Rattus norvegicus

16 known processes

Ctsk

cathepsin K

Ctsk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to nutrientGO:00075842480.319
cellular response to endogenous stimulusGO:00714953770.294
response to inorganic substanceGO:00100353770.244
response to cytokineGO:00340972150.225
cellular response to oxygen containing compoundGO:19017013860.225
response to estrogenGO:00436272320.217
locomotionGO:00400112370.215
response to woundingGO:00096112540.202
tissue developmentGO:00098882520.192
Rat
response to estradiolGO:00323551640.188
cellular response to cytokine stimulusGO:00713451270.181
cellular response to peptide hormone stimulusGO:00713751200.163
response to corticosteroidGO:00319602350.157
Rat
cellular response to hormone stimulusGO:00328702470.144
cellular response to organic cyclic compoundGO:00714072020.135
macromolecular complex subunit organizationGO:00439333390.126
response to metal ionGO:00100382530.126
response to molecule of bacterial originGO:00022371940.121
cellular response to peptideGO:19016531330.120
cellular response to external stimulusGO:00714961180.119
Rat
kidney developmentGO:0001822670.118
response to peptide hormoneGO:00434342780.117
cellular response to lipidGO:00713962010.109
response to biotic stimulusGO:00096072260.108
cell motilityGO:00488702020.107
cellular response to tumor necrosis factorGO:0071356460.105
embryonic skeletal system developmentGO:004870630.104
cellular component assemblyGO:00226073600.103
urogenital system developmentGO:0001655780.103
response to peptideGO:19016522920.103
response to mechanical stimulusGO:00096121340.096
Zebrafish
reproductive processGO:00224143720.096
Rat
response to tumor necrosis factorGO:0034612560.096
response to vitaminGO:00332731310.094
response to nutrient levelsGO:00316673700.093
Rat
response to lipopolysaccharideGO:00324961910.091
wound healingGO:00420601220.090
positive regulation of multicellular organismal processGO:00512403870.089
renal system developmentGO:0072001670.088
cellular response to transforming growth factor beta stimulusGO:0071560410.088
agingGO:00075682410.088
Rat
regulation of cell motilityGO:20001451310.087
growthGO:00400071650.085
cellular response to growth factor stimulusGO:00713631620.085
positive regulation of cellular biosynthetic processGO:00313282950.084
response to acid chemicalGO:00011012220.083
cellular component biogenesisGO:00440853680.080
response to amino acidGO:0043200750.077
protein complex subunit organizationGO:00718223020.076
response to bacteriumGO:00096172000.076
protein complex assemblyGO:00064612630.076
developmental process involved in reproductionGO:00030061590.074
Rat
localization of cellGO:00516742020.072
positive regulation of nucleobase containing compound metabolic processGO:00459353190.072
response to transition metal nanoparticleGO:19902671220.071
cellular component movementGO:00069282480.071
circulatory system developmentGO:00723591340.071
cellular response to organonitrogen compoundGO:00714171970.070
cardiovascular system developmentGO:00723581340.070
blood vessel developmentGO:0001568690.066
response to growth factorGO:00708481890.065
reproductive system developmentGO:00614581280.065
Rat
positive regulation of biosynthetic processGO:00098913190.061
peptide cross linkingGO:001814910.060
positive regulation of gene expressionGO:00106282440.060
response to purine containing compoundGO:00140741260.059
macromolecular complex assemblyGO:00650032730.058
response to oxidative stressGO:00069791860.058
intracellular signal transductionGO:00355563140.058
programmed cell deathGO:00125013920.056
Rat
protein complex biogenesisGO:00702712630.054
anatomical structure morphogenesisGO:00096532980.054
brain developmentGO:00074202470.053
eye developmentGO:0001654500.053
skeletal system developmentGO:0001501410.052
organic acid metabolic processGO:00060822920.051
positive regulation of macromolecule biosynthetic processGO:00105572470.050
cellular response to nitrogen compoundGO:19016992100.049
reproductive structure developmentGO:00486081280.049
Rat
eye morphogenesisGO:004859240.048
response to campGO:0051591910.048
regulation of phosphate metabolic processGO:00192203490.047
response to fibroblast growth factorGO:0071774290.046
tube developmentGO:0035295890.045
neuron deathGO:00709971270.044
