Rattus norvegicus

43 known processes

Ptgis

prostaglandin I2 (prostacyclin) synthase

(Aliases: PGIS)

Ptgis biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular component assemblyGO:00226073600.348
cellular response to cytokine stimulusGO:00713451270.218
Human
macromolecular complex assemblyGO:00650032730.150
protein complex subunit organizationGO:00718223020.147
macromolecular complex subunit organizationGO:00439333390.141
regulation of multicellular organismal developmentGO:20000263760.139
Human
cellular component biogenesisGO:00440853680.130
carboxylic acid metabolic processGO:00197522890.125
response to inorganic substanceGO:00100353770.125
protein oligomerizationGO:00512591910.122
programmed cell deathGO:00125013920.119
Human
cellular response to endogenous stimulusGO:00714953770.118
response to nutrientGO:00075842480.113
protein complex assemblyGO:00064612630.109
response to oxygen levelsGO:00704822650.104
response to other organismGO:00517072200.102
response to biotic stimulusGO:00096072260.097
anatomical structure morphogenesisGO:00096532980.097
Human
response to extracellular stimulusGO:00099913800.096
cellular response to oxygen containing compoundGO:19017013860.091
protein complex biogenesisGO:00702712630.081
response to mechanical stimulusGO:00096121340.081
single organism biosynthetic processGO:00447113420.079
regulation of system processGO:00440572080.078
circulatory system developmentGO:00723591340.077
Human
response to nutrient levelsGO:00316673700.075
intracellular signal transductionGO:00355563140.074
oxoacid metabolic processGO:00434362900.068
regulation of cell proliferationGO:00421273590.067
regulation of programmed cell deathGO:00430673410.062
Human
positive regulation of cell deathGO:00109421840.061
Human
response to lipopolysaccharideGO:00324961910.061
positive regulation of multicellular organismal processGO:00512403870.061
Human
response to monosaccharideGO:00342841590.060
response to external biotic stimulusGO:00432072210.060
multi multicellular organism processGO:00447061380.059
response to vitaminGO:00332731310.059
blood circulationGO:00080151830.057
cellular ketone metabolic processGO:0042180510.055
secretionGO:00469033070.055
response to hexoseGO:00097461440.055
response to bacteriumGO:00096172000.054
cellular response to hormone stimulusGO:00328702470.054
organic acid biosynthetic processGO:0016053830.053
cellular response to external stimulusGO:00714961180.053
cellular response to organic cyclic compoundGO:00714072020.053
cellular amide metabolic processGO:0043603440.052
reproductive processGO:00224143720.052
organic acid metabolic processGO:00060822920.051
positive regulation of cell proliferationGO:00082842490.050
response to molecule of bacterial originGO:00022371940.049
neuron developmentGO:00486662860.047
response to hydrogen peroxideGO:0042542890.047
response to oxidative stressGO:00069791860.047
gland developmentGO:00487321550.045
homeostatic processGO:00425923310.045
regulation of transcription dna templatedGO:00063553740.045
Human
response to glucoseGO:00097491360.045
neuron projection developmentGO:00311752730.045
rhythmic processGO:00485111560.045
Rat
response to peptideGO:19016522920.044
response to glucocorticoidGO:00513842230.044
cellular ion homeostasisGO:00068731840.044
agingGO:00075682410.043
cell adhesionGO:00071551100.043
cellular amino acid metabolic processGO:00065201070.042
positive regulation of response to stimulusGO:00485842850.041
Human
enzyme linked receptor protein signaling pathwayGO:00071671160.041
regulation of cellular localizationGO:00603412630.041
response to hyperoxiaGO:0055093450.039
organophosphate metabolic processGO:00196373700.039
response to cytokineGO:00340972150.037
Human
inflammatory responseGO:00069541500.036
Human
apoptotic processGO:00069153810.036
Human
organonitrogen compound biosynthetic processGO:19015661670.036
small molecule biosynthetic processGO:00442831240.036
