IMP: Integrative Multi-species Prediction

Rattus norvegicus

353 known processes

Adora2a

adenosine A2a receptor

(Aliases: A2ar,ADENO,MGC93190,Adora2l1)

RGD: 2049
Entrez: 25369
Ensembl: ENSRNOG00000001302
UniProtKB: P30543

Process Predictions
Disease Predictions

Adora2a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of intracellular signal transduction	GO:1902531	218	0.860	Rat
prepulse inhibition	GO:0060134	1	0.821
programmed cell death	GO:0012501	392	0.788
g protein coupled receptor signaling pathway	GO:0007186	242	0.771
metal ion homeostasis	GO:0055065	186	0.715
regulation of cell development	GO:0060284	263	0.692
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.678
regulation of synaptic transmission	GO:0050804	141	0.664
positive regulation of multicellular organismal process	GO:0051240	387	0.610
intracellular signal transduction	GO:0035556	314	0.602	Rat
immune system process	GO:0002376	204	0.594	Mouse
startle response	GO:0001964	2	0.558
adenylate cyclase inhibiting g protein coupled receptor signaling pathway	GO:0007193	19	0.555	Rat
apoptotic process	GO:0006915	381	0.548
positive regulation of response to stimulus	GO:0048584	285	0.539
regulation of behavior	GO:0050795	61	0.525
regulation of cell differentiation	GO:0045595	320	0.518
regulation of synaptic plasticity	GO:0048167	70	0.514
leukocyte activation	GO:0045321	76	0.509	Mouse
regulation of stress activated protein kinase signaling cascade	GO:0070302	23	0.508
regulation of homeostatic process	GO:0032844	101	0.504
positive regulation of cell communication	GO:0010647	271	0.503
regulation of locomotion	GO:0040012	148	0.500
positive regulation of nucleotide metabolic process	GO:0045981	91	0.493	Human Mouse Rat
positive regulation of phosphorus metabolic process	GO:0010562	262	0.482	Human Mouse Rat
defense response	GO:0006952	194	0.475	Mouse Rat
regulation of multicellular organismal development	GO:2000026	376	0.472	Rat
cation homeostasis	GO:0055080	195	0.469
synaptic transmission	GO:0007268	235	0.469
signal transduction by phosphorylation	GO:0023014	144	0.468	Rat
smooth muscle contraction	GO:0006939	37	0.461	Rat
regulation of secretion by cell	GO:1903530	208	0.454
positive regulation of signaling	GO:0023056	270	0.450
cell cell signaling	GO:0007267	335	0.448
positive regulation of intracellular signal transduction	GO:1902533	138	0.433	Rat
mapk cascade	GO:0000165	140	0.431	Rat
response to oxygen levels	GO:0070482	265	0.431	Rat
regulation of signal transduction	GO:0009966	318	0.427	Mouse Rat
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger	GO:0007187	55	0.426
positive regulation of mapk cascade	GO:0043410	92	0.420	Rat
organophosphate metabolic process	GO:0019637	370	0.419	Human Mouse Rat
positive regulation of behavior	GO:0048520	38	0.412
rna biosynthetic process	GO:0032774	380	0.410
regulation of phosphorus metabolic process	GO:0051174	349	0.396
positive regulation of cell proliferation	GO:0008284	249	0.390	Rat
nucleic acid templated transcription	GO:0097659	379	0.389
calcium ion homeostasis	GO:0055074	162	0.383
negative regulation of response to stimulus	GO:0048585	155	0.380
protein transport	GO:0015031	132	0.379
positive regulation of synaptic transmission	GO:0050806	62	0.378
rna metabolic process	GO:0016070	406	0.374
negative regulation of signaling	GO:0023057	157	0.366	Rat
regulation of nervous system development	GO:0051960	264	0.363
positive regulation of nucleoside metabolic process	GO:0045979	55	0.363
regulation of programmed cell death	GO:0043067	341	0.360
positive regulation of homeostatic process	GO:0032846	49	0.357
positive regulation of cell differentiation	GO:0045597	217	0.356
cellular calcium ion homeostasis	GO:0006874	160	0.355
regulation of rna metabolic process	GO:0051252	391	0.354
regulation of cellular localization	GO:0060341	263	0.341
inflammatory response	GO:0006954	150	0.340	Mouse Rat
positive regulation of transport	GO:0051050	245	0.336
secretion by cell	GO:0032940	248	0.326
response to amine	GO:0014075	46	0.323	Mouse
nitrogen compound transport	GO:0071705	229	0.321
negative regulation of multicellular organismal process	GO:0051241	203	0.318	Rat
homeostatic process	GO:0042592	331	0.312
organonitrogen compound biosynthetic process	GO:1901566	167	0.311	Human Mouse Rat
