Rattus norvegicus

38 known processes

Hk2

hexokinase 2

Hk2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to extracellular stimulusGO:00099913800.283
Yeast
regulation of cellular component organizationGO:00511283680.261
oxoacid metabolic processGO:00434362900.236
Yeast
neuron differentiationGO:00301823680.212
cellular response to endogenous stimulusGO:00714953770.210
response to hypoxiaGO:00016662310.208
protein complex assemblyGO:00064612630.190
anatomical structure morphogenesisGO:00096532980.186
Yeast
carboxylic acid metabolic processGO:00197522890.185
Yeast
macromolecular complex assemblyGO:00650032730.171
cellular amino acid metabolic processGO:00065201070.170
neuron deathGO:00709971270.154
cellular component movementGO:00069282480.146
cellular component assemblyGO:00226073600.141
cell migrationGO:00164771970.139
response to oxygen levelsGO:00704822650.138
cellular response to oxygen containing compoundGO:19017013860.137
organic acid metabolic processGO:00060822920.135
Yeast
response to nutrientGO:00075842480.132
Yeast
cellular component biogenesisGO:00440853680.129
regenerationGO:00310991630.129
regulation of cell differentiationGO:00455953200.127
protein complex biogenesisGO:00702712630.126
single organism biosynthetic processGO:00447113420.117
protein phosphorylationGO:00064683450.117
response to estradiolGO:00323551640.117
negative regulation of cell deathGO:00605482290.116
tissue developmentGO:00098882520.115
regulation of cell proliferationGO:00421273590.114
regulation of cellular protein metabolic processGO:00322682670.114
positive regulation of multicellular organismal processGO:00512403870.113
carbohydrate derivative metabolic processGO:19011353460.113
Yeast
response to decreased oxygen levelsGO:00362932370.108
cellular response to stressGO:00335542690.107
cellular response to hormone stimulusGO:00328702470.106
response to nutrient levelsGO:00316673700.101
Yeast
regulation of cell migrationGO:00303341280.100
protein oligomerizationGO:00512591910.100
negative regulation of apoptotic processGO:00430661810.099
neuron projection developmentGO:00311752730.098
positive regulation of cell projection organizationGO:00313461110.098
single organism catabolic processGO:00447122830.097
Yeast
positive regulation of cell differentiationGO:00455972170.097
apoptotic processGO:00069153810.096
Human
programmed cell deathGO:00125013920.095
Human
catabolic processGO:00090563510.094
Yeast
response to biotic stimulusGO:00096072260.093
regulation of cell developmentGO:00602842630.092
circulatory system developmentGO:00723591340.092
positive regulation of cellular component organizationGO:00511302000.091
transmembrane transportGO:00550854120.090
regulation of apoptotic processGO:00429813350.089
cell motilityGO:00488702020.089
regulation of programmed cell deathGO:00430673410.089
regulation of neurogenesisGO:00507672470.089
regulation of nervous system developmentGO:00519602640.089
regulation of neuron differentiationGO:00456642080.088
negative regulation of programmed cell deathGO:00430691830.088
response to other organismGO:00517072200.086
regulation of phosphorus metabolic processGO:00511743490.086
cell type specific apoptotic processGO:00972851340.084
regulation of cellular component movementGO:00512701500.083
regulation of lymphocyte migrationGO:200040110.083
alpha amino acid metabolic processGO:1901605710.082
gliogenesisGO:0042063930.081
positive regulation of phosphate metabolic processGO:00459372620.080
regulation of cell projection organizationGO:00313441750.080
response to growth factorGO:00708481890.080
positive regulation of gene expressionGO:00106282440.079
Yeast
intracellular signal transductionGO:00355563140.078
response to woundingGO:00096112540.077
positive regulation of cell proliferationGO:00082842490.077
peptidyl tyrosine phosphorylationGO:0018108720.076
organic substance catabolic processGO:19015753160.075
Yeast
regulation of phosphorylationGO:00423252480.074
response to external biotic stimulusGO:00432072210.073
gland developmentGO:00487321550.073
organophosphate metabolic processGO:00196373700.072
Yeast
multi organism reproductive processGO:00447032620.072
Yeast
response to estrogenGO:00436272320.072
protein complex subunit organizationGO:00718223020.071
