Rattus norvegicus

78 known processes

Ctsb

cathepsin B

Ctsb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell motilityGO:00488702020.384
organic substance catabolic processGO:19015753160.371
Human
regulation of cellular component movementGO:00512701500.328
carboxylic acid metabolic processGO:00197522890.293
regulation of programmed cell deathGO:00430673410.282
single organism carbohydrate catabolic processGO:0044724400.266
autophagic cell deathGO:004810240.256
Fly
multicellular organism reproductionGO:00325042330.249
single organism catabolic processGO:00447122830.249
Human
dna geometric changeGO:003239240.239
pentose metabolic processGO:001932180.238
negative regulation of cell deathGO:00605482290.233
regulation of blood coagulationGO:003019390.221
regulation of apoptotic processGO:00429813350.206
response to growth factorGO:00708481890.176
hepaticobiliary system developmentGO:0061008900.167
oxoacid metabolic processGO:00434362900.161
positive regulation of cell migrationGO:0030335960.153
regulation of cell proliferationGO:00421273590.153
monocarboxylic acid metabolic processGO:00327871520.152
keratan sulfate metabolic processGO:004233910.147
regulation of sperm motilityGO:190131720.142
hepatocyte differentiationGO:007036580.142
catabolic processGO:00090563510.140
regulation of cell motilityGO:20001451310.134
response to peptideGO:19016522920.126
negative regulation of coagulationGO:005081970.125
response to metal ionGO:00100382530.124
organic acid metabolic processGO:00060822920.121
reproductive processGO:00224143720.117
coagulationGO:0050817280.116
positive regulation of cellular component organizationGO:00511302000.114
regulation of body fluid levelsGO:0050878900.109
locomotionGO:00400112370.104
positive regulation of cell motilityGO:2000147970.102
regulation of neurogenesisGO:00507672470.097
multicellular organismal reproductive processGO:00486092330.095
vesicle mediated transportGO:00161921810.094
organic acid biosynthetic processGO:0016053830.094
pentose phosphate shunt non oxidative branchGO:000905240.091
lymphocyte activationGO:0046649430.090
positive regulation of cell differentiationGO:00455972170.088
t cell activationGO:0042110290.087
regulation of hormone levelsGO:00108171870.087
regulation of cellular component organizationGO:00511283680.085
cellular amide metabolic processGO:0043603440.085
regulation of cell projection organizationGO:00313441750.084
estrous cycle phaseGO:0060206150.083
angiogenesisGO:0001525530.082
positive regulation of cell developmentGO:00107201760.078
single organism reproductive processGO:00447022970.078
regulation of protein metabolic processGO:00512462890.076
regulation of neuron differentiationGO:00456642080.075
regulation of nervous system developmentGO:00519602640.074
organonitrogen compound catabolic processGO:19015651790.074
synaptic transmissionGO:00072682350.073
multi organism reproductive processGO:00447032620.073
multicellular organismal homeostasisGO:0048871490.072
response to glucocorticoidGO:00513842230.070
rubidium ion transportGO:003582610.068
carbohydrate derivative metabolic processGO:19011353460.068
negative regulation of hemostasisGO:190004760.066
sexual reproductionGO:00199531480.066
protein maturationGO:0051604680.064
negative regulation of response to stimulusGO:00485851550.064
programmed cell deathGO:00125013920.063
Fly
response to glucoseGO:00097491360.062
macrophage chemotaxisGO:004824620.060
cell projection organizationGO:00300303020.058
cellular catabolic processGO:00442482950.058
localization of cellGO:00516742020.057
positive regulation of nervous system developmentGO:00519621780.057
single organism intracellular transportGO:19025821660.057
positive regulation of signal transductionGO:00099671750.056
negative regulation of cell proliferationGO:00082851190.055
positive regulation of developmental processGO:00510942830.055
regulation of hemostasisGO:190004690.054
positive regulation of multicellular organismal processGO:00512403870.054
