IMP: Integrative Multi-species Prediction

Rattus norvegicus

90 known processes

Col1a1

collagen, type I, alpha 1

(Aliases: COLIA1)

Entrez: 29393
Ensembl: ENSRNOG00000003897
RGD: 61817
UniProtKB: P02454

Process Predictions
Disease Predictions

Col1a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
endochondral bone morphogenesis	GO:0060350	7	0.998	Mouse Rat
cellular response to nicotine	GO:0071316	7	0.995	Rat
cartilage development involved in endochondral bone morphogenesis	GO:0060351	3	0.992	Mouse Rat
endochondral bone growth	GO:0003416	3	0.991	Rat
collagen fibril organization	GO:0030199	1	0.991	Human
growth plate cartilage development	GO:0003417	2	0.991	Rat
tooth eruption	GO:0044691	1	0.984
extracellular fibril organization	GO:0043206	1	0.974
aorta development	GO:0035904	2	0.968
response to mechanical stimulus	GO:0009612	134	0.962
cellular response to thyroid hormone stimulus	GO:0097067	5	0.955	Rat
response to camp	GO:0051591	91	0.943
skeletal system development	GO:0001501	41	0.937	Human Mouse Rat
peptide cross linking	GO:0018149	1	0.937
skeletal system morphogenesis	GO:0048705	12	0.934	Mouse Rat
cartilage development	GO:0051216	22	0.924	Mouse Rat
bone development	GO:0060348	25	0.918	Mouse Rat
response to tumor necrosis factor	GO:0034612	56	0.906
response to increased oxygen levels	GO:0036296	45	0.905
response to transforming growth factor beta	GO:0071559	46	0.894
odontogenesis	GO:0042476	32	0.881
cellular response to tumor necrosis factor	GO:0071356	46	0.859
response to estradiol	GO:0032355	164	0.848
response to hyperoxia	GO:0055093	45	0.837
cellular response to peptide hormone stimulus	GO:0071375	120	0.806	Rat
response to norepinephrine	GO:0071873	5	0.802	Rat
bone morphogenesis	GO:0060349	11	0.789	Mouse Rat
cellular response to organic cyclic compound	GO:0071407	202	0.786
transforming growth factor beta receptor signaling pathway	GO:0007179	18	0.781
cellular response to hormone stimulus	GO:0032870	247	0.780	Rat
connective tissue development	GO:0061448	33	0.779	Mouse Rat
embryonic skeletal system development	GO:0048706	3	0.774	Human
response to estrogen	GO:0043627	232	0.750
response to cytokine	GO:0034097	215	0.748
response to purine containing compound	GO:0014074	126	0.727
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	27	0.720
tissue development	GO:0009888	252	0.718	Human Zebrafish Mouse Rat
response to fibroblast growth factor	GO:0071774	29	0.708
cellular response to alkaloid	GO:0071312	25	0.698	Rat
response to organophosphorus	GO:0046683	102	0.680
artery development	GO:0060840	3	0.672
response to vitamin e	GO:0033197	24	0.672
response to wounding	GO:0009611	254	0.660
cellular response to cytokine stimulus	GO:0071345	127	0.641
response to x ray	GO:0010165	15	0.632	Rat
response to nutrient	GO:0007584	248	0.631
cellular response to epidermal growth factor stimulus	GO:0071364	12	0.620
response to oxygen levels	GO:0070482	265	0.616
cellular response to endogenous stimulus	GO:0071495	377	0.590
response to extracellular stimulus	GO:0009991	380	0.567
protein heterotrimerization	GO:0070208	2	0.555	Mouse
response to biotic stimulus	GO:0009607	226	0.550
organ growth	GO:0035265	24	0.548	Rat
response to retinoic acid	GO:0032526	63	0.548
cellular response to vitamin e	GO:0071306	3	0.536
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.527
chondrocyte differentiation	GO:0002062	10	0.524	Rat
cellular response to peptide	GO:1901653	133	0.524	Rat
response to corticosteroid	GO:0031960	235	0.494
cellular response to lipid	GO:0071396	201	0.491
