IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Mll5

myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)

Entrez: 311968
RGD: 1309641
Ensembl: ENSRNOG00000021614

Process Predictions
Disease Predictions

Mll5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of rna metabolic process	GO:0051252	391	0.586	Human
regulation of transcription dna templated	GO:0006355	374	0.415	Human
rna biosynthetic process	GO:0032774	380	0.341	Human
positive regulation of gene expression	GO:0010628	244	0.268	Human
rna metabolic process	GO:0016070	406	0.264	Human
nucleic acid templated transcription	GO:0097659	379	0.231	Human
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.229	Human
positive regulation of rna metabolic process	GO:0051254	203	0.201	Human
positive regulation of cellular biosynthetic process	GO:0031328	295	0.196	Human
macromolecular complex subunit organization	GO:0043933	339	0.191	Human
transcription dna templated	GO:0006351	377	0.173	Human
positive regulation of biosynthetic process	GO:0009891	319	0.166	Human
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.147
regulation of programmed cell death	GO:0043067	341	0.133
regulation of nucleic acid templated transcription	GO:1903506	380	0.121	Human
multi organism reproductive process	GO:0044703	262	0.120
multicellular organismal reproductive process	GO:0048609	233	0.119
positive regulation of rna biosynthetic process	GO:1902680	197	0.114	Human
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.111	Human
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.110	Human
negative regulation of rna metabolic process	GO:0051253	123	0.108
reproduction	GO:0000003	245	0.097
multicellular organism reproduction	GO:0032504	233	0.094
positive regulation of programmed cell death	GO:0043068	157	0.087
positive regulation of cell death	GO:0010942	184	0.082
single organism reproductive process	GO:0044702	297	0.082
positive regulation of response to stimulus	GO:0048584	285	0.081
transcription from rna polymerase ii promoter	GO:0006366	252	0.077
eye development	GO:0001654	50	0.071
brain development	GO:0007420	247	0.068
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.068	Human
protein complex subunit organization	GO:0071822	302	0.068
organic acid metabolic process	GO:0006082	292	0.064
regulation of apoptotic process	GO:0042981	335	0.063
central nervous system development	GO:0007417	311	0.060
cellular component biogenesis	GO:0044085	368	0.057
positive regulation of transcription dna templated	GO:0045893	197	0.057	Human
forebrain development	GO:0030900	98	0.056
single organism organelle organization	GO:1902589	180	0.055	Human
regulation of molecular function	GO:0065009	398	0.054
tissue development	GO:0009888	252	0.054
cellular component assembly	GO:0022607	360	0.053
positive regulation of apoptotic process	GO:0043065	154	0.048
camera type eye development	GO:0043010	48	0.047
cellular response to oxygen containing compound	GO:1901701	386	0.046	Human
sexual reproduction	GO:0019953	148	0.046
motor neuron axon guidance	GO:0008045	1	0.043
negative regulation of transcription dna templated	GO:0045892	116	0.043
organelle organization	GO:0006996	266	0.042	Human
regulation of phosphorus metabolic process	GO:0051174	349	0.040
glycoside transport	GO:1901656	2	0.040
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.040
negative regulation of metabolic process	GO:0009892	331	0.040
neuron death	GO:0070997	127	0.040
regulation of rna biosynthetic process	GO:2001141	381	0.039	Human
positive regulation of multicellular organismal process	GO:0051240	387	0.038	Human
cellular response to lipid	GO:0071396	201	0.037	Human
developmental process involved in reproduction	GO:0003006	159	0.037
response to biotic stimulus	GO:0009607	226	0.036
neuron apoptotic process	GO:0051402	88	0.035
reproductive process	GO:0022414	372	0.034
carboxylic acid metabolic process	GO:0019752	289	0.033
head development	GO:0060322	247	0.033
calcium ion export	GO:1901660	6	0.032
positive regulation of phosphorus metabolic process	GO:0010562	262	0.032
response to wounding	GO:0009611	254	0.032
regulation of calcineurin nfat signaling cascade	GO:0070884	3	0.032
nucleoside phosphate metabolic process	GO:0006753	283	0.032
gland development	GO:0048732	155	0.031
sensory organ development	GO:0007423	74	0.030
regulation of protein localization	GO:0032880	81	0.029
cellular response to hormone stimulus	GO:0032870	247	0.029
regulation of extent of cell growth	GO:0061387	25	0.029
synaptic transmission	GO:0007268	235	0.029
growth	GO:0040007	165	0.029
positive regulation of cellular protein metabolic process	GO:0032270	167	0.029
cytosolic calcium ion homeostasis	GO:0051480	140	0.029
locomotion	GO:0040011	237	0.029