positive regulation of nitrogen compound metabolic processGO:00511733340.044
response to extracellular stimulusGO:00099913800.044
Rat
apoptotic processGO:00069153810.043
response to monosaccharideGO:00342841590.042
Rat
response to transforming growth factor betaGO:0071559460.042
oxoacid metabolic processGO:00434362900.042
regulation of catalytic activityGO:00507903040.042
cellular response to ketoneGO:1901655510.042
gastrulationGO:000736920.042
response to ketoneGO:19016541820.041
cellular homeostasisGO:00197252520.041
non canonical wnt signaling pathwayGO:003556730.041
neurological system processGO:00508772190.041
carbohydrate derivative metabolic processGO:19011353460.041
cell migrationGO:00164771970.040
response to glucoseGO:00097491360.039
Rat
regulation of cell proliferationGO:00421273590.039
central nervous system developmentGO:00074173110.039
organ morphogenesisGO:0009887750.039
regulation of cell developmentGO:00602842630.038
collagen fibril organizationGO:003019910.038
vasculature developmentGO:0001944700.038
response to organophosphorusGO:00466831020.038
regulation of phosphorus metabolic processGO:00511743490.038
positive regulation of phosphorylationGO:00423271770.038
response to retinoic acidGO:0032526630.038
negative regulation of multicellular organismal processGO:00512412030.037
positive regulation of developmental processGO:00510942830.037
protein phosphorylationGO:00064683450.037
response to glucocorticoidGO:00513842230.037
Rat
positive regulation of cellular component movementGO:00512721020.037
positive regulation of response to stimulusGO:00485842850.037
artery developmentGO:006084030.036
single organism reproductive processGO:00447022970.036
Rat
rna metabolic processGO:00160704060.036
response to radiationGO:00093141370.036
negative regulation of gene expressionGO:00106291990.036
positive regulation of rna biosynthetic processGO:19026801970.036
cellular catabolic processGO:00442482950.035
Human
positive regulation of cell differentiationGO:00455972170.035
carboxylic acid metabolic processGO:00197522890.035
regulation of signal transductionGO:00099663180.035
protein transportGO:00150311320.035
aorta developmentGO:003590420.035
homeostatic processGO:00425923310.034
regulation of hormone levelsGO:00108171870.034
regenerationGO:00310991630.034
protein oligomerizationGO:00512591910.034
odontogenesisGO:0042476320.034
response to hexoseGO:00097461440.033
Rat
cellular ion homeostasisGO:00068731840.033
rhythmic processGO:00485111560.033
ossificationGO:0001503700.033
multi organism reproductive processGO:00447032620.032
Rat
regulation of molecular functionGO:00650093980.032
cellular response to steroid hormone stimulusGO:0071383930.032
reproductionGO:00000032450.032
Rat
developmental growthGO:00485891000.031
regulation of phosphorylationGO:00423252480.031
regulation of cellular component movementGO:00512701500.031
transcription dna templatedGO:00063513770.031
positive regulation of molecular functionGO:00440932300.031
regulation of protein modification processGO:00313991940.031
transforming growth factor beta receptor signaling pathwayGO:0007179180.031
positive regulation of nucleic acid templated transcriptionGO:19035081970.030
positive regulation of phosphate metabolic processGO:00459372620.030
regulation of apoptotic processGO:00429813350.030
chemical homeostasisGO:00488782920.030
extracellular matrix organizationGO:0030198130.029
regulation of nervous system developmentGO:00519602640.029
regulation of rna biosynthetic processGO:20011413810.029
connective tissue developmentGO:0061448330.029
cartilage developmentGO:0051216220.028
establishment of protein localizationGO:00451841410.028
cell cell signalingGO:00072673350.028
transcription from rna polymerase ii promoterGO:00063662520.027
response to carbohydrateGO:00097431830.027
Rat
single organism biosynthetic processGO:00447113420.027
oxidation reduction processGO:00551143040.027
positive regulation of cell deathGO:00109421840.027
negative regulation of programmed cell deathGO:00430691830.027
head developmentGO:00603222470.026
formation of primary germ layerGO:000170410.026
cellular ketone metabolic processGO:0042180510.026
negative regulation of response to stimulusGO:00485851550.026
response to oxygen levelsGO:00704822650.026
sex differentiationGO:00075481130.026