membrane organizationGO:0061024940.054
synaptic vesicle endocytosisGO:004848840.053
tissue homeostasisGO:0001894280.053
response to hexoseGO:00097461440.052
carbohydrate catabolic processGO:0016052400.051
lipid metabolic processGO:00066292830.051
homeostatic processGO:00425923310.050
regulation of cellular protein metabolic processGO:00322682670.050
peptide metabolic processGO:0006518320.050
carbohydrate derivative catabolic processGO:19011361470.049
positive regulation of protein phosphorylationGO:00019341350.049
regulation of cell differentiationGO:00455953200.049
hexose catabolic processGO:0019320100.049
head developmentGO:00603222470.049
neuron differentiationGO:00301823680.048
pyridine containing compound metabolic processGO:0072524320.048
fatty acid metabolic processGO:0006631990.048
cellular ketone metabolic processGO:0042180510.047
peptide catabolic processGO:004317150.047
regulation of angiotensin metabolic processGO:006017730.047
regulation of cell cell adhesionGO:0022407140.047
enzyme linked receptor protein signaling pathwayGO:00071671160.046
carboxylic acid biosynthetic processGO:0046394830.045
positive regulation of cell projection organizationGO:00313461110.043
hemostasisGO:0007599260.043
antigen processing and presentationGO:001988220.043
regulation of systemic arterial blood pressure by circulatory renin angiotensinGO:000199140.043
response to nutrient levelsGO:00316673700.043
positive regulation of gene expressionGO:00106282440.042
multi multicellular organism processGO:00447061380.042
Mouse
cellular component movementGO:00069282480.042
cell substrate adhesionGO:0031589290.042
positive regulation of angiogenesisGO:0045766280.042
neuron projection developmentGO:00311752730.042
response to inorganic substanceGO:00100353770.041
protein phosphorylationGO:00064683450.041
male mating behaviorGO:006017930.041
negative regulation of cell communicationGO:00106481580.041
single organism carbohydrate metabolic processGO:00447231180.040
response to acid chemicalGO:00011012220.039
reproductionGO:00000032450.039
sulfur compound catabolic processGO:004427330.039
t cell proliferationGO:0042098190.039
epithelial cell differentiationGO:0030855710.038
Human
cellular lipid metabolic processGO:00442552080.038
regulation of signal transductionGO:00099663180.038
positive regulation of cellular component movementGO:00512721020.038
response to corticosteroidGO:00319602350.038
regulation of cell migrationGO:00303341280.038
regulation of molecular functionGO:00650093980.038
positive regulation of neurogenesisGO:00507691650.037
hexose metabolic processGO:0019318580.037
leukocyte proliferationGO:0070661290.037
regulation of locomotionGO:00400121480.036
regulation of response to stressGO:00801341260.036
calcium ion importGO:0070509220.036
chemical homeostasisGO:00488782920.036
sulfur compound metabolic processGO:0006790700.036
negative regulation of response to woundingGO:1903035230.036
regulation of coagulationGO:0050818110.035
regulation of cellular ketone metabolic processGO:0010565270.035
cellular amino acid metabolic processGO:00065201070.035
epithelium developmentGO:0060429960.034
Human
positive regulation of locomotionGO:00400171020.034
cell activationGO:0001775970.034
regulation of phosphorylationGO:00423252480.034
positive regulation of neuron differentiationGO:00456661260.034
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.034
amine metabolic processGO:0009308380.034
lymphocyte proliferationGO:0046651290.033
cellular response to oxygen containing compoundGO:19017013860.032
protein localization to membraneGO:0072657360.032
fatty acid derivative metabolic processGO:1901568380.032
female pregnancyGO:00075651220.032
Mouse
protein autoprocessingGO:001654070.032
apoptotic processGO:00069153810.031
dna duplex unwindingGO:003250830.031
monosaccharide catabolic processGO:0046365100.031
positive regulation of protein metabolic processGO:00512471780.031
negative regulation of lipase activityGO:006019230.030
