Rattus norvegicus

0 known processes

Phex

phosphate regulating endopeptidase homolog, X-linked

(Aliases: PEX)

Phex biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of cell proliferationGO:00421273590.415
response to inorganic substanceGO:00100353770.388
Rat
response to nutrient levelsGO:00316673700.372
cellular response to oxygen containing compoundGO:19017013860.290
regulation of hormone levelsGO:00108171870.290
cellular response to endogenous stimulusGO:00714953770.269
behaviorGO:00076102050.258
oxoacid metabolic processGO:00434362900.239
cellular response to organic cyclic compoundGO:00714072020.221
response to acid chemicalGO:00011012220.213
positive regulation of response to stimulusGO:00485842850.200
Rat
response to peptideGO:19016522920.188
defense responseGO:00069521940.178
homeostatic processGO:00425923310.175
programmed cell deathGO:00125013920.173
Rat
regulation of signal transductionGO:00099663180.164
Rat
lipid metabolic processGO:00066292830.162
carboxylic acid metabolic processGO:00197522890.161
central nervous system developmentGO:00074173110.159
cellular response to hormone stimulusGO:00328702470.155
response to metal ionGO:00100382530.155
Rat
regulation of programmed cell deathGO:00430673410.155
hormone metabolic processGO:0042445690.150
response to glucocorticoidGO:00513842230.140
negative regulation of metabolic processGO:00098923310.138
response to oxidative stressGO:00069791860.133
organic acid metabolic processGO:00060822920.133
response to corticosteroidGO:00319602350.132
positive regulation of cell proliferationGO:00082842490.132
positive regulation of signal transductionGO:00099671750.129
Rat
response to reactive oxygen speciesGO:00003021200.128
cellular homeostasisGO:00197252520.124
response to insulinGO:00328681330.119
macromolecular complex assemblyGO:00650032730.118
regulation of apoptotic processGO:00429813350.115
response to extracellular stimulusGO:00099913800.115
positive regulation of multicellular organismal processGO:00512403870.115
Rat
protein localizationGO:00081041910.115
response to peptide hormoneGO:00434342780.109
renal system developmentGO:0072001670.107
cellular response to steroid hormone stimulusGO:0071383930.106
anatomical structure morphogenesisGO:00096532980.106
regulation of immune system processGO:00026821230.104
forebrain developmentGO:0030900980.103
cellular response to nitrogen compoundGO:19016992100.103
regulation of molecular functionGO:00650093980.102
transmembrane transportGO:00550854120.102
regulation of cellular localizationGO:00603412630.101
regulation of rna metabolic processGO:00512523910.100
positive regulation of signalingGO:00230562700.099
Rat
agingGO:00075682410.098
cation transportGO:00068123820.098
positive regulation of biosynthetic processGO:00098913190.098
Rat
chemical homeostasisGO:00488782920.097
kidney developmentGO:0001822670.094
cardiovascular system developmentGO:00723581340.093
cellular response to alcoholGO:0097306870.092
cellular ketone metabolic processGO:0042180510.091
response to other organismGO:00517072200.089
cellular response to peptide hormone stimulusGO:00713751200.087
positive regulation of cell communicationGO:00106472710.086
Rat
regulation of cell motilityGO:20001451310.085
establishment of protein localizationGO:00451841410.085
steroid metabolic processGO:0008202730.083
immune system processGO:00023762040.082
positive regulation of neurogenesisGO:00507691650.082
signal releaseGO:00230611450.080
regulation of phosphorylationGO:00423252480.077
Rat
cellular response to oxidative stressGO:0034599760.077
tissue developmentGO:00098882520.075
brain developmentGO:00074202470.075
intracellular signal transductionGO:00355563140.072
Rat
negative regulation of apoptotic processGO:00430661810.071
response to ethanolGO:00454711620.071
response to estradiolGO:00323551640.070
head developmentGO:00603222470.069
urogenital system developmentGO:0001655780.069
rna metabolic processGO:00160704060.068
response to woundingGO:00096112540.068
response to oxygen levelsGO:00704822650.067
Rat
positive regulation of developmental processGO:00510942830.066
response to nutrientGO:00075842480.066
nucleobase containing small molecule metabolic processGO:00550863160.065
