Rattus norvegicus

40 known processes

Plk1

polo-like kinase 1 (Drosophila)

(Aliases: Plk)

Plk1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
mitotic sister chromatid separationGO:005130610.255
Human
metaphase anaphase transition of cell cycleGO:004478410.200
Human
macromolecular complex assemblyGO:00650032730.196
Yeast Fly
reproductive processGO:00224143720.186
Worm Fly
organelle organizationGO:00069962660.145
chromosome segregationGO:000705920.126
Human Yeast Worm
regulation of molecular functionGO:00650093980.123
Human Yeast Rat
regulation of chromosome segregationGO:005198310.122
Human
positive regulation of hepatocyte differentiationGO:007036820.117
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic processGO:003114510.115
Human
protein complex assemblyGO:00064612630.112
Yeast Fly
neuron differentiationGO:00301823680.105
Rat
single organism organelle organizationGO:19025891800.098
Human Yeast Worm Fly
cellular component assemblyGO:00226073600.097
Yeast Fly
negative regulation of developmental processGO:00510931250.092
Rat Fly
cellular response to iron iii ionGO:007128330.088
protein phosphorylationGO:00064683450.088
metaphase plate congressionGO:005131010.086
regulation of cellular protein metabolic processGO:00322682670.083
Human Rat
protein complex subunit organizationGO:00718223020.082
Yeast Worm Fly
macromolecular complex subunit organizationGO:00439333390.080
Yeast Worm Fly
programmed cell deathGO:00125013920.078
Human Worm
cytoskeleton organizationGO:00070101110.078
Human Yeast Worm Fly
mitotic cell cycle phase transitionGO:0044772200.078
Human
centrosome organizationGO:005129710.077
Human Worm Fly
positive regulation of cellular protein metabolic processGO:00322701670.076
Human Rat
cell cycleGO:00070491010.074
positive regulation of multicellular organismal processGO:00512403870.070
response to extracellular stimulusGO:00099913800.068
positive regulation of nucleic acid templated transcriptionGO:19035081970.066
regulation of organelle organizationGO:0033043800.065
Human Yeast Worm
regulation of cellular component organizationGO:00511283680.064
Human Yeast Rat Worm
cellular component biogenesisGO:00440853680.060
Yeast Fly
regulation of protein metabolic processGO:00512462890.059
Human Rat
regulation of phosphorus metabolic processGO:00511743490.059
Human
regulation of catalytic activityGO:00507903040.059
Human Yeast
reproductionGO:00000032450.057
regulation of transferase activityGO:00513381230.056
Human
catabolic processGO:00090563510.056
Human Rat
spindle organizationGO:000705120.054
Yeast Worm Fly
negative regulation of transcription dna templatedGO:00458921160.054
Human
positive regulation of developmental processGO:00510942830.053
regulation of cell differentiationGO:00455953200.053
Rat Fly
regulation of cell proliferationGO:00421273590.053
Fly
neuron developmentGO:00486662860.052
Rat
rna metabolic processGO:00160704060.052
Human
cellular response to stressGO:00335542690.052
Human
proteolysis involved in cellular protein catabolic processGO:0051603190.052
Human Rat
negative regulation of metabolic processGO:00098923310.050
Human
agingGO:00075682410.050
regulation of cell cycleGO:0051726730.050
Human Yeast Worm
proteolysisGO:00065081750.049
Human Rat
positive regulation of synaptic plasticityGO:003191530.049
positive regulation of synapse maturationGO:009012920.049
cellular macromolecule catabolic processGO:0044265290.048
Human Rat
response to nutrient levelsGO:00316673700.047
meiotic cell cycle processGO:190304630.046
microtubule polymerization or depolymerizationGO:0031109130.045
Fly
microtubule organizing center organizationGO:003102310.044
Human Yeast Worm Fly
single organism reproductive processGO:00447022970.044
Worm Fly
negative regulation of nuclear divisionGO:005178410.043
Human
cellular protein localizationGO:00346131220.043
Human Fly
mitotic spindle organizationGO:000705220.043
Worm Fly
organelle localizationGO:0051640550.043
Fly
regulation of phosphate metabolic processGO:00192203490.042
Human
negative regulation of macromolecule biosynthetic processGO:00105581480.041
Human
cell projection organizationGO:00300303020.040
Rat
response to nutrientGO:00075842480.039
regulation of ubiquitin protein transferase activityGO:005143810.039
Human
