IMP: Integrative Multi-species Prediction

Rattus norvegicus

65 known processes

Tnfsf11

tumor necrosis factor (ligand) superfamily, member 11

(Aliases: RANKL)

RGD: 620784
Entrez: 117516
Ensembl: ENSRNOG00000009559
UniProtKB: Q9ESE2

Process Predictions
Disease Predictions

Tnfsf11 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of response to stimulus	GO:0048584	285	0.181	Human Rat
response to nutrient levels	GO:0031667	370	0.171	Rat
regulation of programmed cell death	GO:0043067	341	0.157	Rat
cellular response to endogenous stimulus	GO:0071495	377	0.149
regulation of apoptotic process	GO:0042981	335	0.133	Rat
cellular response to stress	GO:0033554	269	0.130
positive regulation of multicellular organismal process	GO:0051240	387	0.128
programmed cell death	GO:0012501	392	0.122	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.115
response to extracellular stimulus	GO:0009991	380	0.107	Rat
response to ketone	GO:1901654	182	0.106
response to cytokine	GO:0034097	215	0.101	Human
intracellular signal transduction	GO:0035556	314	0.095	Human Rat
apoptotic process	GO:0006915	381	0.093	Rat
multicellular organismal reproductive process	GO:0048609	233	0.091
response to lipopolysaccharide	GO:0032496	191	0.089	Rat
reproductive process	GO:0022414	372	0.085	Rat
positive regulation of signaling	GO:0023056	270	0.079	Human Rat
positive regulation of apoptotic process	GO:0043065	154	0.079	Rat
regulation of catalytic activity	GO:0050790	304	0.074	Human Rat
single organism reproductive process	GO:0044702	297	0.072	Rat
cellular ketone metabolic process	GO:0042180	51	0.071
cellular response to hormone stimulus	GO:0032870	247	0.070
neuron death	GO:0070997	127	0.069	Rat
neuron development	GO:0048666	286	0.068
defense response	GO:0006952	194	0.068	Rat
positive regulation of cell differentiation	GO:0045597	217	0.068
positive regulation of cell development	GO:0010720	176	0.065	Rat
macromolecular complex subunit organization	GO:0043933	339	0.065
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.061	Human Rat
response to radiation	GO:0009314	137	0.061
positive regulation of biosynthetic process	GO:0009891	319	0.061	Human Rat
positive regulation of cell death	GO:0010942	184	0.056	Rat
regulation of cell differentiation	GO:0045595	320	0.056
positive regulation of immune system process	GO:0002684	90	0.055
cellular response to lipid	GO:0071396	201	0.054
multicellular organism reproduction	GO:0032504	233	0.053
cell projection organization	GO:0030030	302	0.053
regulation of cellular ketone metabolic process	GO:0010565	27	0.053
positive regulation of protein phosphorylation	GO:0001934	135	0.052	Human
regulation of intracellular signal transduction	GO:1902531	218	0.052	Human Rat
tube development	GO:0035295	89	0.051
regulation of multicellular organismal development	GO:2000026	376	0.049
g protein coupled receptor signaling pathway	GO:0007186	242	0.049
cell type specific apoptotic process	GO:0097285	134	0.049	Rat
response to estrogen	GO:0043627	232	0.047
response to external biotic stimulus	GO:0043207	221	0.047	Rat
regulation of phosphate metabolic process	GO:0019220	349	0.047	Human
response to other organism	GO:0051707	220	0.046	Rat
cellular response to external stimulus	GO:0071496	118	0.046
nucleobase containing small molecule metabolic process	GO:0055086	316	0.046
regulation of neurogenesis	GO:0050767	247	0.045	Rat
regulation of neuron death	GO:1901214	115	0.045	Rat
jak stat cascade	GO:0007259	26	0.045
cellular catabolic process	GO:0044248	295	0.044
positive regulation of cell communication	GO:0010647	271	0.044	Human Rat
inflammatory response	GO:0006954	150	0.043	Rat