behaviorGO:00076102050.071
neuron developmentGO:00486662860.070
regulation of multicellular organismal developmentGO:20000263760.070
central nervous system developmentGO:00074173110.070
multi multicellular organism processGO:00447061380.070
response to campGO:0051591910.070
peptidyl amino acid modificationGO:00181931260.070
positive regulation of protein metabolic processGO:00512471780.069
cell projection organizationGO:00300303020.068
positive regulation of cellular biosynthetic processGO:00313282950.067
Yeast
regulation of transcription dna templatedGO:00063553740.067
Yeast
regulation of neuron projection developmentGO:00109751610.067
organelle organizationGO:00069962660.066
Human
rna biosynthetic processGO:00327743800.065
Yeast
anatomical structure formation involved in morphogenesisGO:0048646830.064
Yeast
positive regulation of nitrogen compound metabolic processGO:00511733340.064
Yeast
neurological system processGO:00508772190.064
homeostatic processGO:00425923310.063
regulation of protein metabolic processGO:00512462890.063
cellular ketone metabolic processGO:0042180510.063
reproductive processGO:00224143720.063
Yeast
regulation of cellular ketone metabolic processGO:0010565270.063
blood vessel developmentGO:0001568690.062
nucleoside phosphate metabolic processGO:00067532830.061
response to corticosteroidGO:00319602350.061
positive regulation of protein modification processGO:00314011420.059
hepaticobiliary system developmentGO:0061008900.058
blood circulationGO:00080151830.057
regulation of system processGO:00440572080.056
regulation of intracellular signal transductionGO:19025312180.056
cardiovascular system developmentGO:00723581340.056
cellular catabolic processGO:00442482950.056
regulation of cellular amino acid metabolic processGO:000652120.056
localization of cellGO:00516742020.055
organophosphate biosynthetic processGO:00904071430.055
cellular response to lipidGO:00713962010.055
positive regulation of cellular component movementGO:00512721020.055
brain developmentGO:00074202470.054
regulation of protein modification processGO:00313991940.054
regulation of phosphate metabolic processGO:00192203490.053
regulation of neuron deathGO:19012141150.052
cellular response to organic cyclic compoundGO:00714072020.051
positive regulation of nervous system developmentGO:00519621780.051
amine metabolic processGO:0009308380.051
negative regulation of multicellular organismal processGO:00512412030.051
response to radiationGO:00093141370.050
ribonucleotide metabolic processGO:00092592310.050
response to purine containing compoundGO:00140741260.049
positive regulation of neuron projection developmentGO:0010976990.049
positive regulation of cellular amino acid metabolic processGO:004576410.049
regulation of cellular amine metabolic processGO:003323880.048
positive regulation of biosynthetic processGO:00098913190.048
Yeast
macromolecular complex subunit organizationGO:00439333390.048
response to bacteriumGO:00096172000.047
regulation of protein phosphorylationGO:00019321830.046
response to molecule of bacterial originGO:00022371940.046
positive regulation of developmental processGO:00510942830.046
positive regulation of phosphorus metabolic processGO:00105622620.046
positive regulation of cell developmentGO:00107201760.045
regulation of neuron apoptotic processGO:0043523830.045
nucleotide metabolic processGO:00091172790.045
positive regulation of phosphorylationGO:00423271770.043
regulation of blood vessel sizeGO:0050880890.043
cellular amine metabolic processGO:0044106380.043
leukocyte migrationGO:0050900380.043
negative regulation of metabolic processGO:00098923310.042
small gtpase mediated signal transductionGO:0007264360.042
action potentialGO:0001508540.041
regulation of molecular functionGO:00650093980.041
nucleic acid templated transcriptionGO:00976593790.041
Yeast
carbohydrate derivative catabolic processGO:19011361470.040
gastrulationGO:000736920.040
regulation of growthGO:00400081050.040
neuronal action potentialGO:0019228350.040
peptidyl tyrosine modificationGO:0018212720.039
response to ethanolGO:00454711620.039
cellular homeostasisGO:00197252520.039
positive regulation of cellular amine metabolic processGO:003324030.039