cellular component assembly	GO:0022607	360	0.486	Mouse
extracellular matrix organization	GO:0030198	13	0.486	Human
macromolecular complex subunit organization	GO:0043933	339	0.485	Human Mouse
response to peptide hormone	GO:0043434	278	0.484
wound healing	GO:0042060	122	0.483
response to nutrient levels	GO:0031667	370	0.455
cellular response to organonitrogen compound	GO:0071417	197	0.451	Mouse Rat
urogenital system development	GO:0001655	78	0.446
cellular response to nitrogen compound	GO:1901699	210	0.445	Mouse Rat
ossification	GO:0001503	70	0.434
response to external biotic stimulus	GO:0043207	221	0.422
aging	GO:0007568	241	0.414	Rat
cellular response to growth factor stimulus	GO:0071363	162	0.413
macromolecular complex assembly	GO:0065003	273	0.404	Mouse
response to growth factor	GO:0070848	189	0.404
cellular response to mechanical stimulus	GO:0071260	48	0.396
protein complex subunit organization	GO:0071822	302	0.385	Human Mouse
cellular response to oxygen containing compound	GO:1901701	386	0.384
response to inorganic substance	GO:0010035	377	0.382
response to reactive oxygen species	GO:0000302	120	0.373
muscle tissue development	GO:0060537	58	0.369
response to hydrogen peroxide	GO:0042542	89	0.367
cardiovascular system development	GO:0072358	134	0.365	Human Mouse
response to oxidative stress	GO:0006979	186	0.360
response to peptide	GO:1901652	292	0.352
developmental growth involved in morphogenesis	GO:0060560	33	0.346	Rat
digestive system development	GO:0055123	41	0.344
kidney development	GO:0001822	67	0.330
cellular response to external stimulus	GO:0071496	118	0.329
response to vitamin	GO:0033273	131	0.320
organ morphogenesis	GO:0009887	75	0.314
renal system development	GO:0072001	67	0.311
response to molecule of bacterial origin	GO:0002237	194	0.309
response to lipopolysaccharide	GO:0032496	191	0.304
response to monoamine	GO:0071867	17	0.290	Rat
cellular response to acid chemical	GO:0071229	75	0.285
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.280
cellular response to nutrient	GO:0031670	30	0.280
response to acid chemical	GO:0001101	222	0.276
cellular component biogenesis	GO:0044085	368	0.274	Mouse
muscle organ morphogenesis	GO:0048644	1	0.254
blood vessel development	GO:0001568	69	0.245	Human Mouse
cell adhesion	GO:0007155	110	0.244	Mouse
vasculature development	GO:0001944	70	0.230	Human Mouse
tissue remodeling	GO:0048771	40	0.230
response to fluoride	GO:1902617	3	0.229
response to nicotine	GO:0035094	51	0.229	Rat
response to other organism	GO:0051707	220	0.225
eye morphogenesis	GO:0048592	4	0.220
cellular response to vitamin	GO:0071295	21	0.219
response to ionizing radiation	GO:0010212	59	0.207	Rat
tube development	GO:0035295	89	0.206
cellular response to abiotic stimulus	GO:0071214	85	0.206
protein complex assembly	GO:0006461	263	0.197	Mouse
response to catecholamine	GO:0071869	16	0.195	Rat
response to radiation	GO:0009314	137	0.195	Rat
response to bacterium	GO:0009617	200	0.185
muscle organ development	GO:0007517	50	0.177
telencephalon development	GO:0021537	62	0.175
response to glucocorticoid	GO:0051384	223	0.162
skin morphogenesis	GO:0043589	2	0.158	Human
response to epidermal growth factor	GO:0070849	18	0.156
cellular response to retinoic acid	GO:0071300	27	0.154
formation of primary germ layer	GO:0001704	1	0.153
protein complex biogenesis	GO:0070271	263	0.147	Mouse
protein oligomerization	GO:0051259	191	0.147	Mouse
developmental growth	GO:0048589	100	0.145	Zebrafish Rat
digestive tract development	GO:0048565	39	0.144
anatomical structure morphogenesis	GO:0009653	298	0.138