metaphase anaphase transition of mitotic cell cycleGO:000709110.038
Human
multi organism reproductive processGO:00447032620.038
Worm Fly
mitotic cell cycle processGO:1903047350.037
Human Worm Fly
negative regulation of gene expressionGO:00106291990.037
Human
organic substance catabolic processGO:19015753160.036
Human Rat
sister chromatid segregationGO:000081910.035
Human
bmp signaling pathwayGO:003050940.035
positive regulation of rna metabolic processGO:00512542030.035
positive regulation of biosynthetic processGO:00098913190.035
oxoacid metabolic processGO:00434362900.035
negative regulation of rna metabolic processGO:00512531230.035
Human
negative regulation of transcription from rna polymerase ii promoterGO:0000122750.034
Human
negative regulation of cellular component organizationGO:0051129830.034
Human Rat
regulation of phosphorylationGO:00423252480.034
Human
positive regulation of cellular component organizationGO:00511302000.034
Human Yeast
microtubule anchoringGO:003445310.033
regulation of protein kinase activityGO:00458591050.033
Human
negative regulation of macromolecule metabolic processGO:00106052600.033
Human
positive regulation of protein modification processGO:00314011420.032
Human
transcription dna templatedGO:00063513770.032
Human
cell cycle processGO:0022402570.031
multicellular organism reproductionGO:00325042330.031
Worm Fly
macromolecule catabolic processGO:0009057580.031
Human Rat
regulation of rna biosynthetic processGO:20011413810.031
Human
response to estrogenGO:00436272320.031
organelle assemblyGO:0070925220.030
Yeast Fly
negative regulation of microtubule depolymerizationGO:000702630.030
amine metabolic processGO:0009308380.030
ras protein signal transductionGO:0007265290.029
Rat
cellular response to lipidGO:00713962010.029
cellular ketone metabolic processGO:0042180510.029
protein complex biogenesisGO:00702712630.029
Yeast Fly
intracellular signal transductionGO:00355563140.029
Rat
regulation of rna metabolic processGO:00512523910.028
Human
regulation of apoptotic processGO:00429813350.028
Human
response to transition metal nanoparticleGO:19902671220.028
cell cycle phase transitionGO:0044770210.028
Human
response to ddtGO:004668010.028
protein localizationGO:00081041910.028
Human Yeast Fly
cell cycle checkpointGO:000007520.028
Human
regulation of multicellular organismal developmentGO:20000263760.027
Rat Fly
regulation of kinase activityGO:00435491170.027
Human
single organism cellular localizationGO:19025801020.027
response to glucocorticoidGO:00513842230.027
brain developmentGO:00074202470.027
positive regulation of nucleobase containing compound metabolic processGO:00459353190.027
small gtpase mediated signal transductionGO:0007264360.026
Rat
response to corticosteroidGO:00319602350.026
positive regulation of cellular biosynthetic processGO:00313282950.026
negative regulation of cell divisionGO:005178210.025
Human
cellular amine metabolic processGO:0044106380.025
regulation of sister chromatid segregationGO:003304510.025
Human
cellular catabolic processGO:00442482950.025
Human Rat
response to peptideGO:19016522920.025
regulation of microtubule polymerization or depolymerizationGO:0031110120.025
regulation of proteasomal protein catabolic processGO:006113640.025
Human Rat
regulation of transcription from rna polymerase ii promoterGO:00063572340.025
Human
double strand break repairGO:000630210.024
regulation of neuron differentiationGO:00456642080.024
Rat
regulation of nervous system developmentGO:00519602640.024
Rat Fly
dna packagingGO:000632340.024
macromolecule localizationGO:00330362520.024
Human Yeast Fly
central nervous system developmentGO:00074173110.024
regulation of synapse maturationGO:009012820.024
positive regulation of cell proliferationGO:00082842490.023
negative regulation of programmed cell deathGO:00430691830.023
Human
negative regulation of molecular functionGO:00440921330.023
Human
developmental process involved in reproductionGO:00030061590.023
Worm Fly
positive regulation of catalytic activityGO:00430851840.023
Human Yeast
single organism biosynthetic processGO:00447113420.023
dendrite developmentGO:0016358720.023
Rat
multicellular organismal reproductive processGO:00486092330.023
Worm Fly
nucleic acid templated transcriptionGO:00976593790.023
Human
negative regulation of cell deathGO:00605482290.023
