IMP: Integrative Multi-species Prediction

Rattus norvegicus

53 known processes

Gnmt

glycine N-methyltransferase

Ensembl: ENSRNOG00000016349
RGD: 2719
Entrez: 25134
UniProtKB: P13255

Process Predictions
Disease Predictions

Gnmt biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
organ regeneration	GO:0031100	101	0.530
lipid metabolic process	GO:0006629	283	0.488
nicotine metabolic process	GO:0018933	1	0.465
response to peptide hormone	GO:0043434	278	0.400
alkaloid metabolic process	GO:0009820	3	0.334
organic acid metabolic process	GO:0006082	292	0.316
carboxylic acid metabolic process	GO:0019752	289	0.299
pyridine containing compound metabolic process	GO:0072524	32	0.289
response to sulfur dioxide	GO:0010477	3	0.268
response to extracellular stimulus	GO:0009991	380	0.257
response to insulin	GO:0032868	133	0.253
alpha amino acid metabolic process	GO:1901605	71	0.233
single organism biosynthetic process	GO:0044711	342	0.211
multi organism reproductive process	GO:0044703	262	0.209
oxoacid metabolic process	GO:0043436	290	0.202
trichloroethylene metabolic process	GO:0018979	1	0.194
regulation of cellular localization	GO:0060341	263	0.163
response to metal ion	GO:0010038	253	0.162
cellular amino acid metabolic process	GO:0006520	107	0.155
response to transition metal nanoparticle	GO:1990267	122	0.153
positive regulation of multicellular organismal process	GO:0051240	387	0.150
response to peptide	GO:1901652	292	0.143
neutral lipid metabolic process	GO:0006638	21	0.141
response to cesium ion	GO:0010164	2	0.139
female pregnancy	GO:0007565	122	0.133
cellular chemical homeostasis	GO:0055082	247	0.133
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.132
multi multicellular organism process	GO:0044706	138	0.130
reproductive process	GO:0022414	372	0.130
monocarboxylic acid metabolic process	GO:0032787	152	0.124
response to carbohydrate	GO:0009743	183	0.123
gland development	GO:0048732	155	0.121
halogenated hydrocarbon metabolic process	GO:0042197	4	0.121
organic substance catabolic process	GO:1901575	316	0.110
cellular catabolic process	GO:0044248	295	0.107
alpha amino acid catabolic process	GO:1901606	20	0.104
epoxygenase p450 pathway	GO:0019373	1	0.101
aging	GO:0007568	241	0.098
response to nutrient levels	GO:0031667	370	0.098
response to zinc ion	GO:0010043	39	0.097
small molecule catabolic process	GO:0044282	59	0.096
chemical homeostasis	GO:0048878	292	0.095
hepaticobiliary system development	GO:0061008	90	0.095
response to inorganic substance	GO:0010035	377	0.092
reproduction	GO:0000003	245	0.091
response to acid chemical	GO:0001101	222	0.091
glycerolipid metabolic process	GO:0046486	67	0.087
response to mercury ion	GO:0046689	15	0.084
response to other organism	GO:0051707	220	0.081
naphthalene containing compound metabolic process	GO:0090420	2	0.080
cellular response to external stimulus	GO:0071496	118	0.078
cellular response to oxygen containing compound	GO:1901701	386	0.077
cellular lipid metabolic process	GO:0044255	208	0.076
organonitrogen compound catabolic process	GO:1901565	179	0.073
response to biotic stimulus	GO:0009607	226	0.073
single organism catabolic process	GO:0044712	283	0.071
immune system process	GO:0002376	204	0.071
cellular response to organic cyclic compound	GO:0071407	202	0.070
nucleobase containing small molecule metabolic process	GO:0055086	316	0.069
response to ethanol	GO:0045471	162	0.069
cellular amino acid catabolic process	GO:0009063	21	0.068
fatty acid metabolic process	GO:0006631	99	0.068
response to alkaloid	GO:0043279	132	0.067
response to monosaccharide	GO:0034284	159	0.067
catabolic process	GO:0009056	351	0.067
