellular transportGO:0032386650.013
regulation of secretion by cellGO:19035302080.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.013
negative regulation of transportGO:00510511360.013
cellular ion homeostasisGO:00068731840.013
negative regulation of cell cycle g1 s phase transitionGO:190280720.013
multicellular organism growthGO:003526410.013
nucleoside phosphate biosynthetic processGO:19012931020.012
peptidyl tyrosine modificationGO:0018212720.012
positive regulation of protein kinase activityGO:0045860730.012
dna replicationGO:0006260370.012
regulation of establishment of protein localizationGO:0070201690.012
regulation of cell cycle processGO:0010564310.012
response to purine containing compoundGO:00140741260.012
small gtpase mediated signal transductionGO:0007264360.012
cellular protein localizationGO:00346131220.012
actin filament based processGO:0030029860.012
motor neuron axon guidanceGO:000804510.012
cellular response to abiotic stimulusGO:0071214850.012
purine ribonucleoside monophosphate catabolic processGO:0009169550.012
reactive oxygen species biosynthetic processGO:190340980.012
cellular response to metal ionGO:0071248550.012
mitotic cell cycleGO:0000278490.012
carbohydrate derivative biosynthetic processGO:19011371240.012
nitrogen compound transportGO:00717052290.012
regulation of membrane potentialGO:00423911100.012
regulation of cellular component biogenesisGO:0044087860.012
negative regulation of neurogenesisGO:0050768780.012
glucan metabolic processGO:0044042230.012
positive regulation of cellular component movementGO:00512721020.012
purine ribonucleotide metabolic processGO:00091502270.012
translationGO:0006412350.012
ovulation cycleGO:0042698670.012
positive regulation of nucleocytoplasmic transportGO:0046824170.012
circulatory system processGO:00030131830.012
response to fatty acidGO:0070542650.012
cellular carbohydrate metabolic processGO:0044262720.011
g1 s transition of mitotic cell cycleGO:0000082120.011
regulation of catabolic processGO:00098941130.011
response to alkaloidGO:00432791320.011
chemosensory behaviorGO:000763520.011
cell morphogenesis involved in neuron differentiationGO:00486671060.011
cellular response to extracellular stimulusGO:0031668730.011
heart morphogenesisGO:000300730.011
protein transportGO:00150311320.011
reactive oxygen species metabolic processGO:0072593370.011
defense response to gram negative bacteriumGO:005082930.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
regulation of cell adhesionGO:0030155520.011
purine containing compound biosynthetic processGO:0072522850.011
single organism nuclear importGO:1902593350.011
apoptotic signaling pathwayGO:0097190270.011
response to light stimulusGO:0009416520.011
mitotic cell cycle processGO:1903047350.011
spermatogenesisGO:0007283990.011
camera type eye developmentGO:0043010480.011
calcium ion homeostasisGO:00550741620.011
tetrahydrofolate metabolic processGO:004665390.011
response to transition metal nanoparticleGO:19902671220.011
regulation of mapk cascadeGO:00434081160.011
innate immune responseGO:0045087350.011
limb morphogenesisGO:003510840.011
development of primary female sexual characteristicsGO:0046545560.011
organophosphate catabolic processGO:00464341480.011
regulation of cell cycle phase transitionGO:1901987120.011
gonad developmentGO:00084061040.011
chromatin disassemblyGO:003149810.011
carboxylic acid biosynthetic processGO:0046394830.011
negative regulation of cellular component organizationGO:0051129830.010
gamete generationGO:00072761240.010
liver developmentGO:0001889900.010
cell activationGO:0001775970.010
rna localizationGO:000640340.010
cellular response to glucocorticoid stimulusGO:0071385680.010
muscle structure developmentGO:0061061870.010
regulation of neuron apoptotic processGO:0043523830.010
protein autophosphorylationGO:0046777660.010
cytosolic calcium ion homeostasisGO:00514801400.010
signal releaseGO:00230611450.010
metal ion homeostasisGO:00550651860.010
protein heterooligomerizationGO:0051291890.010
negative regulation of neuron differentiationGO:0045665620.010
organic anion transportGO:00157111320.010
mitotic cell cycle checkpointGO:000709310.010
regulation of hormone levelsGO:00108171870.010

Parp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.017
disease of anatomical entityDOID:700.017
central nervous system diseaseDOID:33100.010