Rattus norvegicus

55 known processes

Kcnh2

potassium voltage-gated channel, subfamily H (eag-related), member 2

(Aliases: ERG1)

Kcnh2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
inorganic ion transmembrane transportGO:00986602290.283
inorganic cation transmembrane transportGO:00986622020.237
regulation of cellular component organizationGO:00511283680.235
positive regulation of transportGO:00510502450.230
Human
heart processGO:0003015570.206
Human Mouse
regulation of cellular localizationGO:00603412630.192
regulation of hormone secretionGO:00468831060.184
regulation of metal ion transportGO:00109591180.167
Human
signal releaseGO:00230611450.164
striated muscle contractionGO:0006941440.158
Human
cation transmembrane transportGO:00986552630.152
regulation of striated muscle contractionGO:0006942210.145
Human
regulation of system processGO:00440572080.129
Human Mouse Worm
hormone transportGO:00099141210.123
cation transportGO:00068123820.115
potassium ion transmembrane transportGO:0071805710.113
amide transportGO:00428861050.105
regulation of ion transportGO:00432692450.099
cell cell signalingGO:00072673350.099
nucleotide metabolic processGO:00091172790.097
carbohydrate derivative metabolic processGO:19011353460.096
lipid localizationGO:0010876620.095
establishment of protein localizationGO:00451841410.094
transmembrane transportGO:00550854120.092
rhythmic processGO:00485111560.091
Rat
nitrogen compound transportGO:00717052290.090
secretionGO:00469033070.086
divalent metal ion transportGO:00708381320.084
negative regulation of transportGO:00510511360.083
Human
purine ribonucleotide metabolic processGO:00091502270.080
negative regulation of cellular biosynthetic processGO:00313271610.077
response to extracellular stimulusGO:00099913800.073
purine containing compound metabolic processGO:00725212530.072
ribonucleotide biosynthetic processGO:0009260850.071
nucleoside phosphate biosynthetic processGO:19012931020.070
negative regulation of peptide hormone secretionGO:0090278300.068
cellular response to peptide hormone stimulusGO:00713751200.066
regulation of peptide transportGO:0090087870.065
secretion by cellGO:00329402480.064
regulation of muscle system processGO:0090257790.064
Human Worm
hormone secretionGO:00468791150.063
anatomical structure morphogenesisGO:00096532980.063
positive regulation of nitrogen compound metabolic processGO:00511733340.063
muscle system processGO:00030121150.062
Human Worm
ribonucleotide metabolic processGO:00092592310.061
regulation of nucleotide metabolic processGO:00061401170.059
vesicle mediated transportGO:00161921810.058
cellular response to nitrogen compoundGO:19016992100.057
positive regulation of nucleotide metabolic processGO:0045981910.057
cellular response to organonitrogen compoundGO:00714171970.057
regulation of hormone levelsGO:00108171870.056
response to decreased oxygen levelsGO:00362932370.056
organelle organizationGO:00069962660.056
potassium ion transportGO:0006813970.055
divalent inorganic cation transportGO:00725111340.055
multicellular organismal signalingGO:0035637440.055
Human Mouse
ribonucleoside metabolic processGO:00091191740.054
regulation of cell differentiationGO:00455953200.053
purine nucleotide metabolic processGO:00061632290.053
circulatory system processGO:00030131830.052
Human Mouse
cyclic nucleotide metabolic processGO:0009187800.051
macromolecule localizationGO:00330362520.051
response to hexoseGO:00097461440.051
regulation of membrane repolarizationGO:006030610.051
Human Mouse
heart contractionGO:0060047570.051
Human Mouse
cellular component assemblyGO:00226073600.050
regulation of peptide secretionGO:0002791820.050
blood circulationGO:00080151830.050
Human Mouse
carbohydrate metabolic processGO:00059751300.049
positive regulation of cellular component organizationGO:00511302000.048
nucleoside phosphate metabolic processGO:00067532830.048
actin filament based movementGO:0030048160.048
peptide transportGO:0015833970.047
