IMP: Integrative Multi-species Prediction

Rattus norvegicus

101 known processes

Guca1a

guanylate cyclase activator 1a (retina)

RGD: 1308712
Ensembl: ENSRNOG00000015402
Entrez: 301233
UniProtKB: D3ZII9

Process Predictions
Disease Predictions

Guca1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
response to extracellular stimulus	GO:0009991	380	0.205
intracellular signal transduction	GO:0035556	314	0.202
transmembrane transport	GO:0055085	412	0.189
regulation of phosphorus metabolic process	GO:0051174	349	0.134
regulation of hormone levels	GO:0010817	187	0.112
macromolecule localization	GO:0033036	252	0.086
regulation of cellular protein metabolic process	GO:0032268	267	0.085
macromolecular complex subunit organization	GO:0043933	339	0.084
regulation of molecular function	GO:0065009	398	0.082
response to nutrient levels	GO:0031667	370	0.077
regulation of cellular localization	GO:0060341	263	0.073
response to biotic stimulus	GO:0009607	226	0.073
response to external biotic stimulus	GO:0043207	221	0.071
apoptotic process	GO:0006915	381	0.071
cellular response to stress	GO:0033554	269	0.071
programmed cell death	GO:0012501	392	0.068
organelle organization	GO:0006996	266	0.066
response to other organism	GO:0051707	220	0.066
purine nucleotide metabolic process	GO:0006163	229	0.065
anion transport	GO:0006820	178	0.060
ribonucleotide metabolic process	GO:0009259	231	0.058
protein phosphorylation	GO:0006468	345	0.057
regulation of protein modification process	GO:0031399	194	0.056
positive regulation of phosphorus metabolic process	GO:0010562	262	0.056
hormone transport	GO:0009914	121	0.056
regulation of phosphorylation	GO:0042325	248	0.056
cellular ketone metabolic process	GO:0042180	51	0.055
protein complex subunit organization	GO:0071822	302	0.054
response to estrogen	GO:0043627	232	0.054
response to peptide	GO:1901652	292	0.054
regulation of protein metabolic process	GO:0051246	289	0.053
positive regulation of transport	GO:0051050	245	0.053
response to glucocorticoid	GO:0051384	223	0.052
regulation of programmed cell death	GO:0043067	341	0.052
dna metabolic process	GO:0006259	96	0.052
purine containing compound metabolic process	GO:0072521	253	0.052
transcription dna templated	GO:0006351	377	0.050
negative regulation of metabolic process	GO:0009892	331	0.050
macromolecular complex assembly	GO:0065003	273	0.050
protein complex biogenesis	GO:0070271	263	0.049
regulation of cellular ketone metabolic process	GO:0010565	27	0.049
regulation of secretion	GO:0051046	224	0.049
action potential	GO:0001508	54	0.047
response to inorganic substance	GO:0010035	377	0.046
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.046
nitrogen compound transport	GO:0071705	229	0.046
negative regulation of apoptotic process	GO:0043066	181	0.045
regulation of apoptotic process	GO:0042981	335	0.045
amine metabolic process	GO:0009308	38	0.045
carbohydrate derivative metabolic process	GO:1901135	346	0.044
regulation of catalytic activity	GO:0050790	304	0.044
cell cycle	GO:0007049	101	0.044
reproductive process	GO:0022414	372	0.043
regulation of multicellular organismal development	GO:2000026	376	0.043
single organism organelle organization	GO:1902589	180	0.042
cation transport	GO:0006812	382	0.042
cellular response to corticosteroid stimulus	GO:0071384	69	0.042
response to wounding	GO:0009611	254	0.041
rna metabolic process	GO:0016070	406	0.041
regulation of neurogenesis	GO:0050767	247	0.041
regulation of secretion by cell	GO:1903530	208	0.041
regulation of cell proliferation	GO:0042127	359	0.040
positive regulation of molecular function	GO:0044093	230	0.040
regulation of intracellular signal transduction	GO:1902531	218	0.039
negative regulation of signaling	GO:0023057	157	0.039
response to molecule of bacterial origin	GO:0002237	194	0.038
oxoacid metabolic process	GO:0043436	290	0.038
response to corticosteroid	GO:0031960	235	0.037
response to carbohydrate	GO:0009743	183	0.037
response to growth factor	GO:0070848	189	0.037
response to peptide hormone	GO:0043434	278	0.036
regulation of phosphate metabolic process	GO:0019220	349	0.036
regulation of kinase activity	GO:0043549	117	0.036
aging	GO:0007568	241	0.035
