IMP: Integrative Multi-species Prediction

Rattus norvegicus

120 known processes

Hmgcs2

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)

(Aliases: Hmgcs1,Mt3h3mg)

RGD: 2804
Entrez: 24450
Ensembl: ENSRNOG00000019120
UniProtKB: Q68G44

Process Predictions
Disease Predictions

Hmgcs2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
monocarboxylic acid metabolic process	GO:0032787	152	0.683
cellular lipid metabolic process	GO:0044255	208	0.648
organic acid metabolic process	GO:0006082	292	0.597
oxoacid metabolic process	GO:0043436	290	0.529
response to nutrient levels	GO:0031667	370	0.449
acylglycerol metabolic process	GO:0006639	21	0.440
long chain fatty acid metabolic process	GO:0001676	32	0.404
cellular lipid catabolic process	GO:0044242	37	0.343
cellular catabolic process	GO:0044248	295	0.336
lipid metabolic process	GO:0006629	283	0.330
monocarboxylic acid catabolic process	GO:0072329	28	0.297
fatty acid beta oxidation	GO:0006635	22	0.294
carboxylic acid metabolic process	GO:0019752	289	0.275
organic acid catabolic process	GO:0016054	49	0.228
cellular response to lipid	GO:0071396	201	0.227
oxidation reduction process	GO:0055114	304	0.222
single organism biosynthetic process	GO:0044711	342	0.221
fatty acid oxidation	GO:0019395	29	0.209
response to corticosteroid	GO:0031960	235	0.204
catabolic process	GO:0009056	351	0.181
response to acid chemical	GO:0001101	222	0.171
fatty acid metabolic process	GO:0006631	99	0.169
response to metal ion	GO:0010038	253	0.160
cellular response to oxygen containing compound	GO:1901701	386	0.154
response to hypoxia	GO:0001666	231	0.154
response to extracellular stimulus	GO:0009991	380	0.154
aging	GO:0007568	241	0.144
response to inorganic substance	GO:0010035	377	0.143
response to glucocorticoid	GO:0051384	223	0.140
organic hydroxy compound metabolic process	GO:1901615	115	0.139
response to decreased oxygen levels	GO:0036293	237	0.138
cellular response to organic cyclic compound	GO:0071407	202	0.137
response to other organism	GO:0051707	220	0.129
response to oxygen levels	GO:0070482	265	0.129
neutral lipid metabolic process	GO:0006638	21	0.127
glycerolipid metabolic process	GO:0046486	67	0.126
lipid modification	GO:0030258	52	0.126
organic substance catabolic process	GO:1901575	316	0.119
small molecule catabolic process	GO:0044282	59	0.112
reproductive process	GO:0022414	372	0.112	Rat
triglyceride metabolic process	GO:0006641	21	0.111
response to camp	GO:0051591	91	0.107
liver development	GO:0001889	90	0.101
positive regulation of fatty acid beta oxidation	GO:0032000	4	0.101
sulfur compound metabolic process	GO:0006790	70	0.100
protein oligomerization	GO:0051259	191	0.098
protein complex assembly	GO:0006461	263	0.094
response to peptide	GO:1901652	292	0.093
response to biotic stimulus	GO:0009607	226	0.093
response to toxic substance	GO:0009636	133	0.092
regulation of hormone levels	GO:0010817	187	0.091
neurological system process	GO:0050877	219	0.089
multicellular organism reproduction	GO:0032504	233	0.087
antral ovarian follicle growth	GO:0001547	3	0.081
single organism catabolic process	GO:0044712	283	0.081
regulation of apoptotic process	GO:0042981	335	0.078
multi organism reproductive process	GO:0044703	262	0.076
nitrogen compound transport	GO:0071705	229	0.074
gland development	GO:0048732	155	0.073
response to insecticide	GO:0017085	21	0.073
macromolecular complex assembly	GO:0065003	273	0.073
programmed cell death	GO:0012501	392	0.070
macromolecular complex subunit organization	GO:0043933	339	0.070
secretion	GO:0046903	307	0.070
positive regulation of lipid catabolic process	GO:0050996	4	0.070
steroid metabolic process	GO:0008202	73	0.069
response to ethanol	GO:0045471	162	0.068