regulation of cell migration	GO:0030334	128	0.138	Human
skin development	GO:0043588	17	0.138	Human Mouse
growth	GO:0040007	165	0.134	Zebrafish Rat
response to thyroid hormone	GO:0097066	17	0.132	Rat
response to monosaccharide	GO:0034284	159	0.132
gastrulation	GO:0007369	2	0.130
cellular response to extracellular stimulus	GO:0031668	73	0.127
regulation of proteasomal protein catabolic process	GO:0061136	4	0.124
proteolysis	GO:0006508	175	0.111
extracellular structure organization	GO:0043062	13	0.110	Human
ras protein signal transduction	GO:0007265	29	0.103
striated muscle tissue development	GO:0014706	58	0.099
cellular response to nutrient levels	GO:0031669	60	0.098
regulation of anatomical structure morphogenesis	GO:0022603	141	0.096	Human
embryonic cranial skeleton morphogenesis	GO:0048701	2	0.096
regeneration	GO:0031099	163	0.095	Zebrafish
response to glucose	GO:0009749	136	0.094
negative regulation of multicellular organismal process	GO:0051241	203	0.094
positive regulation of gene expression	GO:0010628	244	0.094	Human
embryonic morphogenesis	GO:0048598	14	0.093
negative regulation of nervous system development	GO:0051961	79	0.093
rna biosynthetic process	GO:0032774	380	0.089	Human
positive regulation of cell motility	GO:2000147	97	0.087	Human
reproductive process	GO:0022414	372	0.086
small gtpase mediated signal transduction	GO:0007264	36	0.083
eye development	GO:0001654	50	0.082
regulation of transforming growth factor beta receptor signaling pathway	GO:0017015	5	0.080
positive regulation of developmental process	GO:0051094	283	0.079	Human
circulatory system process	GO:0003013	183	0.076
cellular component movement	GO:0006928	248	0.075	Human
response to amino acid	GO:0043200	75	0.074	Mouse
response to carbohydrate	GO:0009743	183	0.073
cell migration	GO:0016477	197	0.072	Human
developmental process involved in reproduction	GO:0003006	159	0.071
head development	GO:0060322	247	0.070	Mouse
response to alkaloid	GO:0043279	132	0.069	Rat
regulation of blood pressure	GO:0008217	83	0.068
negative regulation of cell differentiation	GO:0045596	99	0.065
regulation of cell motility	GO:2000145	131	0.065	Human
response to hexose	GO:0009746	144	0.065
blood vessel morphogenesis	GO:0048514	58	0.064
immune system process	GO:0002376	204	0.064
female pregnancy	GO:0007565	122	0.063
cellular response to glucocorticoid stimulus	GO:0071385	68	0.062
intramembranous ossification	GO:0001957	1	0.060	Mouse
transcription dna templated	GO:0006351	377	0.060	Human
regulation of immune system process	GO:0002682	123	0.059
cell cell signaling	GO:0007267	335	0.059
camera type eye morphogenesis	GO:0048593	2	0.059
negative regulation of cell proliferation	GO:0008285	119	0.057
regulation of transcription dna templated	GO:0006355	374	0.056	Human
single organism reproductive process	GO:0044702	297	0.055
transcription from rna polymerase ii promoter	GO:0006366	252	0.054
cell motility	GO:0048870	202	0.053	Human
regulation of nucleic acid templated transcription	GO:1903506	380	0.051	Human
muscle structure development	GO:0061061	87	0.051
positive regulation of rna metabolic process	GO:0051254	203	0.051	Human
forebrain development	GO:0030900	98	0.050
negative regulation of developmental process	GO:0051093	125	0.050
cell projection organization	GO:0030030	302	0.047
positive regulation of non canonical wnt signaling pathway	GO:2000052	1	0.045
cell matrix adhesion	GO:0007160	19	0.045
reproductive system development	GO:0061458	128	0.045
protein trimerization	GO:0070206	16	0.044	Mouse
