IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Lamp2

lysosomal-associated membrane protein 2

Ensembl: ENSRNOG00000000164
Entrez: 24944
RGD: 2990
UniProtKB: Q6P6W1

Process Predictions
Disease Predictions

Lamp2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
organic substance catabolic process	GO:1901575	316	0.610
cellular catabolic process	GO:0044248	295	0.542
catabolic process	GO:0009056	351	0.330
response to molecule of bacterial origin	GO:0002237	194	0.276
hair follicle development	GO:0001942	2	0.248
nucleoside triphosphate metabolic process	GO:0009141	144	0.229
response to oxidative stress	GO:0006979	186	0.206
organic acid metabolic process	GO:0006082	292	0.184
regulation of vesicle mediated transport	GO:0060627	81	0.180
lipid metabolic process	GO:0006629	283	0.178
response to biotic stimulus	GO:0009607	226	0.165
acute inflammatory response	GO:0002526	58	0.156
single organism catabolic process	GO:0044712	283	0.145
organonitrogen compound catabolic process	GO:1901565	179	0.126
organic cyclic compound catabolic process	GO:1901361	175	0.124
proteolysis	GO:0006508	175	0.117
positive regulation of transport	GO:0051050	245	0.109
vesicle mediated transport	GO:0016192	181	0.106
programmed cell death	GO:0012501	392	0.104
oxoacid metabolic process	GO:0043436	290	0.100
hair cycle process	GO:0022405	2	0.097
carbohydrate derivative catabolic process	GO:1901136	147	0.088
response to glucocorticoid	GO:0051384	223	0.087
response to other organism	GO:0051707	220	0.086
regulation of apoptotic process	GO:0042981	335	0.077
response to nutrient levels	GO:0031667	370	0.075
endocytosis	GO:0006897	84	0.074
metal ion homeostasis	GO:0055065	186	0.074
response to external biotic stimulus	GO:0043207	221	0.073
skin morphogenesis	GO:0043589	2	0.071
macromolecule catabolic process	GO:0009057	58	0.067
single organism carbohydrate catabolic process	GO:0044724	40	0.066
cation transport	GO:0006812	382	0.064
multicellular organismal homeostasis	GO:0048871	49	0.064
aging	GO:0007568	241	0.063
nucleoside phosphate catabolic process	GO:1901292	140	0.063
response to cytokine	GO:0034097	215	0.063
glycosyl compound catabolic process	GO:1901658	126	0.063
homeostatic process	GO:0042592	331	0.063
phenylpropanoid catabolic process	GO:0046271	3	0.062
glycosyl compound metabolic process	GO:1901657	182	0.062
organic anion transport	GO:0015711	132	0.062
purine containing compound catabolic process	GO:0072523	138	0.061
negative regulation of cell death	GO:0060548	229	0.061
carbohydrate metabolic process	GO:0005975	130	0.061
regulation of angiogenesis	GO:0045765	39	0.060
carbohydrate derivative metabolic process	GO:1901135	346	0.060
molting cycle process	GO:0022404	2	0.059
purine ribonucleotide catabolic process	GO:0009154	136	0.059
regulation of cell maturation	GO:1903429	3	0.058
anatomical structure morphogenesis	GO:0009653	298	0.054
regulation of synaptic transmission	GO:0050804	141	0.053
regulation of protein metabolic process	GO:0051246	289	0.052
response to starvation	GO:0042594	59	0.052
aromatic compound catabolic process	GO:0019439	168	0.052
carboxylic acid metabolic process	GO:0019752	289	0.051
epithelium development	GO:0060429	96	0.051
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	3	0.049
regulation of body fluid levels	GO:0050878	90	0.048
cellular lipid metabolic process	GO:0044255	208	0.048
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.048
synaptic transmission	GO:0007268	235	0.048
lipid biosynthetic process	GO:0008610	128	0.047
cellular chemical homeostasis	GO:0055082	247	0.047
response to bacterium	GO:0009617	200	0.047
response to inorganic substance	GO:0010035	377	0.046
neuron death	GO:0070997	127	0.044