regulation of protein modification process	GO:0031399	194	0.043	Human
brain development	GO:0007420	247	0.042
single organism biosynthetic process	GO:0044711	342	0.042
response to estradiol	GO:0032355	164	0.041
cellular response to organonitrogen compound	GO:0071417	197	0.041
carboxylic acid metabolic process	GO:0019752	289	0.041
positive regulation of rna biosynthetic process	GO:1902680	197	0.040	Human
protein phosphorylation	GO:0006468	345	0.040	Human
positive regulation of developmental process	GO:0051094	283	0.040
cell activation	GO:0001775	97	0.039	Human Rat
renal system development	GO:0072001	67	0.039
positive regulation of transcription dna templated	GO:0045893	197	0.039	Human
cellular response to cytokine stimulus	GO:0071345	127	0.039	Human
immune system process	GO:0002376	204	0.038
cellular response to oxygen containing compound	GO:1901701	386	0.038
macromolecular complex assembly	GO:0065003	273	0.038
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.038
multi organism reproductive process	GO:0044703	262	0.038
single organism cell adhesion	GO:0098602	46	0.037	Human
regulation of nucleotide metabolic process	GO:0006140	117	0.037
sexual reproduction	GO:0019953	148	0.037
regulation of phosphorylation	GO:0042325	248	0.037	Human
protein complex subunit organization	GO:0071822	302	0.035
positive regulation of rna metabolic process	GO:0051254	203	0.035	Human
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.034	Human
neuron projection development	GO:0031175	273	0.034
positive regulation of molecular function	GO:0044093	230	0.034	Human Rat
regeneration	GO:0031099	163	0.034
response to growth factor	GO:0070848	189	0.033	Rat
positive regulation of neurogenesis	GO:0050769	165	0.033	Rat
development of primary sexual characteristics	GO:0045137	107	0.033	Rat
rhythmic process	GO:0048511	156	0.033
response to nutrient	GO:0007584	248	0.033	Rat
positive regulation of cell proliferation	GO:0008284	249	0.033	Rat
neuron differentiation	GO:0030182	368	0.032
response to ethanol	GO:0045471	162	0.032
cellular response to extracellular stimulus	GO:0031668	73	0.032
organonitrogen compound catabolic process	GO:1901565	179	0.031
cellular component biogenesis	GO:0044085	368	0.031
positive regulation of protein metabolic process	GO:0051247	178	0.031	Human Rat
positive regulation of phosphate metabolic process	GO:0045937	262	0.031	Human
response to peptide	GO:1901652	292	0.031	Rat
calcium ion transport	GO:0006816	131	0.031
positive regulation of phosphorus metabolic process	GO:0010562	262	0.031	Human
macromolecule localization	GO:0033036	252	0.030	Rat
positive regulation of jak stat cascade	GO:0046427	19	0.030
positive regulation of nervous system development	GO:0051962	178	0.030	Rat
regulation of cellular amine metabolic process	GO:0033238	8	0.030
nucleoside phosphate metabolic process	GO:0006753	283	0.029
divalent inorganic cation transport	GO:0072511	134	0.029
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.029	Rat
gamete generation	GO:0007276	124	0.029
activation of janus kinase activity	GO:0042976	5	0.029
regulation of phosphorus metabolic process	GO:0051174	349	0.029	Human
homeostatic process	GO:0042592	331	0.028
regulation of cellular protein metabolic process	GO:0032268	267	0.028	Human Rat
protein localization	GO:0008104	191	0.028	Rat
positive regulation of phosphorylation	GO:0042327	177	0.028	Human
positive regulation of catalytic activity	GO:0043085	184	0.028	Human Rat
positive regulation of programmed cell death	GO:0043068	157	0.028	Rat
steroid metabolic process	GO:0008202	73	0.028
response to ionizing radiation	GO:0010212	59	0.027
