IMP: Integrative Multi-species Prediction

Rattus norvegicus

166 known processes

Apoe

apolipoprotein E

(Aliases: APOEA)

Entrez: 25728
Ensembl: ENSRNOG00000018454
RGD: 2138
UniProtKB: P02650

Process Predictions
Disease Predictions

Apoe biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
embryo implantation	GO:0007566	15	0.389
regulation of glycoprotein metabolic process	GO:1903018	6	0.348
response to nutrient levels	GO:0031667	370	0.238
regulation of cell differentiation	GO:0045595	320	0.222
sensory organ development	GO:0007423	74	0.208
central nervous system development	GO:0007417	311	0.199
reproductive process	GO:0022414	372	0.199
single organism reproductive process	GO:0044702	297	0.190
single organism behavior	GO:0044708	130	0.185
response to extracellular stimulus	GO:0009991	380	0.178
negative regulation of cell death	GO:0060548	229	0.178
response to other organism	GO:0051707	220	0.178
tissue development	GO:0009888	252	0.174
response to glucocorticoid	GO:0051384	223	0.167
response to biotic stimulus	GO:0009607	226	0.157
regulation of cell proliferation	GO:0042127	359	0.152
response to metal ion	GO:0010038	253	0.138
cellular catabolic process	GO:0044248	295	0.135
regulation of multicellular organismal development	GO:2000026	376	0.126
response to wounding	GO:0009611	254	0.117
positive regulation of cell differentiation	GO:0045597	217	0.114
brain development	GO:0007420	247	0.114
response to chromate	GO:0046687	3	0.112
extracellular fibril organization	GO:0043206	1	0.110
cell projection organization	GO:0030030	302	0.109
response to estradiol	GO:0032355	164	0.109
head development	GO:0060322	247	0.107
development of primary sexual characteristics	GO:0045137	107	0.104
aging	GO:0007568	241	0.098
reproductive structure development	GO:0048608	128	0.095
positive regulation of developmental process	GO:0051094	283	0.094
collagen catabolic process	GO:0030574	2	0.093
developmental process involved in reproduction	GO:0003006	159	0.091
multi organism reproductive process	GO:0044703	262	0.090
multi multicellular organism process	GO:0044706	138	0.084
cellular amide metabolic process	GO:0043603	44	0.078
reproductive system development	GO:0061458	128	0.077
response to external biotic stimulus	GO:0043207	221	0.076
regulation of protein metabolic process	GO:0051246	289	0.076
rhythmic process	GO:0048511	156	0.074
neuron differentiation	GO:0030182	368	0.072
behavior	GO:0007610	205	0.069
male gonad development	GO:0008584	59	0.069
male sex differentiation	GO:0046661	64	0.068
epithelium development	GO:0060429	96	0.064
salivary gland development	GO:0007431	3	0.064
protein maturation	GO:0051604	68	0.064
positive regulation of neurogenesis	GO:0050769	165	0.064
positive regulation of nervous system development	GO:0051962	178	0.063
negative regulation of multicellular organismal metabolic process	GO:0044252	4	0.062
negative regulation of cellular protein metabolic process	GO:0032269	106	0.062
catabolic process	GO:0009056	351	0.060
response to lead ion	GO:0010288	33	0.058
proteolysis	GO:0006508	175	0.057
neuron development	GO:0048666	286	0.054
response to camp	GO:0051591	91	0.054
reproduction	GO:0000003	245	0.053
positive regulation of cell development	GO:0010720	176	0.052
response to organophosphorus	GO:0046683	102	0.052
response to inorganic substance	GO:0010035	377	0.050
gonad development	GO:0008406	104	0.050
positive regulation of neuron projection development	GO:0010976	99	0.050
nitrogen compound transport	GO:0071705	229	0.050
multicellular organism reproduction	GO:0032504	233	0.050
development of primary male sexual characteristics	GO:0046546	59	0.050