Rat
cellular chemical homeostasisGO:00550822470.064
cellular ion homeostasisGO:00068731840.064
response to increased oxygen levelsGO:0036296450.064
regulation of synaptic transmissionGO:00508041410.063
regulation of blood circulationGO:19035221100.063
Rat
amine metabolic processGO:0009308380.063
metal ion transportGO:00300012890.062
rna biosynthetic processGO:00327743800.062
response to vitaminGO:00332731310.062
nitrogen compound transportGO:00717052290.061
cellular response to glucocorticoid stimulusGO:0071385680.061
response to growth factorGO:00708481890.060
oxidation reduction processGO:00551143040.060
regulation of locomotionGO:00400121480.060
regulation of cellular protein metabolic processGO:00322682670.060
cellular response to reactive oxygen speciesGO:0034614550.060
regulation of multicellular organismal developmentGO:20000263760.059
positive regulation of cell developmentGO:00107201760.058
heart morphogenesisGO:000300730.058
cardiac muscle contractionGO:0060048270.058
positive regulation of phosphorylationGO:00423271770.058
rhythmic processGO:00485111560.057
chlorinated hydrocarbon metabolic processGO:004219640.056
cellular lipid metabolic processGO:00442552080.056
appendage morphogenesisGO:003510740.055
negative regulation of nitrogen compound metabolic processGO:00511721610.055
cellular response to organonitrogen compoundGO:00714171970.054
intracellular transportGO:00469071850.054
negative regulation of gene expressionGO:00106291990.053
cellular amino acid metabolic processGO:00065201070.053
response to glucoseGO:00097491360.053
positive regulation of protein phosphorylationGO:00019341350.053
regulation of cellular amine metabolic processGO:003323880.053
positive regulation of macromolecule biosynthetic processGO:00105572470.053
regenerationGO:00310991630.051
cofactor metabolic processGO:0051186950.051
ion transmembrane transportGO:00342203650.051
negative regulation of nucleic acid templated transcriptionGO:19035071170.051
cation transmembrane transportGO:00986552630.051
positive regulation of immune system processGO:0002684900.051
localization of cellGO:00516742020.051
organic substance catabolic processGO:19015753160.050
positive regulation of cellular amino acid metabolic processGO:004576410.049
telencephalon developmentGO:0021537620.049
positive regulation of nervous system developmentGO:00519621780.048
cellular hormone metabolic processGO:0034754490.048
negative regulation of cellular metabolic processGO:00313242810.048
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480840.048
negative regulation of cell communicationGO:00106481580.048
g protein coupled receptor signaling pathwayGO:00071862420.048
Rat
hormone secretionGO:00468791150.047
regulation of leukocyte migrationGO:0002685240.047
cellular response to insulin stimulusGO:0032869810.047
response to carbohydrateGO:00097431830.047
regulation of catalytic activityGO:00507903040.047
inorganic cation transmembrane transportGO:00986622020.047
negative regulation of molecular functionGO:00440921330.047
heart contractionGO:0060047570.047
limb morphogenesisGO:003510840.047
negative regulation of signalingGO:00230571570.047
apoptotic processGO:00069153810.047
Rat
response to hydrogen peroxideGO:0042542890.046
protein phosphorylationGO:00064683450.046
single organism catabolic processGO:00447122830.045
positive regulation of protein metabolic processGO:00512471780.045
negative regulation of macromolecule metabolic processGO:00106052600.045
amide transportGO:00428861050.045
positive regulation of gene expressionGO:00106282440.045
reproductionGO:00000032450.045
regulation of cellular component movementGO:00512701500.045
comma shaped body morphogenesisGO:007204920.044
regulation of cellular amino acid metabolic processGO:000652120.044
neuron neuron synaptic transmissionGO:0007270600.044
divalent metal ion transportGO:00708381320.044
response to decreased oxygen levelsGO:00362932370.043
Rat
cellular response to stressGO:00335542690.043
embryonic appendage morphogenesisGO:003511340.043
regulation of cellular ketone metabolic processGO:0010565270.043
transcription dna templatedGO:00063513770.043
response to hexoseGO:00097461440.042
positive regulation of cellular amine metabolic processGO:003324030.042