cellular ketone metabolic process	GO:0042180	51	0.066
response to peptide hormone	GO:0043434	278	0.065
lipid localization	GO:0010876	62	0.064
regulation of cell proliferation	GO:0042127	359	0.064
carboxylic acid biosynthetic process	GO:0046394	83	0.063
protein complex biogenesis	GO:0070271	263	0.062
response to wounding	GO:0009611	254	0.061
response to fatty acid	GO:0070542	65	0.060
reproductive system development	GO:0061458	128	0.058	Rat
lipid catabolic process	GO:0016042	46	0.058
organic acid transport	GO:0015849	116	0.056
regulation of catalytic activity	GO:0050790	304	0.056
phenol containing compound metabolic process	GO:0018958	30	0.056
apoptotic process	GO:0006915	381	0.055
reproduction	GO:0000003	245	0.055
cellular component biogenesis	GO:0044085	368	0.055
cell cell signaling	GO:0007267	335	0.053
cofactor metabolic process	GO:0051186	95	0.053
single organism behavior	GO:0044708	130	0.053
regulation of secretion by cell	GO:1903530	208	0.051
circulatory system process	GO:0003013	183	0.050
carbohydrate metabolic process	GO:0005975	130	0.049
protein homooligomerization	GO:0051260	91	0.049
female pregnancy	GO:0007565	122	0.048
carboxylic acid transport	GO:0046942	115	0.047
cellular hormone metabolic process	GO:0034754	49	0.047
lipid transport	GO:0006869	61	0.046
sex differentiation	GO:0007548	113	0.046	Rat
chemical homeostasis	GO:0048878	292	0.046
response to molecule of bacterial origin	GO:0002237	194	0.045
coenzyme metabolic process	GO:0006732	86	0.045
xenobiotic metabolic process	GO:0006805	19	0.045
organic anion transport	GO:0015711	132	0.044
amine metabolic process	GO:0009308	38	0.044
multicellular organismal reproductive process	GO:0048609	233	0.042
single organism reproductive process	GO:0044702	297	0.042	Rat
linoleic acid metabolic process	GO:0043651	4	0.041
sulfur compound biosynthetic process	GO:0044272	19	0.041
cellular amine metabolic process	GO:0044106	38	0.040
carboxylic acid catabolic process	GO:0046395	49	0.040
single organism carbohydrate metabolic process	GO:0044723	118	0.040
lipid oxidation	GO:0034440	30	0.040
neurotransmitter biosynthetic process	GO:0042136	2	0.039
cognition	GO:0050890	92	0.039
gonad development	GO:0008406	104	0.039	Rat
regulation of cellular ketone metabolic process	GO:0010565	27	0.039
head development	GO:0060322	247	0.039
cellular amino acid metabolic process	GO:0006520	107	0.039
developmental process involved in reproduction	GO:0003006	159	0.039	Rat
peptide hormone secretion	GO:0030072	84	0.038
regeneration	GO:0031099	163	0.038
epithelial cell differentiation	GO:0030855	71	0.038
protein complex subunit organization	GO:0071822	302	0.038
hexose metabolic process	GO:0019318	58	0.037
anion transport	GO:0006820	178	0.037
monocarboxylic acid transport	GO:0015718	52	0.037
response to external biotic stimulus	GO:0043207	221	0.037
cellular response to peptide hormone stimulus	GO:0071375	120	0.036
response to vitamin	GO:0033273	131	0.036	Rat
regulation of cellular catabolic process	GO:0031329	101	0.036
epithelium development	GO:0060429	96	0.035
cellular component assembly	GO:0022607	360	0.035
feeding behavior	GO:0007631	53	0.035
regulation of programmed cell death	GO:0043067	341	0.035
amide transport	GO:0042886	105	0.035
blood circulation	GO:0008015	183	0.034
regulation of hormone secretion	GO:0046883	106	0.034
regulation of peptide hormone secretion	GO:0090276	80	0.034
organophosphate metabolic process	GO:0019637	370	0.033
sulfur amino acid metabolic process	GO:0000096	9	0.033
hepaticobiliary system development	GO:0061008	90	0.033
drug metabolic process	GO:0017144	11	0.032
isoprenoid metabolic process	GO:0006720	45	0.032
development of primary sexual characteristics	GO:0045137	107	0.032	Rat
regulation of fatty acid metabolic process	GO:0019217	18	0.032