cyclic purine nucleotide metabolic processGO:0052652620.047
regulation of cardiac muscle cell contractionGO:0086004110.047
Human
cellular potassium ion transportGO:0071804720.047
negative regulation of hormone secretionGO:0046888460.045
regulation of potassium ion transportGO:0043266290.045
Human
ribose phosphate metabolic processGO:00196932350.045
negative regulation of cellular metabolic processGO:00313242810.044
organophosphate biosynthetic processGO:00904071430.044
negative regulation of metabolic processGO:00098923310.043
peptide secretionGO:0002790860.043
negative regulation of nucleobase containing compound metabolic processGO:00459341530.043
regulation of molecular functionGO:00650093980.043
regulation of cardiac muscle contractionGO:0055117170.041
Human
negative regulation of signalingGO:00230571570.041
circadian rhythmGO:0007623880.041
Rat
action potentialGO:0001508540.041
Human
cytoplasmic transportGO:00164821150.041
cellular response to oxygen containing compoundGO:19017013860.040
membrane repolarizationGO:008600910.039
Human Mouse
nucleobase containing small molecule metabolic processGO:00550863160.039
purine ribonucleoside catabolic processGO:00461301240.039
ribose phosphate biosynthetic processGO:0046390870.039
single organism intracellular transportGO:19025821660.038
regulation of secretion by cellGO:19035302080.038
organophosphate metabolic processGO:00196373700.038
cellular metal ion homeostasisGO:00068751720.038
regulation of phosphorus metabolic processGO:00511743490.037
regulation of cell projection organizationGO:00313441750.037
purine nucleotide catabolic processGO:00061951360.037
negative regulation of gene expressionGO:00106291990.037
cardiac muscle cell contractionGO:0086003100.037
regulation of lipid metabolic processGO:0019216680.037
neuron differentiationGO:00301823680.037
regulation of neurotransmitter secretionGO:0046928190.037
sodium ion transmembrane transportGO:0035725670.037
metal ion homeostasisGO:00550651860.037
Human
negative regulation of nitrogen compound metabolic processGO:00511721610.036
cellular component biogenesisGO:00440853680.036
defecationGO:003042110.036
positive regulation of peptide hormone secretionGO:0090277500.036
insulin secretionGO:0030073690.036
purine nucleotide biosynthetic processGO:0006164830.036
intracellular protein transportGO:0006886790.035
cell projection organizationGO:00300303020.035
purine ribonucleotide biosynthetic processGO:0009152810.035
cardiac muscle contractionGO:0060048270.035
Human
regulation of catalytic activityGO:00507903040.035
regulation of ion transmembrane transportGO:00347651210.035
developmental growthGO:00485891000.034
negative regulation of biosynthetic processGO:00098901680.034
regulation of insulin secretionGO:0050796650.034
response to carbohydrateGO:00097431830.034
regulation of phosphate metabolic processGO:00192203490.034
regulation of anatomical structure morphogenesisGO:00226031410.034
regulation of ion transmembrane transporter activityGO:0032412480.033
transmission of nerve impulseGO:0019226420.033
nucleobase containing compound catabolic processGO:00346551520.033
positive regulation of purine nucleotide metabolic processGO:1900544910.033
negative regulation of ion transmembrane transportGO:0034766160.033
Human
intracellular transportGO:00469071850.033
regulation of vesicle mediated transportGO:0060627810.033
regulation of developmental growthGO:0048638450.032
response to inorganic substanceGO:00100353770.032
carboxylic acid transportGO:00469421150.032
response to hypoxiaGO:00016662310.032
synaptic transmissionGO:00072682350.032
locomotory exploration behaviorGO:003564110.031
sequestering of calcium ionGO:005120880.031
negative regulation of secretionGO:0051048820.031
exocytosisGO:0006887600.031
nucleic acid templated transcriptionGO:00976593790.031
Rat
regulation of secretionGO:00510462240.031
nucleoside metabolic processGO:00091161790.031
negative regulation of multicellular organismal processGO:00512412030.031
growthGO:00400071650.031
