| regulation of molecular function | GO:0065009 | 398 | 0.221 | |
| positive regulation of protein metabolic process | GO:0051247 | 178 | 0.127 | |
| cellular metal ion homeostasis | GO:0006875 | 172 | 0.103 | |
| intracellular signal transduction | GO:0035556 | 314 | 0.103 | |
| regulation of phosphorus metabolic process | GO:0051174 | 349 | 0.092 | |
| regulation of phosphate metabolic process | GO:0019220 | 349 | 0.075 | |
| regulation of catalytic activity | GO:0050790 | 304 | 0.073 | |
| positive regulation of response to stimulus | GO:0048584 | 285 | 0.072 | Human Mouse |
| positive regulation of cellular protein metabolic process | GO:0032270 | 167 | 0.069 | |
| positive regulation of phosphate metabolic process | GO:0045937 | 262 | 0.060 | |
| protein phosphorylation | GO:0006468 | 345 | 0.059 | |
| positive regulation of molecular function | GO:0044093 | 230 | 0.057 | |
| cellular response to endogenous stimulus | GO:0071495 | 377 | 0.057 | |
| response to nutrient | GO:0007584 | 248 | 0.057 | |
| positive regulation of catalytic activity | GO:0043085 | 184 | 0.056 | |
| regulation of phosphorylation | GO:0042325 | 248 | 0.052 | |
| single organism biosynthetic process | GO:0044711 | 342 | 0.050 | |
| positive regulation of phosphorus metabolic process | GO:0010562 | 262 | 0.049 | |
| regulation of apoptotic process | GO:0042981 | 335 | 0.047 | |
| regulation of intracellular signal transduction | GO:1902531 | 218 | 0.047 | Fly |
| immune system process | GO:0002376 | 204 | 0.046 | Human Mouse Fly |
| regulation of protein kinase activity | GO:0045859 | 105 | 0.045 | |
| regulation of protein metabolic process | GO:0051246 | 289 | 0.045 | |
| protein complex assembly | GO:0006461 | 263 | 0.042 | |
| organic acid metabolic process | GO:0006082 | 292 | 0.042 | |
| regulation of protein phosphorylation | GO:0001932 | 183 | 0.041 | |
| response to corticosteroid | GO:0031960 | 235 | 0.040 | |
| positive regulation of transferase activity | GO:0051347 | 81 | 0.039 | |
| tissue development | GO:0009888 | 252 | 0.036 | |
| cellular ion homeostasis | GO:0006873 | 184 | 0.035 | |
| response to glucocorticoid | GO:0051384 | 223 | 0.034 | |
| positive regulation of cell communication | GO:0010647 | 271 | 0.034 | Human |
| cellular calcium ion homeostasis | GO:0006874 | 160 | 0.033 | |
| positive regulation of mapk cascade | GO:0043410 | 92 | 0.032 | |
| erk1 and erk2 cascade | GO:0070371 | 48 | 0.031 | |
| cytoskeleton organization | GO:0007010 | 111 | 0.031 | |
| regulation of kinase activity | GO:0043549 | 117 | 0.031 | |
| secretion | GO:0046903 | 307 | 0.029 | Mouse |
| regulation of cellular protein metabolic process | GO:0032268 | 267 | 0.029 | |
| positive regulation of protein phosphorylation | GO:0001934 | 135 | 0.029 | |
| response to cytokine | GO:0034097 | 215 | 0.029 | |
| g protein coupled receptor signaling pathway | GO:0007186 | 242 | 0.029 | |
| positive regulation of protein modification process | GO:0031401 | 142 | 0.028 | |
| cellular response to alcohol | GO:0097306 | 87 | 0.028 | |
| inflammatory response | GO:0006954 | 150 | 0.028 | |
| nucleotide metabolic process | GO:0009117 | 279 | 0.028 | |
| ribose phosphate metabolic process | GO:0019693 | 235 | 0.028 | |
| cation homeostasis | GO:0055080 | 195 | 0.028 | |
| small molecule biosynthetic process | GO:0044283 | 124 | 0.028 | |
| protein localization | GO:0008104 | 191 | 0.028 | |
| regulation of transferase activity | GO:0051338 | 123 | 0.026 | |
| myeloid leukocyte activation | GO:0002274 | 36 | 0.026 | Mouse |
| positive regulation of intracellular signal transduction | GO:1902533 | 138 | 0.026 | |