cofactor metabolic process	GO:0051186	95	0.067
response to bacterium	GO:0009617	200	0.066
organonitrogen compound biosynthetic process	GO:1901566	167	0.065
response to hexose	GO:0009746	144	0.065
cellular response to peptide hormone stimulus	GO:0071375	120	0.064
macromolecular complex assembly	GO:0065003	273	0.061
response to ketone	GO:1901654	182	0.061
regulation of nervous system development	GO:0051960	264	0.058
response to glucose	GO:0009749	136	0.058
carbohydrate derivative metabolic process	GO:1901135	346	0.058
gamete generation	GO:0007276	124	0.058
response to estrogen	GO:0043627	232	0.058
response to glucocorticoid	GO:0051384	223	0.057
secretion	GO:0046903	307	0.057
innate immune response	GO:0045087	35	0.056
response to lipopolysaccharide	GO:0032496	191	0.056
single organism reproductive process	GO:0044702	297	0.056
cellular component biogenesis	GO:0044085	368	0.055
isoprenoid metabolic process	GO:0006720	45	0.052
positive regulation of transport	GO:0051050	245	0.051
cellular modified amino acid metabolic process	GO:0006575	61	0.049
response to external biotic stimulus	GO:0043207	221	0.049
drug metabolic process	GO:0017144	11	0.049
urea metabolic process	GO:0019627	5	0.049
behavior	GO:0007610	205	0.048
aromatic amino acid family catabolic process	GO:0009074	7	0.048
regulation of hormone levels	GO:0010817	187	0.047
cellular response to hormone stimulus	GO:0032870	247	0.046
arginine metabolic process	GO:0006525	6	0.045
triglyceride metabolic process	GO:0006641	21	0.045
cellular response to lipid	GO:0071396	201	0.045
sexual reproduction	GO:0019953	148	0.044
cellular response to steroid hormone stimulus	GO:0071383	93	0.043
oxidation reduction process	GO:0055114	304	0.042
response to calcium ion	GO:0051592	59	0.041
actin filament based process	GO:0030029	86	0.041
negative regulation of metabolic process	GO:0009892	331	0.040
liver development	GO:0001889	90	0.040
response to molecule of bacterial origin	GO:0002237	194	0.040
ion homeostasis	GO:0050801	212	0.040
anatomical structure morphogenesis	GO:0009653	298	0.039
single organism organelle organization	GO:1902589	180	0.038
multicellular organism reproduction	GO:0032504	233	0.038
developmental process involved in reproduction	GO:0003006	159	0.038
cellular response to insulin stimulus	GO:0032869	81	0.038
response to nutrient	GO:0007584	248	0.038
regulation of peptide hormone secretion	GO:0090276	80	0.038
homeostatic process	GO:0042592	331	0.037
organophosphate metabolic process	GO:0019637	370	0.036
regulation of cell differentiation	GO:0045595	320	0.036
unsaturated fatty acid metabolic process	GO:0033559	39	0.036
cellular response to endogenous stimulus	GO:0071495	377	0.035
carbohydrate homeostasis	GO:0033500	75	0.035
fatty acid derivative metabolic process	GO:1901568	38	0.035
cellular amino acid biosynthetic process	GO:0008652	32	0.035
acylglycerol metabolic process	GO:0006639	21	0.034
response to oxygen levels	GO:0070482	265	0.034
response to radiation	GO:0009314	137	0.034
organic acid catabolic process	GO:0016054	49	0.034
rhythmic process	GO:0048511	156	0.033
regulation of secretion by cell	GO:1903530	208	0.033
positive regulation of response to stimulus	GO:0048584	285	0.032
glutamine family amino acid metabolic process	GO:0009064	15	0.032
multicellular organismal reproductive process	GO:0048609	233	0.032
cellular response to extracellular stimulus	GO:0031668	73	0.031
coenzyme metabolic process	GO:0006732	86	0.031
single organism carbohydrate metabolic process	GO:0044723	118	0.031
central nervous system development	GO:0007417	311	0.030
regulation of rna metabolic process	GO:0051252	391	0.030
