IMP: Integrative Multi-species Prediction

Rattus norvegicus

40 known processes

Aars

alanyl-tRNA synthetase

RGD: 1304832
Ensembl: ENSRNOG00000018404
Entrez: 292023
UniProtKB: P50475

Process Predictions
Disease Predictions

Aars biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
trna aminoacylation	GO:0043039	3	0.379
amino acid activation	GO:0043038	3	0.373
trna aminoacylation for protein translation	GO:0006418	3	0.281
trna metabolic process	GO:0006399	4	0.252
organic acid metabolic process	GO:0006082	292	0.161
carboxylic acid metabolic process	GO:0019752	289	0.149
cellular amino acid metabolic process	GO:0006520	107	0.143
translation	GO:0006412	35	0.130
oxoacid metabolic process	GO:0043436	290	0.128
organophosphate metabolic process	GO:0019637	370	0.086
nucleoside phosphate metabolic process	GO:0006753	283	0.075
nucleotide metabolic process	GO:0009117	279	0.072
mitochondrial rna metabolic process	GO:0000959	1	0.070
nucleobase containing small molecule metabolic process	GO:0055086	316	0.062
ncrna metabolic process	GO:0034660	8	0.057
multicellular organism growth	GO:0035264	1	0.050
cation transport	GO:0006812	382	0.047
single organism biosynthetic process	GO:0044711	342	0.045
regulation of apoptotic process	GO:0042981	335	0.045	Mouse
positive regulation of multicellular organismal process	GO:0051240	387	0.043
cellular response to stress	GO:0033554	269	0.042	Mouse
growth	GO:0040007	165	0.042
response to nutrient levels	GO:0031667	370	0.041
regulation of multicellular organismal development	GO:2000026	376	0.041
intracellular signal transduction	GO:0035556	314	0.040
apoptotic process	GO:0006915	381	0.040	Mouse
metal ion transport	GO:0030001	289	0.038
response to decreased oxygen levels	GO:0036293	237	0.037
regulation of intracellular signal transduction	GO:1902531	218	0.035
regulation of protein metabolic process	GO:0051246	289	0.035	Mouse
regulation of cellular protein metabolic process	GO:0032268	267	0.034	Mouse
carbohydrate derivative metabolic process	GO:1901135	346	0.033
purine containing compound metabolic process	GO:0072521	253	0.032
regulation of programmed cell death	GO:0043067	341	0.032	Mouse
regulation of signal transduction	GO:0009966	318	0.031
positive regulation of developmental process	GO:0051094	283	0.031
aromatic compound catabolic process	GO:0019439	168	0.030
macromolecule localization	GO:0033036	252	0.029
central nervous system development	GO:0007417	311	0.029	Mouse
amine metabolic process	GO:0009308	38	0.029
regulation of cellular component organization	GO:0051128	368	0.028
neuron differentiation	GO:0030182	368	0.028
regulation of phosphorus metabolic process	GO:0051174	349	0.028
cellular amine metabolic process	GO:0044106	38	0.028
regulation of cell differentiation	GO:0045595	320	0.027
ribose phosphate metabolic process	GO:0019693	235	0.027
regulation of cell development	GO:0060284	263	0.026
response to extracellular stimulus	GO:0009991	380	0.026
nucleobase containing compound catabolic process	GO:0034655	152	0.025
response to peptide	GO:1901652	292	0.025
cellular component biogenesis	GO:0044085	368	0.025
cellular catabolic process	GO:0044248	295	0.025
reproduction	GO:0000003	245	0.024
cation transmembrane transport	GO:0098655	263	0.024
organelle organization	GO:0006996	266	0.024
purine nucleotide metabolic process	GO:0006163	229	0.024
cellular response to oxygen containing compound	GO:1901701	386	0.023
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.023
homeostatic process	GO:0042592	331	0.023
cellular component movement	GO:0006928	248	0.022
nucleoside metabolic process	GO:0009116	179	0.022
transmembrane transport	GO:0055085	412	0.022
ribonucleotide metabolic process	GO:0009259	231	0.022
regulation of anatomical structure morphogenesis	GO:0022603	141	0.022
response to other organism	GO:0051707	220	0.022
ion transmembrane transport	GO:0034220	365	0.022
positive regulation of response to stimulus	GO:0048584	285	0.021
macromolecular complex subunit organization	GO:0043933	339	0.021
purine ribonucleoside catabolic process	GO:0046130	124	0.021
programmed cell death	GO:0012501	392	0.021	Mouse
organonitrogen compound catabolic process	GO:1901565	179	0.021
nucleoside phosphate biosynthetic process	GO:1901293	102	0.021
monovalent inorganic cation transport	GO:0015672	172	0.021
cellular ketone metabolic process	GO:0042180	51	0.020
head development	GO:0060322	247	0.020	Mouse
catabolic process	GO:0009056	351	0.020
ribonucleoside metabolic process	GO:0009119	174	0.020
carbohydrate metabolic process	GO:0005975	130	0.020
glycosyl compound metabolic process	GO:1901657	182	0.020
regulation of phosphate metabolic process	GO:0019220	349	0.019
single organism intracellular transport	GO:1902582	166	0.019
negative regulation of cellular metabolic process	GO:0031324	281	0.019