response to peptide	GO:1901652	292	0.049
regulation of ion transport	GO:0043269	245	0.048
response to ketone	GO:1901654	182	0.048
regulation of establishment of planar polarity	GO:0090175	2	0.048
response to corticosteroid	GO:0031960	235	0.047
anatomical structure morphogenesis	GO:0009653	298	0.046
eye development	GO:0001654	50	0.046
neurological system process	GO:0050877	219	0.046
regulation of myeloid cell differentiation	GO:0045637	12	0.045
circadian sleep wake cycle	GO:0042745	23	0.045
female pregnancy	GO:0007565	122	0.045
regulation of immune response	GO:0050776	55	0.044
regulation of programmed cell death	GO:0043067	341	0.044
negative regulation of developmental process	GO:0051093	125	0.042
response to purine containing compound	GO:0014074	126	0.042
response to acid chemical	GO:0001101	222	0.042
multicellular organismal catabolic process	GO:0044243	2	0.040
response to estrogen	GO:0043627	232	0.040
negative regulation of response to stimulus	GO:0048585	155	0.040
negative regulation of cellular metabolic process	GO:0031324	281	0.040
circadian sleep wake cycle sleep	GO:0050802	21	0.039
circadian rhythm	GO:0007623	88	0.039
sexual reproduction	GO:0019953	148	0.039
negative regulation of protein metabolic process	GO:0051248	114	0.038
response to nutrient	GO:0007584	248	0.038
single organism catabolic process	GO:0044712	283	0.037
regulation of cellular protein metabolic process	GO:0032268	267	0.037
positive regulation of cell proliferation	GO:0008284	249	0.035
negative regulation of molecular function	GO:0044092	133	0.035
sex differentiation	GO:0007548	113	0.035
negative regulation of multicellular organismal process	GO:0051241	203	0.034
response to carbohydrate	GO:0009743	183	0.033
neuron projection development	GO:0031175	273	0.033
cell projection morphogenesis	GO:0048858	123	0.033
tissue remodeling	GO:0048771	40	0.032
negative regulation of macromolecule metabolic process	GO:0010605	260	0.032
regulation of immune system process	GO:0002682	123	0.032
negative regulation of metabolic process	GO:0009892	331	0.031
protein processing	GO:0016485	68	0.031
negative regulation of collagen metabolic process	GO:0010713	4	0.031
chemical homeostasis	GO:0048878	292	0.031
response to bacterium	GO:0009617	200	0.030
negative regulation of innate immune response	GO:0045824	4	0.030
neuronal action potential	GO:0019228	35	0.030
response to vitamin	GO:0033273	131	0.030
positive regulation of response to stimulus	GO:0048584	285	0.030
regulation of neurogenesis	GO:0050767	247	0.029
response to hydrogen peroxide	GO:0042542	89	0.029
rhythmic behavior	GO:0007622	24	0.029
positive regulation of multicellular organismal process	GO:0051240	387	0.029
complement activation	GO:0006956	11	0.029
homeostatic process	GO:0042592	331	0.029
regulation of nervous system development	GO:0051960	264	0.028
negative regulation of protein processing	GO:0010955	47	0.028
regulation of anatomical structure morphogenesis	GO:0022603	141	0.028
regulation of neuron projection development	GO:0010975	161	0.028
regulation of protein processing	GO:0070613	50	0.027
cellular response to stress	GO:0033554	269	0.027
response to monosaccharide	GO:0034284	159	0.027
heart morphogenesis	GO:0003007	3	0.026
positive regulation of cell projection organization	GO:0031346	111	0.026
response to molecule of bacterial origin	GO:0002237	194	0.026
regulation of neuron differentiation	GO:0045664	208	0.026
elastin metabolic process	GO:0051541	1	0.026
negative regulation of protein maturation	GO:1903318	47	0.025
multicellular organismal reproductive process	GO:0048609	233	0.025
response to hypoxia	GO:0001666	231	0.025