spermatogenesis	GO:0007283	99	0.030
amine metabolic process	GO:0009308	38	0.030
heart morphogenesis	GO:0003007	3	0.030
amide transport	GO:0042886	105	0.030
purine containing compound metabolic process	GO:0072521	253	0.029
cell motility	GO:0048870	202	0.029
cellular response to glucocorticoid stimulus	GO:0071385	68	0.029
regulation of phosphorus metabolic process	GO:0051174	349	0.028
cellular amine metabolic process	GO:0044106	38	0.028
drug catabolic process	GO:0042737	1	0.028
circulatory system process	GO:0003013	183	0.028
rna biosynthetic process	GO:0032774	380	0.028
positive regulation of neuron differentiation	GO:0045666	126	0.028
negative regulation of cellular metabolic process	GO:0031324	281	0.027
regulation of cell motility	GO:2000145	131	0.027
neuron differentiation	GO:0030182	368	0.027
negative regulation of programmed cell death	GO:0043069	183	0.027
positive regulation of nervous system development	GO:0051962	178	0.027
nucleotide metabolic process	GO:0009117	279	0.027
protein complex assembly	GO:0006461	263	0.027
defense response	GO:0006952	194	0.027
phosphatidylinositol dephosphorylation	GO:0046856	4	0.026
ribonucleoside metabolic process	GO:0009119	174	0.026
hexose metabolic process	GO:0019318	58	0.026
protein phosphorylation	GO:0006468	345	0.026
metal ion homeostasis	GO:0055065	186	0.026
regulation of transcription dna templated	GO:0006355	374	0.026
hormone metabolic process	GO:0042445	69	0.026
skeletal system development	GO:0001501	41	0.026
negative regulation of macromolecule metabolic process	GO:0010605	260	0.026
urea cycle	GO:0000050	5	0.026
positive regulation of cell development	GO:0010720	176	0.026
negative regulation of gene expression	GO:0010629	199	0.026
lipid biosynthetic process	GO:0008610	128	0.026
long chain fatty acid metabolic process	GO:0001676	32	0.025
nicotinamide nucleotide metabolic process	GO:0046496	28	0.025
mesoderm development	GO:0007498	2	0.025
regeneration	GO:0031099	163	0.025
protein complex biogenesis	GO:0070271	263	0.025
response to decreased oxygen levels	GO:0036293	237	0.025
nitrogen compound transport	GO:0071705	229	0.025
response to purine containing compound	GO:0014074	126	0.025
neurological system process	GO:0050877	219	0.025
blood circulation	GO:0008015	183	0.024
organic hydroxy compound metabolic process	GO:1901615	115	0.024
negative regulation of molecular function	GO:0044092	133	0.024
regulation of cellular component organization	GO:0051128	368	0.024
regulation of growth	GO:0040008	105	0.024
response to camp	GO:0051591	91	0.024
rna metabolic process	GO:0016070	406	0.023
regulation of cell development	GO:0060284	263	0.023
cellular nitrogen compound catabolic process	GO:0044270	163	0.023
exogenous drug catabolic process	GO:0042738	1	0.023
male gamete generation	GO:0048232	99	0.023
signal release	GO:0023061	145	0.023
cellular response to xenobiotic stimulus	GO:0071466	19	0.022
regulation of cellular ketone metabolic process	GO:0010565	27	0.022
response to toxic substance	GO:0009636	133	0.022
organic cyclic compound catabolic process	GO:1901361	175	0.022
regulation of system process	GO:0044057	208	0.022
cellular homeostasis	GO:0019725	252	0.022
vesicle mediated transport	GO:0016192	181	0.022
serine family amino acid biosynthetic process	GO:0009070	4	0.022
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.022
response to ionizing radiation	GO:0010212	59	0.022
positive regulation of secretion	GO:0051047	140	0.021
response to hypoxia	GO:0001666	231	0.021
positive regulation of neurogenesis	GO:0050769	165	0.021
protein complex subunit organization	GO:0071822	302	0.021