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.027	Human
regulation of protein metabolic process	GO:0051246	289	0.027	Human Rat
response to oxygen levels	GO:0070482	265	0.027	Rat
protein complex assembly	GO:0006461	263	0.026
response to wounding	GO:0009611	254	0.026	Rat
vitamin d metabolic process	GO:0042359	4	0.026
cell adhesion	GO:0007155	110	0.025	Human
protein complex biogenesis	GO:0070271	263	0.025
neuron apoptotic process	GO:0051402	88	0.025	Rat
reproduction	GO:0000003	245	0.025
cellular homeostasis	GO:0019725	252	0.025	Rat
positive regulation of gene expression	GO:0010628	244	0.025	Human
neuropeptide signaling pathway	GO:0007218	29	0.024
regulation of hormone levels	GO:0010817	187	0.024
response to corticosteroid	GO:0031960	235	0.024
wound healing	GO:0042060	122	0.024
positive regulation of intracellular signal transduction	GO:1902533	138	0.024	Human Rat
regulation of jak stat cascade	GO:0046425	21	0.024
catabolic process	GO:0009056	351	0.024
carbohydrate derivative catabolic process	GO:1901136	147	0.024
purine containing compound metabolic process	GO:0072521	253	0.024
camp metabolic process	GO:0046058	63	0.023
cellular response to ammonium ion	GO:0071242	17	0.023
gonad development	GO:0008406	104	0.023	Rat
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.023
central nervous system development	GO:0007417	311	0.023
proteolysis	GO:0006508	175	0.023	Rat
gastrulation	GO:0007369	2	0.022
ribose phosphate metabolic process	GO:0019693	235	0.022
organic cyclic compound catabolic process	GO:1901361	175	0.022
positive regulation of hydrolase activity	GO:0051345	86	0.022	Rat
response to alkaloid	GO:0043279	132	0.022
glycosyl compound metabolic process	GO:1901657	182	0.022
organic substance catabolic process	GO:1901575	316	0.022
positive regulation of neuron differentiation	GO:0045666	126	0.022
amine metabolic process	GO:0009308	38	0.022
cellular cation homeostasis	GO:0030003	180	0.022	Rat
metal ion transport	GO:0030001	289	0.022
response to glucocorticoid	GO:0051384	223	0.022
spermatogenesis	GO:0007283	99	0.022
cellular component movement	GO:0006928	248	0.022	Human
negative regulation of metabolic process	GO:0009892	331	0.021
immune system development	GO:0002520	41	0.021
positive regulation of cellular component organization	GO:0051130	200	0.021	Rat
chemical homeostasis	GO:0048878	292	0.021	Rat
regulation of transferase activity	GO:0051338	123	0.021	Human
positive regulation of neuron projection development	GO:0010976	99	0.021
regulation of cell proliferation	GO:0042127	359	0.021	Rat
liver development	GO:0001889	90	0.021
positive regulation of blood pressure by epinephrine norepinephrine	GO:0003321	2	0.021
cellular amine metabolic process	GO:0044106	38	0.021
adenylate cyclase inhibiting g protein coupled receptor signaling pathway	GO:0007193	19	0.020
aromatic compound catabolic process	GO:0019439	168	0.020
purine nucleotide metabolic process	GO:0006163	229	0.020
localization of cell	GO:0051674	202	0.020	Human
regulation of anatomical structure size	GO:0090066	135	0.020
appendage morphogenesis	GO:0035107	4	0.020
secretion by cell	GO:0032940	248	0.020	Rat
organophosphate catabolic process	GO:0046434	148	0.020
response to molecule of bacterial origin	GO:0002237	194	0.020	Rat
regulation of leukocyte proliferation	GO:0070663	26	0.020	Rat
antigen receptor mediated signaling pathway	GO:0050851	1	0.020
cytosolic calcium ion homeostasis	GO:0051480	140	0.020
positive regulation of cellular protein metabolic process	GO:0032270	167	0.020	Human Rat
regulation of rna biosynthetic process	GO:2001141	381	0.020	Human