cellular chemical homeostasis	GO:0055082	247	0.034
regulation of transferase activity	GO:0051338	123	0.034
response to lipopolysaccharide	GO:0032496	191	0.034
regulation of system process	GO:0044057	208	0.034
single organism biosynthetic process	GO:0044711	342	0.034
catabolic process	GO:0009056	351	0.033
mapk cascade	GO:0000165	140	0.033
cellular response to ketone	GO:1901655	51	0.033
cellular component assembly	GO:0022607	360	0.033
reproduction	GO:0000003	245	0.033
regulation of cellular component organization	GO:0051128	368	0.033
organic acid metabolic process	GO:0006082	292	0.033
response to nutrient	GO:0007584	248	0.032
hormone metabolic process	GO:0042445	69	0.032
regulation of protein phosphorylation	GO:0001932	183	0.032
neurological system process	GO:0050877	219	0.031
muscle system process	GO:0003012	115	0.030
response to acid chemical	GO:0001101	222	0.030
protein complex assembly	GO:0006461	263	0.030
response to transition metal nanoparticle	GO:1990267	122	0.030
cellular amine metabolic process	GO:0044106	38	0.030
reproductive system development	GO:0061458	128	0.030
organonitrogen compound biosynthetic process	GO:1901566	167	0.029
positive regulation of protein modification process	GO:0031401	142	0.029
peptide transport	GO:0015833	97	0.029
cellular catabolic process	GO:0044248	295	0.029
cellular homeostasis	GO:0019725	252	0.028
positive regulation of peptide hormone secretion	GO:0090277	50	0.028
protein localization	GO:0008104	191	0.028
negative regulation of molecular function	GO:0044092	133	0.028
response to organophosphorus	GO:0046683	102	0.028
multi organism reproductive process	GO:0044703	262	0.027
positive regulation of cellular biosynthetic process	GO:0031328	295	0.027
response to dexamethasone	GO:0071548	49	0.027
proteolysis	GO:0006508	175	0.027
cellular response to hormone stimulus	GO:0032870	247	0.026
male sex differentiation	GO:0046661	64	0.026
cellular response to lipid	GO:0071396	201	0.026
ion transmembrane transport	GO:0034220	365	0.026
negative regulation of cellular metabolic process	GO:0031324	281	0.026
positive regulation of secretion	GO:0051047	140	0.026
positive regulation of hormone secretion	GO:0046887	65	0.026
response to metal ion	GO:0010038	253	0.026
carbohydrate derivative biosynthetic process	GO:1901137	124	0.025
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.025
regulation of protein kinase activity	GO:0045859	105	0.025
multicellular organismal reproductive process	GO:0048609	233	0.025
cellular response to growth factor stimulus	GO:0071363	162	0.025
cellular response to oxygen containing compound	GO:1901701	386	0.025
neuron differentiation	GO:0030182	368	0.024
positive regulation of cellular protein metabolic process	GO:0032270	167	0.024
nucleotide metabolic process	GO:0009117	279	0.024
single organism behavior	GO:0044708	130	0.024
negative regulation of cell death	GO:0060548	229	0.024
single organism reproductive process	GO:0044702	297	0.024
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.024
carboxylic acid metabolic process	GO:0019752	289	0.024
cellular protein localization	GO:0034613	122	0.023
multicellular organism reproduction	GO:0032504	233	0.023
response to toxic substance	GO:0009636	133	0.023
muscle contraction	GO:0006936	88	0.023
negative regulation of macromolecule metabolic process	GO:0010605	260	0.023
regulation of cell development	GO:0060284	263	0.023
blood circulation	GO:0008015	183	0.023
positive regulation of signaling	GO:0023056	270	0.023
neural crest cell development	GO:0014032	2	0.023
single organism catabolic process	GO:0044712	283	0.023
developmental process involved in reproduction	GO:0003006	159	0.022
central nervous system development	GO:0007417	311	0.022
cellular response to organic cyclic compound	GO:0071407	202	0.022
cellular component biogenesis	GO:0044085	368	0.022
regulation of peptide transport	GO:0090087	87	0.022
cell activation	GO:0001775	97	0.022
cyclic purine nucleotide metabolic process	GO:0052652	62	0.022
cellular response to steroid hormone stimulus	GO:0071383	93	0.022
secretion	GO:0046903	307	0.022
learning or memory	GO:0007611	90	0.022
gonad development	GO:0008406	104	0.021
