IMP: Integrative Multi-species Prediction

Rattus norvegicus

74 known processes

Hmgcs1

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

Entrez: 29637
RGD: 70970
Ensembl: ENSRNOG00000016552
UniProtKB: P17425

Process Predictions
Disease Predictions

Hmgcs1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
lipid biosynthetic process	GO:0008610	128	1.000
alcohol biosynthetic process	GO:0046165	38	0.993
isoprenoid metabolic process	GO:0006720	45	0.980
cholesterol metabolic process	GO:0008203	17	0.921
lipid metabolic process	GO:0006629	283	0.915
single organism biosynthetic process	GO:0044711	342	0.858	Rat
steroid biosynthetic process	GO:0006694	48	0.855
sterol metabolic process	GO:0016125	18	0.844
response to fatty acid	GO:0070542	65	0.787	Rat
steroid metabolic process	GO:0008202	73	0.780
sterol biosynthetic process	GO:0016126	10	0.779
alcohol metabolic process	GO:0006066	77	0.712
isoprenoid biosynthetic process	GO:0008299	12	0.653
cellular lipid metabolic process	GO:0044255	208	0.645
gonad development	GO:0008406	104	0.584
cellular response to oxygen containing compound	GO:1901701	386	0.562
cellular ketone body metabolic process	GO:0046950	4	0.537	Rat
response to acid chemical	GO:0001101	222	0.495	Rat
positive regulation of cardiac muscle cell apoptotic process	GO:0010666	3	0.493
regulation of cholesterol metabolic process	GO:0090181	5	0.476
response to peptide hormone	GO:0043434	278	0.442	Rat
cellular response to nitrogen compound	GO:1901699	210	0.427	Rat
head development	GO:0060322	247	0.403
metanephric tubule development	GO:0072170	4	0.383
organic hydroxy compound metabolic process	GO:1901615	115	0.366
cellular response to organonitrogen compound	GO:0071417	197	0.365	Rat
metanephric epithelium development	GO:0072207	4	0.346
cholesterol biosynthetic process	GO:0006695	10	0.337
small molecule biosynthetic process	GO:0044283	124	0.328	Rat
tissue development	GO:0009888	252	0.283	Rat
cofactor metabolic process	GO:0051186	95	0.218
organophosphate metabolic process	GO:0019637	370	0.194
demethylation	GO:0070988	7	0.181
muscle cell apoptotic process	GO:0010657	30	0.173
secretion	GO:0046903	307	0.156
organic hydroxy compound biosynthetic process	GO:1901617	51	0.148
regulation of response to wounding	GO:1903034	69	0.146
positive regulation of cell growth	GO:0030307	44	0.137
organophosphate biosynthetic process	GO:0090407	143	0.131
coenzyme metabolic process	GO:0006732	86	0.125
intracellular signal transduction	GO:0035556	314	0.095
regulation of developmental growth	GO:0048638	45	0.092
regulation of multicellular organismal development	GO:2000026	376	0.089
positive regulation of skeletal muscle tissue development	GO:0048643	4	0.083
fatty acid metabolic process	GO:0006631	99	0.078
brain development	GO:0007420	247	0.075
cation transport	GO:0006812	382	0.071
positive regulation of muscle organ development	GO:0048636	13	0.070
monocarboxylic acid metabolic process	GO:0032787	152	0.070
regulation of muscle organ development	GO:0048634	26	0.069
thioester metabolic process	GO:0035383	28	0.066
striated muscle tissue development	GO:0014706	58	0.059
carboxylic acid metabolic process	GO:0019752	289	0.058
positive regulation of smooth muscle cell proliferation	GO:0048661	51	0.057
phospholipid biosynthetic process	GO:0008654	29	0.057
response to interleukin 15	GO:0070672	4	0.056
cellular response to lipid	GO:0071396	201	0.053
acetate metabolic process	GO:0006083	2	0.052
neuron differentiation	GO:0030182	368	0.052
negative regulation of vasodilation	GO:0045908	3	0.051
cellular chemical homeostasis	GO:0055082	247	0.051
response to ketone	GO:1901654	182	0.050	Rat
reproductive process	GO:0022414	372	0.050
positive regulation of response to stimulus	GO:0048584	285	0.049
oxidoreduction coenzyme metabolic process	GO:0006733	31	0.048
growth	GO:0040007	165	0.047
response to metal ion	GO:0010038	253	0.046	Rat
positive regulation of multicellular organismal process	GO:0051240	387	0.046