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.043	Mouse
protein heterooligomerization	GO:0051291	89	0.043	Mouse
negative regulation of neurogenesis	GO:0050768	78	0.042
response to metal ion	GO:0010038	253	0.042
rna metabolic process	GO:0016070	406	0.042	Human
intracellular signal transduction	GO:0035556	314	0.041
positive regulation of phosphate metabolic process	GO:0045937	262	0.040
regulation of cellular component organization	GO:0051128	368	0.040	Human
muscle tissue morphogenesis	GO:0060415	1	0.039
wound healing spreading of cells	GO:0044319	2	0.039
blood circulation	GO:0008015	183	0.037
regulation of protein metabolic process	GO:0051246	289	0.037
response to transition metal nanoparticle	GO:1990267	122	0.037
positive regulation of cellular biosynthetic process	GO:0031328	295	0.037	Human
sensory organ development	GO:0007423	74	0.036
positive regulation of cell death	GO:0010942	184	0.035
circulatory system development	GO:0072359	134	0.035	Human Mouse
c21 steroid hormone biosynthetic process	GO:0006700	10	0.034
positive regulation of multicellular organismal process	GO:0051240	387	0.034	Human
negative regulation of response to stimulus	GO:0048585	155	0.034
epiboly	GO:0090504	2	0.034
epithelial cell differentiation	GO:0030855	71	0.033
regulation of secretion	GO:0051046	224	0.033
brain development	GO:0007420	247	0.032
protein phosphorylation	GO:0006468	345	0.032
placenta development	GO:0001890	22	0.032
regulation of nervous system development	GO:0051960	264	0.031
aldosterone secretion	GO:0035932	3	0.031
tissue morphogenesis	GO:0048729	22	0.031
hormone metabolic process	GO:0042445	69	0.030
apoptotic process	GO:0006915	381	0.030
reproductive structure development	GO:0048608	128	0.029
regulation of immune response	GO:0050776	55	0.029
immune response	GO:0006955	104	0.029
positive regulation of corticosteroid hormone secretion	GO:2000848	4	0.029
cellular response to metal ion	GO:0071248	55	0.028
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.028	Human
cellular response to iron iii ion	GO:0071283	3	0.027
digestive tract morphogenesis	GO:0048546	8	0.027
response to dexamethasone	GO:0071548	49	0.027
regulation of rna biosynthetic process	GO:2001141	381	0.026	Human
regulation of vasculature development	GO:1901342	44	0.026
nucleic acid templated transcription	GO:0097659	379	0.026	Human
embryonic skeletal system morphogenesis	GO:0048704	3	0.026
cellular hormone metabolic process	GO:0034754	49	0.026
positive regulation of cell communication	GO:0010647	271	0.025	Human
organ regeneration	GO:0031100	101	0.025
positive regulation of transcription dna templated	GO:0045893	197	0.025	Human
positive regulation of endothelial cell migration	GO:0010595	4	0.025
neuron differentiation	GO:0030182	368	0.025
heart development	GO:0007507	72	0.024
lipid biosynthetic process	GO:0008610	128	0.024
negative regulation of immune system process	GO:0002683	39	0.024
neuron projection development	GO:0031175	273	0.024
cerebral cortex development	GO:0021987	18	0.023
multicellular organismal catabolic process	GO:0044243	2	0.022
cellular response to steroid hormone stimulus	GO:0071383	93	0.022
regulation of embryonic development	GO:0045995	2	0.022
negative regulation of cellular biosynthetic process	GO:0031327	161	0.022
biological adhesion	GO:0022610	110	0.022	Mouse
cellular ketone metabolic process	GO:0042180	51	0.022
cellular response to corticosteroid stimulus	GO:0071384	69	0.021
positive regulation of catalytic activity	GO:0043085	184	0.021
positive regulation of signal transduction	GO:0009967	175	0.021	Human