regulation of nucleic acid templated transcription	GO:1903506	380	0.021
organophosphate metabolic process	GO:0019637	370	0.021
cellular amino acid metabolic process	GO:0006520	107	0.021
negative regulation of gene expression	GO:0010629	199	0.021
response to electrical stimulus	GO:0051602	56	0.021
positive regulation of cell communication	GO:0010647	271	0.021
positive regulation of multicellular organismal process	GO:0051240	387	0.020
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.020
cell cycle process	GO:0022402	57	0.020
positive regulation of developmental process	GO:0051094	283	0.020
rhythmic process	GO:0048511	156	0.020
organic hydroxy compound metabolic process	GO:1901615	115	0.020
positive regulation of catalytic activity	GO:0043085	184	0.020
cellular hormone metabolic process	GO:0034754	49	0.020
negative regulation of cell differentiation	GO:0045596	99	0.020
negative regulation of cellular protein metabolic process	GO:0032269	106	0.019
positive regulation of cell proliferation	GO:0008284	249	0.019
positive regulation of phosphorylation	GO:0042327	177	0.019
response to radiation	GO:0009314	137	0.019
regulation of signal transduction	GO:0009966	318	0.019
ossification	GO:0001503	70	0.019
response to temperature stimulus	GO:0009266	94	0.019
negative regulation of protein metabolic process	GO:0051248	114	0.019
regulation of tube size	GO:0035150	89	0.018
regulation of cellular amino acid metabolic process	GO:0006521	2	0.018
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.018
vesicle mediated transport	GO:0016192	181	0.018
negative regulation of catalytic activity	GO:0043086	103	0.018
regulation of transmembrane transport	GO:0034762	122	0.018
cellular response to glucocorticoid stimulus	GO:0071385	68	0.018
head development	GO:0060322	247	0.018
secretion by cell	GO:0032940	248	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.018
cell projection organization	GO:0030030	302	0.018
protein transport	GO:0015031	132	0.018
regulation of blood circulation	GO:1903522	110	0.018
gamete generation	GO:0007276	124	0.018
neuron projection development	GO:0031175	273	0.018
homeostatic process	GO:0042592	331	0.017
male gonad development	GO:0008584	59	0.017
aromatic compound catabolic process	GO:0019439	168	0.017
regulation of cellular amine metabolic process	GO:0033238	8	0.017
nucleoside phosphate biosynthetic process	GO:1901293	102	0.017
signal transduction by phosphorylation	GO:0023014	144	0.017
positive regulation of leukocyte activation	GO:0002696	30	0.017
response to glucose	GO:0009749	136	0.017
organic acid transport	GO:0015849	116	0.017
positive regulation of protein phosphorylation	GO:0001934	135	0.017
tissue development	GO:0009888	252	0.017
development of primary sexual characteristics	GO:0045137	107	0.017
hormone secretion	GO:0046879	115	0.017
neurotransmitter uptake	GO:0001504	3	0.016
cardiovascular system development	GO:0072358	134	0.016
positive regulation of protein kinase activity	GO:0045860	73	0.016
behavior	GO:0007610	205	0.016
glutathione transport	GO:0034635	2	0.016
negative regulation of neuron differentiation	GO:0045665	62	0.016
cell cell signaling	GO:0007267	335	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.016
epithelial cell differentiation	GO:0030855	71	0.016
amide transport	GO:0042886	105	0.016
establishment of protein localization	GO:0045184	141	0.016
negative regulation of signal transduction	GO:0009968	83	0.016
organic substance catabolic process	GO:1901575	316	0.016
negative regulation of biosynthetic process	GO:0009890	168	0.016
response to cytokine	GO:0034097	215	0.016
regulation of peptide secretion	GO:0002791	82	0.016
positive regulation of biosynthetic process	GO:0009891	319	0.016
neuron development	GO:0048666	286	0.016
male gamete generation	GO:0048232	99	0.016
response to camp	GO:0051591	91	0.015
intracellular transport	GO:0046907	185	0.015
positive regulation of rna metabolic process	GO:0051254	203	0.015
regulation of immune system process	GO:0002682	123	0.015
amine transport	GO:0015837	57	0.015
cellular response to endogenous stimulus	GO:0071495	377	0.015
salivary gland development	GO:0007431	3	0.015
positive regulation of transferase activity	GO:0051347	81	0.015