neuromuscular synaptic transmissionGO:000727420.031
regulation of calcium ion transportGO:0051924770.030
regulation of apoptotic processGO:00429813350.030
Rat
neurotransmitter secretionGO:0007269330.030
cellular macromolecule localizationGO:00707271220.030
maintenance of locationGO:0051235170.030
positive regulation of phosphorus metabolic processGO:00105622620.030
camp biosynthetic processGO:0006171470.029
negative regulation of macromolecule metabolic processGO:00106052600.029
catabolic processGO:00090563510.029
Worm
regulation of cell developmentGO:00602842630.029
positive regulation of ion transportGO:0043270940.029
Human
positive regulation of nucleobase containing compound metabolic processGO:00459353190.029
monovalent inorganic cation transportGO:00156721720.028
carbohydrate derivative biosynthetic processGO:19011371240.028
single organism organelle organizationGO:19025891800.028
response to peptideGO:19016522920.028
nucleoside catabolic processGO:00091641260.028
neurological system processGO:00508772190.028
Fly
heterocycle catabolic processGO:00467001670.027
regulation of purine nucleotide metabolic processGO:19005421150.027
central nervous system developmentGO:00074173110.027
calcium ion transmembrane transportGO:0070588700.027
cellular response to external stimulusGO:00714961180.027
regulation of neurogenesisGO:00507672470.026
purine containing compound biosynthetic processGO:0072522850.026
macromolecular complex assemblyGO:00650032730.026
protein localizationGO:00081041910.026
apoptotic processGO:00069153810.026
Rat
negative regulation of secretion by cellGO:1903531720.026
glycosyl compound metabolic processGO:19016571820.026
response to nutrient levelsGO:00316673700.026
purine containing compound catabolic processGO:00725231380.025
single organism biosynthetic processGO:00447113420.025
regulation of actin filament based movementGO:1903115120.025
Human
negative regulation of phosphorus metabolic processGO:0010563800.025
nucleoside phosphate catabolic processGO:19012921400.025
positive regulation of phosphate metabolic processGO:00459372620.025
cellular response to acid chemicalGO:0071229750.024
ribonucleoside catabolic processGO:00424541260.024
lipid transportGO:0006869610.024
positive regulation of calcium ion transportGO:0051928360.024
regulation of transmembrane transporter activityGO:0022898490.024
response to monosaccharideGO:00342841590.024
regulation of transmembrane transportGO:00347621220.024
positive regulation of molecular functionGO:00440932300.023
cardiac muscle cell action potentialGO:008600150.023
Human
cellular nitrogen compound catabolic processGO:00442701630.023
ribonucleoside triphosphate metabolic processGO:00091991410.023
nucleotide catabolic processGO:00091661390.023
positive regulation of cell deathGO:00109421840.023
regulation of cellular ketone metabolic processGO:0010565270.023
neuron developmentGO:00486662860.023
phosphatidylinositol dephosphorylationGO:004685640.023
cell morphogenesisGO:00009021420.022
purine nucleoside triphosphate catabolic processGO:00091461220.022
negative regulation of cell communicationGO:00106481580.022
regulation of growthGO:00400081050.022
cardiovascular system developmentGO:00723581340.022
brain developmentGO:00074202470.022
membrane organizationGO:0061024940.022
monosaccharide metabolic processGO:0005996610.022
cellular response to stressGO:00335542690.022
rna biosynthetic processGO:00327743800.022
Rat
actin filament based processGO:0030029860.022
positive regulation of multicellular organismal processGO:00512403870.022
response to metal ionGO:00100382530.022
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.021
positive regulation of cell differentiationGO:00455972170.021
regulation of programmed cell deathGO:00430673410.021
Rat
divalent inorganic cation homeostasisGO:00725071650.021
oxoacid metabolic processGO:00434362900.021
regulation of cellular catabolic processGO:00313291010.021
purine nucleoside triphosphate metabolic processGO:00091441410.021