gamete generation	GO:0007276	124	0.025
programmed cell death	GO:0012501	392	0.025
localization of cell	GO:0051674	202	0.025
carbohydrate derivative metabolic process	GO:1901135	346	0.024
negative regulation of apoptotic process	GO:0043066	181	0.024
cellular response to oxidative stress	GO:0034599	76	0.024
defense response	GO:0006952	194	0.024
negative regulation of peptidase activity	GO:0010466	38	0.023
negative regulation of programmed cell death	GO:0043069	183	0.023
negative regulation of immune system process	GO:0002683	39	0.023
regulation of molecular function	GO:0065009	398	0.022
positive regulation of neuron differentiation	GO:0045666	126	0.022
negative regulation of endopeptidase activity	GO:0010951	36	0.022
regulation of catabolic process	GO:0009894	113	0.021
cellular response to endogenous stimulus	GO:0071495	377	0.021
response to lipopolysaccharide	GO:0032496	191	0.021
acute inflammatory response	GO:0002526	58	0.021
regulation of fibrinolysis	GO:0051917	2	0.021
respiratory system development	GO:0060541	45	0.021
regulation of proteolysis	GO:0030162	66	0.021
cellular component movement	GO:0006928	248	0.020
regulation of cell development	GO:0060284	263	0.020
cell killing	GO:0001906	13	0.020
cellular chemical homeostasis	GO:0055082	247	0.020
regulation of metal ion transport	GO:0010959	118	0.020
lipid transport	GO:0006869	61	0.020
regulation of protein maturation	GO:1903317	50	0.020
kidney development	GO:0001822	67	0.020
negative regulation of proteolysis	GO:0045861	41	0.020
negative regulation of gene expression	GO:0010629	199	0.020
circadian sleep wake cycle process	GO:0022410	21	0.020
spermatogenesis	GO:0007283	99	0.020
regulation of defense response	GO:0031347	68	0.019
regulation of cellular catabolic process	GO:0031329	101	0.019
organic substance catabolic process	GO:1901575	316	0.019
regulation of cell projection organization	GO:0031344	175	0.018
axon development	GO:0061564	96	0.018
activation of immune response	GO:0002253	26	0.018
hair cycle process	GO:0022405	2	0.017
regulation of blood pressure	GO:0008217	83	0.017
neuron projection morphogenesis	GO:0048812	122	0.017
response to oxygen levels	GO:0070482	265	0.017
cell morphogenesis	GO:0000902	142	0.017
regulation of cellular component organization	GO:0051128	368	0.017
response to decreased oxygen levels	GO:0036293	237	0.017
cell motility	GO:0048870	202	0.017
response to retinoic acid	GO:0032526	63	0.017
response to reactive oxygen species	GO:0000302	120	0.017
epithelial cell differentiation	GO:0030855	71	0.016
immune system process	GO:0002376	204	0.016
regulation of catalytic activity	GO:0050790	304	0.016
carbohydrate derivative catabolic process	GO:1901136	147	0.016
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.016
hormone metabolic process	GO:0042445	69	0.015
dna replication	GO:0006260	37	0.015
endocytosis	GO:0006897	84	0.015
organic acid metabolic process	GO:0006082	292	0.015
apoptotic process	GO:0006915	381	0.015
cardiovascular system development	GO:0072358	134	0.015
mapk cascade	GO:0000165	140	0.015
ossification	GO:0001503	70	0.015
multicellular organismal signaling	GO:0035637	44	0.014
male gamete generation	GO:0048232	99	0.014
regulation of apoptotic process	GO:0042981	335	0.014
regulation of peptidase activity	GO:0052547	55	0.014
renal system development	GO:0072001	67	0.014
sleep	GO:0030431	30	0.014
cytosolic calcium ion homeostasis	GO:0051480	140	0.014
cellular response to oxygen containing compound	GO:1901701	386	0.014
organ morphogenesis	GO:0009887	75	0.014
immune effector process	GO:0002252	53	0.014
response to potassium ion	GO:0035864	9	0.014