negative regulation of multicellular organismal process	GO:0051241	203	0.021
positive regulation of developmental process	GO:0051094	283	0.021
steroid metabolic process	GO:0008202	73	0.021
monosaccharide metabolic process	GO:0005996	61	0.020
positive regulation of cellular biosynthetic process	GO:0031328	295	0.020
cellular response to alcohol	GO:0097306	87	0.020
response to testosterone	GO:0033574	55	0.020
response to estradiol	GO:0032355	164	0.020
locomotion	GO:0040011	237	0.020
response to cytokine	GO:0034097	215	0.020
negative regulation of catalytic activity	GO:0043086	103	0.020
organelle organization	GO:0006996	266	0.020
response to corticosteroid	GO:0031960	235	0.020
organ morphogenesis	GO:0009887	75	0.020
cellular response to corticosteroid stimulus	GO:0071384	69	0.020
acyl coa metabolic process	GO:0006637	28	0.020
carboxylic acid catabolic process	GO:0046395	49	0.020
peptide hormone secretion	GO:0030072	84	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.020
cofactor biosynthetic process	GO:0051188	28	0.020
regulation of cellular amino acid metabolic process	GO:0006521	2	0.019
regulation of neurogenesis	GO:0050767	247	0.019
naphthalene metabolic process	GO:0018931	2	0.019
regulation of hormone secretion	GO:0046883	106	0.019
response to vitamin	GO:0033273	131	0.019
tolerance induction dependent upon immune response	GO:0002461	2	0.019
catecholamine biosynthetic process	GO:0042423	9	0.019
cell projection organization	GO:0030030	302	0.019
tetrahydrofolate metabolic process	GO:0046653	9	0.019
carbohydrate metabolic process	GO:0005975	130	0.019
glucose metabolic process	GO:0006006	52	0.018
sulfur amino acid metabolic process	GO:0000096	9	0.018
purine ribonucleoside metabolic process	GO:0046128	168	0.018
hematopoietic or lymphoid organ development	GO:0048534	36	0.018
cellular ion homeostasis	GO:0006873	184	0.018
organic acid biosynthetic process	GO:0016053	83	0.018
regulation of multicellular organismal development	GO:2000026	376	0.017
cell adhesion	GO:0007155	110	0.017
cation homeostasis	GO:0055080	195	0.017
regulation of cellular amine metabolic process	GO:0033238	8	0.017
negative regulation of signaling	GO:0023057	157	0.017
divalent inorganic cation transport	GO:0072511	134	0.017
negative regulation of transcription dna templated	GO:0045892	116	0.017
negative regulation of cell death	GO:0060548	229	0.017
phenol containing compound biosynthetic process	GO:0046189	9	0.016
pyruvate metabolic process	GO:0006090	27	0.016
cellular response to peptide	GO:1901653	133	0.016
regulation of programmed cell death	GO:0043067	341	0.016
positive regulation of cell differentiation	GO:0045597	217	0.016
circulatory system development	GO:0072359	134	0.016
growth	GO:0040007	165	0.016
peptidyl amino acid modification	GO:0018193	126	0.016
response to starvation	GO:0042594	59	0.016
cellular ketone metabolic process	GO:0042180	51	0.016
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.016
regulation of rna biosynthetic process	GO:2001141	381	0.016
transcription from rna polymerase ii promoter	GO:0006366	252	0.016
insulin secretion	GO:0030073	69	0.016
sulfur compound metabolic process	GO:0006790	70	0.016
positive regulation of gene expression	GO:0010628	244	0.016
purine nucleoside metabolic process	GO:0042278	169	0.016
nucleoside phosphate metabolic process	GO:0006753	283	0.016
protein homotetramerization	GO:0051289	25	0.016
icosanoid metabolic process	GO:0006690	38	0.015
sex differentiation	GO:0007548	113	0.015
response to lead ion	GO:0010288	33	0.015
cellular component assembly	GO:0022607	360	0.015
organic hydroxy compound transport	GO:0015850	77	0.015