heterocycle catabolic process	GO:0046700	167	0.044
single organism carbohydrate metabolic process	GO:0044723	118	0.044
regulation of ion transport	GO:0043269	245	0.043
nucleotide catabolic process	GO:0009166	139	0.041
cellular amino acid metabolic process	GO:0006520	107	0.040
blood vessel morphogenesis	GO:0048514	58	0.040
g protein coupled receptor signaling pathway	GO:0007186	242	0.039
cell projection organization	GO:0030030	302	0.039
purine nucleoside metabolic process	GO:0042278	169	0.039
purine ribonucleoside catabolic process	GO:0046130	124	0.039
peptide metabolic process	GO:0006518	32	0.039
chemical homeostasis	GO:0048878	292	0.039
organophosphate metabolic process	GO:0019637	370	0.038
reproductive system development	GO:0061458	128	0.038
development of primary sexual characteristics	GO:0045137	107	0.037
regulation of cellular localization	GO:0060341	263	0.036
cellular response to fluid shear stress	GO:0071498	4	0.036
nucleoside triphosphate catabolic process	GO:0009143	123	0.036
response to camp	GO:0051591	91	0.035
nucleoside metabolic process	GO:0009116	179	0.035
male sex differentiation	GO:0046661	64	0.034
metal ion transport	GO:0030001	289	0.034
regulation of hemostasis	GO:1900046	9	0.034
coagulation	GO:0050817	28	0.033
leydig cell differentiation	GO:0033327	8	0.033
negative regulation of programmed cell death	GO:0043069	183	0.032
ion homeostasis	GO:0050801	212	0.032
angiogenesis	GO:0001525	53	0.032
response to extracellular stimulus	GO:0009991	380	0.032
gonad development	GO:0008406	104	0.031
regulation of endocytosis	GO:0030100	42	0.031
organelle organization	GO:0006996	266	0.031
cellular response to hydroperoxide	GO:0071447	2	0.031
neuron differentiation	GO:0030182	368	0.031
signal transduction by phosphorylation	GO:0023014	144	0.030
locomotion	GO:0040011	237	0.030
positive regulation of signal transduction	GO:0009967	175	0.029
endothelial cell apoptotic process	GO:0072577	3	0.029
purine nucleotide metabolic process	GO:0006163	229	0.029
ribonucleotide metabolic process	GO:0009259	231	0.029
cation homeostasis	GO:0055080	195	0.029
negative regulation of apoptotic process	GO:0043066	181	0.028
response to peptide	GO:1901652	292	0.028
response to lipopolysaccharide	GO:0032496	191	0.027
antigen processing and presentation of peptide antigen	GO:0048002	2	0.027
cellular amine metabolic process	GO:0044106	38	0.027
cellular response to external stimulus	GO:0071496	118	0.026
monovalent inorganic cation transport	GO:0015672	172	0.025
regulation of cellular amine metabolic process	GO:0033238	8	0.025
positive regulation of cellular amine metabolic process	GO:0033240	3	0.025
nucleobase containing compound catabolic process	GO:0034655	152	0.025
regulation of organelle organization	GO:0033043	80	0.025
amine metabolic process	GO:0009308	38	0.024
cell part morphogenesis	GO:0032990	123	0.024
response to reactive oxygen species	GO:0000302	120	0.024
small molecule catabolic process	GO:0044282	59	0.024
nerve development	GO:0021675	11	0.024
response to growth factor	GO:0070848	189	0.024
response to estradiol	GO:0032355	164	0.024
membrane organization	GO:0061024	94	0.024
regulation of exocytosis	GO:0017157	37	0.024
secretion	GO:0046903	307	0.023
reproductive structure development	GO:0048608	128	0.023
cellular protein catabolic process	GO:0044257	19	0.023
reactive oxygen species metabolic process	GO:0072593	37	0.023
regulation of endothelial cell apoptotic process	GO:2000351	3	0.023
defense response	GO:0006952	194	0.023
cellular response to stress	GO:0033554	269	0.022
protein autoprocessing	GO:0016540	7	0.022
response to metal ion	GO:0010038	253	0.022
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.022