rna metabolic processGO:00160704060.039
Yeast
positive regulation of cellular protein metabolic processGO:00322701670.039
chemical homeostasisGO:00488782920.038
cell morphogenesisGO:00009021420.038
ribose phosphate metabolic processGO:00196932350.038
single organism reproductive processGO:00447022970.038
Yeast
regulation of anatomical structure morphogenesisGO:00226031410.038
vascular process in circulatory systemGO:0003018960.038
positive regulation of neuron differentiationGO:00456661260.037
female pregnancyGO:00075651220.037
response to lipopolysaccharideGO:00324961910.037
cellular component morphogenesisGO:00329891550.037
response to organophosphorusGO:00466831020.037
response to carbohydrateGO:00097431830.036
transcription dna templatedGO:00063513770.036
Yeast
wound healingGO:00420601220.036
agingGO:00075682410.036
Yeast
cell cell signalingGO:00072673350.036
Fly
regulation of nucleic acid templated transcriptionGO:19035063800.035
Yeast
cell growthGO:00160491040.035
carbohydrate metabolic processGO:00059751300.035
locomotionGO:00400112370.035
Fly
regulation of locomotionGO:00400121480.035
motor neuron axon guidanceGO:000804510.034
regulation of rna metabolic processGO:00512523910.034
Yeast
purine nucleotide metabolic processGO:00061632290.034
formation of primary germ layerGO:000170410.034
positive regulation of neurogenesisGO:00507691650.034
neuron apoptotic processGO:0051402880.034
response to inorganic substanceGO:00100353770.033
regulation of secretionGO:00510462240.033
cellular response to growth factor stimulusGO:00713631620.033
head developmentGO:00603222470.033
positive regulation of response to stimulusGO:00485842850.033
response to glucocorticoidGO:00513842230.032
organ regenerationGO:00311001010.032
negative regulation of cellular protein metabolic processGO:00322691060.032
positive regulation of protein phosphorylationGO:00019341350.032
positive regulation of cell communicationGO:00106472710.032
positive regulation of phagocytosis engulfmentGO:006010040.032
response to vitaminGO:00332731310.032
response to ketoneGO:19016541820.032
ensheathment of neuronsGO:0007272400.031
generation of precursor metabolites and energyGO:0006091620.031
Yeast
axon ensheathmentGO:0008366400.031
ion homeostasisGO:00508012120.031
anion transportGO:00068201780.031
response to monosaccharideGO:00342841590.031
regulation of transferase activityGO:00513381230.031
regulation of leukocyte migrationGO:0002685240.031
cell part morphogenesisGO:00329901230.031
cellular response to insulin stimulusGO:0032869810.031
regulation of anatomical structure sizeGO:00900661350.031
Yeast
response to metal ionGO:00100382530.030
neuron projection morphogenesisGO:00488121220.030
positive regulation of cell migrationGO:0030335960.030
enzyme linked receptor protein signaling pathwayGO:00071671160.030
liver developmentGO:0001889900.030
regulation of immune system processGO:00026821230.030
protein localizationGO:00081041910.029
ras protein signal transductionGO:0007265290.029
regulation of cell motilityGO:20001451310.029
growthGO:00400071650.029
oxidation reduction processGO:00551143040.029
response to peptide hormoneGO:00434342780.029
vasculature developmentGO:0001944700.029
regulation of catalytic activityGO:00507903040.029
vitamin transportGO:0051180140.029
myelinationGO:0042552390.029
negative regulation of macromolecule metabolic processGO:00106052600.028
developmental process involved in reproductionGO:00030061590.028
Yeast
glial cell differentiationGO:0010001650.028
regulation of signal transductionGO:00099663180.028
response to insulinGO:00328681330.028
regulation of membrane potentialGO:00423911100.028
negative regulation of macromolecule biosynthetic processGO:00105581480.028
regulation of protein kinase activityGO:00458591050.027
cellular response to external stimulusGO:00714961180.027
Yeast
negative regulation of cell communicationGO:00106481580.027
positive regulation of cell deathGO:00109421840.027
axon developmentGO:0061564960.027
positive regulation of macromolecule biosynthetic processGO:00105572470.027
Yeast
purine ribonucleotide metabolic processGO:00091502270.027
multicellular organismal reproductive processGO:00486092330.027
positive regulation of cell motilityGO:2000147970.027