anatomical structure morphogenesis	GO:0009653	298	0.020
divalent inorganic cation homeostasis	GO:0072507	165	0.020
aging	GO:0007568	241	0.019
response to monosaccharide	GO:0034284	159	0.019
gland development	GO:0048732	155	0.019
response to peptide hormone	GO:0043434	278	0.019	Rat
regulation of protein phosphorylation	GO:0001932	183	0.019	Human
single organism catabolic process	GO:0044712	283	0.019
immune response	GO:0006955	104	0.019	Rat
cation transport	GO:0006812	382	0.019
carbohydrate derivative metabolic process	GO:1901135	346	0.019
regulation of cellular component organization	GO:0051128	368	0.019	Rat
ovulation cycle	GO:0042698	67	0.019
hepaticobiliary system development	GO:0061008	90	0.018
nucleotide metabolic process	GO:0009117	279	0.018
cellular component assembly	GO:0022607	360	0.018
cation homeostasis	GO:0055080	195	0.018	Rat
cellular nitrogen compound catabolic process	GO:0044270	163	0.018
forebrain development	GO:0030900	98	0.018
divalent metal ion transport	GO:0070838	132	0.018
purine ribonucleotide biosynthetic process	GO:0009152	81	0.018
positive regulation of protein modification process	GO:0031401	142	0.018	Human
regulation of response to stress	GO:0080134	126	0.018	Rat
secretion	GO:0046903	307	0.017	Rat
regulation of neuron differentiation	GO:0045664	208	0.017
regulation of signal transduction	GO:0009966	318	0.017	Human Rat
head development	GO:0060322	247	0.017
negative regulation of developmental process	GO:0051093	125	0.017
response to toxic substance	GO:0009636	133	0.017
positive regulation of cell projection organization	GO:0031346	111	0.017
regulation of cell development	GO:0060284	263	0.017	Rat
regulation of kinase activity	GO:0043549	117	0.017	Human
response to dexamethasone	GO:0071548	49	0.017
multicellular organismal homeostasis	GO:0048871	49	0.017
positive regulation of signal transduction	GO:0009967	175	0.017	Human Rat
ribonucleotide metabolic process	GO:0009259	231	0.017
regulation of hormone secretion	GO:0046883	106	0.017
regulation of cellular amino acid metabolic process	GO:0006521	2	0.017
nucleoside catabolic process	GO:0009164	126	0.016
regulation of secretion by cell	GO:1903530	208	0.016	Rat
mononuclear cell proliferation	GO:0032943	29	0.016	Rat
ribonucleotide biosynthetic process	GO:0009260	85	0.016
limb morphogenesis	GO:0035108	4	0.016
negative regulation of biosynthetic process	GO:0009890	168	0.016
ras protein signal transduction	GO:0007265	29	0.016
regulation of body fluid levels	GO:0050878	90	0.016
positive regulation of calcium ion transport	GO:0051928	36	0.016
negative regulation of cellular biosynthetic process	GO:0031327	161	0.016
urogenital system development	GO:0001655	78	0.016
calcium ion homeostasis	GO:0055074	162	0.016
embryonic appendage morphogenesis	GO:0035113	4	0.016
peptidyl amino acid modification	GO:0018193	126	0.015
organonitrogen compound biosynthetic process	GO:1901566	167	0.015
temperature homeostasis	GO:0001659	17	0.015
regulation of system process	GO:0044057	208	0.015
cell growth	GO:0016049	104	0.015
heterocycle catabolic process	GO:0046700	167	0.015
regulation of neuron projection development	GO:0010975	161	0.015
positive regulation of protein kinase activity	GO:0045860	73	0.015	Human
protein homooligomerization	GO:0051260	91	0.015
female pregnancy	GO:0007565	122	0.015
regulation of cellular extravasation	GO:0002691	2	0.015
nucleotide biosynthetic process	GO:0009165	98	0.015
negative regulation of nervous system development	GO:0051961	79	0.015
response to hexose	GO:0009746	144	0.014
nucleobase containing compound catabolic process	GO:0034655	152	0.014
leukocyte activation	GO:0045321	76	0.014	Human Rat