Human
positive regulation of molecular functionGO:00440932300.023
Human Yeast Rat
regulation of cellular ketone metabolic processGO:0010565270.023
potassium ion transportGO:0006813970.023
positive regulation of transportGO:00510502450.022
regulation of cell projection organizationGO:00313441750.022
Rat
regulation of programmed cell deathGO:00430673410.022
Human
regulation of cellular amine metabolic processGO:003323880.022
organic acid metabolic processGO:00060822920.022
response to organophosphorusGO:00466831020.022
meiosis iGO:000712720.022
Yeast Worm
regulation of response to stressGO:00801341260.022
anatomical structure morphogenesisGO:00096532980.021
proteasome mediated ubiquitin dependent protein catabolic processGO:004316170.021
Human Rat
reproductive system developmentGO:00614581280.021
Worm
nucleosome organizationGO:003472810.021
head developmentGO:00603222470.021
receptor mediated endocytosisGO:0006898420.020
chromosome separationGO:005130410.020
Human Yeast
regulation of cellular amino acid metabolic processGO:000652120.020
regulation of proteasomal ubiquitin dependent protein catabolic processGO:003243430.020
Human Rat
cellular protein catabolic processGO:0044257190.020
Human Rat
positive regulation of cellular amino acid metabolic processGO:004576410.020
positive regulation of phosphorylationGO:00423271770.020
Human
protein processingGO:0016485680.019
Human
response to hypoxiaGO:00016662310.019
regulation of neurogenesisGO:00507672470.019
Rat Fly
response to cytokineGO:00340972150.019
regulation of cellular catabolic processGO:00313291010.019
Human Rat
positive regulation of nitrogen compound metabolic processGO:00511733340.019
centrosome cycleGO:000709810.019
Worm
positive regulation of rna biosynthetic processGO:19026801970.019
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.019
negative regulation of transportGO:00510511360.018
regulation of protein modification processGO:00313991940.018
Human
mitotic sister chromatid segregationGO:000007010.018
Human
negative regulation of cell proliferationGO:00082851190.018
Fly
ubiquitin dependent protein catabolic processGO:0006511140.018
Human Rat
response to ethanolGO:00454711620.018
response to peptide hormoneGO:00434342780.017
intracellular transportGO:00469071850.017
cellular macromolecule localizationGO:00707271220.017
Human Fly
regulation of transcription dna templatedGO:00063553740.017
Human
embryo developmentGO:0009790490.017
Worm Fly
positive regulation of macromolecule biosynthetic processGO:00105572470.017
positive regulation of gene expressionGO:00106282440.017
carboxylic acid metabolic processGO:00197522890.017
dna metabolic processGO:0006259960.017
Yeast
response to oxidative stressGO:00069791860.017
regulation of protein catabolic processGO:0042176160.017
Human Rat
developmental growthGO:00485891000.017
response to oxygen levelsGO:00704822650.017
negative regulation of nucleic acid templated transcriptionGO:19035071170.017
Human
microtubule based processGO:0007017360.017
Human Yeast Worm Fly
negative regulation of nitrogen compound metabolic processGO:00511721610.016
Human
reproductive structure developmentGO:00486081280.016
Worm
negative regulation of protein processingGO:0010955470.016
Human
regulation of protein phosphorylationGO:00019321830.016
Human
negative regulation of cell differentiationGO:0045596990.015
Rat Fly
negative regulation of mitotic cell cycle phase transitionGO:190199130.015
Human
apoptotic processGO:00069153810.015
Human Worm
gastrulationGO:000736920.015
acetate ester biosynthetic processGO:190062020.015
response to fatty acidGO:0070542650.015
dephosphorylationGO:0016311980.014
response to decreased oxygen levelsGO:00362932370.014
heterocycle catabolic processGO:00467001670.014
regulation of nucleic acid templated transcriptionGO:19035063800.014
Human
cellular response to oxygen containing compoundGO:19017013860.014
mitotic cell cycleGO:0000278490.014
Human Zebrafish Worm Fly
single organism catabolic processGO:00447122830.014
Human
regulation of neuron projection developmentGO:00109751610.014
Rat
regulation of cellular localizationGO:00603412630.014
response to metal ionGO:00100382530.014
negative regulation of protein metabolic processGO:00512481140.014
Human