cellular calcium ion homeostasisGO:00068741600.027
nucleoside metabolic processGO:00091161790.027
organic anion transportGO:00157111320.027
regulation of cell growthGO:0001558850.026
regulation of mapk cascadeGO:00434081160.026
negative regulation of gene expressionGO:00106291990.026
regulation of tube sizeGO:0035150890.026
multicellular organismal signalingGO:0035637440.026
translationGO:0006412350.026
circulatory system processGO:00030131830.026
response to toxic substanceGO:00096361330.026
cellular response to peptideGO:19016531330.026
regulation of hydrolase activityGO:00513361430.026
negative regulation of cellular metabolic processGO:00313242810.026
cellular response to nitrogen compoundGO:19016992100.026
polysaccharide metabolic processGO:0005976250.025
reproductive structure developmentGO:00486081280.025
regulation of synaptic plasticityGO:0048167700.025
intracellular transportGO:00469071850.025
axonogenesisGO:0007409710.025
secretionGO:00469033070.025
ribonucleoside metabolic processGO:00091191740.025
cellular response to abiotic stimulusGO:0071214850.025
purine ribonucleoside triphosphate metabolic processGO:00092051400.025
vasculogenesisGO:000157030.025
lipid metabolic processGO:00066292830.024
positive regulation of rna metabolic processGO:00512542030.024
Yeast
positive regulation of locomotionGO:00400171020.024
gamete generationGO:00072761240.024
cellular response to molecule of bacterial originGO:0071219560.024
tissue regenerationGO:0042246360.024
cation transportGO:00068123820.024
regulation of rna biosynthetic processGO:20011413810.024
Yeast
protein processingGO:0016485680.024
positive regulation of transcription dna templatedGO:00458931970.024
Yeast
regulation of endocytosisGO:0030100420.024
anterior posterior pattern specificationGO:000995210.023
negative regulation of protein metabolic processGO:00512481140.023
positive regulation of programmed cell deathGO:00430681570.023
glycogen metabolic processGO:0005977230.023
carbohydrate derivative biosynthetic processGO:19011371240.023
response to acid chemicalGO:00011012220.023
positive regulation of signalingGO:00230562700.023
response to mechanical stimulusGO:00096121340.023
anion transmembrane transportGO:0098656770.023
organic cyclic compound catabolic processGO:19013611750.023
response to hyperoxiaGO:0055093450.023
glycosyl compound catabolic processGO:19016581260.022
organonitrogen compound catabolic processGO:19015651790.022
single organism behaviorGO:00447081300.022
ion transmembrane transportGO:00342203650.022
cellular response to fluid shear stressGO:007149840.022
single organism intracellular transportGO:19025821660.022
cellular protein localizationGO:00346131220.022
protein heterooligomerizationGO:0051291890.022
cellular cation homeostasisGO:00300031800.022
regulation of vasculature developmentGO:1901342440.022
response to interleukin 1GO:0070555550.022
cell morphogenesis involved in differentiationGO:00009041190.022
positive regulation of transportGO:00510502450.022
negative regulation of neuron deathGO:1901215690.022
heterocycle catabolic processGO:00467001670.022
positive regulation of chemotaxisGO:0050921230.022
metal ion transportGO:00300012890.021
cellular metal ion homeostasisGO:00068751720.021
purine ribonucleoside catabolic processGO:00461301240.021
cellular macromolecule localizationGO:00707271220.021
nucleobase containing small molecule metabolic processGO:00550863160.021
multicellular organism reproductionGO:00325042330.021
blood vessel morphogenesisGO:0048514580.021
regulation of behaviorGO:0050795610.021
cognitionGO:0050890920.021
regulation of kinase activityGO:00435491170.021
positive regulation of molecular functionGO:00440932300.021
single organism membrane organizationGO:0044802740.020
nucleotide catabolic processGO:00091661390.020
dephosphorylationGO:0016311980.020
response to hydrogen peroxideGO:0042542890.020
renal system processGO:0003014400.020
regulation of cell morphogenesisGO:0022604770.020
cellular nitrogen compound catabolic processGO:00442701630.020
positive regulation of nucleotide metabolic processGO:0045981910.020
positive regulation of signal transductionGO:00099671750.020
membrane organizationGO:0061024940.020