regulation of mapk cascade	GO:0043408	116	0.015
renal system process	GO:0003014	40	0.015
spermatogenesis	GO:0007283	99	0.015
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.015
positive regulation of humoral immune response	GO:0002922	2	0.015
regulation of transcription dna templated	GO:0006355	374	0.015
lipid metabolic process	GO:0006629	283	0.015
cell morphogenesis	GO:0000902	142	0.015
cyclic nucleotide metabolic process	GO:0009187	80	0.015
regulation of muscle system process	GO:0090257	79	0.015
multi multicellular organism process	GO:0044706	138	0.015
regulation of metal ion transport	GO:0010959	118	0.014
response to estradiol	GO:0032355	164	0.014
positive regulation of cell development	GO:0010720	176	0.014
regulation of cell cycle	GO:0051726	73	0.014
positive regulation of phosphate metabolic process	GO:0045937	262	0.014
monocarboxylic acid transport	GO:0015718	52	0.014
divalent inorganic cation transport	GO:0072511	134	0.014
response to calcium ion	GO:0051592	59	0.014
sulfur compound transport	GO:0072348	8	0.014
regulation of homeostatic process	GO:0032844	101	0.014
alcohol metabolic process	GO:0006066	77	0.014
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.014
eye morphogenesis	GO:0048592	4	0.014
neuron death	GO:0070997	127	0.014
response to ketone	GO:1901654	182	0.014
positive regulation of cellular amine metabolic process	GO:0033240	3	0.014
signal release	GO:0023061	145	0.014
calcium ion transport	GO:0006816	131	0.014
regulation of nervous system development	GO:0051960	264	0.014
protein homooligomerization	GO:0051260	91	0.014
negative regulation of phosphate metabolic process	GO:0045936	80	0.014
negative regulation of cell communication	GO:0010648	158	0.014
ribose phosphate metabolic process	GO:0019693	235	0.014
positive regulation of cellular component organization	GO:0051130	200	0.014
actin filament based process	GO:0030029	86	0.014
actin filament organization	GO:0007015	42	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.014
regulation of calcium ion transport	GO:0051924	77	0.013
organ morphogenesis	GO:0009887	75	0.013
purine nucleoside metabolic process	GO:0042278	169	0.013
negative regulation of programmed cell death	GO:0043069	183	0.013
regulation of anatomical structure size	GO:0090066	135	0.013
sex differentiation	GO:0007548	113	0.013
response to hypoxia	GO:0001666	231	0.013
response to mechanical stimulus	GO:0009612	134	0.013
antral ovarian follicle growth	GO:0001547	3	0.013
nucleobase containing small molecule metabolic process	GO:0055086	316	0.013
cellular metal ion homeostasis	GO:0006875	172	0.013
carbohydrate derivative catabolic process	GO:1901136	147	0.013
organic anion transport	GO:0015711	132	0.013
protein oligomerization	GO:0051259	191	0.013
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.013
purine containing compound biosynthetic process	GO:0072522	85	0.013
chemokine metabolic process	GO:0050755	3	0.013
nucleoside phosphate metabolic process	GO:0006753	283	0.013
regulation of cell differentiation	GO:0045595	320	0.013
intracellular protein transport	GO:0006886	79	0.013
response to vitamin	GO:0033273	131	0.013
heart morphogenesis	GO:0003007	3	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
cation transmembrane transport	GO:0098655	263	0.013
nucleic acid templated transcription	GO:0097659	379	0.012
regulation of lipid metabolic process	GO:0019216	68	0.012
cellular nitrogen compound catabolic process	GO:0044270	163	0.012
cellular macromolecule localization	GO:0070727	122	0.012
divalent metal ion transport	GO:0070838	132	0.012
negative regulation of rna metabolic process	GO:0051253	123	0.012
positive regulation of response to stimulus	GO:0048584	285	0.012
regulation of neuron differentiation	GO:0045664	208	0.012
positive regulation of protein kinase b signaling	GO:0051897	10	0.012
response to oxidative stress	GO:0006979	186	0.012
cytoskeleton organization	GO:0007010	111	0.012
metal ion transport	GO:0030001	289	0.012
glycosyl compound catabolic process	GO:1901658	126	0.012
organic cyclic compound catabolic process	GO:1901361	175	0.012
rna biosynthetic process	GO:0032774	380	0.012
