IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Sgca

sarcoglycan, alpha (dystrophin-associated glycoprotein)

Ensembl: ENSRNOG00000003998
RGD: 1308062
Entrez: 303468
UniProtKB: D3ZDQ9

Process Predictions
Disease Predictions

Sgca biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of cell death	GO:0060548	229	0.083
regulation of cellular component organization	GO:0051128	368	0.078
response to extracellular stimulus	GO:0009991	380	0.062
brain development	GO:0007420	247	0.057
catabolic process	GO:0009056	351	0.052
single organism catabolic process	GO:0044712	283	0.052
neuron development	GO:0048666	286	0.052
carboxylic acid metabolic process	GO:0019752	289	0.051
apoptotic process	GO:0006915	381	0.050
organic substance catabolic process	GO:1901575	316	0.050
secretion	GO:0046903	307	0.050
central nervous system development	GO:0007417	311	0.047
regulation of programmed cell death	GO:0043067	341	0.046
regulation of cell proliferation	GO:0042127	359	0.046
multi organism reproductive process	GO:0044703	262	0.045
regulation of nervous system development	GO:0051960	264	0.043
response to estrogen	GO:0043627	232	0.041
cellular ketone metabolic process	GO:0042180	51	0.040
head development	GO:0060322	247	0.039
regulation of growth	GO:0040008	105	0.039
regulation of blood vessel size	GO:0050880	89	0.039
negative regulation of metabolic process	GO:0009892	331	0.039
organic acid metabolic process	GO:0006082	292	0.036
response to estradiol	GO:0032355	164	0.035
regulation of cell differentiation	GO:0045595	320	0.035
cellular component morphogenesis	GO:0032989	155	0.035
programmed cell death	GO:0012501	392	0.034
response to purine containing compound	GO:0014074	126	0.034
regulation of molecular function	GO:0065009	398	0.033
neuron death	GO:0070997	127	0.033
defense response	GO:0006952	194	0.032
formation of primary germ layer	GO:0001704	1	0.032
anatomical structure morphogenesis	GO:0009653	298	0.030
nucleobase containing small molecule metabolic process	GO:0055086	316	0.030
negative regulation of cellular metabolic process	GO:0031324	281	0.030
oxoacid metabolic process	GO:0043436	290	0.030
response to nutrient levels	GO:0031667	370	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.029
single organism biosynthetic process	GO:0044711	342	0.029
neuron projection development	GO:0031175	273	0.029
regulation of apoptotic process	GO:0042981	335	0.029
response to nutrient	GO:0007584	248	0.028
single organism reproductive process	GO:0044702	297	0.028
potassium ion transport	GO:0006813	97	0.028
regulation of cell projection organization	GO:0031344	175	0.027
intracellular signal transduction	GO:0035556	314	0.027
response to hexose	GO:0009746	144	0.026
regulation of system process	GO:0044057	208	0.026
cellular amino acid metabolic process	GO:0006520	107	0.026
regulation of cellular ketone metabolic process	GO:0010565	27	0.026
purine containing compound metabolic process	GO:0072521	253	0.025
chemical homeostasis	GO:0048878	292	0.025
negative regulation of apoptotic process	GO:0043066	181	0.025
positive regulation of cellular component organization	GO:0051130	200	0.025
negative regulation of developmental process	GO:0051093	125	0.025
regulation of catalytic activity	GO:0050790	304	0.025
ribose phosphate metabolic process	GO:0019693	235	0.025
regulation of neuron differentiation	GO:0045664	208	0.025
purine ribonucleotide metabolic process	GO:0009150	227	0.024
regulation of neuron projection development	GO:0010975	161	0.024
multi multicellular organism process	GO:0044706	138	0.024
positive regulation of cell communication	GO:0010647	271	0.023
positive regulation of cell proliferation	GO:0008284	249	0.023