protein complex biogenesis	GO:0070271	263	0.045
regulation of cell development	GO:0060284	263	0.042
regulation of cell differentiation	GO:0045595	320	0.041
response to hexose	GO:0009746	144	0.040
tube development	GO:0035295	89	0.040	Rat
regulation of phosphate metabolic process	GO:0019220	349	0.039
positive regulation of signaling	GO:0023056	270	0.039
neuron projection development	GO:0031175	273	0.039
metanephric nephron tubule development	GO:0072234	3	0.038
positive regulation of phosphorus metabolic process	GO:0010562	262	0.038
response to external biotic stimulus	GO:0043207	221	0.038	Rat
macromolecular complex assembly	GO:0065003	273	0.038
regulation of cell growth	GO:0001558	85	0.038
positive regulation of developmental process	GO:0051094	283	0.038
acyl coa metabolic process	GO:0006637	28	0.038
nitrogen compound transport	GO:0071705	229	0.037
organonitrogen compound biosynthetic process	GO:1901566	167	0.037
regulation of cell proliferation	GO:0042127	359	0.036
cellular response to peptide hormone stimulus	GO:0071375	120	0.036	Rat
regulation of intracellular signal transduction	GO:1902531	218	0.036
regulation of secretion by cell	GO:1903530	208	0.036
regulation of phosphorus metabolic process	GO:0051174	349	0.035
regulation of hormone levels	GO:0010817	187	0.035
cellular component assembly	GO:0022607	360	0.035
response to nutrient	GO:0007584	248	0.035
regulation of cell growth involved in cardiac muscle cell development	GO:0061050	6	0.035
regulation of alcohol biosynthetic process	GO:1902930	12	0.034
regulation of signal transduction	GO:0009966	318	0.034
protein oligomerization	GO:0051259	191	0.034
response to extracellular stimulus	GO:0009991	380	0.034
central nervous system development	GO:0007417	311	0.034
cellular response to peptide	GO:1901653	133	0.034	Rat
single organism catabolic process	GO:0044712	283	0.033
cell cell signaling	GO:0007267	335	0.033
spinal cord dorsal ventral patterning	GO:0021513	2	0.033
regulation of cellular localization	GO:0060341	263	0.032
organic acid metabolic process	GO:0006082	292	0.032
cellular homeostasis	GO:0019725	252	0.031
amide transport	GO:0042886	105	0.031
regulation of stress activated protein kinase signaling cascade	GO:0070302	23	0.031
regulation of stress activated mapk cascade	GO:0032872	23	0.031
regulation of cholesterol biosynthetic process	GO:0045540	4	0.030
response to glucose	GO:0009749	136	0.030
response to estrogen	GO:0043627	232	0.030
positive regulation of phosphorylation	GO:0042327	177	0.030
cellular amino acid metabolic process	GO:0006520	107	0.029
positive regulation of intracellular signal transduction	GO:1902533	138	0.029
regulation of apoptotic process	GO:0042981	335	0.029
muscle system process	GO:0003012	115	0.028
regulation of rna biosynthetic process	GO:2001141	381	0.028
regulation of programmed cell death	GO:0043067	341	0.028
regulation of cellular amine metabolic process	GO:0033238	8	0.028
cellular catabolic process	GO:0044248	295	0.028
mapk cascade	GO:0000165	140	0.028
organic acid biosynthetic process	GO:0016053	83	0.028
positive regulation of striated muscle cell apoptotic process	GO:0010663	3	0.027
reproduction	GO:0000003	245	0.027
cellular response to stress	GO:0033554	269	0.027
insulin secretion	GO:0030073	69	0.027
long chain fatty acid transport	GO:0015909	14	0.026
response to peptide	GO:1901652	292	0.026	Rat
regulation of cellular component organization	GO:0051128	368	0.026
programmed cell death	GO:0012501	392	0.026
neuron development	GO:0048666	286	0.026
regulation of secretion	GO:0051046	224	0.026
positive regulation of cell development	GO:0010720	176	0.026
metal ion transport	GO:0030001	289	0.026
gamete generation	GO:0007276	124	0.025
response to estradiol	GO:0032355	164	0.025
regulation of system process	GO:0044057	208	0.025
response to nutrient levels	GO:0031667	370	0.025
secretion by cell	GO:0032940	248	0.024
negative regulation of cell communication	GO:0010648	158	0.024
cellular component biogenesis	GO:0044085	368	0.024