purine ribonucleotide metabolic process	GO:0009150	227	0.022
monocarboxylic acid metabolic process	GO:0032787	152	0.022
nucleoside catabolic process	GO:0009164	126	0.022
regulation of catalytic activity	GO:0050790	304	0.021
regulation of signal transduction	GO:0009966	318	0.021
positive regulation of protein modification process	GO:0031401	142	0.021
development of primary male sexual characteristics	GO:0046546	59	0.021
complement activation	GO:0006956	11	0.021
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.021
l serine transport	GO:0015825	3	0.021
positive regulation of immune system process	GO:0002684	90	0.021
regulation of cellular component organization	GO:0051128	368	0.021
anion transport	GO:0006820	178	0.021
protein maturation	GO:0051604	68	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
apoptotic process	GO:0006915	381	0.020
calcium ion homeostasis	GO:0055074	162	0.020
cellular nitrogen compound catabolic process	GO:0044270	163	0.020
nucleotide metabolic process	GO:0009117	279	0.020
insecticide metabolic process	GO:0017143	4	0.020
response to glucose	GO:0009749	136	0.019
carboxylic acid biosynthetic process	GO:0046394	83	0.019
purine nucleoside catabolic process	GO:0006152	124	0.019
response to carbohydrate	GO:0009743	183	0.019
immune response	GO:0006955	104	0.019
intracellular signal transduction	GO:0035556	314	0.019
positive regulation of gene expression	GO:0010628	244	0.019
cellular response to reactive oxygen species	GO:0034614	55	0.018
response to fluid shear stress	GO:0034405	16	0.018
tissue regeneration	GO:0042246	36	0.018
cell type specific apoptotic process	GO:0097285	134	0.018
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.018
regulation of secretion	GO:0051046	224	0.018
cellular homeostasis	GO:0019725	252	0.018
melanosome localization	GO:0032400	1	0.018
peptidyl amino acid modification	GO:0018193	126	0.018
regulation of molecular function	GO:0065009	398	0.018
t cell activation	GO:0042110	29	0.018
cell migration	GO:0016477	197	0.017
cellular response to oxygen containing compound	GO:1901701	386	0.017
smooth muscle cell migration	GO:0014909	36	0.017
organic hydroxy compound metabolic process	GO:1901615	115	0.017
cellular macromolecule catabolic process	GO:0044265	29	0.017
neuron projection morphogenesis	GO:0048812	122	0.017
male gonad development	GO:0008584	59	0.017
regulation of phosphorylation	GO:0042325	248	0.016
female pregnancy	GO:0007565	122	0.016
response to cadmium ion	GO:0046686	35	0.016
brain development	GO:0007420	247	0.016
coumarin catabolic process	GO:0046226	3	0.016
mapk cascade	GO:0000165	140	0.016
divalent inorganic cation homeostasis	GO:0072507	165	0.016
cellular response to extracellular stimulus	GO:0031668	73	0.016
ribonucleoside catabolic process	GO:0042454	126	0.016
positive regulation of transferase activity	GO:0051347	81	0.016
cellular response to nutrient levels	GO:0031669	60	0.016
cellular modified amino acid metabolic process	GO:0006575	61	0.016
cellular response to nitrogen compound	GO:1901699	210	0.016
single organism biosynthetic process	GO:0044711	342	0.016
sex differentiation	GO:0007548	113	0.016
ribose phosphate metabolic process	GO:0019693	235	0.016
regulation of defense response	GO:0031347	68	0.016
sexual reproduction	GO:0019953	148	0.016
positive regulation of reactive oxygen species metabolic process	GO:2000379	16	0.015
positive regulation of response to stimulus	GO:0048584	285	0.015
nucleobase containing small molecule metabolic process	GO:0055086	316	0.015
decidualization	GO:0046697	14	0.015
neuron development	GO:0048666	286	0.015
ribonucleotide catabolic process	GO:0009261	136	0.015
protein processing	GO:0016485	68	0.015
ribonucleoside metabolic process	GO:0009119	174	0.015