| ribonucleotide metabolic process | GO:0009259 | 231 | 0.025 | |
| response to peptide | GO:1901652 | 292 | 0.025 | |
| cellular chemical homeostasis | GO:0055082 | 247 | 0.024 | |
| regulation of transcription dna templated | GO:0006355 | 374 | 0.024 | |
| positive regulation of phosphorylation | GO:0042327 | 177 | 0.023 | |
| signal transduction by phosphorylation | GO:0023014 | 144 | 0.023 | |
| regulation of protein modification process | GO:0031399 | 194 | 0.023 | |
| divalent inorganic cation homeostasis | GO:0072507 | 165 | 0.023 | |
| response to lipopolysaccharide | GO:0032496 | 191 | 0.023 | |
| regulation of stem cell differentiation | GO:2000736 | 2 | 0.023 | |
| ion transmembrane transport | GO:0034220 | 365 | 0.022 | |
| regulation of immune system process | GO:0002682 | 123 | 0.022 | Mouse |
| regulation of signal transduction | GO:0009966 | 318 | 0.022 | Human Fly |
| regulation of cellular amino acid metabolic process | GO:0006521 | 2 | 0.022 | |
| cell adhesion | GO:0007155 | 110 | 0.022 | |
| biological adhesion | GO:0022610 | 110 | 0.022 | |
| regulation of cellular amine metabolic process | GO:0033238 | 8 | 0.021 | |
| reproductive process | GO:0022414 | 372 | 0.021 | |
| cellular response to glucocorticoid stimulus | GO:0071385 | 68 | 0.021 | |
| purine containing compound metabolic process | GO:0072521 | 253 | 0.021 | |
| protein complex biogenesis | GO:0070271 | 263 | 0.020 | |
| response to acid chemical | GO:0001101 | 222 | 0.020 | |
| dephosphorylation | GO:0016311 | 98 | 0.020 | |
| organophosphate biosynthetic process | GO:0090407 | 143 | 0.020 | |
| carbohydrate derivative metabolic process | GO:1901135 | 346 | 0.020 | |
| negative regulation of transport | GO:0051051 | 136 | 0.019 | |
| metal ion homeostasis | GO:0055065 | 186 | 0.019 | |
| rna metabolic process | GO:0016070 | 406 | 0.019 | |
| positive regulation of cellular amine metabolic process | GO:0033240 | 3 | 0.019 | |
| regulation of nucleic acid templated transcription | GO:1903506 | 380 | 0.019 | |
| response to nutrient levels | GO:0031667 | 370 | 0.019 | |
| positive regulation of kinase activity | GO:0033674 | 77 | 0.019 | |
| response to growth factor | GO:0070848 | 189 | 0.019 | |
| ion homeostasis | GO:0050801 | 212 | 0.019 | |
| nucleoside phosphate biosynthetic process | GO:1901293 | 102 | 0.018 | |
| response to peptide hormone | GO:0043434 | 278 | 0.018 | |
| regulation of mapk cascade | GO:0043408 | 116 | 0.018 | |
| cell type specific apoptotic process | GO:0097285 | 134 | 0.018 | |
| negative regulation of molecular function | GO:0044092 | 133 | 0.018 | |
| cellular cation homeostasis | GO:0030003 | 180 | 0.018 | |
| regulation of homeostatic process | GO:0032844 | 101 | 0.018 | |
| adenylate cyclase modulating g protein coupled receptor signaling pathway | GO:0007188 | 51 | 0.018 | |
| brain development | GO:0007420 | 247 | 0.018 | |
| apoptotic process | GO:0006915 | 381 | 0.018 | |
| positive regulation of nitrogen compound metabolic process | GO:0051173 | 334 | 0.018 | |
| negative regulation of signaling | GO:0023057 | 157 | 0.018 | |
| cellular amino acid metabolic process | GO:0006520 | 107 | 0.017 | |
| cellular divalent inorganic cation homeostasis | GO:0072503 | 162 | 0.017 | |
| regulation of programmed cell death | GO:0043067 | 341 | 0.017 | |
| reactive oxygen species metabolic process | GO:0072593 | 37 | 0.017 | |
| organophosphate catabolic process | GO:0046434 | 148 | 0.017 | |
| cellular amine metabolic process | GO:0044106 | 38 | 0.017 | |
| intracellular transport | GO:0046907 | 185 | 0.017 | Mouse |