dendrite morphogenesis	GO:0048813	43	0.014
neural crest cell development	GO:0014032	2	0.014
regulation of ion transport	GO:0043269	245	0.014	Rat
small gtpase mediated signal transduction	GO:0007264	36	0.014
activation of protein kinase activity	GO:0032147	47	0.014
cellular response to nitrogen compound	GO:1901699	210	0.014
gtp catabolic process	GO:0006184	71	0.014
regulation of lipid biosynthetic process	GO:0046890	38	0.014
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.014
regulation of camp biosynthetic process	GO:0030817	38	0.014
cellular amino acid metabolic process	GO:0006520	107	0.014
regulation of nervous system development	GO:0051960	264	0.014	Rat
male gamete generation	GO:0048232	99	0.014
glutamate receptor signaling pathway	GO:0007215	43	0.014
response to hypoxia	GO:0001666	231	0.014	Rat
cellular macromolecule catabolic process	GO:0044265	29	0.014
regulation of protein kinase activity	GO:0045859	105	0.014	Human
cellular response to nutrient levels	GO:0031669	60	0.014
organic hydroxy compound metabolic process	GO:1901615	115	0.014
establishment of protein localization	GO:0045184	141	0.014	Rat
protein oligomerization	GO:0051259	191	0.014
oxoacid metabolic process	GO:0043436	290	0.014
purine ribonucleotide metabolic process	GO:0009150	227	0.014
nucleoside triphosphate catabolic process	GO:0009143	123	0.014
developmental process involved in reproduction	GO:0003006	159	0.014	Rat
cerebral cortex tangential migration	GO:0021800	1	0.014
ribose phosphate biosynthetic process	GO:0046390	87	0.014
cytokine production	GO:0001816	61	0.014	Rat
negative regulation of cellular component organization	GO:0051129	83	0.013
regulation of cell projection organization	GO:0031344	175	0.013
camp biosynthetic process	GO:0006171	47	0.013
behavior	GO:0007610	205	0.013
response to ammonium ion	GO:0060359	71	0.013
innate immune response	GO:0045087	35	0.013
axis specification	GO:0009798	4	0.013
cellular chemical homeostasis	GO:0055082	247	0.013	Rat
cellular response to alcohol	GO:0097306	87	0.013
embryonic limb morphogenesis	GO:0030326	4	0.013
cellular response to growth factor stimulus	GO:0071363	162	0.013
cell part morphogenesis	GO:0032990	123	0.013
cellular response to oxygen levels	GO:0071453	60	0.013
regulation of lipid metabolic process	GO:0019216	68	0.013
positive regulation of mononuclear cell proliferation	GO:0032946	20	0.013	Rat
sex differentiation	GO:0007548	113	0.013	Rat
purine nucleoside metabolic process	GO:0042278	169	0.013
synaptic transmission	GO:0007268	235	0.013	Rat
organophosphate metabolic process	GO:0019637	370	0.012
transcription dna templated	GO:0006351	377	0.012	Human
dendrite development	GO:0016358	72	0.012
positive regulation of transport	GO:0051050	245	0.012	Rat
response to amine	GO:0014075	46	0.012
response to glucose	GO:0009749	136	0.012
embryonic hindlimb morphogenesis	GO:0035116	2	0.012
saliva secretion	GO:0046541	3	0.012
positive regulation of lymphocyte proliferation	GO:0050671	20	0.012	Rat
regulation of ossification	GO:0030278	32	0.012
motor neuron axon guidance	GO:0008045	1	0.012
ion homeostasis	GO:0050801	212	0.012	Rat
positive regulation of transferase activity	GO:0051347	81	0.012	Human
rna metabolic process	GO:0016070	406	0.012	Human
organic acid metabolic process	GO:0006082	292	0.012
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.012
cell morphogenesis	GO:0000902	142	0.012
feeding behavior	GO:0007631	53	0.012
biological adhesion	GO:0022610	110	0.012	Human
peptidyl tyrosine phosphorylation	GO:0018108	72	0.012
carbohydrate derivative biosynthetic process	GO:1901137	124	0.012
nucleoside metabolic process	GO:0009116	179	0.012