purine ribonucleoside metabolic processGO:00461281680.021
negative regulation of phosphate metabolic processGO:0045936800.021
nucleotide biosynthetic processGO:0009165980.021
cell growthGO:00160491040.020
positive regulation of hormone secretionGO:0046887650.020
negative regulation of macromolecule biosynthetic processGO:00105581480.020
positive regulation of signalingGO:00230562700.020
regulation of behaviorGO:0050795610.020
single organism cellular localizationGO:19025801020.020
positive regulation of cellular catabolic processGO:0031331710.020
camp metabolic processGO:0046058630.020
regulation of neuron projection developmentGO:00109751610.020
behaviorGO:00076102050.019
Worm
cyclic nucleotide biosynthetic processGO:0009190630.019
sodium ion transportGO:0006814820.019
heart developmentGO:0007507720.019
protein transportGO:00150311320.019
positive regulation of cellular component biogenesisGO:0044089550.019
regulation of rna biosynthetic processGO:20011413810.019
Rat
response to glucocorticoidGO:00513842230.019
neuron projection developmentGO:00311752730.019
positive regulation of catalytic activityGO:00430851840.019
purine nucleoside catabolic processGO:00061521240.019
cellular amine metabolic processGO:0044106380.019
regulation of cellular component biogenesisGO:0044087860.019
regulation of membrane potentialGO:00423911100.019
purine nucleoside metabolic processGO:00422781690.019
regulation of cell growthGO:0001558850.019
regulation of camp biosynthetic processGO:0030817380.019
regulation of anatomical structure sizeGO:00900661350.018
peptide hormone secretionGO:0030072840.018
anion transportGO:00068201780.018
positive regulation of ion transmembrane transportGO:0034767240.018
Human
muscle structure developmentGO:0061061870.018
rna metabolic processGO:00160704060.018
Rat
cellular response to abiotic stimulusGO:0071214850.018
muscle tissue developmentGO:0060537580.018
lipid modificationGO:0030258520.018
membrane depolarization during action potentialGO:008601010.018
Human
neuron projection morphogenesisGO:00488121220.018
regulation of transferase activityGO:00513381230.018
macromolecular complex subunit organizationGO:00439333390.017
cellular lipid metabolic processGO:00442552080.017
epithelium developmentGO:0060429960.017
regulation of peptide hormone secretionGO:0090276800.017
cellular catabolic processGO:00442482950.017
positive regulation of blood circulationGO:1903524650.017
regulation of transporter activityGO:0032409500.017
cellular response to endogenous stimulusGO:00714953770.017
calcium ion transportGO:00068161310.017
cell communication involved in cardiac conductionGO:008606520.017
ion transmembrane transportGO:00342203650.017
regulation of protein localizationGO:0032880810.017
regulation of camp metabolic processGO:0030814430.016
regulation of purine nucleotide biosynthetic processGO:1900371460.016
lipid storageGO:001991510.016
positive regulation of intracellular signal transductionGO:19025331380.016
organic anion transportGO:00157111320.016
cellular ion homeostasisGO:00068731840.016
regulation of muscle contractionGO:0006937530.016
Human Worm
cation homeostasisGO:00550801950.016
Human
response to glucoseGO:00097491360.016
negative regulation of ion transmembrane transporter activityGO:0032413120.016
cellular amino acid metabolic processGO:00065201070.016
positive regulation of response to stimulusGO:00485842850.016
regulation of synaptic transmissionGO:00508041410.016
glycosyl compound catabolic processGO:19016581260.016
positive regulation of gene expressionGO:00106282440.016
response to nutrientGO:00075842480.015
regulation of cyclic nucleotide biosynthetic processGO:0030802450.015
cellular chemical homeostasisGO:00550822470.015
positive regulation of cell projection organizationGO:00313461110.015
protein tetramerizationGO:0051262380.015
regulation of phosphatidylinositol dephosphorylationGO:006030410.015
regulation of synaptic plasticityGO:0048167700.015
actin mediated cell contractionGO:0070252120.015