response to cholesterol	GO:0070723	13	0.024
positive regulation of cellular component organization	GO:0051130	200	0.024
positive regulation of cell communication	GO:0010647	271	0.024
positive regulation of transport	GO:0051050	245	0.024
regulation of nucleic acid templated transcription	GO:1903506	380	0.023
single organism reproductive process	GO:0044702	297	0.023
peptide secretion	GO:0002790	86	0.023
cellular response to insulin stimulus	GO:0032869	81	0.023	Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.022
negative regulation of multicellular organismal process	GO:0051241	203	0.022
response to carbohydrate	GO:0009743	183	0.022	Rat
neuron death	GO:0070997	127	0.022
regulation of peptide transport	GO:0090087	87	0.022
protein complex assembly	GO:0006461	263	0.022
cellular amine metabolic process	GO:0044106	38	0.022
circulatory system development	GO:0072359	134	0.022
terpenoid biosynthetic process	GO:0016114	8	0.022
hormone transport	GO:0009914	121	0.022
multicellular organism reproduction	GO:0032504	233	0.022
multicellular organismal signaling	GO:0035637	44	0.021
developmental growth	GO:0048589	100	0.021
organic acid transport	GO:0015849	116	0.021
hormone secretion	GO:0046879	115	0.021
response to fungus	GO:0009620	8	0.021
chemical homeostasis	GO:0048878	292	0.021
response to stilbenoid	GO:0035634	1	0.021
rna metabolic process	GO:0016070	406	0.021
ras protein signal transduction	GO:0007265	29	0.021
regulation of neuron differentiation	GO:0045664	208	0.021
cell projection organization	GO:0030030	302	0.021
positive regulation of cellular amine metabolic process	GO:0033240	3	0.021
positive regulation of cell proliferation	GO:0008284	249	0.021
response to ethanol	GO:0045471	162	0.021	Rat
phospholipid metabolic process	GO:0006644	61	0.021
catabolic process	GO:0009056	351	0.020
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	17	0.020
oxoacid metabolic process	GO:0043436	290	0.020
positive regulation of programmed cell death	GO:0043068	157	0.020
regulation of cell projection organization	GO:0031344	175	0.020
regulation of lipid biosynthetic process	GO:0046890	38	0.020
cellular response to fatty acid	GO:0071398	29	0.020	Rat
cellular response to endogenous stimulus	GO:0071495	377	0.020
cell type specific apoptotic process	GO:0097285	134	0.020
amine metabolic process	GO:0009308	38	0.020
single organism behavior	GO:0044708	130	0.020
positive regulation of cell differentiation	GO:0045597	217	0.020
response to corticosteroid	GO:0031960	235	0.020	Rat
blood circulation	GO:0008015	183	0.019
regulation of molecular function	GO:0065009	398	0.019
acid secretion	GO:0046717	48	0.019
aging	GO:0007568	241	0.019
carbohydrate derivative biosynthetic process	GO:1901137	124	0.019
negative regulation of developmental process	GO:0051093	125	0.019
response to monosaccharide	GO:0034284	159	0.019	Rat
negative regulation of signaling	GO:0023057	157	0.019
response to biotic stimulus	GO:0009607	226	0.018	Rat
nucleobase containing small molecule metabolic process	GO:0055086	316	0.018
multicellular organismal reproductive process	GO:0048609	233	0.018
salivary gland development	GO:0007431	3	0.018
cellular ketone metabolic process	GO:0042180	51	0.018
signal transduction by phosphorylation	GO:0023014	144	0.018
dendrite development	GO:0016358	72	0.018
macromolecular complex subunit organization	GO:0043933	339	0.018
cation transmembrane transport	GO:0098655	263	0.018
carboxylic acid transport	GO:0046942	115	0.018
regulation of ion transport	GO:0043269	245	0.018
developmental process involved in reproduction	GO:0003006	159	0.018
organic substance catabolic process	GO:1901575	316	0.018
positive regulation of secretion	GO:0051047	140	0.017
neurological system process	GO:0050877	219	0.017
cellular response to carbohydrate stimulus	GO:0071322	72	0.017
response to oxygen levels	GO:0070482	265	0.017
muscle structure development	GO:0061061	87	0.017
regulation of cellular ketone metabolic process	GO:0010565	27	0.017