| carboxylic acid metabolic process | GO:0019752 | 289 | 0.017 | |
| single organism intracellular transport | GO:1902582 | 166 | 0.016 | Mouse |
| negative regulation of cell death | GO:0060548 | 229 | 0.016 | |
| regulation of transcription from rna polymerase ii promoter | GO:0006357 | 234 | 0.016 | |
| nucleoside phosphate metabolic process | GO:0006753 | 283 | 0.016 | |
| positive regulation of multicellular organismal process | GO:0051240 | 387 | 0.016 | |
| chemical homeostasis | GO:0048878 | 292 | 0.016 | |
| positive regulation of cellular amino acid metabolic process | GO:0045764 | 1 | 0.016 | |
| purine ribonucleotide metabolic process | GO:0009150 | 227 | 0.016 | |
| amine metabolic process | GO:0009308 | 38 | 0.016 | |
| cellular response to steroid hormone stimulus | GO:0071383 | 93 | 0.015 | |
| adult locomotory behavior | GO:0008344 | 4 | 0.015 | |
| cytosolic calcium ion homeostasis | GO:0051480 | 140 | 0.015 | |
| kidney development | GO:0001822 | 67 | 0.015 | |
| positive regulation of developmental process | GO:0051094 | 283 | 0.015 | |
| cellular homeostasis | GO:0019725 | 252 | 0.015 | |
| activation of protein kinase activity | GO:0032147 | 47 | 0.015 | |
| blood circulation | GO:0008015 | 183 | 0.015 | |
| axis specification | GO:0009798 | 4 | 0.015 | |
| nucleobase containing small molecule metabolic process | GO:0055086 | 316 | 0.015 | |
| calcium ion homeostasis | GO:0055074 | 162 | 0.015 | |
| regulation of catabolic process | GO:0009894 | 113 | 0.014 | |
| positive regulation of nucleobase containing compound metabolic process | GO:0045935 | 319 | 0.014 | |
| enzyme linked receptor protein signaling pathway | GO:0007167 | 116 | 0.014 | Human |
| purine nucleotide metabolic process | GO:0006163 | 229 | 0.014 | |
| regulation of neuron apoptotic process | GO:0043523 | 83 | 0.014 | |
| regulation of purine nucleotide metabolic process | GO:1900542 | 115 | 0.014 | |
| positive regulation of cell death | GO:0010942 | 184 | 0.014 | |
| aging | GO:0007568 | 241 | 0.014 | |
| response to radiation | GO:0009314 | 137 | 0.014 | |
| renal system development | GO:0072001 | 67 | 0.014 | |
| positive regulation of signaling | GO:0023056 | 270 | 0.014 | Human |
| lens development in camera type eye | GO:0002088 | 13 | 0.014 | |
| mapk cascade | GO:0000165 | 140 | 0.014 | |
| macromolecular complex subunit organization | GO:0043933 | 339 | 0.013 | |
| single organism catabolic process | GO:0044712 | 283 | 0.013 | |
| signal transduction involved in regulation of gene expression | GO:0023019 | 4 | 0.013 | |
| muscle cell proliferation | GO:0033002 | 84 | 0.013 | |
| regulation of nucleotide metabolic process | GO:0006140 | 117 | 0.013 | |
| heart morphogenesis | GO:0003007 | 3 | 0.013 | |
| cation transport | GO:0006812 | 382 | 0.013 | |
| response to ionizing radiation | GO:0010212 | 59 | 0.013 | |
| small gtpase mediated signal transduction | GO:0007264 | 36 | 0.013 | Fly |
| liver development | GO:0001889 | 90 | 0.013 | |
| response to decreased oxygen levels | GO:0036293 | 237 | 0.013 | |
| cellular catabolic process | GO:0044248 | 295 | 0.013 | |
| glycosyl compound metabolic process | GO:1901657 | 182 | 0.013 | |
| urogenital system development | GO:0001655 | 78 | 0.013 | |
| positive regulation of gene expression | GO:0010628 | 244 | 0.013 | |
| organelle organization | GO:0006996 | 266 | 0.013 | |
| ras protein signal transduction | GO:0007265 | 29 | 0.013 | Fly |
| organic anion transport | GO:0015711 | 132 | 0.013 | |
| rna biosynthetic process | GO:0032774 | 380 | 0.013 | |
| wound healing | GO:0042060 | 122 | 0.013 | |