cellular response to peptideGO:19016531330.015
cellular ketone metabolic processGO:0042180510.015
negative regulation of programmed cell deathGO:00430691830.015
Rat
positive regulation of purine nucleotide catabolic processGO:0033123530.015
homeostatic processGO:00425923310.015
Human
negative regulation of purine nucleotide biosynthetic processGO:1900372120.015
organic cyclic compound catabolic processGO:19013611750.015
response to axon injuryGO:0048678590.015
cellular cation homeostasisGO:00300031800.015
protein phosphorylationGO:00064683450.015
cellular response to organic cyclic compoundGO:00714072020.015
negative regulation of nucleic acid templated transcriptionGO:19035071170.015
negative regulation of neurogenesisGO:0050768780.014
negative regulation of rna metabolic processGO:00512531230.014
calcium ion importGO:0070509220.014
cellular component morphogenesisGO:00329891550.014
neuronal action potentialGO:0019228350.014
cellular response to insulin stimulusGO:0032869810.014
aromatic compound catabolic processGO:00194391680.014
response to estradiolGO:00323551640.014
single organism catabolic processGO:00447122830.014
regulation of rna metabolic processGO:00512523910.014
Rat
negative regulation of peptide secretionGO:0002792300.014
regulation of purine nucleotide catabolic processGO:0033121650.014
positive regulation of catabolic processGO:0009896780.014
chemical homeostasisGO:00488782920.014
Human
carbohydrate derivative catabolic processGO:19011361470.014
metal ion transportGO:00300012890.014
protein complex assemblyGO:00064612630.014
ribonucleoside triphosphate catabolic processGO:00092031220.014
positive regulation of nucleoside metabolic processGO:0045979550.014
regulation of neurotransmitter levelsGO:0001505420.014
positive regulation of biosynthetic processGO:00098913190.014
regulation of multicellular organismal developmentGO:20000263760.014
regulation of neuron differentiationGO:00456642080.014
negative regulation of transporter activityGO:0032410130.014
positive regulation of cellular biosynthetic processGO:00313282950.014
anterior posterior pattern specificationGO:000995210.014
carboxylic acid metabolic processGO:00197522890.014
positive regulation of signal transductionGO:00099671750.014
negative regulation of developmental processGO:00510931250.014
cellular divalent inorganic cation homeostasisGO:00725031620.013
glucose metabolic processGO:0006006520.013
cellular component movementGO:00069282480.013
regulation of erk1 and erk2 cascadeGO:0070372410.013
regulation of nucleotide catabolic processGO:0030811650.013
endocrine hormone secretionGO:0060986210.013
negative regulation of camp metabolic processGO:0030815140.013
regulation of organelle organizationGO:0033043800.013
negative regulation of cyclic nucleotide metabolic processGO:0030800150.013
protein complex subunit organizationGO:00718223020.013
cellular calcium ion homeostasisGO:00068741600.013
regulation of calcium ion transmembrane transportGO:1903169180.013
regulation of cyclic nucleotide metabolic processGO:0030799510.013
development of primary female sexual characteristicsGO:0046545560.013
hexose metabolic processGO:0019318580.013
positive regulation of hydrolase activityGO:0051345860.013
positive regulation of macromolecule biosynthetic processGO:00105572470.013
positive regulation of secretion by cellGO:19035321280.013
amine metabolic processGO:0009308380.013
regulation of catabolic processGO:00098941130.013
regulation of nucleotide biosynthetic processGO:0030808470.013
dephosphorylationGO:0016311980.013
cellular response to hormone stimulusGO:00328702470.013
negative regulation of heart growthGO:006111730.013
adult locomotory behaviorGO:000834440.013
single organism carbohydrate metabolic processGO:00447231180.013
negative regulation of apoptotic processGO:00430661810.013
Rat
female sex differentiationGO:0046660590.013
purine ribonucleoside triphosphate metabolic processGO:00092051400.012
cellular response to oxidative stressGO:0034599760.012