purine ribonucleoside metabolic processGO:00461281680.019
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.019
synaptic transmissionGO:00072682350.019
mesoderm developmentGO:000749820.019
negative regulation of molecular functionGO:00440921330.019
reproductionGO:00000032450.019
Yeast
energy derivation by oxidation of organic compoundsGO:0015980460.019
cellular response to biotic stimulusGO:0071216590.019
inflammatory responseGO:00069541500.019
regulation of potassium ion transportGO:0043266290.019
purine containing compound metabolic processGO:00725212530.018
purine nucleoside catabolic processGO:00061521240.018
activation of protein kinase activityGO:0032147470.018
response to peptideGO:19016522920.018
axis specificationGO:000979840.018
positive regulation of hydrolase activityGO:0051345860.018
cellular chemical homeostasisGO:00550822470.018
response to cytokineGO:00340972150.018
positive regulation of behaviorGO:0048520380.018
negative regulation of signalingGO:00230571570.018
ribonucleoside catabolic processGO:00424541260.018
carboxylic acid transportGO:00469421150.018
response to ionizing radiationGO:0010212590.018
angiogenesisGO:0001525530.018
regulation of axonogenesisGO:0050770370.018
smooth muscle cell proliferationGO:0048659770.018
cellular response to alcoholGO:0097306870.017
mapk cascadeGO:00001651400.017
posttranscriptional regulation of gene expressionGO:0010608370.017
response to glucoseGO:00097491360.017
positive regulation of transferase activityGO:0051347810.017
glycosyl compound metabolic processGO:19016571820.017
regulation of chemotaxisGO:0050920290.017
response to starvationGO:0042594590.017
purine nucleoside triphosphate catabolic processGO:00091461220.017
cytosolic calcium ion homeostasisGO:00514801400.017
nitrogen compound transportGO:00717052290.017
glucan metabolic processGO:0044042230.017
response to amineGO:0014075460.017
cellular divalent inorganic cation homeostasisGO:00725031620.017
cellular response to steroid hormone stimulusGO:0071383930.017
detection of stimulusGO:0051606240.017
cellular response to extracellular stimulusGO:0031668730.017
Yeast
nucleoside phosphate biosynthetic processGO:19012931020.017
regulation of homeostatic processGO:00328441010.017
positive regulation of nucleobase containing compound metabolic processGO:00459353190.017
Yeast
synaptic growth at neuromuscular junctionGO:005112410.016
cellular polysaccharide metabolic processGO:0044264230.016
transmission of nerve impulseGO:0019226420.016
cell adhesionGO:00071551100.016
regulation of metal ion transportGO:00109591180.016
tube developmentGO:0035295890.016
cellular lipid metabolic processGO:00442552080.016
regulation of angiogenesisGO:0045765390.016
single organism organelle organizationGO:19025891800.016
regulation of muscle system processGO:0090257790.016
positive regulation of smooth muscle cell migrationGO:0014911270.016
programmed necrotic cell deathGO:009730020.016
response to hexoseGO:00097461440.016
regulation of transcription from rna polymerase ii promoterGO:00063572340.016
Yeast
regulation of synaptic transmissionGO:00508041410.016
carboxylic acid biosynthetic processGO:0046394830.016
lipid biosynthetic processGO:00086101280.016
lipid storageGO:001991510.016
regulation of cellular localizationGO:00603412630.016
positive regulation of kinase activityGO:0033674770.015
regulation of translationGO:0006417270.015
negative regulation of neuron apoptotic processGO:0043524450.015
calcium ion homeostasisGO:00550741620.015
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.015
Yeast
positive regulation of catalytic activityGO:00430851840.015
response to axon injuryGO:0048678590.015
positive regulation of ion transportGO:0043270940.015
nucleoside monophosphate metabolic processGO:0009123930.015
nucleoside triphosphate metabolic processGO:00091411440.015
negative regulation of neuron differentiationGO:0045665620.015
leukocyte cell cell adhesionGO:000715940.015
response to activityGO:0014823730.015
actin filament based processGO:0030029860.015
negative regulation of response to stimulusGO:00485851550.015
taxisGO:0042330670.015
organ morphogenesisGO:0009887750.015
positive regulation of rna biosynthetic processGO:19026801970.015
Yeast
response to reactive oxygen speciesGO:00003021200.015