regulation of anatomical structure size	GO:0090066	135	0.032
regulation of cellular amine metabolic process	GO:0033238	8	0.031
secretion by cell	GO:0032940	248	0.031
cellular response to endogenous stimulus	GO:0071495	377	0.031
macromolecule localization	GO:0033036	252	0.031
developmental growth	GO:0048589	100	0.031
terpenoid metabolic process	GO:0006721	37	0.031
regulation of molecular function	GO:0065009	398	0.031
regulation of multicellular organismal development	GO:2000026	376	0.031
cellular modified amino acid metabolic process	GO:0006575	61	0.030
female gonad development	GO:0008585	53	0.030
central nervous system development	GO:0007417	311	0.030
multicellular organismal signaling	GO:0035637	44	0.029
positive regulation of cell death	GO:0010942	184	0.029
regulation of lipid metabolic process	GO:0019216	68	0.029
amino acid betaine metabolic process	GO:0006577	3	0.029
regulation of secretion	GO:0051046	224	0.029
response to transition metal nanoparticle	GO:1990267	122	0.029
regulation of blood pressure	GO:0008217	83	0.029
response to cytokine	GO:0034097	215	0.028
alcohol metabolic process	GO:0006066	77	0.028
intracellular signal transduction	GO:0035556	314	0.028
positive regulation of lipid metabolic process	GO:0045834	33	0.028
peptide secretion	GO:0002790	86	0.028
regulation of peptide secretion	GO:0002791	82	0.028
fatty acid catabolic process	GO:0009062	26	0.028
regulation of cellular amino acid metabolic process	GO:0006521	2	0.027
learning or memory	GO:0007611	90	0.027
behavior	GO:0007610	205	0.027
response to carbohydrate	GO:0009743	183	0.027
negative regulation of programmed cell death	GO:0043069	183	0.026
cellular response to external stimulus	GO:0071496	118	0.026
reproductive structure development	GO:0048608	128	0.026	Rat
inflammatory response	GO:0006954	150	0.025
cellular response to hormone stimulus	GO:0032870	247	0.025
anatomical structure morphogenesis	GO:0009653	298	0.025
regulation of catabolic process	GO:0009894	113	0.025
regulation of cellular localization	GO:0060341	263	0.025
negative regulation of metabolic process	GO:0009892	331	0.025
hormone transport	GO:0009914	121	0.024
hormone metabolic process	GO:0042445	69	0.024
cellular response to alcohol	GO:0097306	87	0.024	Rat
response to organophosphorus	GO:0046683	102	0.024
transmission of nerve impulse	GO:0019226	42	0.024
positive regulation of molecular function	GO:0044093	230	0.024
neuron projection development	GO:0031175	273	0.024
negative regulation of apoptotic process	GO:0043066	181	0.024
regulation of membrane potential	GO:0042391	110	0.024
growth	GO:0040007	165	0.023
g protein coupled receptor signaling pathway	GO:0007186	242	0.023
peptide transport	GO:0015833	97	0.023
nucleobase containing small molecule metabolic process	GO:0055086	316	0.023
brain development	GO:0007420	247	0.023
organ regeneration	GO:0031100	101	0.023
negative regulation of multicellular organismal process	GO:0051241	203	0.023
response to herbicide	GO:0009635	16	0.023
cellular response to acid chemical	GO:0071229	75	0.023
regulation of hydrolase activity	GO:0051336	143	0.023
rhythmic process	GO:0048511	156	0.023
regulation of neuron projection development	GO:0010975	161	0.023
regulation of body fluid levels	GO:0050878	90	0.022
response to activity	GO:0014823	73	0.022
response to ketone	GO:1901654	182	0.022
regulation of phosphorus metabolic process	GO:0051174	349	0.022
response to purine containing compound	GO:0014074	126	0.022
organonitrogen compound biosynthetic process	GO:1901566	167	0.022
regulation of fatty acid beta oxidation	GO:0031998	8	0.022
response to retinoic acid	GO:0032526	63	0.022
negative regulation of cellular metabolic process	GO:0031324	281	0.022