response to mechanical stimulus	GO:0009612	134	0.310
purine nucleotide biosynthetic process	GO:0006164	83	0.309	Human Mouse Rat
behavior	GO:0007610	205	0.307
regulation of metal ion transport	GO:0010959	118	0.305
regulation of vasculature development	GO:1901342	44	0.302	Rat
regulation of molecular function	GO:0065009	398	0.297
regulation of cellular component organization	GO:0051128	368	0.296
stress activated protein kinase signaling cascade	GO:0031098	37	0.296
regulation of nucleic acid templated transcription	GO:1903506	380	0.295
divalent metal ion transport	GO:0070838	132	0.290
muscle contraction	GO:0006936	88	0.289	Rat
blood circulation	GO:0008015	183	0.286
regulation of mapk cascade	GO:0043408	116	0.284	Rat
amine transport	GO:0015837	57	0.284
sensory perception	GO:0007600	101	0.283	Rat
regulation of protein phosphorylation	GO:0001932	183	0.279
regulation of catecholamine secretion	GO:0050433	32	0.277
regulation of apoptotic process	GO:0042981	335	0.276
organic substance catabolic process	GO:1901575	316	0.269	Rat
cellular cation homeostasis	GO:0030003	180	0.268
muscle system process	GO:0003012	115	0.268	Rat
positive regulation of purine nucleotide metabolic process	GO:1900544	91	0.263	Human Mouse Rat
ribonucleotide metabolic process	GO:0009259	231	0.263	Human Mouse Rat
carbohydrate derivative metabolic process	GO:1901135	346	0.260	Human Mouse Rat
inflammatory response to antigenic stimulus	GO:0002437	18	0.257
negative regulation of programmed cell death	GO:0043069	183	0.255
ion homeostasis	GO:0050801	212	0.254
divalent inorganic cation homeostasis	GO:0072507	165	0.250
negative regulation of cell death	GO:0060548	229	0.249
regulation of cellular protein metabolic process	GO:0032268	267	0.249
cellular homeostasis	GO:0019725	252	0.248
negative regulation of cellular metabolic process	GO:0031324	281	0.248
regulation of neurological system process	GO:0031644	43	0.247
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.245
positive regulation of catalytic activity	GO:0043085	184	0.244	Human Rat
glutamate secretion	GO:0014047	19	0.242
positive regulation of cell development	GO:0010720	176	0.240
positive regulation of protein metabolic process	GO:0051247	178	0.240	Rat
protein kinase c activating g protein coupled receptor signaling pathway	GO:0007205	12	0.239
calcium ion transport	GO:0006816	131	0.238
cellular ion homeostasis	GO:0006873	184	0.234
neuron differentiation	GO:0030182	368	0.232
response to cytokine	GO:0034097	215	0.231
heart process	GO:0003015	57	0.230	Zebrafish Rat
positive regulation of molecular function	GO:0044093	230	0.227	Human Rat
long term synaptic potentiation	GO:0060291	21	0.226
regulation of nucleotide metabolic process	GO:0006140	117	0.224	Human Mouse Rat
regulation of protein transport	GO:0051223	68	0.218
negative regulation of macromolecule metabolic process	GO:0010605	260	0.218
regulation of protein modification process	GO:0031399	194	0.218
protein secretion	GO:0009306	34	0.217
establishment of protein localization	GO:0045184	141	0.215
transcription from rna polymerase ii promoter	GO:0006366	252	0.214
cellular chemical homeostasis	GO:0055082	247	0.213
purine containing compound metabolic process	GO:0072521	253	0.212	Human Mouse Rat
anatomical structure morphogenesis	GO:0009653	298	0.212
regulation of hydrolase activity	GO:0051336	143	0.212
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	27	0.211
positive regulation of developmental process	GO:0051094	283	0.210
positive regulation of gene expression	GO:0010628	244	0.209
circulatory system process	GO:0003013	183	0.209
amide transport	GO:0042886	105	0.209	Rat
transcription dna templated	GO:0006351	377	0.207
regulation of cyclic nucleotide metabolic process	GO:0030799	51	0.202	Human Mouse Rat
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.202
response to amphetamine	GO:0001975	25	0.200	Mouse
regulation of g protein coupled receptor protein signaling pathway	GO:0008277	28	0.198
positive regulation of phosphate metabolic process	GO:0045937	262	0.198	Human Mouse Rat
regulation of purine nucleotide metabolic process	GO:1900542	115	0.198	Human Mouse Rat
circulatory system development	GO:0072359	134	0.196	Rat