response to interleukin 2	GO:0070669	1	0.020
synaptic transmission	GO:0007268	235	0.020
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.020
response to ketone	GO:1901654	182	0.020
negative regulation of biosynthetic process	GO:0009890	168	0.020
regulation of small gtpase mediated signal transduction	GO:0051056	48	0.019
regulation of growth	GO:0040008	105	0.019
limb morphogenesis	GO:0035108	4	0.019
regulation of cell development	GO:0060284	263	0.019	Human
locomotion	GO:0040011	237	0.019	Human
membrane organization	GO:0061024	94	0.019
response to hypoxia	GO:0001666	231	0.019
central nervous system development	GO:0007417	311	0.018
multi organism reproductive process	GO:0044703	262	0.018
negative regulation of immune response	GO:0050777	15	0.018
oxoacid metabolic process	GO:0043436	290	0.018
single organism intracellular transport	GO:1902582	166	0.018
response to starvation	GO:0042594	59	0.018
reproduction	GO:0000003	245	0.018
cellular macromolecule localization	GO:0070727	122	0.018	Human
establishment of protein localization	GO:0045184	141	0.018	Mouse
regulation of protein kinase activity	GO:0045859	105	0.018
localization of cell	GO:0051674	202	0.018	Human
cellular response to interleukin 2	GO:0071352	1	0.018
rho protein signal transduction	GO:0007266	11	0.017
cellular response to fibroblast growth factor stimulus	GO:0044344	24	0.017
semicircular canal development	GO:0060872	1	0.017
negative regulation of cell development	GO:0010721	82	0.017
skeletal muscle tissue development	GO:0007519	31	0.017
regulation of hormone levels	GO:0010817	187	0.017
intermediate filament organization	GO:0045109	1	0.017
multicellular organism reproduction	GO:0032504	233	0.016
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.016
positive regulation of synaptic plasticity	GO:0031915	3	0.016
macromolecule localization	GO:0033036	252	0.016	Human Mouse
multicellular organismal metabolic process	GO:0044236	22	0.016	Human
regulation of synaptic transmission	GO:0050804	141	0.016
cell substrate adhesion	GO:0031589	29	0.016	Mouse
regulation of cellular localization	GO:0060341	263	0.016
regulation of locomotion	GO:0040012	148	0.016	Human
positive regulation of cell differentiation	GO:0045597	217	0.015	Human
cell morphogenesis	GO:0000902	142	0.015	Human
regulation of cell differentiation	GO:0045595	320	0.015	Human
morphogenesis of an epithelium	GO:0002009	20	0.015
carboxylic acid metabolic process	GO:0019752	289	0.015
regulation of protein modification process	GO:0031399	194	0.015
positive regulation of cellular protein metabolic process	GO:0032270	167	0.015
cellular amine metabolic process	GO:0044106	38	0.015
regulation of stem cell differentiation	GO:2000736	2	0.014	Human
regulation of cellular component movement	GO:0051270	150	0.014	Human
regulation of programmed cell death	GO:0043067	341	0.014
positive regulation of dna metabolic process	GO:0051054	39	0.014
multi multicellular organism process	GO:0044706	138	0.014
regulation of epithelial to mesenchymal transition	GO:0010717	2	0.014	Human
regulation of multicellular organismal development	GO:2000026	376	0.014	Human
response to corticosterone	GO:0051412	40	0.014
schwann cell migration	GO:0036135	2	0.014
positive regulation of transforming growth factor beta receptor signaling pathway	GO:0030511	2	0.014
positive regulation of stem cell differentiation	GO:2000738	2	0.014	Human
organelle organization	GO:0006996	266	0.013
epiboly involved in wound healing	GO:0090505	2	0.013
cellular response to oxygen levels	GO:0071453	60	0.013