peptidyl tyrosine phosphorylationGO:0018108720.030
fatty acid biosynthetic processGO:0006633330.030
positive regulation of phosphorus metabolic processGO:00105622620.030
cellular response to stressGO:00335542690.029
cell type specific apoptotic processGO:00972851340.029
ribose phosphate metabolic processGO:00196932350.029
regulation of cellular amine metabolic processGO:003323880.029
organophosphate metabolic processGO:00196373700.029
spermatogenesisGO:0007283990.029
cellular response to endogenous stimulusGO:00714953770.029
Human
negative regulation of signalingGO:00230571570.029
cellular response to hormone stimulusGO:00328702470.028
Human
response to lead ionGO:0010288330.028
protein localizationGO:00081041910.028
positive regulation of neuron projection developmentGO:0010976990.028
cell growthGO:00160491040.028
metal ion homeostasisGO:00550651860.028
endocytosisGO:0006897840.028
positive regulation of cell communicationGO:00106472710.028
macromolecule localizationGO:00330362520.028
antigen processing and presentation of peptide antigenGO:004800220.027
skin morphogenesisGO:004358920.027
response to estrogenGO:00436272320.027
regulation of blood pressureGO:0008217830.027
liver developmentGO:0001889900.027
small molecule biosynthetic processGO:00442831240.027
dendritic spine developmentGO:0060996200.027
cell adhesionGO:00071551100.026
nadp metabolic processGO:0006739130.026
regulation of secretionGO:00510462240.026
male sex differentiationGO:0046661640.026
response to radiationGO:00093141370.026
negative regulation of programmed cell deathGO:00430691830.026
response to gonadotropinGO:0034698340.025
peptidyl amino acid modificationGO:00181931260.025
response to cytokineGO:00340972150.025
ribose phosphate biosynthetic processGO:0046390870.025
regulation of cellular localizationGO:00603412630.025
epithelial cell migrationGO:0010631190.025
icosanoid metabolic processGO:0006690380.025
pentose phosphate shuntGO:000609880.025
carbohydrate metabolic processGO:00059751300.024
antigen processing and presentation of exogenous peptide antigen via mhc class iiGO:001988610.024
anatomical structure morphogenesisGO:00096532980.024
Fly
regulation of dendrite developmentGO:0050773590.024
tissue developmentGO:00098882520.024
protein targeting to plasma membraneGO:007266140.023
regulation of cell developmentGO:00602842630.023
brain developmentGO:00074202470.023
regulation of epithelial cell proliferationGO:0050678490.023
eosinophil migrationGO:007267730.023
biological phaseGO:0044848170.022
gland developmentGO:00487321550.022
Fly
biological adhesionGO:00226101100.022
negative regulation of signal transductionGO:0009968830.022
ion transmembrane transportGO:00342203650.022
regulation of phosphorus metabolic processGO:00511743490.022
protein processingGO:0016485680.022
regulation of protein modification processGO:00313991940.022
dna metabolic processGO:0006259960.022
proteolysisGO:00065081750.022
regulation of rna biosynthetic processGO:20011413810.021
unsaturated fatty acid biosynthetic processGO:0006636210.021
monosaccharide metabolic processGO:0005996610.021
neuron developmentGO:00486662860.021
cellular response to nutrient levelsGO:0031669600.021
positive regulation of cell deathGO:00109421840.021
response to purine containing compoundGO:00140741260.021
exocytosisGO:0006887600.021
synaptic vesicle localizationGO:0097479240.021
regulation of multicellular organismal developmentGO:20000263760.021
negative regulation of transportGO:00510511360.020
regulation of angiotensin levels in bloodGO:000200220.020
reproductive structure developmentGO:00486081280.020
Mouse
response to campGO:0051591910.020
blood circulationGO:00080151830.020
negative regulation of wound healingGO:006104580.020
gliogenesisGO:0042063930.020
glial cell differentiationGO:0010001650.019
establishment of protein localizationGO:00451841410.019
positive regulation of cellular protein metabolic processGO:00322701670.018