lipid storage	GO:0019915	1	0.015
arachidonic acid metabolic process	GO:0019369	20	0.015
negative regulation of cell communication	GO:0010648	158	0.015
positive regulation of biosynthetic process	GO:0009891	319	0.015
regulation of cellular component biogenesis	GO:0044087	86	0.015
cellular response to oxidative stress	GO:0034599	76	0.015
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.015
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.015
vitamin transport	GO:0051180	14	0.015
erythrocyte differentiation	GO:0030218	1	0.015
organic hydroxy compound biosynthetic process	GO:1901617	51	0.015
secondary metabolite catabolic process	GO:0090487	1	0.014
hormone secretion	GO:0046879	115	0.014
regulation of body fluid levels	GO:0050878	90	0.014
regulation of neuron projection development	GO:0010975	161	0.014
small molecule biosynthetic process	GO:0044283	124	0.014
positive regulation of hormone secretion	GO:0046887	65	0.014
macromolecular complex subunit organization	GO:0043933	339	0.014
insecticide metabolic process	GO:0017143	4	0.014
transcription dna templated	GO:0006351	377	0.014
response to oxidative stress	GO:0006979	186	0.014
catechol containing compound biosynthetic process	GO:0009713	9	0.014
positive regulation of rna metabolic process	GO:0051254	203	0.014
regulation of peptide transport	GO:0090087	87	0.014
programmed cell death	GO:0012501	392	0.014
regulation of apoptotic process	GO:0042981	335	0.014
regulation of molecular function	GO:0065009	398	0.014
regulation of neuron differentiation	GO:0045664	208	0.014
response to vitamin e	GO:0033197	24	0.014
ribonucleotide metabolic process	GO:0009259	231	0.014
negative regulation of rna biosynthetic process	GO:1902679	118	0.013
cellular metal ion homeostasis	GO:0006875	172	0.013
negative regulation of response to stimulus	GO:0048585	155	0.013
myeloid cell differentiation	GO:0030099	22	0.013
regulation of immune system process	GO:0002682	123	0.013
hormone transport	GO:0009914	121	0.013
positive regulation of cellular amine metabolic process	GO:0033240	3	0.013
positive regulation of cell communication	GO:0010647	271	0.013
cytoskeleton organization	GO:0007010	111	0.013
muscle system process	GO:0003012	115	0.013
positive regulation of transcription dna templated	GO:0045893	197	0.013
regulation of insulin secretion	GO:0050796	65	0.013
response to organophosphorus	GO:0046683	102	0.013
regulation of cell projection organization	GO:0031344	175	0.013
nucleoside metabolic process	GO:0009116	179	0.013
defense response to gram negative bacterium	GO:0050829	3	0.012
insulin receptor signaling pathway	GO:0008286	24	0.012
positive regulation of phosphate metabolic process	GO:0045937	262	0.012
positive regulation of rna biosynthetic process	GO:1902680	197	0.012
negative regulation of cell proliferation	GO:0008285	119	0.012
cellular response to stress	GO:0033554	269	0.012
regulation of phosphate metabolic process	GO:0019220	349	0.012
cellular response to nitrogen compound	GO:1901699	210	0.012
response to lithium ion	GO:0010226	28	0.012
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.012
immune response	GO:0006955	104	0.012
response to interferon gamma	GO:0034341	20	0.012
cellular response to vitamin e	GO:0071306	3	0.012
actin cytoskeleton organization	GO:0030036	73	0.012
hematopoietic progenitor cell differentiation	GO:0002244	2	0.012
cell growth	GO:0016049	104	0.012
beta alanine metabolic process	GO:0019482	3	0.012
anterior posterior pattern specification	GO:0009952	1	0.012
regulation of cell growth	GO:0001558	85	0.012
head development	GO:0060322	247	0.012
regulation of catalytic activity	GO:0050790	304	0.012