blood circulationGO:00080151830.042
Rat
negative regulation of cellular biosynthetic processGO:00313271610.042
positive regulation of cellular protein metabolic processGO:00322701670.042
negative regulation of secretionGO:0051048820.042
positive regulation of programmed cell deathGO:00430681570.041
regulation of protein metabolic processGO:00512462890.041
regulation of response to stressGO:00801341260.041
tube developmentGO:0035295890.041
macromolecular complex subunit organizationGO:00439333390.041
negative regulation of transcription dna templatedGO:00458921160.040
single organism biosynthetic processGO:00447113420.040
Rat
regulation of kinase activityGO:00435491170.040
catabolic processGO:00090563510.040
hormone transportGO:00099141210.039
cell migrationGO:00164771970.039
synaptic transmissionGO:00072682350.039
protein complex biogenesisGO:00702712630.039
cellular component biogenesisGO:00440853680.039
cellular component movementGO:00069282480.038
regulation of secretion by cellGO:19035302080.038
cell part morphogenesisGO:00329901230.038
protein complex assemblyGO:00064612630.038
positive regulation of locomotionGO:00400171020.038
regulation of protein phosphorylationGO:00019321830.038
response to alkaloidGO:00432791320.038
macromolecule localizationGO:00330362520.038
response to xenobiotic stimulusGO:0009410230.037
regulation of phosphorus metabolic processGO:00511743490.037
Rat
peptidyl tyrosine phosphorylationGO:0018108720.037
positive regulation of nitrogen compound metabolic processGO:00511733340.037
Rat
response to transition metal nanoparticleGO:19902671220.037
negative regulation of biosynthetic processGO:00098901680.037
immune responseGO:00069551040.036
positive regulation of cell motilityGO:2000147970.036
cellular amine metabolic processGO:0044106380.036
secretion by cellGO:00329402480.036
limbic system developmentGO:0021761380.036
regulation of metal ion transportGO:00109591180.036
hormone catabolic processGO:004244720.036
positive regulation of intracellular signal transductionGO:19025331380.036
locomotionGO:00400112370.035
leukocyte activationGO:0045321760.035
regulation of cell activationGO:0050865500.035
response to estrogenGO:00436272320.034
cation homeostasisGO:00550801950.034
response to external biotic stimulusGO:00432072210.034
regulation of lipid metabolic processGO:0019216680.034
regulation of intracellular signal transductionGO:19025312180.034
Rat
cellular response to peptideGO:19016531330.033
monocarboxylic acid metabolic processGO:00327871520.033
neuron developmentGO:00486662860.033
peptidyl amino acid modificationGO:00181931260.033
reproductive processGO:00224143720.033
negative regulation of macromolecule biosynthetic processGO:00105581480.033
response to radiationGO:00093141370.033
acute inflammatory responseGO:0002526580.032
cellular macromolecule localizationGO:00707271220.032
regulation of system processGO:00440572080.032
Rat
negative regulation of cell deathGO:00605482290.032
negative regulation of rna metabolic processGO:00512531230.032
cellular response to external stimulusGO:00714961180.032
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.032
positive regulation of rna metabolic processGO:00512542030.032
negative regulation of programmed cell deathGO:00430691830.032
regulation of protein modification processGO:00313991940.031
positive regulation of cellular biosynthetic processGO:00313282950.031
Rat
negative regulation of transportGO:00510511360.031
heart processGO:0003015570.031
negative regulation of rna biosynthetic processGO:19026791180.031
response to hyperoxiaGO:0055093450.031
secretionGO:00469033070.031
growthGO:00400071650.031
potassium ion transportGO:0006813970.031
response to monosaccharideGO:00342841590.031
positive regulation of transferase activityGO:0051347810.031
regulation of transferase activityGO:00513381230.030
positive regulation of catalytic activityGO:00430851840.030
regulation of peptide secretionGO:0002791820.030
positive regulation of nucleobase containing compound metabolic processGO:00459353190.030
Rat
single organism reproductive processGO:00447022970.030
response to vitamin aGO:0033189360.030
peptide hormone secretionGO:0030072840.030