cellular chemical homeostasisGO:00550822470.036
multicellular organismal reproductive processGO:00486092330.036
response to reactive oxygen speciesGO:00003021200.035
negative regulation of multicellular organismal processGO:00512412030.035
regulation of cellular component organizationGO:00511283680.035
response to transforming growth factor betaGO:0071559460.035
response to woundingGO:00096112540.035
Human
cellular amine metabolic processGO:0044106380.035
chemical homeostasisGO:00488782920.035
positive regulation of gene expressionGO:00106282440.035
response to vitamin dGO:0033280340.034
response to organophosphorusGO:00466831020.034
Rat
neuron differentiationGO:00301823680.034
cell morphogenesisGO:00009021420.034
head developmentGO:00603222470.034
tissue developmentGO:00098882520.034
cardiovascular system developmentGO:00723581340.034
Human
kidney developmentGO:0001822670.034
positive regulation of rna biosynthetic processGO:19026801970.034
reproductionGO:00000032450.033
response to ketoneGO:19016541820.033
response to decreased oxygen levelsGO:00362932370.033
response to peptide hormoneGO:00434342780.032
response to corticosteroidGO:00319602350.032
positive regulation of macromolecule biosynthetic processGO:00105572470.031
brain developmentGO:00074202470.031
regulation of cell migrationGO:00303341280.031
carbohydrate derivative metabolic processGO:19011353460.031
regulation of cellular ketone metabolic processGO:0010565270.031
amine metabolic processGO:0009308380.031
regulation of neurogenesisGO:00507672470.031
response to temperature stimulusGO:0009266940.031
response to growth factorGO:00708481890.030
renal system developmentGO:0072001670.030
oxidation reduction processGO:00551143040.030
Rat
positive regulation of nitrogen compound metabolic processGO:00511733340.030
response to tumor necrosis factorGO:0034612560.029
cellular calcium ion homeostasisGO:00068741600.029
regulation of secretion by cellGO:19035302080.029
positive regulation of phosphorus metabolic processGO:00105622620.028
cell projection organizationGO:00300303020.028
defense responseGO:00069521940.028
Human
response to carbohydrateGO:00097431830.028
positive regulation of biosynthetic processGO:00098913190.027
response to metal ionGO:00100382530.027
blood vessel developmentGO:0001568690.027
Human
regulation of cell activationGO:0050865500.027
cellular metal ion homeostasisGO:00068751720.027
regulation of phosphorus metabolic processGO:00511743490.027
regulation of rna metabolic processGO:00512523910.027
Human
response to estrogenGO:00436272320.027
regulation of cell differentiationGO:00455953200.027
biological adhesionGO:00226101100.027
vasculature developmentGO:0001944700.027
Human
positive regulation of developmental processGO:00510942830.026
Human
regulation of cell developmentGO:00602842630.026
peptide metabolic processGO:0006518320.026
response to hypoxiaGO:00016662310.026
negative regulation of apoptotic processGO:00430661810.026
response to ethanolGO:00454711620.026
reproductive structure developmentGO:00486081280.026
cellular cation homeostasisGO:00300031800.026
regulation of protein metabolic processGO:00512462890.026
cellular homeostasisGO:00197252520.026
response to campGO:0051591910.026
Rat
female pregnancyGO:00075651220.026
regulation of molecular functionGO:00650093980.026
Human
multicellular organism reproductionGO:00325042330.025
locomotionGO:00400112370.025
cellular lipid metabolic processGO:00442552080.025
positive regulation of transportGO:00510502450.025
response to amino acidGO:0043200750.025
positive regulation of rna metabolic processGO:00512542030.024
regulation of hormone levelsGO:00108171870.024
regulation of response to stressGO:00801341260.024
Human
regulation of nervous system developmentGO:00519602640.024
cellular response to abiotic stimulusGO:0071214850.024
positive regulation of cellular biosynthetic processGO:00313282950.024
protein homooligomerizationGO:0051260910.024