Rat
lipid biosynthetic processGO:00086101280.026
regulation of multicellular organismal developmentGO:20000263760.025
response to hydrogen peroxideGO:0042542890.025
positive regulation of cell communicationGO:00106472710.025
ras protein signal transductionGO:0007265290.025
tissue remodelingGO:0048771400.025
immune system processGO:00023762040.025
response to interleukin 1GO:0070555550.025
female pregnancyGO:00075651220.025
Rat
positive regulation of nervous system developmentGO:00519621780.024
negative regulation of macromolecule metabolic processGO:00106052600.024
alcohol metabolic processGO:0006066770.024
cell projection organizationGO:00300303020.024
small gtpase mediated signal transductionGO:0007264360.024
positive regulation of signal transductionGO:00099671750.024
regulation of programmed cell deathGO:00430673410.023
organic substance catabolic processGO:19015753160.023
Human
behaviorGO:00076102050.023
regulation of neuron deathGO:19012141150.023
neuron differentiationGO:00301823680.023
embryo developmentGO:0009790490.023
negative regulation of nucleobase containing compound metabolic processGO:00459341530.023
inflammatory responseGO:00069541500.023
gonad developmentGO:00084061040.022
Rat
catabolic processGO:00090563510.022
Human
positive regulation of transcription dna templatedGO:00458931970.022
positive regulation of non canonical wnt signaling pathwayGO:200005210.022
cellular response to retinoic acidGO:0071300270.022
cellular amino acid metabolic processGO:00065201070.022
response to reactive oxygen speciesGO:00003021200.022
regulation of cell differentiationGO:00455953200.021
receptor mediated endocytosisGO:0006898420.021
positive regulation of rna metabolic processGO:00512542030.021
regulation of cellular component organizationGO:00511283680.021
heart morphogenesisGO:000300730.021
regulation of nucleic acid templated transcriptionGO:19035063800.021
regulation of locomotionGO:00400121480.021
purine ribonucleotide metabolic processGO:00091502270.021
organic hydroxy compound metabolic processGO:19016151150.021
peptidyl amino acid modificationGO:00181931260.021
regulation of neurogenesisGO:00507672470.021
response to hyperoxiaGO:0055093450.020
negative regulation of biosynthetic processGO:00098901680.020
regulation of cellular ketone metabolic processGO:0010565270.020
intracellular transportGO:00469071850.020
enzyme linked receptor protein signaling pathwayGO:00071671160.020
negative regulation of cell proliferationGO:00082851190.020
wnt signaling pathway planar cell polarity pathwayGO:006007120.020
calcium ion transport from endoplasmic reticulum to cytosolGO:190351440.020
sulfur compound metabolic processGO:0006790700.020
cellular response to vitaminGO:0071295210.020
cellular chemical homeostasisGO:00550822470.020
cellular response to metal ionGO:0071248550.020
nucleic acid templated transcriptionGO:00976593790.020
anatomical structure formation involved in morphogenesisGO:0048646830.019
negative regulation of macromolecule biosynthetic processGO:00105581480.019
negative regulation of metabolic processGO:00098923310.019
cation homeostasisGO:00550801950.019
neuron projection developmentGO:00311752730.019
respiratory system developmentGO:0060541450.019
sensory organ developmentGO:0007423740.019
positive regulation of neurogenesisGO:00507691650.019
proteolysisGO:00065081750.019
Human Rat
response to x rayGO:0010165150.019
positive regulation of protein metabolic processGO:00512471780.018
cellular amine metabolic processGO:0044106380.018
positive regulation of phosphorus metabolic processGO:00105622620.018
negative regulation of cellular biosynthetic processGO:00313271610.018
cellular response to vitamin eGO:007130630.018
ribonucleotide metabolic processGO:00092592310.018
blood circulationGO:00080151830.018
organophosphate metabolic processGO:00196373700.018
response to alkaloidGO:00432791320.018
small molecule biosynthetic processGO:00442831240.018
secretion by cellGO:00329402480.018
mast cell migrationGO:009753140.018
negative regulation of innate immune responseGO:004582440.018
cellular response to stressGO:00335542690.018
Rat
rna biosynthetic processGO:00327743800.018
negative regulation of signalingGO:00230571570.017
cellular response to glucocorticoid stimulusGO:0071385680.017