macromolecule catabolic process	GO:0009057	58	0.014
cellular response to gonadotropin stimulus	GO:0071371	17	0.013
circadian behavior	GO:0048512	24	0.013
cellular homeostasis	GO:0019725	252	0.013
gland development	GO:0048732	155	0.013
inflammatory response	GO:0006954	150	0.013
cellular calcium ion homeostasis	GO:0006874	160	0.013
regulation of proteasomal protein catabolic process	GO:0061136	4	0.013
cell type specific apoptotic process	GO:0097285	134	0.013
neuromuscular process	GO:0050905	2	0.013
response to insulin	GO:0032868	133	0.013
rna localization	GO:0006403	4	0.013
nucleobase containing small molecule metabolic process	GO:0055086	316	0.013
immunoglobulin mediated immune response	GO:0016064	4	0.013
regulation of endopeptidase activity	GO:0052548	51	0.012
sulfur compound metabolic process	GO:0006790	70	0.012
cellular hormone metabolic process	GO:0034754	49	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.012
response to toxic substance	GO:0009636	133	0.012
negative regulation of catalytic activity	GO:0043086	103	0.012
metal ion transport	GO:0030001	289	0.012
response to hexose	GO:0009746	144	0.012
cellular response to lipid	GO:0071396	201	0.012
cell part morphogenesis	GO:0032990	123	0.012
metal ion homeostasis	GO:0055065	186	0.012
cell cell signaling involved in cell fate commitment	GO:0045168	2	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.012
innate immune response	GO:0045087	35	0.012
cellular response to alcohol	GO:0097306	87	0.012
response to oxidative stress	GO:0006979	186	0.012
response to amino acid	GO:0043200	75	0.011
negative regulation of cell proliferation	GO:0008285	119	0.011
cellular amino acid metabolic process	GO:0006520	107	0.011
cellular response to hormone stimulus	GO:0032870	247	0.011
regulation of tolerance induction to nonself antigen	GO:0002655	1	0.011
negative regulation of myeloid cell differentiation	GO:0045638	3	0.011
organelle organization	GO:0006996	266	0.011
ion homeostasis	GO:0050801	212	0.011
purine ribonucleotide metabolic process	GO:0009150	227	0.011
organelle inheritance	GO:0048308	2	0.011
immune response	GO:0006955	104	0.011
ear development	GO:0043583	21	0.011
glutamine family amino acid metabolic process	GO:0009064	15	0.011
astrocyte development	GO:0014002	4	0.011
monovalent inorganic cation transport	GO:0015672	172	0.011
cellular response to follicle stimulating hormone stimulus	GO:0071372	13	0.011
isoprenoid metabolic process	GO:0006720	45	0.010
molting cycle	GO:0042303	3	0.010
b cell mediated immunity	GO:0019724	4	0.010
cellular response to molecule of bacterial origin	GO:0071219	56	0.010
cellular response to nitrogen compound	GO:1901699	210	0.010
cation transport	GO:0006812	382	0.010
positive regulation of programmed cell death	GO:0043068	157	0.010
blood circulation	GO:0008015	183	0.010
cellular macromolecule catabolic process	GO:0044265	29	0.010
response to antibiotic	GO:0046677	39	0.010

Apoe disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.242
nervous system disease	DOID:863	0.118
sensory system disease	DOID:0050155	0.118
disease of anatomical entity	DOID:7	0.118
eye and adnexa disease	DOID:1492	0.118
eye disease	DOID:5614	0.079
degeneration of macula and posterior pole	DOID:2007	0.079
macular degeneration	DOID:4448	0.079
retinal disease	DOID:5679	0.079
retinal degeneration	DOID:8466	0.079
age related macular degeneration	DOID:10871	0.079
acquired metabolic disease	DOID:0060158	0.053
inherited metabolic disorder	DOID:655	0.035
lysosomal storage disease	DOID:3211	0.012
metal metabolism disorder	DOID:896	0.011

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