response to bacterium	GO:0009617	200	0.022
transmembrane transport	GO:0055085	412	0.022
synaptic transmission	GO:0007268	235	0.021
positive regulation of fatty acid oxidation	GO:0046321	6	0.021
toxin metabolic process	GO:0009404	9	0.021
regulation of neurogenesis	GO:0050767	247	0.021
small molecule biosynthetic process	GO:0044283	124	0.021
glucose metabolic process	GO:0006006	52	0.021
regulation of cell projection organization	GO:0031344	175	0.021
signal release	GO:0023061	145	0.021
unsaturated fatty acid metabolic process	GO:0033559	39	0.020
cellular response to organonitrogen compound	GO:0071417	197	0.020
regulation of protein metabolic process	GO:0051246	289	0.020
regulation of cellular protein metabolic process	GO:0032268	267	0.020
gamete generation	GO:0007276	124	0.020
naphthalene containing compound metabolic process	GO:0090420	2	0.020
development of primary female sexual characteristics	GO:0046545	56	0.020
female sex differentiation	GO:0046660	59	0.020
acetate ester metabolic process	GO:1900619	4	0.020
regulation of nervous system development	GO:0051960	264	0.020
regulation of signal transduction	GO:0009966	318	0.020
multi multicellular organism process	GO:0044706	138	0.020
tissue development	GO:0009888	252	0.019
cellular response to nutrient levels	GO:0031669	60	0.019
memory	GO:0007613	54	0.019
regulation of cell development	GO:0060284	263	0.019
response to alkaloid	GO:0043279	132	0.019
carnitine metabolic process	GO:0009437	3	0.019
acetylcholine biosynthetic process	GO:0008292	2	0.019
positive regulation of biosynthetic process	GO:0009891	319	0.019
cellular amino acid biosynthetic process	GO:0008652	32	0.019
lipid biosynthetic process	GO:0008610	128	0.019
regulation of cell differentiation	GO:0045595	320	0.019
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.019
positive regulation of developmental process	GO:0051094	283	0.019
sexual reproduction	GO:0019953	148	0.019
positive regulation of catabolic process	GO:0009896	78	0.018
diterpenoid metabolic process	GO:0016101	33	0.018
nucleotide metabolic process	GO:0009117	279	0.018
neuron differentiation	GO:0030182	368	0.018
regulation of phosphorylation	GO:0042325	248	0.018
positive regulation of apoptotic process	GO:0043065	154	0.018
thioester metabolic process	GO:0035383	28	0.018
response to lipopolysaccharide	GO:0032496	191	0.018
positive regulation of cellular component organization	GO:0051130	200	0.018
insulin secretion	GO:0030073	69	0.018
action potential	GO:0001508	54	0.018
defense response	GO:0006952	194	0.018
positive regulation of cellular amine metabolic process	GO:0033240	3	0.017
organic acid biosynthetic process	GO:0016053	83	0.017
positive regulation of cellular catabolic process	GO:0031331	71	0.017
metal ion transport	GO:0030001	289	0.017
regulation of insulin secretion	GO:0050796	65	0.017
epithelial cell proliferation	GO:0050673	54	0.017
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.017
positive regulation of multicellular organismal process	GO:0051240	387	0.017
negative regulation of cell communication	GO:0010648	158	0.017
neuron development	GO:0048666	286	0.017
regulation of protein modification process	GO:0031399	194	0.016
proteolysis	GO:0006508	175	0.016
negative regulation of cell death	GO:0060548	229	0.016
heterocycle catabolic process	GO:0046700	167	0.016
response to estradiol	GO:0032355	164	0.016
response to estrogen	GO:0043627	232	0.016
long chain fatty acid transport	GO:0015909	14	0.016
response to nicotine	GO:0035094	51	0.016
naphthalene metabolic process	GO:0018931	2	0.016
positive regulation of cell proliferation	GO:0008284	249	0.016
cellular response to extracellular stimulus	GO:0031668	73	0.016
heart morphogenesis	GO:0003007	3	0.016