purine ribonucleoside catabolic process	GO:0046130	124	0.023
regulation of multicellular organismal development	GO:2000026	376	0.023
response to monosaccharide	GO:0034284	159	0.023
aging	GO:0007568	241	0.022
inorganic cation transmembrane transport	GO:0098662	202	0.022
cellular component assembly	GO:0022607	360	0.022
regulation of neurogenesis	GO:0050767	247	0.022
reproductive system development	GO:0061458	128	0.022
carbohydrate derivative metabolic process	GO:1901135	346	0.022
multicellular organismal reproductive process	GO:0048609	233	0.022
cellular response to hormone stimulus	GO:0032870	247	0.021
inorganic ion transmembrane transport	GO:0098660	229	0.021
nucleotide metabolic process	GO:0009117	279	0.021
multicellular organism reproduction	GO:0032504	233	0.021
peptide transport	GO:0015833	97	0.021
regulation of protein metabolic process	GO:0051246	289	0.021
cellular amine metabolic process	GO:0044106	38	0.021
negative regulation of protein metabolic process	GO:0051248	114	0.021
cellular response to endogenous stimulus	GO:0071495	377	0.020
ras protein signal transduction	GO:0007265	29	0.020
behavior	GO:0007610	205	0.020
regulation of transcription dna templated	GO:0006355	374	0.020
regulation of cellular amine metabolic process	GO:0033238	8	0.020
reproductive process	GO:0022414	372	0.020
regulation of cell development	GO:0060284	263	0.020
amine metabolic process	GO:0009308	38	0.019
negative regulation of cellular protein metabolic process	GO:0032269	106	0.019
monovalent inorganic cation transport	GO:0015672	172	0.019
carbohydrate metabolic process	GO:0005975	130	0.019
regulation of cellular protein metabolic process	GO:0032268	267	0.019
positive regulation of biosynthetic process	GO:0009891	319	0.019
regulation of secretion	GO:0051046	224	0.019
cellular chemical homeostasis	GO:0055082	247	0.019
cold acclimation	GO:0009631	1	0.019
cellular response to abiotic stimulus	GO:0071214	85	0.019
oxidation reduction process	GO:0055114	304	0.019
lipid metabolic process	GO:0006629	283	0.018
regulation of anatomical structure morphogenesis	GO:0022603	141	0.018
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.018
positive regulation of cell differentiation	GO:0045597	217	0.018
locomotion	GO:0040011	237	0.018
female pregnancy	GO:0007565	122	0.018
gastrulation	GO:0007369	2	0.018
negative regulation of programmed cell death	GO:0043069	183	0.018
muscle structure development	GO:0061061	87	0.018
nucleoside metabolic process	GO:0009116	179	0.018
neuron differentiation	GO:0030182	368	0.018
cellular response to oxygen containing compound	GO:1901701	386	0.017
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.017
proteolysis	GO:0006508	175	0.017
regulation of cell growth	GO:0001558	85	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
tissue development	GO:0009888	252	0.017
response to metal ion	GO:0010038	253	0.017
nitrogen compound transport	GO:0071705	229	0.017
response to carbohydrate	GO:0009743	183	0.017
heart morphogenesis	GO:0003007	3	0.017
regulation of body fluid levels	GO:0050878	90	0.016
regulation of muscle contraction	GO:0006937	53	0.016
regulation of ras protein signal transduction	GO:0046578	45	0.016
regulation of cellular localization	GO:0060341	263	0.016
protein phosphorylation	GO:0006468	345	0.016
transmembrane transport	GO:0055085	412	0.016
neurological system process	GO:0050877	219	0.016
reproductive structure development	GO:0048608	128	0.016
organophosphate metabolic process	GO:0019637	370	0.016
negative regulation of macromolecule metabolic process	GO:0010605	260	0.016
regulation of cellular amino acid metabolic process	GO:0006521	2	0.016
cellular catabolic process	GO:0044248	295	0.015