cellular hormone metabolic processGO:0034754490.017
response to temperature stimulusGO:0009266940.017
multi multicellular organism processGO:00447061380.017
Rat
regulation of canonical wnt signaling pathwayGO:006082840.017
positive regulation of signalingGO:00230562700.017
negative regulation of cell deathGO:00605482290.017
positive regulation of intracellular signal transductionGO:19025331380.017
response to external biotic stimulusGO:00432072210.017
cellular response to alcoholGO:0097306870.017
single organism intracellular transportGO:19025821660.017
sequestering of metal ionGO:005123890.017
gland developmentGO:00487321550.017
amine metabolic processGO:0009308380.017
response to increased oxygen levelsGO:0036296450.017
digestive tract developmentGO:0048565390.017
organic acid biosynthetic processGO:0016053830.017
positive regulation of neuron differentiationGO:00456661260.017
positive regulation of programmed cell deathGO:00430681570.016
positive regulation of cell developmentGO:00107201760.016
regulation of rna metabolic processGO:00512523910.016
embryonic skeletal system morphogenesisGO:004870430.016
positive regulation of cell proliferationGO:00082842490.016
circulatory system processGO:00030131830.016
respiratory tube developmentGO:0030323430.016
cellular response to nutrientGO:0031670300.016
regulation of cytokine productionGO:0001817560.016
calcium ion homeostasisGO:00550741620.015
response to zinc ionGO:0010043390.015
negative regulation of molecular functionGO:00440921330.015
organonitrogen compound catabolic processGO:19015651790.015
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178270.015
camera type eye morphogenesisGO:004859320.015
development of primary sexual characteristicsGO:00451371070.015
Rat
multicellular organismal reproductive processGO:00486092330.015
Rat
regulation of growthGO:00400081050.015
cellular response to nutrient levelsGO:0031669600.015
Rat
cellular metal ion homeostasisGO:00068751720.015
response to ionizing radiationGO:0010212590.015
negative regulation of cellular metabolic processGO:00313242810.015
positive regulation of cellular component organizationGO:00511302000.014
rho protein signal transductionGO:0007266110.014
regulation of cellular protein metabolic processGO:00322682670.014
cellular response to fibroblast growth factor stimulusGO:0044344240.014
cartilage development involved in endochondral bone morphogenesisGO:006035130.014
endocrine system developmentGO:0035270300.014
positive regulation of cell migrationGO:0030335960.014
response to nicotineGO:0035094510.014
regulation of response to stressGO:00801341260.014
regulation of homeostatic processGO:00328441010.014
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.014
negative regulation of cell communicationGO:00106481580.014
regulation of cellular amino acid metabolic processGO:000652120.014
cellular response to alkaloidGO:0071312250.014
vesicle mediated transportGO:00161921810.014
cellular response to lipopolysaccharideGO:0071222550.014
positive regulation of cytokine productionGO:0001819420.014
positive regulation of stem cell differentiationGO:200073820.014
regulation of transcription dna templatedGO:00063553740.014
cellular response to acid chemicalGO:0071229750.014
striated muscle tissue developmentGO:0014706580.014
positive regulation of apoptotic processGO:00430651540.014
cellular cation homeostasisGO:00300031800.014
cellular calcium ion homeostasisGO:00068741600.013
cellular response to interleukin 1GO:0071347370.013
negative regulation of apoptotic processGO:00430661810.013
neuron apoptotic processGO:0051402880.013
negative regulation of nitrogen compound metabolic processGO:00511721610.013
release of sequestered calcium ion into cytosol by sarcoplasmic reticulumGO:001480840.013
regulation of intracellular signal transductionGO:19025312180.013
cation transportGO:00068123820.013
forebrain developmentGO:0030900980.013
regulation of mapk cascadeGO:00434081160.013
positive regulation of cellular protein metabolic processGO:00322701670.013
regulation of protein transportGO:0051223680.013
regulation of metanephros developmentGO:007221540.013
renin secretion into blood streamGO:000200110.013
response to other organismGO:00517072200.013
cellular response to hexose stimulusGO:0071331650.013
circadian rhythmGO:0007623880.013