regulation of epithelial cell proliferation	GO:0050678	49	0.012
negative regulation of cell death	GO:0060548	229	0.012
hormone metabolic process	GO:0042445	69	0.011
inorganic ion transmembrane transport	GO:0098660	229	0.011
cellular response to corticosteroid stimulus	GO:0071384	69	0.011
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.011
nucleoside triphosphate metabolic process	GO:0009141	144	0.011
salivary gland development	GO:0007431	3	0.011
ribonucleoside metabolic process	GO:0009119	174	0.011
cellular response to starvation	GO:0009267	27	0.011
mapk cascade	GO:0000165	140	0.011	Human
response to light stimulus	GO:0009416	52	0.011
protein modification by small protein conjugation	GO:0032446	31	0.011
cation transmembrane transport	GO:0098655	263	0.011
positive regulation of cellular biosynthetic process	GO:0031328	295	0.011	Human
nucleic acid templated transcription	GO:0097659	379	0.011	Human
cytoplasmic transport	GO:0016482	115	0.011
positive regulation of cellular catabolic process	GO:0031331	71	0.011
purine ribonucleotide catabolic process	GO:0009154	136	0.011
negative regulation of neuron differentiation	GO:0045665	62	0.011
regulation of purine nucleotide catabolic process	GO:0033121	65	0.011
purine containing compound biosynthetic process	GO:0072522	85	0.011
urinary tract smooth muscle contraction	GO:0014848	4	0.011
regulation of cell growth	GO:0001558	85	0.011
negative regulation of uterine smooth muscle contraction	GO:0070473	2	0.011
regulation of catabolic process	GO:0009894	113	0.011
epithelial cell proliferation	GO:0050673	54	0.011
hormone transport	GO:0009914	121	0.011
regulation of nucleoside metabolic process	GO:0009118	66	0.011
maintenance of location	GO:0051235	17	0.011
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.011
positive regulation of cellular amine metabolic process	GO:0033240	3	0.011
purine nucleoside catabolic process	GO:0006152	124	0.011
monovalent inorganic cation transport	GO:0015672	172	0.010
response to biotic stimulus	GO:0009607	226	0.010	Rat
negative regulation of signaling	GO:0023057	157	0.010
regulation of dendrite development	GO:0050773	59	0.010
regulation of gluconeogenesis	GO:0006111	4	0.010
purine containing compound catabolic process	GO:0072523	138	0.010
autophagic cell death	GO:0048102	4	0.010
purine nucleotide catabolic process	GO:0006195	136	0.010
transcription from rna polymerase ii promoter	GO:0006366	252	0.010	Human
multicellular organismal catabolic process	GO:0044243	2	0.010
protein modification by small protein conjugation or removal	GO:0070647	35	0.010
regulation of secretion	GO:0051046	224	0.010	Rat
response to cocaine	GO:0042220	39	0.010
cytokine mediated signaling pathway	GO:0019221	43	0.010	Human
single organismal cell cell adhesion	GO:0016337	42	0.010	Human
response to heat	GO:0009408	60	0.010
female gonad development	GO:0008585	53	0.010
regulation of nucleotide biosynthetic process	GO:0030808	47	0.010
negative regulation of multicellular organismal process	GO:0051241	203	0.010
reproductive system development	GO:0061458	128	0.010	Rat

Tnfsf11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.016	Human
cardiovascular system disease	DOID:1287	0.016
nervous system disease	DOID:863	0.015
musculoskeletal system disease	DOID:17	0.015	Human
connective tissue disease	DOID:65	0.015	Human
vascular disease	DOID:178	0.011
hypertension	DOID:10763	0.011
artery disease	DOID:0050828	0.011
immune system disease	DOID:2914	0.011
bone disease	DOID:0080001	0.011	Human
central nervous system disease	DOID:331	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network