positive regulation of cellular amino acid metabolic processGO:004576410.018
regulation of leukocyte proliferationGO:0070663260.018
ion homeostasisGO:00508012120.018
glutamine family amino acid biosynthetic processGO:000908420.018
alpha amino acid metabolic processGO:1901605710.018
fibroblast proliferationGO:0048144220.018
regulation of neuron projection developmentGO:00109751610.018
negative regulation of protein metabolic processGO:00512481140.018
single organism membrane organizationGO:0044802740.017
positive regulation of response to stimulusGO:00485842850.017
response to hypoxiaGO:00016662310.017
cell cell signalingGO:00072673350.017
terpenoid metabolic processGO:0006721370.017
dendrite developmentGO:0016358720.017
negative regulation of secretionGO:0051048820.017
negative regulation of apoptotic processGO:00430661810.017
organic cyclic compound catabolic processGO:19013611750.017
male gamete generationGO:0048232990.017
positive regulation of cellular amine metabolic processGO:003324030.017
cell migrationGO:00164771970.017
nucleic acid templated transcriptionGO:00976593790.017
protein homooligomerizationGO:0051260910.016
regulation of organelle organizationGO:0033043800.016
glycosyl compound metabolic processGO:19016571820.016
negative regulation of extrinsic apoptotic signaling pathwayGO:200123740.016
response to estradiolGO:00323551640.016
regulation of protein phosphorylationGO:00019321830.016
positive regulation of phosphorylationGO:00423271770.016
regulation of hydrolase activityGO:00513361430.016
respiratory system developmentGO:0060541450.016
fatty acid derivative biosynthetic processGO:1901570180.016
regulation of transcription from rna polymerase ii promoterGO:00063572340.016
regulation of anatomical structure morphogenesisGO:00226031410.016
positive regulation of transportGO:00510502450.016
positive regulation of apoptotic processGO:00430651540.016
cellular macromolecule localizationGO:00707271220.016
purine nucleoside monophosphate metabolic processGO:0009126840.016
positive regulation of cell proliferationGO:00082842490.016
positive regulation of cellular biosynthetic processGO:00313282950.016
cytokinetic processGO:003250610.015
regulation of immune system processGO:00026821230.015
purine nucleoside triphosphate metabolic processGO:00091441410.015
hormone secretionGO:00468791150.015
blood vessel morphogenesisGO:0048514580.015
nitrogen compound transportGO:00717052290.015
single organism biosynthetic processGO:00447113420.015
regulation of phospholipase a2 activityGO:003242910.015
nucleobase containing small molecule metabolic processGO:00550863160.015
positive regulation of dendritic spine developmentGO:006099990.015
positive regulation of nitrogen compound metabolic processGO:00511733340.015
cellular protein localizationGO:00346131220.015
positive regulation of dendrite developmentGO:1900006350.014
response to monosaccharideGO:00342841590.014
regulation of dendritic spine developmentGO:0060998160.014
lipid biosynthetic processGO:00086101280.014
positive regulation of fatty acid metabolic processGO:0045923140.014
cellular amine metabolic processGO:0044106380.014
positive regulation of phosphate metabolic processGO:00459372620.014
erythrocyte aggregationGO:003411710.014
organelle localizationGO:0051640550.014
behaviorGO:00076102050.014
vascular endothelial growth factor signaling pathwayGO:003808440.014
regulation of angiogenesisGO:0045765390.014
nucleoside phosphate metabolic processGO:00067532830.014
macromolecule catabolic processGO:0009057580.014
Human
angiotensin maturationGO:000200320.013
peptide secretionGO:0002790860.013
immune system processGO:00023762040.013
Worm
growthGO:00400071650.013
Zebrafish
mononuclear cell migrationGO:007167430.013
cellular chemical homeostasisGO:00550822470.013
regulation of lipid biosynthetic processGO:0046890380.013
regulation of vesicle mediated transportGO:0060627810.013
response to hyperoxiaGO:0055093450.013
signal releaseGO:00230611450.013
amide transportGO:00428861050.013