response to oxidative stressGO:00069791860.015
transcription from rna polymerase ii promoterGO:00063662520.015
Yeast
cellular glucan metabolic processGO:0006073230.014
lymphocyte migrationGO:007267630.014
necroptotic processGO:007026620.014
regulation of synaptic growth at neuromuscular junctionGO:000858210.014
regulation of catabolic processGO:00098941130.014
protein maturationGO:0051604680.014
nucleotide biosynthetic processGO:0009165980.014
regulation of response to woundingGO:1903034690.014
regulation of purine nucleotide metabolic processGO:19005421150.014
biological adhesionGO:00226101100.014
regulation of response to external stimulusGO:00321011060.014
response to gamma radiationGO:0010332240.014
ribonucleoside triphosphate catabolic processGO:00092031220.014
spermatogenesisGO:0007283990.014
cellular response to lipopolysaccharideGO:0071222550.014
placenta developmentGO:0001890220.014
chemotaxisGO:0006935660.014
regulation of nucleotide metabolic processGO:00061401170.014
negative regulation of blood pressureGO:0045776290.014
positive regulation of intracellular signal transductionGO:19025331380.014
g protein coupled receptor signaling pathwayGO:00071862420.014
aromatic compound catabolic processGO:00194391680.013
positive regulation of mapk cascadeGO:0043410920.013
vasodilationGO:0042311440.013
kidney developmentGO:0001822670.013
rhythmic processGO:00485111560.013
potassium ion transportGO:0006813970.013
regulation of cellular component biogenesisGO:0044087860.013
response to electrical stimulusGO:0051602560.013
cell cycle checkpointGO:000007520.013
purine nucleotide catabolic processGO:00061951360.013
negative regulation of cell proliferationGO:00082851190.013
heart morphogenesisGO:000300730.013
immune system processGO:00023762040.013
epithelium developmentGO:0060429960.013
regulation of protein processingGO:0070613500.013
regulation of smooth muscle cell proliferationGO:0048660750.013
purine nucleoside triphosphate metabolic processGO:00091441410.013
regulation of hormone levelsGO:00108171870.013
regulation of phagocytosis engulfmentGO:006009940.013
sexual reproductionGO:00199531480.013
Yeast
regulation of cell adhesionGO:0030155520.013
muscle system processGO:00030121150.013
proteolysisGO:00065081750.013
regulation of body fluid levelsGO:0050878900.013
ribonucleotide catabolic processGO:00092611360.013
negative regulation of cellular component organizationGO:0051129830.013
regulation of homotypic cell cell adhesionGO:003411040.013
regulation of cellular catabolic processGO:00313291010.013
defense responseGO:00069521940.013
regulation of ion transportGO:00432692450.013
protein dephosphorylationGO:0006470380.013
regulation of fat cell differentiationGO:004559830.012
macromolecule localizationGO:00330362520.012
vesicle mediated transportGO:00161921810.012
negative regulation of catalytic activityGO:00430861030.012
defense response to gram negative bacteriumGO:005082930.012
cellular response to peptide hormone stimulusGO:00713751200.012
sensory perceptionGO:00076001010.012
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.012
monocarboxylic acid metabolic processGO:00327871520.012
Yeast
insulin like growth factor receptor signaling pathwayGO:004800930.012
purine nucleoside monophosphate metabolic processGO:0009126840.012
epithelial cell differentiationGO:0030855710.012
cell morphogenesis involved in neuron differentiationGO:00486671060.012
negative regulation of cell developmentGO:0010721820.012
guanosine containing compound metabolic processGO:1901068740.012
divalent inorganic cation homeostasisGO:00725071650.012

Hk2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
muscular diseaseDOID:008000000.174
muscle tissue diseaseDOID:6600.174
musculoskeletal system diseaseDOID:1700.174
myopathyDOID:42300.174
disease of anatomical entityDOID:700.174
nervous system diseaseDOID:86300.072
cardiovascular system diseaseDOID:128700.037
sensory system diseaseDOID:005015500.021
disease of metabolismDOID:001466700.020
central nervous system diseaseDOID:33100.020
disease of cellular proliferationDOID:1456600.014
eye diseaseDOID:561400.014
eye and adnexa diseaseDOID:149200.014
organ system cancerDOID:005068600.012
cancerDOID:16200.012