positive regulation of phosphorus metabolic process	GO:0010562	262	0.016
positive regulation of protein metabolic process	GO:0051247	178	0.016
cellular response to stress	GO:0033554	269	0.016
nucleoside phosphate metabolic process	GO:0006753	283	0.016
response to xenobiotic stimulus	GO:0009410	23	0.016
protein phosphorylation	GO:0006468	345	0.016
localization of cell	GO:0051674	202	0.016
regulation of synaptic transmission	GO:0050804	141	0.016
response to oxidative stress	GO:0006979	186	0.016
positive regulation of cell development	GO:0010720	176	0.015
regulation of cellular component organization	GO:0051128	368	0.015
negative regulation of signaling	GO:0023057	157	0.015
positive regulation of catalytic activity	GO:0043085	184	0.015
regulation of tube size	GO:0035150	89	0.015
hormone secretion	GO:0046879	115	0.015
regulation of neuron differentiation	GO:0045664	208	0.015
positive regulation of hydrolase activity	GO:0051345	86	0.015
positive regulation of phosphorylation	GO:0042327	177	0.015
response to osmotic stress	GO:0006970	42	0.015
organic cyclic compound catabolic process	GO:1901361	175	0.015
response to nutrient	GO:0007584	248	0.015
positive regulation of secretion	GO:0051047	140	0.015
regulation of peptide transport	GO:0090087	87	0.015
cellular response to corticosteroid stimulus	GO:0071384	69	0.015
regulation of growth	GO:0040008	105	0.015
carbohydrate derivative metabolic process	GO:1901135	346	0.014
regulation of system process	GO:0044057	208	0.014
positive regulation of cell communication	GO:0010647	271	0.014
response to hexose	GO:0009746	144	0.014
ion transmembrane transport	GO:0034220	365	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
mapk cascade	GO:0000165	140	0.014
reactive nitrogen species metabolic process	GO:2001057	1	0.014
regulation of neurotransmitter levels	GO:0001505	42	0.014
response to growth factor	GO:0070848	189	0.014
insecticide metabolic process	GO:0017143	4	0.014
ras protein signal transduction	GO:0007265	29	0.014
response to insulin	GO:0032868	133	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
neuronal action potential	GO:0019228	35	0.013
c21 steroid hormone biosynthetic process	GO:0006700	10	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.013
response to testosterone	GO:0033574	55	0.013
positive regulation of response to stimulus	GO:0048584	285	0.013
organophosphate catabolic process	GO:0046434	148	0.013
regulation of rna biosynthetic process	GO:2001141	381	0.013
acetyl coa metabolic process	GO:0006084	17	0.013
endothelial cell apoptotic process	GO:0072577	3	0.013
vesicle mediated transport	GO:0016192	181	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
cation transport	GO:0006812	382	0.013
regulation of transcription dna templated	GO:0006355	374	0.013
cellular response to glucocorticoid stimulus	GO:0071385	68	0.013
positive regulation of nervous system development	GO:0051962	178	0.013
estrogen metabolic process	GO:0008210	11	0.012
response to mechanical stimulus	GO:0009612	134	0.012
fatty acid derivative metabolic process	GO:1901568	38	0.012
nucleic acid templated transcription	GO:0097659	379	0.012
positive regulation of neurogenesis	GO:0050769	165	0.012
regulation of anatomical structure morphogenesis	GO:0022603	141	0.012
regulation of rna metabolic process	GO:0051252	391	0.012
phthalate metabolic process	GO:0018963	8	0.012
positive regulation of cell differentiation	GO:0045597	217	0.012
positive regulation of cell projection organization	GO:0031346	111	0.012
negative regulation of response to stimulus	GO:0048585	155	0.012
steroid biosynthetic process	GO:0006694	48	0.012
response to calcium ion	GO:0051592	59	0.012
negative regulation of gene expression	GO:0010629	199	0.012
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.012