positive regulation of cell differentiationGO:00455972170.024
cell migrationGO:00164771970.024
sexual reproductionGO:00199531480.024
cellular modified amino acid metabolic processGO:0006575610.023
regulation of cellular amino acid metabolic processGO:000652120.023
secretion by cellGO:00329402480.023
catabolic processGO:00090563510.023
ion homeostasisGO:00508012120.023
regulation of cellular amine metabolic processGO:003323880.023
response to estradiolGO:00323551640.023
positive regulation of apoptotic processGO:00430651540.023
Human
cellular response to growth factor stimulusGO:00713631620.023
rna biosynthetic processGO:00327743800.023
Human
positive regulation of molecular functionGO:00440932300.023
divalent inorganic cation homeostasisGO:00725071650.023
protein phosphorylationGO:00064683450.023
wound healingGO:00420601220.022
positive regulation of nervous system developmentGO:00519621780.022
positive regulation of nucleobase containing compound metabolic processGO:00459353190.022
negative regulation of developmental processGO:00510931250.022
regulation of apoptotic processGO:00429813350.022
Human
cytosolic calcium ion homeostasisGO:00514801400.022
cellular response to mechanical stimulusGO:0071260480.022
response to purine containing compoundGO:00140741260.022
Rat
circulatory system processGO:00030131830.022
regulation of secretionGO:00510462240.022
positive regulation of cell developmentGO:00107201760.022
negative regulation of cell proliferationGO:00082851190.022
nucleoside phosphate metabolic processGO:00067532830.022
epithelium developmentGO:0060429960.022
cellular component movementGO:00069282480.021
positive regulation of secretion by cellGO:19035321280.021
protein heterooligomerizationGO:0051291890.021
regulation of blood circulationGO:19035221100.021
negative regulation of cell differentiationGO:0045596990.021
carboxylic acid biosynthetic processGO:0046394830.021
cell type specific apoptotic processGO:00972851340.021
gastrulationGO:000736920.020
cellular divalent inorganic cation homeostasisGO:00725031620.020
positive regulation of cell communicationGO:00106472710.020
Human
metal ion homeostasisGO:00550651860.020
regulation of locomotionGO:00400121480.020
response to toxic substanceGO:00096361330.020
positive regulation of cellular amine metabolic processGO:003324030.020
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.020
cellular response to lipidGO:00713962010.020
response to increased oxygen levelsGO:0036296450.020
regulation of blood vessel sizeGO:0050880890.020
regulation of cell motilityGO:20001451310.020
negative regulation of nervous system developmentGO:0051961790.020
organelle organizationGO:00069962660.020
positive regulation of cellular component organizationGO:00511302000.019
cell growthGO:00160491040.019
growthGO:00400071650.019
single organismal cell cell adhesionGO:0016337420.019
cation homeostasisGO:00550801950.019
nucleic acid templated transcriptionGO:00976593790.019
Human
cellular response to nitrogen compoundGO:19016992100.019
neuronal action potentialGO:0019228350.019
cellular response to tumor necrosis factorGO:0071356460.019
vascular process in circulatory systemGO:0003018960.018
single organism organelle organizationGO:19025891800.018
regulation of tube sizeGO:0035150890.018
metal ion transportGO:00300012890.018
anion transportGO:00068201780.018
response to alkaloidGO:00432791320.018
single organism cell adhesionGO:0098602460.018
central nervous system developmentGO:00074173110.018
multi organism reproductive processGO:00447032620.018
axis specificationGO:000979840.018
macromolecule localizationGO:00330362520.018
regulation of immune system processGO:00026821230.018
formation of primary germ layerGO:000170410.018
response to transition metal nanoparticleGO:19902671220.018
cellular amino acid biosynthetic processGO:0008652320.017
negative regulation of metabolic processGO:00098923310.017
Human
extracellular matrix organizationGO:0030198130.017