regulation of multicellular organismal development	GO:2000026	376	0.028	Human
microtubule cytoskeleton organization	GO:0000226	25	0.028
hippocampus development	GO:0021766	30	0.028
regulation of phosphate metabolic process	GO:0019220	349	0.026
neuron projection extension	GO:1990138	26	0.025
male gamete generation	GO:0048232	99	0.025
axonogenesis	GO:0007409	71	0.025
regulation of signal transduction	GO:0009966	318	0.025
regulation of cell differentiation	GO:0045595	320	0.025	Human
chromatin remodeling	GO:0006338	3	0.024
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.024
taxis	GO:0042330	67	0.024
cell cell signaling	GO:0007267	335	0.024
cellular response to endogenous stimulus	GO:0071495	377	0.023
regulation of protein kinase activity	GO:0045859	105	0.023
negative regulation of cellular biosynthetic process	GO:0031327	161	0.023
neuron projection development	GO:0031175	273	0.023
positive regulation of phosphate metabolic process	GO:0045937	262	0.023
telencephalon development	GO:0021537	62	0.023
positive regulation of developmental process	GO:0051094	283	0.023	Human
single organism biosynthetic process	GO:0044711	342	0.022
positive regulation of phosphorylation	GO:0042327	177	0.022
cell type specific apoptotic process	GO:0097285	134	0.022
programmed cell death	GO:0012501	392	0.022
gamete generation	GO:0007276	124	0.022
regulation of cellular protein metabolic process	GO:0032268	267	0.022
apoptotic process	GO:0006915	381	0.022
regulation of cellular amino acid metabolic process	GO:0006521	2	0.021
purine ribonucleoside metabolic process	GO:0046128	168	0.021
regulation of synaptic transmission	GO:0050804	141	0.021
positive regulation of cellular amine metabolic process	GO:0033240	3	0.021
positive regulation of neurogenesis	GO:0050769	165	0.021
calcineurin nfat signaling cascade	GO:0033173	3	0.020
axon extension	GO:0048675	26	0.020
regulation of catalytic activity	GO:0050790	304	0.020
glandular epithelial cell differentiation	GO:0002067	4	0.020
multicellular organism growth	GO:0035264	1	0.020
regulation of cellular amine metabolic process	GO:0033238	8	0.020
positive regulation of protein phosphorylation	GO:0001934	135	0.020
epithelium development	GO:0060429	96	0.020
retina development in camera type eye	GO:0060041	27	0.020
regulation of axonogenesis	GO:0050770	37	0.019
response to nutrient levels	GO:0031667	370	0.019
macromolecular complex assembly	GO:0065003	273	0.019
actin filament based process	GO:0030029	86	0.019
spermatogenesis	GO:0007283	99	0.019
axis specification	GO:0009798	4	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.019
positive regulation of cell differentiation	GO:0045597	217	0.019	Human
oxoacid metabolic process	GO:0043436	290	0.019
carbohydrate derivative metabolic process	GO:1901135	346	0.018
negative regulation of cell communication	GO:0010648	158	0.018
negative regulation of cell death	GO:0060548	229	0.018
ras protein signal transduction	GO:0007265	29	0.018
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.018
negative regulation of gene expression	GO:0010629	199	0.018
intracellular signal transduction	GO:0035556	314	0.018
negative regulation of catalytic activity	GO:0043086	103	0.017
regulation of growth	GO:0040008	105	0.017
eye morphogenesis	GO:0048592	4	0.017
negative regulation of macromolecule metabolic process	GO:0010605	260	0.017
cellular response to stress	GO:0033554	269	0.017
spindle organization	GO:0007051	2	0.017
gonad development	GO:0008406	104	0.017
response to fungicide	GO:0060992	20	0.017
cellular chemical homeostasis	GO:0055082	247	0.017
cellular homeostasis	GO:0019725	252	0.017
protein phosphorylation	GO:0006468	345	0.016
cell growth	GO:0016049	104	0.016
negative regulation of biosynthetic process	GO:0009890	168	0.016
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.016
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.016
cell cycle	GO:0007049	101	0.016
regulation of synaptic plasticity	GO:0048167	70	0.016
cell projection organization	GO:0030030	302	0.016
amine metabolic process	GO:0009308	38	0.015
single organism catabolic process	GO:0044712	283	0.015
cellular amine metabolic process	GO:0044106	38	0.015
negative regulation of osteoblast differentiation	GO:0045668	2	0.015
response to lipopolysaccharide	GO:0032496	191	0.015
response to growth factor	GO:0070848	189	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.015
aging	GO:0007568	241	0.015
cell part morphogenesis	GO:0032990	123	0.015
peptidyl amino acid modification	GO:0018193	126	0.015	Human
cellular ketone metabolic process	GO:0042180	51	0.015
cell morphogenesis	GO:0000902	142	0.015
negative regulation of cellular metabolic process	GO:0031324	281	0.015
cellular amino acid metabolic process	GO:0006520	107	0.015
centrosome organization	GO:0051297	1	0.015