anatomical structure morphogenesis	GO:0009653	298	0.017
cellular response to acid chemical	GO:0071229	75	0.017	Rat
vesicle mediated transport	GO:0016192	181	0.017
sexual reproduction	GO:0019953	148	0.017
regulation of organ growth	GO:0046620	13	0.017
positive regulation of neurogenesis	GO:0050769	165	0.016
multi organism reproductive process	GO:0044703	262	0.016
response to wounding	GO:0009611	254	0.016
positive regulation of cell death	GO:0010942	184	0.016
small molecule catabolic process	GO:0044282	59	0.016
forebrain development	GO:0030900	98	0.016
regulation of catalytic activity	GO:0050790	304	0.016
regulation of neurogenesis	GO:0050767	247	0.016
development of primary sexual characteristics	GO:0045137	107	0.016
positive regulation of biosynthetic process	GO:0009891	319	0.016
organic anion transport	GO:0015711	132	0.016
metanephros development	GO:0001656	14	0.016
heart morphogenesis	GO:0003007	3	0.015
smooth muscle cell proliferation	GO:0048659	77	0.015
insecticide metabolic process	GO:0017143	4	0.015
protein homooligomerization	GO:0051260	91	0.015
vascular process in circulatory system	GO:0003018	96	0.015
regulation of neuron projection development	GO:0010975	161	0.015
signal release	GO:0023061	145	0.015
inorganic ion transmembrane transport	GO:0098660	229	0.015
regulation of nervous system development	GO:0051960	264	0.015
protein complex subunit organization	GO:0071822	302	0.015
positive regulation of apoptotic process	GO:0043065	154	0.015
nucleotide metabolic process	GO:0009117	279	0.015
carbohydrate homeostasis	GO:0033500	75	0.015
positive regulation of neuron differentiation	GO:0045666	126	0.015
transmission of nerve impulse	GO:0019226	42	0.015
positive regulation of nervous system development	GO:0051962	178	0.015
purine ribonucleotide biosynthetic process	GO:0009152	81	0.014
negative regulation of peptide hormone secretion	GO:0090278	30	0.014
apoptotic process	GO:0006915	381	0.014
regulation of peptide secretion	GO:0002791	82	0.014
positive regulation of cellular biosynthetic process	GO:0031328	295	0.014
positive regulation of molecular function	GO:0044093	230	0.014
neuronal action potential	GO:0019228	35	0.014
multicellular organism growth	GO:0035264	1	0.014
positive regulation of mapk cascade	GO:0043410	92	0.014
cellular response to extracellular stimulus	GO:0031668	73	0.014
reproductive system development	GO:0061458	128	0.014
regulation of cellular amino acid metabolic process	GO:0006521	2	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.013
regulation of muscle tissue development	GO:1901861	25	0.013
regulation of phosphorylation	GO:0042325	248	0.013
gland development	GO:0048732	155	0.013
sex differentiation	GO:0007548	113	0.013
muscle cell differentiation	GO:0042692	52	0.013
negative regulation of cell death	GO:0060548	229	0.013
organic acid catabolic process	GO:0016054	49	0.013
ion transmembrane transport	GO:0034220	365	0.013
salivary gland morphogenesis	GO:0007435	1	0.013
neuron neuron synaptic transmission	GO:0007270	60	0.013
response to alkaloid	GO:0043279	132	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
oxidation reduction process	GO:0055114	304	0.013
membrane depolarization during action potential	GO:0086010	1	0.013
glucose homeostasis	GO:0042593	75	0.013
purine nucleotide biosynthetic process	GO:0006164	83	0.013
regulation of response to external stimulus	GO:0032101	106	0.013
negative regulation of response to stimulus	GO:0048585	155	0.013
taxis	GO:0042330	67	0.013
cell morphogenesis involved in differentiation	GO:0000904	119	0.013
response to decreased oxygen levels	GO:0036293	237	0.013
cofactor biosynthetic process	GO:0051188	28	0.013
regulation of growth	GO:0040008	105	0.013
synaptic growth at neuromuscular junction	GO:0051124	1	0.012
regulation of homeostatic process	GO:0032844	101	0.012
response to cytokine	GO:0034097	215	0.012
negative regulation of transport	GO:0051051	136	0.012
regulation of mapk cascade	GO:0043408	116	0.012