positive regulation of apoptotic processGO:00430651540.030
insecticide metabolic processGO:001714340.030
regulation of calcium ion transportGO:0051924770.030
inflammatory responseGO:00069541500.030
cardiac chamber developmentGO:000320510.029
negative regulation of signal transductionGO:0009968830.029
multi organism reproductive processGO:00447032620.029
regulation of hormone secretionGO:00468831060.029
enzyme linked receptor protein signaling pathwayGO:00071671160.029
inorganic ion transmembrane transportGO:00986602290.029
jak stat cascadeGO:0007259260.029
response to amino acidGO:0043200750.029
positive regulation of protein modification processGO:00314011420.029
connective tissue developmentGO:0061448330.028
divalent inorganic cation transportGO:00725111340.028
protein complex subunit organizationGO:00718223020.028
regulation of nucleic acid templated transcriptionGO:19035063800.028
regulation of natural killer cell mediated immune response to tumor cellGO:000285510.028
motor neuron axon guidanceGO:000804510.028
neuron projection developmentGO:00311752730.028
cellular response to corticosteroid stimulusGO:0071384690.028
cellular component morphogenesisGO:00329891550.027
muscle system processGO:00030121150.027
Rat
lipid catabolic processGO:0016042460.027
cell cell signalingGO:00072673350.027
nucleic acid templated transcriptionGO:00976593790.027
divalent inorganic cation homeostasisGO:00725071650.027
immune effector processGO:0002252530.027
steroid biosynthetic processGO:0006694480.026
positive regulation of transportGO:00510502450.026
peptide transportGO:0015833970.026
nucleobase containing compound catabolic processGO:00346551520.026
cellular response to growth factor stimulusGO:00713631620.026
response to toxic substanceGO:00096361330.026
muscle cell proliferationGO:0033002840.026
neuron differentiationGO:00301823680.026
regulation of cellular component organizationGO:00511283680.025
cell type specific apoptotic processGO:00972851340.025
neurological system processGO:00508772190.025
progesterone metabolic processGO:004244880.025
cellular nitrogen compound catabolic processGO:00442701630.025
protein targetingGO:0006605610.025
cellular component assemblyGO:00226073600.025
cellular amide metabolic processGO:0043603440.025
Rat
carbohydrate derivative metabolic processGO:19011353460.025
Rat
regulation of cell differentiationGO:00455953200.025
regulation of nervous system developmentGO:00519602640.025
intracellular protein transportGO:0006886790.025
heterocycle catabolic processGO:00467001670.025
regulation of peptide transportGO:0090087870.025
indole containing compound metabolic processGO:0042430110.025
positive regulation of transcription dna templatedGO:00458931970.024
protein oligomerizationGO:00512591910.024
multicellular organism reproductionGO:00325042330.024
organic hydroxy compound metabolic processGO:19016151150.024
circulatory system developmentGO:00723591340.024
regulation of rna biosynthetic processGO:20011413810.024
positive regulation of cell migrationGO:0030335960.024
cellular protein localizationGO:00346131220.024
positive regulation of cell differentiationGO:00455972170.023
peptide metabolic processGO:0006518320.023
Rat
cellular response to alkaloidGO:0071312250.023
negative regulation of secretion by cellGO:1903531720.023
sensory perceptionGO:00076001010.023
positive regulation of response to external stimulusGO:0032103510.023
regulation of phosphate metabolic processGO:00192203490.023
Rat
cell activationGO:0001775970.023
positive regulation of peptide secretionGO:0002793520.023
organonitrogen compound catabolic processGO:19015651790.022
regulation of secretionGO:00510462240.022
regulation of peptide hormone secretionGO:0090276800.022
cellular response to drugGO:0035690300.022
positive regulation of kinase activityGO:0033674770.022
positive regulation of molecular functionGO:00440932300.022
fatty acid metabolic processGO:0006631990.022
cellular divalent inorganic cation homeostasisGO:00725031620.022
regulation of nucleocytoplasmic transportGO:0046822280.022
calcium ion transportGO:00068161310.022
regulation of protein kinase activityGO:00458591050.022
protein transportGO:00150311320.022
response to retinoic acidGO:0032526630.022