response to cytokine	GO:0034097	215	0.015
nucleobase containing compound catabolic process	GO:0034655	152	0.015
cellular response to growth factor stimulus	GO:0071363	162	0.015
cellular response to molecule of bacterial origin	GO:0071219	56	0.015
pallium development	GO:0021543	42	0.015
small gtpase mediated signal transduction	GO:0007264	36	0.014
regulation of neuron death	GO:1901214	115	0.014
cellular calcium ion homeostasis	GO:0006874	160	0.014
regulation of mitotic sister chromatid separation	GO:0010965	1	0.014
negative regulation of epidermal growth factor receptor signaling pathway	GO:0042059	3	0.014
cellular response to biotic stimulus	GO:0071216	59	0.014
positive regulation of signal transduction	GO:0009967	175	0.014
metal ion homeostasis	GO:0055065	186	0.014
regulation of calcium mediated signaling	GO:0050848	8	0.014
response to monosaccharide	GO:0034284	159	0.013
proteolysis	GO:0006508	175	0.013
regulation of cellular ketone metabolic process	GO:0010565	27	0.013
negative regulation of cell differentiation	GO:0045596	99	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.013
neuron fate commitment	GO:0048663	4	0.013
response to estrogen	GO:0043627	232	0.013
nucleoside triphosphate metabolic process	GO:0009141	144	0.013
positive regulation of sarcomere organization	GO:0060298	2	0.013
homeostatic process	GO:0042592	331	0.013
organophosphate metabolic process	GO:0019637	370	0.013
protein complex assembly	GO:0006461	263	0.013
protein complex biogenesis	GO:0070271	263	0.013
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.013
secretion	GO:0046903	307	0.013
rhythmic process	GO:0048511	156	0.013
regulation of ras protein signal transduction	GO:0046578	45	0.013
glycosyl compound metabolic process	GO:1901657	182	0.013
neuron differentiation	GO:0030182	368	0.012
regulation of body fluid levels	GO:0050878	90	0.012
regulation of hydrolase activity	GO:0051336	143	0.012
negative regulation of molecular function	GO:0044092	133	0.012
membrane organization	GO:0061024	94	0.012
positive regulation of cell development	GO:0010720	176	0.012
developmental growth involved in morphogenesis	GO:0060560	33	0.012
regulation of chromosome segregation	GO:0051983	1	0.012
tube development	GO:0035295	89	0.012
positive regulation of molecular function	GO:0044093	230	0.012
positive regulation of growth	GO:0045927	55	0.012
ribonucleotide metabolic process	GO:0009259	231	0.012
nucleobase containing small molecule metabolic process	GO:0055086	316	0.012
response to axon injury	GO:0048678	59	0.012
ion homeostasis	GO:0050801	212	0.012
chromosome segregation	GO:0007059	2	0.011
negative regulation of rna biosynthetic process	GO:1902679	118	0.011
negative regulation of protein metabolic process	GO:0051248	114	0.011
ribonucleotide catabolic process	GO:0009261	136	0.011
chemical homeostasis	GO:0048878	292	0.011
neuron development	GO:0048666	286	0.011
response to hexose	GO:0009746	144	0.011
cellular response to external stimulus	GO:0071496	118	0.011
positive regulation of protein modification process	GO:0031401	142	0.011
chromatin organization	GO:0006325	34	0.011	Human
cellular response to glucocorticoid stimulus	GO:0071385	68	0.011
response to extracellular stimulus	GO:0009991	380	0.011
regulation of response to wounding	GO:1903034	69	0.011
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.011
regulation of cellular response to stress	GO:0080135	49	0.011
response to glucocorticoid	GO:0051384	223	0.011
positive regulation of defense response	GO:0031349	37	0.011
response to oxidative stress	GO:0006979	186	0.011
microtubule based process	GO:0007017	36	0.011
developmental growth	GO:0048589	100	0.011
microtubule organizing center organization	GO:0031023	1	0.011
regulation of mitotic sister chromatid segregation	GO:0033047	1	0.011
canalicular bile acid transport	GO:0015722	5	0.010
regulation of neuronal synaptic plasticity	GO:0048168	31	0.010
regulation of intracellular signal transduction	GO:1902531	218	0.010
somatic stem cell maintenance	GO:0035019	2	0.010
organic substance catabolic process	GO:1901575	316	0.010
regulation of system process	GO:0044057	208	0.010
regulation of kinase activity	GO:0043549	117	0.010
regulation of axon extension	GO:0030516	24	0.010
regulation of transferase activity	GO:0051338	123	0.010
regulation of anatomical structure size	GO:0090066	135	0.010
cellular metal ion homeostasis	GO:0006875	172	0.010
embryonic pattern specification	GO:0009880	1	0.010
response to molecule of bacterial origin	GO:0002237	194	0.010

Mll5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.014
gastrointestinal system cancer	DOID:3119	0.014
cancer	DOID:162	0.014
organ system cancer	DOID:0050686	0.014

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