| cytoplasmic transport | GO:0016482 | 115 | 0.012 | |
| purine nucleotide catabolic process | GO:0006195 | 136 | 0.012 | |
| positive regulation of biosynthetic process | GO:0009891 | 319 | 0.012 | |
| cellular component biogenesis | GO:0044085 | 368 | 0.012 | |
| positive regulation of immune system process | GO:0002684 | 90 | 0.012 | Mouse |
| negative regulation of phosphate metabolic process | GO:0045936 | 80 | 0.012 | |
| negative regulation of apoptotic process | GO:0043066 | 181 | 0.012 | |
| regulation of hydrolase activity | GO:0051336 | 143 | 0.012 | |
| retina morphogenesis in camera type eye | GO:0060042 | 1 | 0.012 | |
| cellular ketone metabolic process | GO:0042180 | 51 | 0.012 | |
| regulation of cellular ketone metabolic process | GO:0010565 | 27 | 0.012 | |
| nucleic acid templated transcription | GO:0097659 | 379 | 0.012 | |
| regulation of sodium ion transmembrane transporter activity | GO:2000649 | 4 | 0.012 | |
| establishment of protein localization | GO:0045184 | 141 | 0.012 | |
| response to estradiol | GO:0032355 | 164 | 0.012 | |
| nucleotide biosynthetic process | GO:0009165 | 98 | 0.012 | |
| cellular response to oxygen containing compound | GO:1901701 | 386 | 0.012 | |
| head development | GO:0060322 | 247 | 0.011 | |
| actin cytoskeleton organization | GO:0030036 | 73 | 0.011 | |
| response to inorganic substance | GO:0010035 | 377 | 0.011 | |
| positive regulation of nucleic acid templated transcription | GO:1903508 | 197 | 0.011 | |
| protein transport | GO:0015031 | 132 | 0.011 | |
| sympathetic nervous system development | GO:0048485 | 1 | 0.011 | |
| behavioral response to ethanol | GO:0048149 | 1 | 0.011 | |
| eye morphogenesis | GO:0048592 | 4 | 0.011 | |
| protein oligomerization | GO:0051259 | 191 | 0.011 | |
| nucleobase containing compound catabolic process | GO:0034655 | 152 | 0.011 | |
| cellular protein localization | GO:0034613 | 122 | 0.011 | |
| organophosphate metabolic process | GO:0019637 | 370 | 0.011 | |
| immune effector process | GO:0002252 | 53 | 0.011 | Mouse |
| glutamate receptor signaling pathway | GO:0007215 | 43 | 0.011 | |
| second messenger mediated signaling | GO:0019932 | 51 | 0.011 | |
| negative regulation of phosphorus metabolic process | GO:0010563 | 80 | 0.011 | |
| oxoacid metabolic process | GO:0043436 | 290 | 0.011 | |
| peptidyl tyrosine phosphorylation | GO:0018108 | 72 | 0.011 | |
| positive regulation of serotonin secretion | GO:0014064 | 1 | 0.011 | |
| positive regulation of signal transduction | GO:0009967 | 175 | 0.011 | Human |
| response to starvation | GO:0042594 | 59 | 0.011 | |
| developmental process involved in reproduction | GO:0003006 | 159 | 0.011 | |
| secretion by cell | GO:0032940 | 248 | 0.011 | Mouse |
| b cell differentiation | GO:0030183 | 2 | 0.011 | |
| dna integrity checkpoint | GO:0031570 | 2 | 0.011 | |
| regulation of rna metabolic process | GO:0051252 | 391 | 0.011 | |
| carboxylic acid transport | GO:0046942 | 115 | 0.011 | |
| positive regulation of locomotion | GO:0040017 | 102 | 0.010 | |
| purine ribonucleotide catabolic process | GO:0009154 | 136 | 0.010 | |
| carboxylic acid biosynthetic process | GO:0046394 | 83 | 0.010 | |
| positive regulation of protein kinase activity | GO:0045860 | 73 | 0.010 | |
| positive regulation of cell proliferation | GO:0008284 | 249 | 0.010 | Human |
| detection of visible light | GO:0009584 | 3 | 0.010 | |
| alcohol metabolic process | GO:0006066 | 77 | 0.010 | |
| bmp signaling pathway | GO:0030509 | 4 | 0.010 | |
| purine nucleoside metabolic process | GO:0042278 | 169 | 0.010 | |