single organism reproductive processGO:00447022970.017
calcium ion homeostasisGO:00550741620.017
positive regulation of programmed cell deathGO:00430681570.017
Human
rna metabolic processGO:00160704060.017
Human
regulation of g0 to g1 transitionGO:007031630.017
nucleotide metabolic processGO:00091172790.017
cellular response to stressGO:00335542690.017
Human
response to interleukin 1GO:0070555550.017
Human
cellular response to alcoholGO:0097306870.017
organophosphate biosynthetic processGO:00904071430.017
heart morphogenesisGO:000300730.017
multicellular organismal signalingGO:0035637440.016
small gtpase mediated signal transductionGO:0007264360.016
immune system processGO:00023762040.016
artery developmentGO:006084030.016
positive regulation of transcription dna templatedGO:00458931970.016
urogenital system developmentGO:0001655780.016
positive regulation of hydrolase activityGO:0051345860.016
eye morphogenesisGO:004859240.016
regulation of phosphate metabolic processGO:00192203490.016
gamete generationGO:00072761240.016
positive regulation of hepatocyte differentiationGO:007036820.016
response to radiationGO:00093141370.016
signal releaseGO:00230611450.016
positive regulation of cytosolic calcium ion concentrationGO:00072041220.016
elastic fiber assemblyGO:004825110.016
cellular response to nutrient levelsGO:0031669600.016
positive regulation of cellular amino acid metabolic processGO:004576410.016
positive regulation of phosphate metabolic processGO:00459372620.015
cellular response to interleukin 1GO:0071347370.015
Human
cellular response to peptideGO:19016531330.015
embryonic appendage morphogenesisGO:003511340.015
regulation of cellular component biogenesisGO:0044087860.015
signal transduction by phosphorylationGO:00230141440.015
regulation of mapk cascadeGO:00434081160.015
cell cell signalingGO:00072673350.015
muscle system processGO:00030121150.015
ribose phosphate metabolic processGO:00196932350.015
cellular response to peptide hormone stimulusGO:00713751200.015
intracellular transportGO:00469071850.015
tissue remodelingGO:0048771400.014
organic substance catabolic processGO:19015753160.014
cation transportGO:00068123820.014
positive regulation of secretionGO:00510471400.014
transmission of nerve impulseGO:0019226420.014
odontogenesisGO:0042476320.014
neurological system processGO:00508772190.014
Rat
embryonic skeletal system morphogenesisGO:004870430.014
ras protein signal transductionGO:0007265290.014
negative regulation of programmed cell deathGO:00430691830.014
fatty acid metabolic processGO:0006631990.014
hematopoietic progenitor cell differentiationGO:000224420.014
organic anion transportGO:00157111320.014
single organism catabolic processGO:00447122830.014
regulation of phosphorylationGO:00423252480.014
cartilage developmentGO:0051216220.014
transcription dna templatedGO:00063513770.014
Human
nucleobase containing small molecule metabolic processGO:00550863160.014
response to acid chemicalGO:00011012220.014
negative regulation of macromolecule metabolic processGO:00106052600.014
peptidyl amino acid modificationGO:00181931260.014
positive regulation of cell motilityGO:2000147970.014
female sex differentiationGO:0046660590.013
response to testosteroneGO:0033574550.013
carbohydrate derivative biosynthetic processGO:19011371240.013
positive regulation of phosphorylationGO:00423271770.013
regulation of cellular protein metabolic processGO:00322682670.013
regulation of anatomical structure sizeGO:00900661350.013
actin filament based processGO:0030029860.013
cellular component morphogenesisGO:00329891550.013
carbohydrate metabolic processGO:00059751300.013
proteolysisGO:00065081750.013
cytoplasmic transportGO:00164821150.013
unsaturated fatty acid metabolic processGO:0033559390.013
localization of cellGO:00516742020.013
positive regulation of signal transductionGO:00099671750.013
Human
response to heatGO:0009408600.013
positive regulation of protein metabolic processGO:00512471780.013