positive regulation of cell communicationGO:00106472710.012
positive regulation of cell developmentGO:00107201760.012
organic hydroxy compound transportGO:0015850770.012
response to transition metal nanoparticleGO:19902671220.012
ventricular cardiac muscle cell action potentialGO:008600520.012
Human
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.012
sequestering of metal ionGO:005123890.012
negative regulation of camp biosynthetic processGO:0030818120.012
regulation of kinase activityGO:00435491170.012
regulation of cellular amine metabolic processGO:003323880.012
regulation of defecationGO:200029210.012
cytoskeleton organizationGO:00070101110.012
positive regulation of cellular amine metabolic processGO:003324030.012
single organism membrane organizationGO:0044802740.012
axis specificationGO:000979840.012
calcium ion transport into cytosolGO:0060402380.012
regulation of cell proliferationGO:00421273590.012
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:0007187550.012
regulation of establishment of protein localizationGO:0070201690.012
gtp metabolic processGO:0046039720.012
regulation of cellular amino acid metabolic processGO:000652120.012
sex differentiationGO:00075481130.012
positive regulation of lipid catabolic processGO:005099640.012
positive regulation of neurogenesisGO:00507691650.012
negative regulation of molecular functionGO:00440921330.012
locomotory behaviorGO:0007626150.012
guanosine containing compound metabolic processGO:1901068740.012
programmed cell deathGO:00125013920.012
Rat
macromolecule catabolic processGO:0009057580.011
Worm
positive regulation of gtpase activityGO:0043547470.011
cell cell signaling involved in cell fate commitmentGO:004516820.011
organonitrogen compound catabolic processGO:19015651790.011
intracellular signal transductionGO:00355563140.011
negative regulation of rna biosynthetic processGO:19026791180.011
small molecule biosynthetic processGO:00442831240.011
cellular homeostasisGO:00197252520.011
cellular protein localizationGO:00346131220.011
regulation of organ growthGO:0046620130.011
endoplasmic reticulum organizationGO:000702910.011
negative regulation of transcription dna templatedGO:00458921160.011
ribonucleotide catabolic processGO:00092611360.011
response to peptide hormoneGO:00434342780.011
purine nucleoside monophosphate metabolic processGO:0009126840.011
endoplasmic reticulum to cytosol transportGO:190351340.011
regulation of actin filament based processGO:0032970420.011
Human
cardiac muscle cell developmentGO:0055013160.011
regulation of lyase activityGO:0051339220.011
regulation of cation channel activityGO:2001257230.011
negative regulation of follicle stimulating hormone secretionGO:004688230.011
muscle organ developmentGO:0007517500.011
regulation of nervous system developmentGO:00519602640.011
sensory perceptionGO:00076001010.011
Fly
regulation of mapk cascadeGO:00434081160.011
purine ribonucleotide catabolic processGO:00091541360.011
negative regulation of signal transductionGO:0009968830.010
regulation of nucleic acid templated transcriptionGO:19035063800.010
Rat
multicellular organism growthGO:003526410.010
positive regulation of rna metabolic processGO:00512542030.010
protein complex biogenesisGO:00702712630.010
proteolysisGO:00065081750.010
respiratory gaseous exchangeGO:000758540.010
microtubule based processGO:0007017360.010
cellular protein complex assemblyGO:0043623440.010
protein localization to organelleGO:0033365570.010
organ regenerationGO:00311001010.010
negative regulation of smooth muscle cell proliferationGO:0048662210.010
heart growthGO:0060419200.010

Kcnh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
long qt syndromeDOID:284300.029
Human
disease of anatomical entityDOID:700.026
nervous system diseaseDOID:86300.026
central nervous system diseaseDOID:33100.012
brain diseaseDOID:93600.012
inherited metabolic disorderDOID:65500.012
disease of metabolismDOID:001466700.012
carbohydrate metabolic disorderDOID:297800.010