developmental maturationGO:0021700250.014
response to mechanical stimulusGO:00096121340.014
positive regulation of cellular amine metabolic processGO:003324030.014
positive regulation of catabolic processGO:0009896780.014
Human Rat
cellular protein complex assemblyGO:0043623440.014
Fly
cellular response to hormone stimulusGO:00328702470.014
negative regulation of rna biosynthetic processGO:19026791180.014
Human
positive regulation of protein metabolic processGO:00512471780.014
Human Rat
synaptic transmissionGO:00072682350.014
Rat
sexual reproductionGO:00199531480.013
Worm Fly
membrane organizationGO:0061024940.013
Worm
chromosome organizationGO:0051276360.013
Human Yeast
striated muscle tissue developmentGO:0014706580.013
response to alkaloidGO:00432791320.013
anterior posterior pattern specificationGO:000995210.013
regulation of protein maturationGO:1903317500.013
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic processGO:003243630.013
Human Rat
protein localization to chromosome centromeric regionGO:007145910.013
organic cyclic compound catabolic processGO:19013611750.013
positive regulation of transferase activityGO:0051347810.013
Human
transcription initiation from rna polymerase ii promoterGO:000636730.013
cellular amino acid metabolic processGO:00065201070.013
synapse maturationGO:006007450.013
regulation of cytoskeleton organizationGO:0051493490.013
Yeast
fatty acid metabolic processGO:0006631990.012
rna biosynthetic processGO:00327743800.012
Human
negative regulation of cell cycle phase transitionGO:190198840.012
Human
positive regulation of protein phosphorylationGO:00019341350.012
Human
positive regulation of cell differentiationGO:00455972170.012
single organism intracellular transportGO:19025821660.012
protein ubiquitinationGO:0016567280.012
Human
response to toxic substanceGO:00096361330.012
response to estradiolGO:00323551640.012
axis specificationGO:000979840.012
response to campGO:0051591910.012
nuclear transportGO:0051169490.012
positive regulation of phosphate metabolic processGO:00459372620.012
Human
regulation of mapk cascadeGO:00434081160.012
positive regulation of apoptotic processGO:00430651540.012
circulatory system developmentGO:00723591340.012
Fly
cytoplasmic transportGO:00164821150.012
regulation of cell developmentGO:00602842630.011
Rat Fly
regulation of meiotic cell cycleGO:005144530.011
Worm
organelle fissionGO:0048285250.011
negative regulation of protein maturationGO:1903318470.011
Human
regulation of cell cycle processGO:0010564310.011
Human Yeast Worm
cell communication involved in cardiac conductionGO:008606520.011
positive regulation of nervous system developmentGO:00519621780.011
vesicle mediated transportGO:00161921810.011
Fly
cellular response to extracellular stimulusGO:0031668730.011
establishment of chromosome localizationGO:005130310.011
response to external biotic stimulusGO:00432072210.011
cellular lipid metabolic processGO:00442552080.011
regulation of cell cycle arrestGO:007115620.011
positive regulation of cellular catabolic processGO:0031331710.011
Human Rat
positive regulation of programmed cell deathGO:00430681570.011
regulation of mrna 3 end processingGO:003144010.011
regulation of catabolic processGO:00098941130.011
Human Rat
gamete generationGO:00072761240.011
Worm Fly
regulation of mitotic sister chromatid separationGO:001096510.011
Human
negative regulation of cell communicationGO:00106481580.011
Rat
transmembrane transportGO:00550854120.011
neuron projection developmentGO:00311752730.011
Rat
chromatin assembly or disassemblyGO:000633310.011
negative regulation of nucleobase containing compound metabolic processGO:00459341530.011
Human
gland developmentGO:00487321550.011
negative regulation of cellular metabolic processGO:00313242810.011
Human
regulation of signal transductionGO:00099663180.010
response to inorganic substanceGO:00100353770.010
protein oligomerizationGO:00512591910.010
cellular macromolecular complex assemblyGO:0034622580.010
Fly
cell cell signalingGO:00072673350.010
Rat
response to radiationGO:00093141370.010
positive regulation of mrna metabolic processGO:190331340.010
mitotic nuclear divisionGO:0007067150.010
Human Worm Fly

Plk1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.016
cancerDOID:16200.015
organ system cancerDOID:005068600.015