glycosyl compound metabolic process	GO:1901657	182	0.015
positive regulation of catalytic activity	GO:0043085	184	0.015
regulation of phosphorus metabolic process	GO:0051174	349	0.015
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.015
response to alkaloid	GO:0043279	132	0.015
regulation of anatomical structure size	GO:0090066	135	0.015
ribonucleotide metabolic process	GO:0009259	231	0.015
nucleobase containing compound catabolic process	GO:0034655	152	0.015
regulation of response to stress	GO:0080134	126	0.015
response to inorganic substance	GO:0010035	377	0.015
regulation of protein modification process	GO:0031399	194	0.015
response to glucose	GO:0009749	136	0.015
membrane repolarization	GO:0086009	1	0.015
organ morphogenesis	GO:0009887	75	0.015
homeostatic process	GO:0042592	331	0.015
positive regulation of signaling	GO:0023056	270	0.015
purine nucleotide catabolic process	GO:0006195	136	0.015
sex differentiation	GO:0007548	113	0.014
developmental process involved in reproduction	GO:0003006	159	0.014
negative regulation of signaling	GO:0023057	157	0.014
response to decreased oxygen levels	GO:0036293	237	0.014
cellular ion homeostasis	GO:0006873	184	0.014
heart development	GO:0007507	72	0.014
nucleoside phosphate metabolic process	GO:0006753	283	0.014
regulation of inflammatory response	GO:0050727	48	0.014
transmission of nerve impulse	GO:0019226	42	0.014
response to wounding	GO:0009611	254	0.014
positive regulation of cellular biosynthetic process	GO:0031328	295	0.014
carbohydrate derivative catabolic process	GO:1901136	147	0.014
growth	GO:0040007	165	0.014
positive regulation of phosphate metabolic process	GO:0045937	262	0.014
response to oxygen levels	GO:0070482	265	0.014
cellular response to growth factor stimulus	GO:0071363	162	0.014
response to oxidative stress	GO:0006979	186	0.014
positive regulation of response to stimulus	GO:0048584	285	0.014
regulation of hormone levels	GO:0010817	187	0.014
response to vitamin	GO:0033273	131	0.014
regulation of phosphate metabolic process	GO:0019220	349	0.014
response to ethanol	GO:0045471	162	0.014
purine nucleotide metabolic process	GO:0006163	229	0.014
axis specification	GO:0009798	4	0.013
rna metabolic process	GO:0016070	406	0.013
positive regulation of voltage gated calcium channel activity	GO:1901387	1	0.013
organic hydroxy compound metabolic process	GO:1901615	115	0.013
positive regulation of nervous system development	GO:0051962	178	0.013
positive regulation of multicellular organismal process	GO:0051240	387	0.013
small molecule biosynthetic process	GO:0044283	124	0.013
cellular lipid catabolic process	GO:0044242	37	0.013
nucleotide catabolic process	GO:0009166	139	0.013
response to ketone	GO:1901654	182	0.013
muscle contraction	GO:0006936	88	0.013
regulation of neuron death	GO:1901214	115	0.013
response to bacterium	GO:0009617	200	0.013
regulation of transmembrane transporter activity	GO:0022898	49	0.013
anion transport	GO:0006820	178	0.013
dna metabolic process	GO:0006259	96	0.013
positive regulation of cell death	GO:0010942	184	0.013
ribonucleoside metabolic process	GO:0009119	174	0.013
skeletal muscle cell differentiation	GO:0035914	2	0.013
rna biosynthetic process	GO:0032774	380	0.013
positive regulation of molecular function	GO:0044093	230	0.013
ion homeostasis	GO:0050801	212	0.013
regulation of hormone secretion	GO:0046883	106	0.013
cellular component movement	GO:0006928	248	0.013
positive regulation of programmed cell death	GO:0043068	157	0.012
purine nucleoside metabolic process	GO:0042278	169	0.012
negative regulation of secretion	GO:0051048	82	0.012
response to transition metal nanoparticle	GO:1990267	122	0.012