metal ion homeostasisGO:00550651860.022
cellular cation homeostasisGO:00300031800.022
mapk cascadeGO:00001651400.022
Rat
multi multicellular organism processGO:00447061380.022
insulin secretionGO:0030073690.022
vasculature developmentGO:0001944700.021
isoprenoid metabolic processGO:0006720450.021
carbohydrate metabolic processGO:00059751300.021
aromatic compound catabolic processGO:00194391680.021
proteolysisGO:00065081750.021
Human Rat Fly
regulation of cytokine productionGO:0001817560.021
positive regulation of cell deathGO:00109421840.021
response to low density lipoprotein particleGO:005509840.021
cell motilityGO:00488702020.020
cognitionGO:0050890920.020
embryonic hindlimb morphogenesisGO:003511620.020
peptide biosynthetic processGO:004304330.020
positive regulation of cellular component movementGO:00512721020.020
metanephric s shaped body morphogenesisGO:007228420.020
response to ketoneGO:19016541820.020
response to cytokineGO:00340972150.020
response to bacteriumGO:00096172000.020
secondary metabolic processGO:0019748150.020
protein maturationGO:0051604680.020
Rat
cellular response to nutrient levelsGO:0031669600.020
cellular metal ion homeostasisGO:00068751720.020
regulation of transcription dna templatedGO:00063553740.020
gland developmentGO:00487321550.020
organic cyclic compound catabolic processGO:19013611750.020
response to fungicideGO:0060992200.020
cellular response to lipidGO:00713962010.020
metanephric comma shaped body morphogenesisGO:007227820.019
cellular catabolic processGO:00442482950.019
purine nucleotide metabolic processGO:00061632290.019
Rat
response to transforming growth factor betaGO:0071559460.019
carbohydrate homeostasisGO:0033500750.019
hindlimb morphogenesisGO:003513720.019
regulation of neurogenesisGO:00507672470.019
nephric duct developmentGO:007217610.019
response to hypoxiaGO:00016662310.019
Rat
single organism behaviorGO:00447081300.019
negative regulation of response to stimulusGO:00485851550.019
single organism carbohydrate metabolic processGO:00447231180.019
nuclear transportGO:0051169490.018
skeletal system developmentGO:0001501410.018
monosaccharide metabolic processGO:0005996610.018
positive regulation of phosphorus metabolic processGO:00105622620.018
Rat
embryonic skeletal system developmentGO:004870630.018
extracellular matrix constituent secretionGO:007027840.018
peptide secretionGO:0002790860.018
immune response to tumor cellGO:000241830.018
regulation of cell developmentGO:00602842630.018
negative regulation of protein metabolic processGO:00512481140.018
single organism nuclear importGO:1902593350.018
halogenated hydrocarbon metabolic processGO:004219740.018
regulation of leukocyte activationGO:0002694450.018
nuclear importGO:0051170350.018
cytokine productionGO:0001816610.018
sexual reproductionGO:00199531480.018
neuron recognitionGO:000803890.018
regulation of epithelial cell proliferationGO:0050678490.018
multicellular organismal macromolecule metabolic processGO:0044259210.018
regulation of cell migrationGO:00303341280.018
positive regulation of cell activationGO:0050867340.018
positive regulation of nucleic acid templated transcriptionGO:19035081970.017
s shaped body morphogenesisGO:007205020.017
regulation of saliva secretionGO:004687730.017
cellular response to extracellular stimulusGO:0031668730.017
glycerolipid metabolic processGO:0046486670.017
regulation of protein localizationGO:0032880810.017
regulation of anatomical structure morphogenesisGO:00226031410.017
circulatory system processGO:00030131830.017
Rat
regulation of synaptic plasticityGO:0048167700.017
positive regulation of cellular component organizationGO:00511302000.017
response to electrical stimulusGO:0051602560.017
transcription from rna polymerase ii promoterGO:00063662520.017
response to tumor cellGO:000234740.017
maternal process involved in female pregnancyGO:0060135380.016
cellular response to inorganic substanceGO:0071241650.016
striated muscle contractionGO:0006941440.016
organelle organizationGO:00069962660.016
single organism intracellular transportGO:19025821660.016
protein homooligomerizationGO:0051260910.016
regulation of muscle system processGO:0090257790.016
Rat
carbohydrate biosynthetic processGO:0016051420.016