negative regulation of cellular metabolic process	GO:0031324	281	0.012
regulation of ion transmembrane transport	GO:0034765	121	0.012
positive regulation of developmental growth	GO:0048639	29	0.012
negative regulation of homeostatic process	GO:0032845	47	0.012
negative regulation of cellular component organization	GO:0051129	83	0.012
muscle tissue development	GO:0060537	58	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
epithelium development	GO:0060429	96	0.012
cellular response to glucose stimulus	GO:0071333	65	0.012
adipose tissue development	GO:0060612	6	0.012	Rat
regulation of purine nucleotide metabolic process	GO:1900542	115	0.012
regulation of organelle organization	GO:0033043	80	0.012
heart growth	GO:0060419	20	0.012
microtubule organizing center organization	GO:0031023	1	0.012
cellular response to hormone stimulus	GO:0032870	247	0.012
fatty acid biosynthetic process	GO:0006633	33	0.012
regulation of anatomical structure size	GO:0090066	135	0.012
cytosolic calcium ion homeostasis	GO:0051480	140	0.012
synaptic transmission	GO:0007268	235	0.012
glycerophospholipid metabolic process	GO:0006650	47	0.012
transcription dna templated	GO:0006351	377	0.011
regulation of lipid metabolic process	GO:0019216	68	0.011
negative regulation of neurogenesis	GO:0050768	78	0.011
cellular response to hexose stimulus	GO:0071331	65	0.011
response to sterol	GO:0036314	13	0.011
regulation of body fluid levels	GO:0050878	90	0.011
regulation of fatty acid oxidation	GO:0046320	10	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.011
positive regulation of cell growth involved in cardiac muscle cell development	GO:0061051	5	0.011
triglyceride metabolic process	GO:0006641	21	0.011
cell growth	GO:0016049	104	0.011
peptide hormone secretion	GO:0030072	84	0.011
response to inorganic substance	GO:0010035	377	0.011
centrosome organization	GO:0051297	1	0.011
carbohydrate derivative metabolic process	GO:1901135	346	0.011
terpenoid metabolic process	GO:0006721	37	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
regulation of response to stress	GO:0080134	126	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
regulation of organic acid transport	GO:0032890	35	0.011
cell motility	GO:0048870	202	0.011
regulation of heart growth	GO:0060420	12	0.011
negative regulation of secretion	GO:0051048	82	0.011
monovalent inorganic cation transport	GO:0015672	172	0.011
ribonucleotide biosynthetic process	GO:0009260	85	0.011
regeneration	GO:0031099	163	0.011
positive regulation of cardiac muscle tissue growth	GO:0055023	9	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
nucleoside phosphate metabolic process	GO:0006753	283	0.011
regulation of catecholamine secretion	GO:0050433	32	0.011
regulation of transmembrane transport	GO:0034762	122	0.010
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.010
ribose phosphate metabolic process	GO:0019693	235	0.010
inorganic cation transmembrane transport	GO:0098662	202	0.010
cellular response to external stimulus	GO:0071496	118	0.010
divalent metal ion transport	GO:0070838	132	0.010
adult locomotory behavior	GO:0008344	4	0.010
positive regulation of neuron projection development	GO:0010976	99	0.010
bmp signaling pathway	GO:0030509	4	0.010
sequestering of metal ion	GO:0051238	9	0.010
positive regulation of growth	GO:0045927	55	0.010
negative regulation of neuron differentiation	GO:0045665	62	0.010
regulation of striated muscle tissue development	GO:0016202	25	0.010
negative regulation of programmed cell death	GO:0043069	183	0.010
embryonic axis specification	GO:0000578	1	0.010
regulation of muscle system process	GO:0090257	79	0.010
negative regulation of response to wounding	GO:1903035	23	0.010
cellular calcium ion homeostasis	GO:0006874	160	0.010

Hmgcs1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	nervous system disease	DOID:863	0	0.016
	disease of anatomical entity	DOID:7	0	0.016

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