dna metabolic processGO:0006259960.013
embryonic skeletal system developmentGO:004870630.013
purine nucleotide metabolic processGO:00061632290.013
regulation of neuron projection developmentGO:00109751610.013
negative regulation of cellular biosynthetic processGO:00313271610.013
Human
single organism cellular localizationGO:19025801020.013
anterior posterior pattern specificationGO:000995210.013
lipid metabolic processGO:00066292830.012
response to calcium ionGO:0051592590.012
regenerationGO:00310991630.012
positive regulation of neuron differentiationGO:00456661260.012
g protein coupled receptor signaling pathwayGO:00071862420.012
positive regulation of blood circulationGO:1903524650.012
regulation of cellular component movementGO:00512701500.012
limb morphogenesisGO:003510840.012
developmental process involved in reproductionGO:00030061590.012
transmembrane transportGO:00550854120.012
embryonic pattern specificationGO:000988010.012
negative regulation of cell developmentGO:0010721820.012
cellular response to extracellular stimulusGO:0031668730.012
action potentialGO:0001508540.012
female gonad developmentGO:0008585530.012
regulation of muscle system processGO:0090257790.012
positive regulation of catalytic activityGO:00430851840.012
establishment of protein localizationGO:00451841410.012
positive regulation of cellular protein metabolic processGO:00322701670.012
response to fatty acidGO:0070542650.012
response to fibroblast growth factorGO:0071774290.012
regulation of neuron apoptotic processGO:0043523830.011
cytokine mediated signaling pathwayGO:0019221430.011
ovulation cycleGO:0042698670.011
positive regulation of nucleic acid templated transcriptionGO:19035081970.011
axon ensheathmentGO:0008366400.011
organonitrogen compound catabolic processGO:19015651790.011
sex differentiationGO:00075481130.011
cellular response to metal ionGO:0071248550.011
cellular response to oxygen levelsGO:0071453600.011
Human
collagen fibril organizationGO:003019910.011
purine ribonucleotide metabolic processGO:00091502270.011
positive regulation of protein transportGO:0051222410.011
regulation of blood pressureGO:0008217830.011
leukotriene biosynthetic processGO:001937030.011
protein localizationGO:00081041910.011
transforming growth factor beta receptor signaling pathwayGO:0007179180.011
glycosyl compound metabolic processGO:19016571820.011
purine containing compound metabolic processGO:00725212530.011
response to mineralocorticoidGO:0051385490.011
regulation of cell adhesionGO:0030155520.011
positive regulation of protein modification processGO:00314011420.011
nitrogen compound transportGO:00717052290.011
cellular catabolic processGO:00442482950.011
glucose homeostasisGO:0042593750.011
sequestering of metal ionGO:005123890.011
regulation of cell growthGO:0001558850.011
tube developmentGO:0035295890.010
retinal metabolic processGO:004257430.010
regulation of nucleic acid templated transcriptionGO:19035063800.010
Human
protein transportGO:00150311320.010
synaptic transmissionGO:00072682350.010
cellular response to inorganic substanceGO:0071241650.010
rho protein signal transductionGO:0007266110.010
cell part morphogenesisGO:00329901230.010
response to retinoic acidGO:0032526630.010
positive regulation of protein phosphorylationGO:00019341350.010
single organism carbohydrate metabolic processGO:00447231180.010
regulation of response to woundingGO:1903034690.010
Human
nucleoside metabolic processGO:00091161790.010
regulation of rna biosynthetic processGO:20011413810.010
Human
vesicle mediated transportGO:00161921810.010
positive regulation of signalingGO:00230562700.010
Human

Ptgis disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.058
Human
musculoskeletal system diseaseDOID:1700.058
nervous system diseaseDOID:86300.017
connective tissue diseaseDOID:6500.012
bone diseaseDOID:008000100.012
osteochondrodysplasiaDOID:225600.012
bone development diseaseDOID:008000600.012