cellular sodium ion homeostasis	GO:0006883	4	0.012
positive regulation of phosphate metabolic process	GO:0045937	262	0.012
regulation of fatty acid oxidation	GO:0046320	10	0.012
regulation of nucleic acid templated transcription	GO:1903506	380	0.012
circadian rhythm	GO:0007623	88	0.012
response to acetate	GO:0010034	3	0.012
response to amino acid	GO:0043200	75	0.012
regulation of blood vessel size	GO:0050880	89	0.012
regulation of inflammatory response	GO:0050727	48	0.012
alpha amino acid metabolic process	GO:1901605	71	0.012
forebrain development	GO:0030900	98	0.011
metal ion homeostasis	GO:0055065	186	0.011
response to food	GO:0032094	27	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
monocarboxylic acid biosynthetic process	GO:0072330	48	0.011
brain renin angiotensin system	GO:0002035	3	0.011
axis specification	GO:0009798	4	0.011
positive regulation of programmed cell death	GO:0043068	157	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
glial cell differentiation	GO:0010001	65	0.011
icosanoid metabolic process	GO:0006690	38	0.011
cellular response to nitrogen compound	GO:1901699	210	0.011
sulfation	GO:0051923	2	0.011
cellular response to fatty acid	GO:0071398	29	0.011
regulation of defense response	GO:0031347	68	0.011
cation transmembrane transport	GO:0098655	263	0.011
artery smooth muscle contraction	GO:0014824	4	0.011
rna biosynthetic process	GO:0032774	380	0.011
response to glucose	GO:0009749	136	0.011
chemosensory behavior	GO:0007635	2	0.011
intestinal absorption	GO:0050892	3	0.011
very long chain fatty acid metabolic process	GO:0000038	3	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.011
purine nucleotide metabolic process	GO:0006163	229	0.011
ribonucleotide metabolic process	GO:0009259	231	0.011
cellular response to steroid hormone stimulus	GO:0071383	93	0.011
positive regulation of transport	GO:0051050	245	0.011
rna metabolic process	GO:0016070	406	0.011
positive regulation of protein modification process	GO:0031401	142	0.011
cellular response to xenobiotic stimulus	GO:0071466	19	0.011
sensory perception of pain	GO:0019233	73	0.011
retinal metabolic process	GO:0042574	3	0.011
catechol containing compound metabolic process	GO:0009712	19	0.011
response to sulfur dioxide	GO:0010477	3	0.011
lipid storage	GO:0019915	1	0.011
axonogenesis	GO:0007409	71	0.011
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.011
response to monosaccharide	GO:0034284	159	0.010
negative regulation of cellular protein metabolic process	GO:0032269	106	0.010
pyridine containing compound metabolic process	GO:0072524	32	0.010
regulation of kinase activity	GO:0043549	117	0.010
positive regulation of cellular biosynthetic process	GO:0031328	295	0.010
cellular homeostasis	GO:0019725	252	0.010
negative regulation of innate immune response	GO:0045824	4	0.010
choline transport	GO:0015871	4	0.010
muscle cell proliferation	GO:0033002	84	0.010
tetrapyrrole metabolic process	GO:0033013	11	0.010
cardiovascular system development	GO:0072358	134	0.010
regulation of endothelial cell apoptotic process	GO:2000351	3	0.010
negative regulation of protein metabolic process	GO:0051248	114	0.010
cell projection organization	GO:0030030	302	0.010
transcription dna templated	GO:0006351	377	0.010
eating behavior	GO:0042755	21	0.010
alpha amino acid biosynthetic process	GO:1901607	23	0.010

Hmgcs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.038
disease of metabolism	DOID:0014667	0.038
artery disease	DOID:0050828	0.011
vascular disease	DOID:178	0.011
disease of anatomical entity	DOID:7	0.011
cardiovascular system disease	DOID:1287	0.011
disease of cellular proliferation	DOID:14566	0.010

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