positive regulation of molecular function	GO:0044093	230	0.015
response to tumor necrosis factor	GO:0034612	56	0.015
response to estrogen	GO:0043627	232	0.015
negative regulation of neuron death	GO:1901215	69	0.015
potassium ion transport	GO:0006813	97	0.015
positive regulation of catabolic process	GO:0009896	78	0.014
negative regulation of neuron apoptotic process	GO:0043524	45	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
response to alkaloid	GO:0043279	132	0.014
cellular response to unfolded protein	GO:0034620	2	0.014
positive regulation of apoptotic process	GO:0043065	154	0.014
response to hydrogen peroxide	GO:0042542	89	0.014
neuron projection development	GO:0031175	273	0.014
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.014
regulation of locomotion	GO:0040012	148	0.014
central nervous system development	GO:0007417	311	0.014
regulation of hydrolase activity	GO:0051336	143	0.014
positive regulation of cell communication	GO:0010647	271	0.014
multi organism reproductive process	GO:0044703	262	0.014
positive regulation of cell migration	GO:0030335	96	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.014
positive regulation of phosphorylation	GO:0042327	177	0.014
regulation of immune response	GO:0050776	55	0.014
single organism organelle organization	GO:1902589	180	0.014
positive regulation of phosphate metabolic process	GO:0045937	262	0.014
regulation of programmed cell death	GO:0043067	341	0.014
hemostasis	GO:0007599	26	0.014
growth	GO:0040007	165	0.014
regulation of response to stress	GO:0080134	126	0.014
developmental process involved in reproduction	GO:0003006	159	0.014
head development	GO:0060322	247	0.013
cellular ketone metabolic process	GO:0042180	51	0.013
cellular response to organonitrogen compound	GO:0071417	197	0.013
neural crest cell differentiation	GO:0014033	2	0.013
anatomical structure maturation	GO:0071695	2	0.013
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.013
tube development	GO:0035295	89	0.013
lymphocyte activation	GO:0046649	43	0.013
synaptic vesicle endocytosis	GO:0048488	4	0.013
protein catabolic process	GO:0030163	30	0.013
response to purine containing compound	GO:0014074	126	0.013
cellular response to growth factor stimulus	GO:0071363	162	0.013
cellular component maintenance	GO:0043954	4	0.013
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.013
cellular response to topologically incorrect protein	GO:0035967	3	0.013
purine containing compound metabolic process	GO:0072521	253	0.013
positive regulation of hemostasis	GO:1900048	4	0.013
leukocyte activation	GO:0045321	76	0.013
response to hexose	GO:0009746	144	0.013
bone resorption	GO:0045453	18	0.013
cellular component assembly	GO:0022607	360	0.013
nucleic acid templated transcription	GO:0097659	379	0.013
regulation of transferase activity	GO:0051338	123	0.013
regulation of cellular catabolic process	GO:0031329	101	0.013
single organism intracellular transport	GO:1902582	166	0.013
localization of cell	GO:0051674	202	0.013
inflammatory response	GO:0006954	150	0.013
cellular response to starvation	GO:0009267	27	0.013
choline transport	GO:0015871	4	0.013
cellular component movement	GO:0006928	248	0.013
single organism reproductive process	GO:0044702	297	0.012
dendrite morphogenesis	GO:0048813	43	0.012
anterior posterior pattern specification	GO:0009952	1	0.012
multicellular organismal reproductive process	GO:0048609	233	0.012
regulation of protein maturation	GO:1903317	50	0.012
response to hypoxia	GO:0001666	231	0.012
response to nicotine	GO:0035094	51	0.012
proteasomal protein catabolic process	GO:0010498	8	0.012
regulation of response to wounding	GO:1903034	69	0.012