gamete generationGO:00072761240.013
positive regulation of fatty acid biosynthetic processGO:004572370.012
insulin secretionGO:0030073690.012
negative regulation of multicellular organismal processGO:00512412030.012
protein localization to plasma membraneGO:0072659150.012
cellular response to external stimulusGO:00714961180.012
establishment of protein localization to membraneGO:0090150160.012
response to ketoneGO:19016541820.012
cellular homeostasisGO:00197252520.012
prolactin secretionGO:007045920.012
establishment of organelle localizationGO:0051656370.012
negative regulation of blood coagulationGO:003019560.012
response to cgmpGO:007030530.012
positive regulation of dna metabolic processGO:0051054390.012
nucleotide metabolic processGO:00091172790.012
cardiovascular system developmentGO:00723581340.012
regulation of leukocyte migrationGO:0002685240.012
regulation of cell adhesionGO:0030155520.012
negative regulation of catalytic activityGO:00430861030.012
glycosyl compound catabolic processGO:19016581260.012
regulation of intracellular signal transductionGO:19025312180.012
central nervous system developmentGO:00074173110.012
body fluid secretionGO:0007589410.012
tetrapyrrole metabolic processGO:0033013110.012
positive regulation of lipid metabolic processGO:0045834330.012
regulation of fatty acid metabolic processGO:0019217180.012
intracellular transportGO:00469071850.011
positive regulation of epithelial cell migrationGO:0010634130.011
anatomical structure homeostasisGO:0060249290.011
regulation of wound healingGO:0061041140.011
reactive nitrogen species metabolic processGO:200105710.011
neuronal action potentialGO:0019228350.011
epithelium migrationGO:0090132190.011
positive regulation of lipid kinase activityGO:009021820.011
response to starvationGO:0042594590.011
positive regulation of cell adhesionGO:0045785300.011
regulation of nucleic acid templated transcriptionGO:19035063800.011
cellular component biogenesisGO:00440853680.011
negative regulation of gene expressionGO:00106291990.011
circulatory system developmentGO:00723591340.011
negative regulation of macromolecule metabolic processGO:00106052600.011
organophosphate biosynthetic processGO:00904071430.011
developmental process involved in reproductionGO:00030061590.011
Mouse
mononuclear cell proliferationGO:0032943290.011
ameboidal type cell migrationGO:0001667260.011
positive regulation of biosynthetic processGO:00098913190.011
regulation of anatomical structure sizeGO:00900661350.011
endocrine system developmentGO:0035270300.011
prostate gland developmentGO:003085090.011
regulation of epithelial cell migrationGO:0010632170.010
regulation of endocytosisGO:0030100420.010
response to molecule of bacterial originGO:00022371940.010
negative regulation of molecular functionGO:00440921330.010
bone remodelingGO:0046849230.010
regulation of actin cytoskeleton organizationGO:0032956300.010
secretionGO:00469033070.010
macroautophagyGO:001623640.010
epithelial cell proliferationGO:0050673540.010
bradykinin catabolic processGO:001081520.010
negative regulation of cell projection organizationGO:0031345500.010

Ctsb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.434
disease of anatomical entityDOID:700.238
nervous system diseaseDOID:86300.238
inherited metabolic disorderDOID:65500.206
lipid storage diseaseDOID:945500.192
lysosomal storage diseaseDOID:321100.192
hematopoietic system diseaseDOID:7400.086
immune system diseaseDOID:291400.086
blood protein diseaseDOID:62000.086
primary immunodeficiency diseaseDOID:61200.046
b cell deficiencyDOID:211500.046
agammaglobulinemiaDOID:258300.046
brain diseaseDOID:93600.038
central nervous system diseaseDOID:33100.038
connective tissue diseaseDOID:6500.035
musculoskeletal system diseaseDOID:1700.035
sensory system diseaseDOID:005015500.022
eye and adnexa diseaseDOID:149200.016
epilepsy syndromeDOID:182600.014
electroclinical syndromeDOID:005070100.014
acquired metabolic diseaseDOID:006015800.013