regulation of system process	GO:0044057	208	0.013
pallium development	GO:0021543	42	0.013
cellular response to stress	GO:0033554	269	0.013
positive regulation of protein phosphorylation	GO:0001934	135	0.013
organic acid metabolic process	GO:0006082	292	0.013
regulation of epithelial cell proliferation	GO:0050678	49	0.013
neuron development	GO:0048666	286	0.013
regulation of intracellular signal transduction	GO:1902531	218	0.012
negative regulation of macromolecule metabolic process	GO:0010605	260	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
positive regulation of apoptotic process	GO:0043065	154	0.012
elastic fiber assembly	GO:0048251	1	0.012
skeletal muscle organ development	GO:0060538	33	0.012
sensory organ morphogenesis	GO:0090596	7	0.012
peptidyl amino acid modification	GO:0018193	126	0.012
endomembrane system organization	GO:0010256	48	0.012
dna metabolic process	GO:0006259	96	0.012
protein localization	GO:0008104	191	0.012	Human Mouse
defense response to gram negative bacterium	GO:0050829	3	0.012
regulation of cell projection organization	GO:0031344	175	0.012
positive regulation of lipid biosynthetic process	GO:0046889	25	0.012
triglyceride homeostasis	GO:0070328	2	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.012	Human
response to ethanol	GO:0045471	162	0.012
multicellular organismal reproductive process	GO:0048609	233	0.012
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.012	Human
regulation of canonical wnt signaling pathway	GO:0060828	4	0.012	Human
epithelial cell proliferation	GO:0050673	54	0.012
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.012
positive regulation of secretion	GO:0051047	140	0.012
neuronal action potential	GO:0019228	35	0.011
regulation of transferase activity	GO:0051338	123	0.011
synaptic vesicle localization	GO:0097479	24	0.011
positive regulation of the force of heart contraction by chemical signal	GO:0003099	2	0.011
response to decreased oxygen levels	GO:0036293	237	0.011
cellular response to monosaccharide stimulus	GO:0071326	67	0.011
wound healing spreading of epidermal cells	GO:0035313	2	0.011
cytoplasmic transport	GO:0016482	115	0.011
positive regulation of biosynthetic process	GO:0009891	319	0.011	Human
regulation of cell proliferation	GO:0042127	359	0.011
positive regulation of angiogenesis	GO:0045766	28	0.011
cellular response to carbohydrate stimulus	GO:0071322	72	0.011
hexose metabolic process	GO:0019318	58	0.011
steroid metabolic process	GO:0008202	73	0.011
synaptic growth at neuromuscular junction	GO:0051124	1	0.011
maternal process involved in female pregnancy	GO:0060135	38	0.011
regulation of molecular function	GO:0065009	398	0.011
positive regulation of secretion by cell	GO:1903532	128	0.010
thyroid gland development	GO:0030878	1	0.010
endocrine system development	GO:0035270	30	0.010
epithelium development	GO:0060429	96	0.010
signal release	GO:0023061	145	0.010

Col1a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.985	Human
musculoskeletal system disease	DOID:17	0.985	Human
connective tissue disease	DOID:65	0.985	Human
osteogenesis imperfecta	DOID:12347	0.985	Human
bone disease	DOID:0080001	0.985	Human
bone development disease	DOID:0080006	0.985	Human
osteochondrodysplasia	DOID:2256	0.985	Human
collagen disease	DOID:854	0.214	Human
ehlers danlos syndrome	DOID:13359	0.214	Human
muscular disease	DOID:0080000	0.107
muscular dystrophy	DOID:9884	0.107
muscle tissue disease	DOID:66	0.107
myopathy	DOID:423	0.107

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