ribose phosphate biosynthetic process	GO:0046390	87	0.012
vascular process in circulatory system	GO:0003018	96	0.012
divalent inorganic cation homeostasis	GO:0072507	165	0.012
steroid metabolic process	GO:0008202	73	0.012
negative regulation of rna biosynthetic process	GO:1902679	118	0.012
anatomical structure morphogenesis	GO:0009653	298	0.012
response to bacterium	GO:0009617	200	0.012
choline transport	GO:0015871	4	0.012
coronary vasculature morphogenesis	GO:0060977	3	0.012
vasoconstriction	GO:0042310	54	0.012
regulation of organelle organization	GO:0033043	80	0.012
cognition	GO:0050890	92	0.012
calcium ion transmembrane transport	GO:0070588	70	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.012
purine ribonucleoside metabolic process	GO:0046128	168	0.012
purine nucleotide biosynthetic process	GO:0006164	83	0.011
development of primary male sexual characteristics	GO:0046546	59	0.011
positive regulation of dna metabolic process	GO:0051054	39	0.011
amino acid transport	GO:0006865	70	0.011
gastrulation	GO:0007369	2	0.011
lens fiber cell differentiation	GO:0070306	3	0.011
response to alkaloid	GO:0043279	132	0.011
acid secretion	GO:0046717	48	0.011
cellular ion homeostasis	GO:0006873	184	0.011
positive regulation of protein metabolic process	GO:0051247	178	0.011
circulatory system process	GO:0003013	183	0.011
carboxylic acid transport	GO:0046942	115	0.011
negative regulation of cellular biosynthetic process	GO:0031327	161	0.011
response to monosaccharide	GO:0034284	159	0.011
lymphocyte proliferation	GO:0046651	29	0.011
positive regulation of kinase activity	GO:0033674	77	0.011
carbohydrate biosynthetic process	GO:0016051	42	0.011
positive regulation of secretion by cell	GO:1903532	128	0.011
regulation of ion transport	GO:0043269	245	0.011
regulation of peptide hormone secretion	GO:0090276	80	0.011
cell type specific apoptotic process	GO:0097285	134	0.011
carbohydrate metabolic process	GO:0005975	130	0.011
nucleobase containing compound catabolic process	GO:0034655	152	0.011
muscle tissue development	GO:0060537	58	0.011
positive regulation of cell differentiation	GO:0045597	217	0.011
regulation of saliva secretion	GO:0046877	3	0.011
positive regulation of peptide secretion	GO:0002793	52	0.011
glucose homeostasis	GO:0042593	75	0.011
mitotic cell cycle	GO:0000278	49	0.011
ribonucleoside metabolic process	GO:0009119	174	0.011
cytoplasmic transport	GO:0016482	115	0.011
regulation of cytoskeleton organization	GO:0051493	49	0.011
organic hydroxy compound transport	GO:0015850	77	0.011
chemical homeostasis	GO:0048878	292	0.011
regulation of hydrolase activity	GO:0051336	143	0.011
regulation of dna metabolic process	GO:0051052	60	0.011
cellular response to alcohol	GO:0097306	87	0.011
dna replication	GO:0006260	37	0.010
positive regulation of cell death	GO:0010942	184	0.010
response to purine containing compound	GO:0014074	126	0.010
neural crest cell migration	GO:0001755	1	0.010
cell cycle checkpoint	GO:0000075	2	0.010
glycosyl compound metabolic process	GO:1901657	182	0.010
purine ribonucleotide catabolic process	GO:0009154	136	0.010
negative regulation of transport	GO:0051051	136	0.010
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.010
sexual reproduction	GO:0019953	148	0.010
positive regulation of neurogenesis	GO:0050769	165	0.010
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.010
cellular macromolecular complex assembly	GO:0034622	58	0.010
peptide secretion	GO:0002790	86	0.010
fertilization	GO:0009566	3	0.010
g protein coupled receptor internalization	GO:0002031	3	0.010

Guca1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
nervous system disease	DOID:863	0.245	Human
sensory system disease	DOID:0050155	0.245	Human
disease of anatomical entity	DOID:7	0.245	Human
retinal disease	DOID:5679	0.222	Human
night blindness	DOID:8499	0.222
eye and adnexa disease	DOID:1492	0.222	Human
eye disease	DOID:5614	0.222	Human
retinal degeneration	DOID:8466	0.030	Human
retinitis pigmentosa	DOID:10584	0.030
musculoskeletal system disease	DOID:17	0.030
muscle tissue disease	DOID:66	0.030
myopathy	DOID:423	0.030
muscular disease	DOID:0080000	0.030

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