IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Lepre1

leucine proline-enriched proteoglycan (leprecan) 1

(Aliases: Gros1)

RGD: 628823
Ensembl: ENSRNOG00000007538
Entrez: 114200
UniProtKB: Q9R1J8

Process Predictions
Disease Predictions

Lepre1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
peptidyl lysine hydroxylation	GO:0017185	1	0.159
oxoacid metabolic process	GO:0043436	290	0.082
secretion	GO:0046903	307	0.072	Human
organic acid metabolic process	GO:0006082	292	0.048
single organism biosynthetic process	GO:0044711	342	0.042
carboxylic acid metabolic process	GO:0019752	289	0.041
response to oxygen levels	GO:0070482	265	0.041
secretion by cell	GO:0032940	248	0.040	Human
regulation of multicellular organismal development	GO:2000026	376	0.031
cellular amino acid metabolic process	GO:0006520	107	0.031
response to hypoxia	GO:0001666	231	0.030
alpha amino acid metabolic process	GO:1901605	71	0.030
circulatory system process	GO:0003013	183	0.030
blood circulation	GO:0008015	183	0.029
tissue development	GO:0009888	252	0.028
response to decreased oxygen levels	GO:0036293	237	0.027
organonitrogen compound biosynthetic process	GO:1901566	167	0.027
cellular response to stress	GO:0033554	269	0.025
cellular homeostasis	GO:0019725	252	0.024
nitrogen compound transport	GO:0071705	229	0.024
cellular ketone metabolic process	GO:0042180	51	0.023
cellular amine metabolic process	GO:0044106	38	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.022
cellular chemical homeostasis	GO:0055082	247	0.021
ion homeostasis	GO:0050801	212	0.021
carbohydrate derivative metabolic process	GO:1901135	346	0.021
positive regulation of multicellular organismal process	GO:0051240	387	0.020
response to nutrient	GO:0007584	248	0.019
multi organism reproductive process	GO:0044703	262	0.019
regulation of anatomical structure size	GO:0090066	135	0.019
transmembrane transport	GO:0055085	412	0.019
homeostatic process	GO:0042592	331	0.018
protein oligomerization	GO:0051259	191	0.018
ion transmembrane transport	GO:0034220	365	0.018
amine metabolic process	GO:0009308	38	0.017
reproductive process	GO:0022414	372	0.017
protein transport	GO:0015031	132	0.017	Human
oxidation reduction process	GO:0055114	304	0.017	Rat
regulation of cell differentiation	GO:0045595	320	0.017
response to nutrient levels	GO:0031667	370	0.016
single organism carbohydrate metabolic process	GO:0044723	118	0.016
macromolecule localization	GO:0033036	252	0.016	Human
regulation of cellular amino acid metabolic process	GO:0006521	2	0.016
cellular component assembly	GO:0022607	360	0.016
carbohydrate derivative biosynthetic process	GO:1901137	124	0.016
positive regulation of cell proliferation	GO:0008284	249	0.016
negative regulation of metabolic process	GO:0009892	331	0.016	Human
multicellular organism reproduction	GO:0032504	233	0.016
regulation of cellular amine metabolic process	GO:0033238	8	0.016
cellular cation homeostasis	GO:0030003	180	0.015
sulfur compound metabolic process	GO:0006790	70	0.015
regulation of cellular ketone metabolic process	GO:0010565	27	0.015
regulation of system process	GO:0044057	208	0.015
reproduction	GO:0000003	245	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.014
cation homeostasis	GO:0055080	195	0.014
cell projection organization	GO:0030030	302	0.014
chemical homeostasis	GO:0048878	292	0.014
carbohydrate metabolic process	GO:0005975	130	0.014
protein heterooligomerization	GO:0051291	89	0.014
regulation of nervous system development	GO:0051960	264	0.014
neuron projection development	GO:0031175	273	0.014
negative regulation of protein metabolic process	GO:0051248	114	0.014	Human
cellular response to oxygen containing compound	GO:1901701	386	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
response to peptide	GO:1901652	292	0.013
cellular component biogenesis	GO:0044085	368	0.013
regulation of phosphate metabolic process	GO:0019220	349	0.013
regulation of cellular component organization	GO:0051128	368	0.013
cellular response to growth factor stimulus	GO:0071363	162	0.013
regulation of tube size	GO:0035150	89	0.013
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
gamete generation	GO:0007276	124	0.012
cellular response to endogenous stimulus	GO:0071495	377	0.012
positive regulation of cellular amine metabolic process	GO:0033240	3	0.012
regulation of transcription dna templated	GO:0006355	374	0.012
multicellular organismal reproductive process	GO:0048609	233	0.012
aging	GO:0007568	241	0.012
neuron differentiation	GO:0030182	368	0.012
regulation of apoptotic process	GO:0042981	335	0.012
positive regulation of nervous system development	GO:0051962	178	0.012
response to peptide hormone	GO:0043434	278	0.012
nucleotide metabolic process	GO:0009117	279	0.012
protein complex subunit organization	GO:0071822	302	0.012	Mouse
positive regulation of developmental process	GO:0051094	283	0.012
response to glucose	GO:0009749	136	0.012
glycosyl compound metabolic process	GO:1901657	182	0.012
neurological system process	GO:0050877	219	0.012
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.011
organic anion transport	GO:0015711	132	0.011
organophosphate metabolic process	GO:0019637	370	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
response to alkaloid	GO:0043279	132	0.011
anion transport	GO:0006820	178	0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.011
cellular ion homeostasis	GO:0006873	184	0.011
macromolecular complex subunit organization	GO:0043933	339	0.011	Mouse
negative regulation of cell communication	GO:0010648	158	0.011
ras protein signal transduction	GO:0007265	29	0.011
response to reactive oxygen species	GO:0000302	120	0.011
response to growth factor	GO:0070848	189	0.011
negative regulation of catalytic activity	GO:0043086	103	0.010
metal ion homeostasis	GO:0055065	186	0.010
cell cell signaling	GO:0007267	335	0.010
nucleobase containing small molecule metabolic process	GO:0055086	316	0.010
protein complex assembly	GO:0006461	263	0.010
positive regulation of neurogenesis	GO:0050769	165	0.010
central nervous system development	GO:0007417	311	0.010
regulation of catalytic activity	GO:0050790	304	0.010
single organism reproductive process	GO:0044702	297	0.010
regulation of signal transduction	GO:0009966	318	0.010
protein secretion	GO:0009306	34	0.010	Human
positive regulation of rna metabolic process	GO:0051254	203	0.010
response to metal ion	GO:0010038	253	0.010
cellular calcium ion homeostasis	GO:0006874	160	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.010
cellular response to hypoxia	GO:0071456	51	0.010

Lepre1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
musculoskeletal system disease	DOID:17	0.251	Human
disease of anatomical entity	DOID:7	0.251	Human
connective tissue disease	DOID:65	0.037	Human
muscular disease	DOID:0080000	0.018
muscle tissue disease	DOID:66	0.018
myopathy	DOID:423	0.018
nervous system disease	DOID:863	0.016
bone disease	DOID:0080001	0.015	Human
muscular dystrophy	DOID:9884	0.012

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