positive regulation of neuron projection developmentGO:0010976990.013
regulation of cellular localizationGO:00603412630.013
positive regulation of catalytic activityGO:00430851840.013
salivary gland developmentGO:000743130.013
negative regulation of rna biosynthetic processGO:19026791180.013
regulation of neuron projection developmentGO:00109751610.013
mapk cascadeGO:00001651400.013
purine containing compound biosynthetic processGO:0072522850.013
cell adhesionGO:00071551100.012
response to dexamethasoneGO:0071548490.012
multicellular organism reproductionGO:00325042330.012
Rat
positive regulation of locomotionGO:00400171020.012
nucleotide metabolic processGO:00091172790.012
regulation of protein phosphorylationGO:00019321830.012
macromolecule localizationGO:00330362520.012
sexual reproductionGO:00199531480.012
Rat
elastic fiber assemblyGO:004825110.012
galactolipid catabolic processGO:001937610.012
camera type eye developmentGO:0043010480.012
nucleobase containing small molecule metabolic processGO:00550863160.012
secretionGO:00469033070.012
negative regulation of protein metabolic processGO:00512481140.012
negative regulation of neurogenesisGO:0050768780.012
cellular response to molecule of bacterial originGO:0071219560.012
organelle localizationGO:0051640550.012
regulation of cell projection organizationGO:00313441750.012
response to vitamin aGO:0033189360.012
synaptic transmissionGO:00072682350.012
cyclic nucleotide metabolic processGO:0009187800.012
regulation of transferase activityGO:00513381230.012
response to insulinGO:00328681330.011
positive regulation of protein transportGO:0051222410.011
cellular response to interleukin 2GO:007135210.011
cellular response to inorganic substanceGO:0071241650.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.011
axon developmentGO:0061564960.011
negative regulation of catalytic activityGO:00430861030.011
regulation of embryonic developmentGO:004599520.011
ribose phosphate metabolic processGO:00196932350.011
male gamete generationGO:0048232990.011
Rat
regulation of cellular amine metabolic processGO:003323880.011
regulation of cellular catabolic processGO:00313291010.011
proteoglycan metabolic processGO:000602930.011
heart developmentGO:0007507720.011
cellular response to mechanical stimulusGO:0071260480.011
response to hypoxiaGO:00016662310.011
regulation of transcription from rna polymerase ii promoterGO:00063572340.011
organonitrogen compound biosynthetic processGO:19015661670.011
cellular response to reactive oxygen speciesGO:0034614550.011
muscle organ developmentGO:0007517500.011
cell growthGO:00160491040.011
sequestering of calcium ionGO:005120880.011
cellular response to biotic stimulusGO:0071216590.011
ion homeostasisGO:00508012120.011
response to activityGO:0014823730.011
cytoplasmic transportGO:00164821150.011
multicellular organism growthGO:003526410.011
positive regulation of immune system processGO:0002684900.011
cellular response to glucose stimulusGO:0071333650.011
purine containing compound metabolic processGO:00725212530.011
ribonucleotide biosynthetic processGO:0009260850.010
digestive system developmentGO:0055123410.010
intracellular protein transportGO:0006886790.010
axis elongationGO:000340120.010
regulation of cell growthGO:0001558850.010
action potentialGO:0001508540.010
morphogenesis of a polarized epitheliumGO:000173810.010
hormone secretionGO:00468791150.010
hematopoietic progenitor cell differentiationGO:000224420.010
response to ethanolGO:00454711620.010
cytokine productionGO:0001816610.010
signal releaseGO:00230611450.010
steroid metabolic processGO:0008202730.010
transmission of nerve impulseGO:0019226420.010
lung developmentGO:0030324430.010
multicellular organismal signalingGO:0035637440.010
regulation of stem cell differentiationGO:200073620.010
neuron developmentGO:00486662860.010

Ctsk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.074
musculoskeletal system diseaseDOID:1700.074
sensory system diseaseDOID:005015500.030
eye and adnexa diseaseDOID:149200.030
retinal degenerationDOID:846600.030
eye diseaseDOID:561400.030
nervous system diseaseDOID:86300.030
retinal diseaseDOID:567900.030
cancerDOID:16200.014
organ system cancerDOID:005068600.014
disease of cellular proliferationDOID:1456600.014
connective tissue diseaseDOID:6500.013