chemical homeostasis	GO:0048878	292	0.019
single organism catabolic process	GO:0044712	283	0.019
purine ribonucleotide metabolic process	GO:0009150	227	0.019
inorganic cation transmembrane transport	GO:0098662	202	0.018
double strand break repair	GO:0006302	1	0.018
positive regulation of gene expression	GO:0010628	244	0.018
regulation of nervous system development	GO:0051960	264	0.018
oxidation reduction process	GO:0055114	304	0.018
ion homeostasis	GO:0050801	212	0.018
regulation of cellular ketone metabolic process	GO:0010565	27	0.018
anatomical structure morphogenesis	GO:0009653	298	0.018
negative regulation of macromolecule metabolic process	GO:0010605	260	0.018
organophosphate biosynthetic process	GO:0090407	143	0.018
response to nutrient	GO:0007584	248	0.018
intracellular transport	GO:0046907	185	0.017
protein localization	GO:0008104	191	0.017
purine ribonucleoside metabolic process	GO:0046128	168	0.017
response to hypoxia	GO:0001666	231	0.017
regulation of cellular amino acid metabolic process	GO:0006521	2	0.017
tissue development	GO:0009888	252	0.017	Mouse
positive regulation of biosynthetic process	GO:0009891	319	0.017
cellular response to nitrogen compound	GO:1901699	210	0.017
negative regulation of protein metabolic process	GO:0051248	114	0.017
regulation of neurogenesis	GO:0050767	247	0.017
regulation of catalytic activity	GO:0050790	304	0.017
purine nucleoside metabolic process	GO:0042278	169	0.017
organic substance catabolic process	GO:1901575	316	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.016
sexual reproduction	GO:0019953	148	0.016
response to inorganic substance	GO:0010035	377	0.016
purine nucleoside catabolic process	GO:0006152	124	0.016
regulation of molecular function	GO:0065009	398	0.016
positive regulation of cell death	GO:0010942	184	0.016
response to oxygen levels	GO:0070482	265	0.016
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.016
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.016
positive regulation of nervous system development	GO:0051962	178	0.016
positive regulation of cell differentiation	GO:0045597	217	0.016
regulation of phosphorylation	GO:0042325	248	0.016
negative regulation of programmed cell death	GO:0043069	183	0.016	Mouse
negative regulation of cell death	GO:0060548	229	0.016	Mouse
diadenosine polyphosphate metabolic process	GO:0015959	2	0.016
rna metabolic process	GO:0016070	406	0.016
organic anion transport	GO:0015711	132	0.015
brain development	GO:0007420	247	0.015	Mouse
nucleic acid templated transcription	GO:0097659	379	0.015
regulation of growth	GO:0040008	105	0.015
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.015
single organism organelle organization	GO:1902589	180	0.015
inorganic ion transmembrane transport	GO:0098660	229	0.015
organic hydroxy compound metabolic process	GO:1901615	115	0.015
gastrulation	GO:0007369	2	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.015
cellular protein localization	GO:0034613	122	0.015
lipid metabolic process	GO:0006629	283	0.015
protein complex subunit organization	GO:0071822	302	0.015
cell projection organization	GO:0030030	302	0.015
protein complex assembly	GO:0006461	263	0.015
hepaticobiliary system development	GO:0061008	90	0.015
neuron development	GO:0048666	286	0.015
cellular component assembly	GO:0022607	360	0.015
nucleoside triphosphate metabolic process	GO:0009141	144	0.015
positive regulation of protein metabolic process	GO:0051247	178	0.015
cellular response to hormone stimulus	GO:0032870	247	0.015
cellular response to endogenous stimulus	GO:0071495	377	0.014
neural crest cell development	GO:0014032	2	0.014
regulation of catabolic process	GO:0009894	113	0.014
cardiovascular system development	GO:0072358	134	0.014
organic cyclic compound catabolic process	GO:1901361	175	0.014
regulation of rna metabolic process	GO:0051252	391	0.014
macromolecular complex assembly	GO:0065003	273	0.014
regulation of cell growth	GO:0001558	85	0.014
organophosphate catabolic process	GO:0046434	148	0.014
developmental growth	GO:0048589	100	0.014
purine nucleotide catabolic process	GO:0006195	136	0.014
positive regulation of apoptotic process	GO:0043065	154	0.014
cell morphogenesis involved in differentiation	GO:0000904	119	0.014
maintenance of location	GO:0051235	17	0.013
nucleoside monophosphate metabolic process	GO:0009123	93	0.013
positive regulation of signaling	GO:0023056	270	0.013
positive regulation of molecular function	GO:0044093	230	0.013
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.013
cellular chemical homeostasis	GO:0055082	247	0.013
cellular nitrogen compound catabolic process	GO:0044270	163	0.013
regulation of cellular catabolic process	GO:0031329	101	0.013
cellular ion homeostasis	GO:0006873	184	0.013
neuron projection development	GO:0031175	273	0.013