multicellular organismal homeostasisGO:0048871490.016
response to biotic stimulusGO:00096072260.016
positive regulation of secretion by cellGO:19035321280.016
cell projection organizationGO:00300303020.016
cellular response to metal ionGO:0071248550.016
establishment of protein localization to organelleGO:0072594440.016
nucleotide metabolic processGO:00091172790.016
Rat
phenol containing compound metabolic processGO:0018958300.016
response to starvationGO:0042594590.016
ossificationGO:0001503700.016
maintenance of locationGO:0051235170.016
negative regulation of phosphorus metabolic processGO:0010563800.016
glomerulus developmentGO:0032835100.015
glucose homeostasisGO:0042593750.015
lipid biosynthetic processGO:00086101280.015
protein localization to nucleusGO:0034504390.015
lymphocyte activationGO:0046649430.015
response to indole 3 methanolGO:007168020.015
cellular response to ketoneGO:1901655510.015
calcitriol biosynthetic process from calciolGO:003637820.015
organ regenerationGO:00311001010.015
regulation of homeostatic processGO:00328441010.015
monovalent inorganic cation transportGO:00156721720.015
regulation of vesicle mediated transportGO:0060627810.015
response to activityGO:0014823730.015
phasic smooth muscle contractionGO:001482130.015
regulation of insulin secretionGO:0050796650.015
regulation of establishment of protein localizationGO:0070201690.015
negative regulation of catalytic activityGO:00430861030.015
regulation of protein targetingGO:1903533280.015
glucose metabolic processGO:0006006520.014
cellular response to mechanical stimulusGO:0071260480.014
cellular response to hexose stimulusGO:0071331650.014
mesenchymal cell proliferationGO:001046340.014
dendrite developmentGO:0016358720.014
regulation of protein transportGO:0051223680.014
fertilizationGO:000956630.014
cellular calcium ion homeostasisGO:00068741600.014
hexose metabolic processGO:0019318580.014
cytokine secretionGO:0050663150.014
male sex differentiationGO:0046661640.014
action potentialGO:0001508540.014
cellular response to vitamin dGO:0071305120.014
tissue remodelingGO:0048771400.014
positive regulation of rna biosynthetic processGO:19026801970.014
response to vitamin dGO:0033280340.014
female pregnancyGO:00075651220.014
muscle tissue morphogenesisGO:006041510.014
alkaloid metabolic processGO:000982030.014
chemotaxisGO:0006935660.014
4 nitrophenol metabolic processGO:001896010.014
regulation of lipid biosynthetic processGO:0046890380.014
negative regulation of natural killer cell mediated immunityGO:000271640.013
vascular process in circulatory systemGO:0003018960.013
Rat
multicellular organism growthGO:003526410.013
cytoplasmic transportGO:00164821150.013
embryonic limb morphogenesisGO:003032640.013
pallium developmentGO:0021543420.013
negative regulation of nucleobase containing compound metabolic processGO:00459341530.013
epithelial cell proliferationGO:0050673540.013
blood vessel developmentGO:0001568690.013
single organism organelle organizationGO:19025891800.013
negative regulation of homeostatic processGO:0032845470.013
developmental process involved in reproductionGO:00030061590.013
actin cytoskeleton organizationGO:0030036730.013
cell morphogenesisGO:00009021420.013
hemidesmosome assemblyGO:003158110.013
cellular response to xenobiotic stimulusGO:0071466190.013
positive regulation of neuron differentiationGO:00456661260.013
organonitrogen compound biosynthetic processGO:19015661670.013
Rat
naphthalene metabolic processGO:001893120.013
myeloid leukocyte differentiationGO:0002573200.013
response to gonadotropinGO:0034698340.013
glycosyl compound metabolic processGO:19016571820.013
negative regulation of chronic inflammatory response to non antigenic stimulusGO:000288110.013

Phex disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
hypertensionDOID:1076300.039
disease of anatomical entityDOID:700.039
cardiovascular system diseaseDOID:128700.039
vascular diseaseDOID:17800.039
essential hypertensionDOID:1082500.039
artery diseaseDOID:005082800.039
central nervous system diseaseDOID:33100.027
brain diseaseDOID:93600.027
nervous system diseaseDOID:86300.027
musculoskeletal system diseaseDOID:1700.021
epilepsy syndromeDOID:182600.017