positive regulation of cellular catabolic process	GO:0031331	71	0.012
potassium ion transmembrane transport	GO:0071805	71	0.012
g protein coupled receptor signaling pathway	GO:0007186	242	0.012
forebrain development	GO:0030900	98	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.012
regulation of dna metabolic process	GO:0051052	60	0.012
regulation of defense response	GO:0031347	68	0.012
circulatory system process	GO:0003013	183	0.012
muscle system process	GO:0003012	115	0.012
cellular potassium ion transport	GO:0071804	72	0.012
respiratory gaseous exchange	GO:0007585	4	0.012
single organism carbohydrate metabolic process	GO:0044723	118	0.012
cation homeostasis	GO:0055080	195	0.012
cation transport	GO:0006812	382	0.012
cellular component biogenesis	GO:0044085	368	0.012
ribonucleotide catabolic process	GO:0009261	136	0.011
cell growth	GO:0016049	104	0.011
response to hypoxia	GO:0001666	231	0.011
positive regulation of apoptotic process	GO:0043065	154	0.011
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
negative regulation of cell communication	GO:0010648	158	0.011
cellular response to mechanical stimulus	GO:0071260	48	0.011
multicellular organismal signaling	GO:0035637	44	0.011
positive regulation of phosphorylation	GO:0042327	177	0.011
regulation of ion homeostasis	GO:2000021	63	0.011
nucleic acid templated transcription	GO:0097659	379	0.011
nucleoside phosphate catabolic process	GO:1901292	140	0.011
purine ribonucleoside metabolic process	GO:0046128	168	0.011
macromolecular complex assembly	GO:0065003	273	0.011
muscle cell proliferation	GO:0033002	84	0.011
positive regulation of cell development	GO:0010720	176	0.011
organophosphate catabolic process	GO:0046434	148	0.011
cell projection organization	GO:0030030	302	0.011
response to lipopolysaccharide	GO:0032496	191	0.011
cellular response to insulin stimulus	GO:0032869	81	0.011
regulation of membrane repolarization	GO:0060306	1	0.011
positive regulation of neuron projection development	GO:0010976	99	0.011
regulation of transporter activity	GO:0032409	50	0.011
ribonucleoside catabolic process	GO:0042454	126	0.011
regulation of rna metabolic process	GO:0051252	391	0.011
retina morphogenesis in camera type eye	GO:0060042	1	0.011
response to heat	GO:0009408	60	0.011
purine containing compound catabolic process	GO:0072523	138	0.011
metal ion transport	GO:0030001	289	0.011
organonitrogen compound biosynthetic process	GO:1901566	167	0.011
transcription dna templated	GO:0006351	377	0.011
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.011
positive regulation of cell projection organization	GO:0031346	111	0.010
regulation of homotypic cell cell adhesion	GO:0034110	4	0.010
organonitrogen compound catabolic process	GO:1901565	179	0.010
protein localization	GO:0008104	191	0.010
regulation of smooth muscle cell proliferation	GO:0048660	75	0.010
erythrocyte differentiation	GO:0030218	1	0.010
gonad development	GO:0008406	104	0.010
response to mechanical stimulus	GO:0009612	134	0.010
response to osmotic stress	GO:0006970	42	0.010
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.010
regulation of fat cell differentiation	GO:0045598	3	0.010
negative regulation of transport	GO:0051051	136	0.010
regulation of secretion by cell	GO:1903530	208	0.010
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.010

Sgca disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.058
muscle tissue disease	DOID:66	0.058
muscular disease	DOID:0080000	0.058
myopathy	DOID:423	0.058
musculoskeletal system disease	DOID:17	0.058
disease of metabolism	DOID:0014667	0.029
nervous system disease	DOID:863	0.015
muscular dystrophy	DOID:9884	0.011

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