negative regulation of metabolic process	GO:0009892	331	0.012
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.012
negative regulation of humoral immune response	GO:0002921	4	0.012
regulation of response to external stimulus	GO:0032101	106	0.012
blood vessel development	GO:0001568	69	0.012
protein homooligomerization	GO:0051260	91	0.012
response to acid chemical	GO:0001101	222	0.012
adult locomotory behavior	GO:0008344	4	0.012
glycerolipid metabolic process	GO:0046486	67	0.012
response to monosaccharide	GO:0034284	159	0.012
lipid oxidation	GO:0034440	30	0.012
bone remodeling	GO:0046849	23	0.012
neural crest cell development	GO:0014032	2	0.012
response to vitamin e	GO:0033197	24	0.012
positive regulation of mapk cascade	GO:0043410	92	0.012
gtp catabolic process	GO:0006184	71	0.012
negative regulation of cell communication	GO:0010648	158	0.012
response to gonadotropin	GO:0034698	34	0.012
peptide biosynthetic process	GO:0043043	3	0.012
unsaturated fatty acid biosynthetic process	GO:0006636	21	0.012
glycerophospholipid metabolic process	GO:0006650	47	0.011
response to activity	GO:0014823	73	0.011
embryonic pattern specification	GO:0009880	1	0.011
positive regulation of catalytic activity	GO:0043085	184	0.011
regulation of embryonic development	GO:0045995	2	0.011
fatty acid metabolic process	GO:0006631	99	0.011
positive regulation of cell motility	GO:2000147	97	0.011
regulation of nucleotide metabolic process	GO:0006140	117	0.011
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.011
regulation of transcription dna templated	GO:0006355	374	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.011
positive regulation of multicellular organismal process	GO:0051240	387	0.011
monosaccharide metabolic process	GO:0005996	61	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
monocarboxylic acid catabolic process	GO:0072329	28	0.011
vasculature development	GO:0001944	70	0.011
response to unfolded protein	GO:0006986	6	0.011
secretion by cell	GO:0032940	248	0.011
cellular response to oxidative stress	GO:0034599	76	0.011
positive regulation of cell proliferation	GO:0008284	249	0.011
cell fate determination	GO:0001709	2	0.011
cellular calcium ion homeostasis	GO:0006874	160	0.011
regulation of cellular amino acid metabolic process	GO:0006521	2	0.011
steroid metabolic process	GO:0008202	73	0.011
response to wounding	GO:0009611	254	0.011
small molecule biosynthetic process	GO:0044283	124	0.010
protein phosphorylation	GO:0006468	345	0.010
tissue development	GO:0009888	252	0.010
negative regulation of macromolecule metabolic process	GO:0010605	260	0.010
macromolecule localization	GO:0033036	252	0.010
positive regulation of transcription dna templated	GO:0045893	197	0.010
response to corticosteroid	GO:0031960	235	0.010
regulation of cellular ketone metabolic process	GO:0010565	27	0.010
cellular component biogenesis	GO:0044085	368	0.010
hair cycle	GO:0042633	3	0.010
negative regulation of signaling	GO:0023057	157	0.010
ossification	GO:0001503	70	0.010
wound healing	GO:0042060	122	0.010
receptor mediated endocytosis	GO:0006898	42	0.010

Lamp2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.090
inherited metabolic disorder	DOID:655	0.090
disease of anatomical entity	DOID:7	0.054
nervous system disease	DOID:863	0.054
sensory system disease	DOID:0050155	0.021
eye and adnexa disease	DOID:1492	0.021
epilepsy syndrome	DOID:1826	0.018
brain disease	DOID:936	0.018
electroclinical syndrome	DOID:0050701	0.018
central nervous system disease	DOID:331	0.018
lysosomal storage disease	DOID:3211	0.017
eye disease	DOID:5614	0.013
retinal degeneration	DOID:8466	0.011
retinal disease	DOID:5679	0.011

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