purine nucleotide metabolic process	GO:0006163	229	0.012
cell cell signaling	GO:0007267	335	0.011
peptide transport	GO:0015833	97	0.011
cellular response to growth factor stimulus	GO:0071363	162	0.011
response to growth factor	GO:0070848	189	0.011
meiotic cell cycle process	GO:1903046	3	0.011
regulation of protein maturation	GO:1903317	50	0.011
response to platinum ion	GO:0070541	4	0.011
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.011
response to nicotine	GO:0035094	51	0.011
glycosyl compound metabolic process	GO:1901657	182	0.011
intracellular signal transduction	GO:0035556	314	0.011
cellular response to carbohydrate stimulus	GO:0071322	72	0.011
response to muscle activity involved in regulation of muscle adaptation	GO:0014873	2	0.011
cellular response to nutrient levels	GO:0031669	60	0.011
cellular response to glucose stimulus	GO:0071333	65	0.011
erythrocyte homeostasis	GO:0034101	2	0.011
nucleic acid templated transcription	GO:0097659	379	0.011
oxidoreduction coenzyme metabolic process	GO:0006733	31	0.011
fructose metabolic process	GO:0006000	1	0.011
hepatocyte proliferation	GO:0072574	3	0.011
sensory perception	GO:0007600	101	0.011
positive regulation of phosphorylation	GO:0042327	177	0.011
response to amino acid	GO:0043200	75	0.011
purine ribonucleotide metabolic process	GO:0009150	227	0.011
regulation of hydrolase activity	GO:0051336	143	0.011
regulation of peptide secretion	GO:0002791	82	0.011
regulation of secretion	GO:0051046	224	0.011
acetyl coa metabolic process	GO:0006084	17	0.011
positive regulation of secretion by cell	GO:1903532	128	0.011
tissue development	GO:0009888	252	0.011
hemopoiesis	GO:0030097	34	0.011
response to wounding	GO:0009611	254	0.011
response to xenobiotic stimulus	GO:0009410	23	0.011
catenin import into nucleus	GO:0035411	1	0.011
sulfur amino acid biosynthetic process	GO:0000097	5	0.011
toxin catabolic process	GO:0009407	1	0.011
single organism intracellular transport	GO:1902582	166	0.011
chromosome segregation	GO:0007059	2	0.011
multicellular organismal signaling	GO:0035637	44	0.010
reactive nitrogen species metabolic process	GO:2001057	1	0.010
apoptotic process	GO:0006915	381	0.010
cellular component movement	GO:0006928	248	0.010
response to stilbenoid	GO:0035634	1	0.010
cardiovascular system development	GO:0072358	134	0.010
negative regulation of cellular biosynthetic process	GO:0031327	161	0.010
regulation of blood circulation	GO:1903522	110	0.010
cell migration	GO:0016477	197	0.010
forebrain development	GO:0030900	98	0.010
vitamin d metabolic process	GO:0042359	4	0.010
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.010
carbohydrate derivative biosynthetic process	GO:1901137	124	0.010
positive regulation of cellular component biogenesis	GO:0044089	55	0.010
mammary gland development	GO:0030879	38	0.010
positive regulation of immune system process	GO:0002684	90	0.010
response to vitamin k	GO:0032571	4	0.010
pyridine nucleotide metabolic process	GO:0019362	28	0.010

Gnmt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
cardiovascular system disease	DOID:1287	0.041
disease of anatomical entity	DOID:7	0.041
musculoskeletal system disease	DOID:17	0.019
vascular disease	DOID:178	0.017
essential hypertension	DOID:10825	0.016
artery disease	DOID:0050828	0.016
hypertension	DOID:10763	0.016
nervous system disease	DOID:863	0.013
respiratory system disease	DOID:1579	0.013
lower respiratory tract disease	DOID:0050161	0.013
inherited metabolic disorder	DOID:655	0.011
amino acid metabolic disorder	DOID:9252	0.011
disease of metabolism	DOID:0014667	0.011

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