positive regulation of cell development	GO:0010720	176	0.013
multicellular organism reproduction	GO:0032504	233	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.013
negative regulation of developmental process	GO:0051093	125	0.013
negative regulation of apoptotic process	GO:0043066	181	0.013	Mouse
protein phosphorylation	GO:0006468	345	0.013
transcription from rna polymerase ii promoter	GO:0006366	252	0.013
lipid storage	GO:0019915	1	0.013
ribonucleotide catabolic process	GO:0009261	136	0.013
amino acid transport	GO:0006865	70	0.013
cellular response to external stimulus	GO:0071496	118	0.013
regulation of ion transport	GO:0043269	245	0.013
carboxylic acid transport	GO:0046942	115	0.013
cellular response to organic cyclic compound	GO:0071407	202	0.013
cellular homeostasis	GO:0019725	252	0.013
cellular response to organonitrogen compound	GO:0071417	197	0.013
glycerolipid metabolic process	GO:0046486	67	0.013
divalent inorganic cation homeostasis	GO:0072507	165	0.013
aging	GO:0007568	241	0.013
multicellular organismal reproductive process	GO:0048609	233	0.013
nucleoside phosphate catabolic process	GO:1901292	140	0.012
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.012
rna biosynthetic process	GO:0032774	380	0.012
eye morphogenesis	GO:0048592	4	0.012
sex differentiation	GO:0007548	113	0.012
positive regulation of cell proliferation	GO:0008284	249	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
transcription dna templated	GO:0006351	377	0.012
regulation of protein modification process	GO:0031399	194	0.012
negative regulation of transport	GO:0051051	136	0.012
response to external biotic stimulus	GO:0043207	221	0.012
neuron death	GO:0070997	127	0.012	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	295	0.012
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090101	2	0.012
nucleoside catabolic process	GO:0009164	126	0.012
gamete generation	GO:0007276	124	0.012
mitochondrion organization	GO:0007005	35	0.012
positive regulation of cellular amine metabolic process	GO:0033240	3	0.012
protein complex biogenesis	GO:0070271	263	0.012
branched chain amino acid transport	GO:0015803	2	0.012
metal ion homeostasis	GO:0055065	186	0.012
response to biotic stimulus	GO:0009607	226	0.012
mapk cascade	GO:0000165	140	0.012
nucleotide catabolic process	GO:0009166	139	0.011
cation homeostasis	GO:0055080	195	0.011
chromosome segregation	GO:0007059	2	0.011
organic acid transport	GO:0015849	116	0.011
atp metabolic process	GO:0046034	72	0.011
response to metal ion	GO:0010038	253	0.011
negative regulation of multicellular organismal process	GO:0051241	203	0.011
response to acid chemical	GO:0001101	222	0.011	Mouse
regulation of neuron differentiation	GO:0045664	208	0.011
purine containing compound catabolic process	GO:0072523	138	0.011
circulatory system process	GO:0003013	183	0.011
regulation of cell morphogenesis	GO:0022604	77	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.011
reproductive process	GO:0022414	372	0.011
membrane organization	GO:0061024	94	0.011
cellular metal ion homeostasis	GO:0006875	172	0.011
locomotion	GO:0040011	237	0.011
negative regulation of signaling	GO:0023057	157	0.011
positive regulation of neurogenesis	GO:0050769	165	0.011
negative regulation of cellular protein metabolic process	GO:0032269	106	0.011
regulation of reactive oxygen species biosynthetic process	GO:1903426	5	0.011
regulation of rna biosynthetic process	GO:2001141	381	0.011
carbohydrate derivative catabolic process	GO:1901136	147	0.011
multi organism reproductive process	GO:0044703	262	0.011
coenzyme metabolic process	GO:0006732	86	0.011
tube development	GO:0035295	89	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
positive regulation of cellular component organization	GO:0051130	200	0.011
cellular response to peptide	GO:1901653	133	0.010
signal transduction by phosphorylation	GO:0023014	144	0.010
glycosyl compound catabolic process	GO:1901658	126	0.010
nitrogen compound transport	GO:0071705	229	0.010
positive regulation of programmed cell death	GO:0043068	157	0.010
alcohol metabolic process	GO:0006066	77	0.010
response to oxidative stress	GO:0006979	186	0.010
negative regulation of metabolic process	GO:0009892	331	0.010
single organism reproductive process	GO:0044702	297	0.010
regulation of membrane potential	GO:0042391	110	0.010

Aars disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.118	Human
neuromuscular disease	DOID:440	0.118	Human
charcot marie tooth disease	DOID:10595	0.118	Human
nervous system disease	DOID:863	0.118	Human
neuropathy	DOID:870	0.118	Human
central nervous system disease	DOID:331	0.017
disease of metabolism	DOID:0014667	0.012
disease of cellular proliferation	DOID:14566	0.011
sensory system disease	DOID:0050155	0.010

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