second messenger mediated signaling	GO:0019932	51	0.196
positive regulation of camp metabolic process	GO:0030816	31	0.191	Human Mouse Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.190
regulation of rna biosynthetic process	GO:2001141	381	0.186
regulation of immune system process	GO:0002682	123	0.185	Mouse
cytosolic calcium ion homeostasis	GO:0051480	140	0.185
positive regulation of long term synaptic potentiation	GO:1900273	4	0.183
response to ethanol	GO:0045471	162	0.183
cognition	GO:0050890	92	0.181	Rat
nucleoside phosphate metabolic process	GO:0006753	283	0.180	Human Mouse Rat
cell projection organization	GO:0030030	302	0.180
regulation of blood circulation	GO:1903522	110	0.180	Rat
nucleotide metabolic process	GO:0009117	279	0.177	Human Mouse Rat
response to corticosteroid	GO:0031960	235	0.175
feeding behavior	GO:0007631	53	0.174
camp metabolic process	GO:0046058	63	0.174	Human Mouse Rat
leukocyte migration	GO:0050900	38	0.172
gliogenesis	GO:0042063	93	0.169
cellular metal ion homeostasis	GO:0006875	172	0.169
positive regulation of locomotion	GO:0040017	102	0.167
regulation of blood pressure	GO:0008217	83	0.167	Rat
g protein coupled purinergic receptor signaling pathway	GO:0035588	8	0.165
regulation of cell proliferation	GO:0042127	359	0.164
nucleobase containing small molecule metabolic process	GO:0055086	316	0.163	Human Mouse Rat
regulation of neurogenesis	GO:0050767	247	0.162
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.162
cellular component movement	GO:0006928	248	0.161
regulation of angiogenesis	GO:0045765	39	0.161	Rat
cell type specific apoptotic process	GO:0097285	134	0.160
cellular response to molecule of bacterial origin	GO:0071219	56	0.160
learning or memory	GO:0007611	90	0.160
regulation of circadian sleep wake cycle sleep	GO:0045187	18	0.158
regulation of cellular component movement	GO:0051270	150	0.157
purine nucleotide metabolic process	GO:0006163	229	0.157	Human Mouse Rat
organelle organization	GO:0006996	266	0.156
ribose phosphate metabolic process	GO:0019693	235	0.155	Human Mouse Rat
macromolecule localization	GO:0033036	252	0.154
negative regulation of response to external stimulus	GO:0032102	37	0.152
blood vessel development	GO:0001568	69	0.152	Rat
regulation of nucleotide biosynthetic process	GO:0030808	47	0.151	Human Mouse Rat
cellular response to endogenous stimulus	GO:0071495	377	0.150
secretion	GO:0046903	307	0.149
neuron death	GO:0070997	127	0.149
neuron development	GO:0048666	286	0.148
excretion	GO:0007588	24	0.147
positive regulation of cellular protein metabolic process	GO:0032270	167	0.146	Rat
regulation of peptide transport	GO:0090087	87	0.145	Rat
negative regulation of circadian sleep wake cycle non rem sleep	GO:0042323	2	0.145	Rat
positive regulation of signal transduction	GO:0009967	175	0.144	Mouse Rat
negative regulation of transport	GO:0051051	136	0.143	Rat
negative adaptation of signaling pathway	GO:0022401	10	0.142
positive regulation of camp biosynthetic process	GO:0030819	28	0.142	Human Mouse Rat
positive regulation of cyclic nucleotide metabolic process	GO:0030801	37	0.141	Human Mouse Rat
regulation of transcription dna templated	GO:0006355	374	0.141
positive regulation of neurotransmitter transport	GO:0051590	9	0.139
regulation of system process	GO:0044057	208	0.139
positive regulation of hydrolase activity	GO:0051345	86	0.136
glycosyl compound metabolic process	GO:1901657	182	0.136
regulation of synaptic transmission glutamatergic	GO:0051966	26	0.135
immune response	GO:0006955	104	0.135
peptide secretion	GO:0002790	86	0.133	Rat
regulation of neuron death	GO:1901214	115	0.133
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.132	Human Mouse Rat
purine ribonucleotide metabolic process	GO:0009150	227	0.132	Human Mouse Rat
negative regulation of apoptotic process	GO:0043066	181	0.130
cell migration	GO:0016477	197	0.130
cell motility	GO:0048870	202	0.130
cell activation	GO:0001775	97	0.130
negative regulation of rna metabolic process	GO:0051253	123	0.129
cardiovascular system development	GO:0072358	134	0.129	Rat
cellular response to lipopolysaccharide	GO:0071222	55	0.128
positive regulation of rna biosynthetic process	GO:1902680	197	0.127
positive regulation of cellular biosynthetic process	GO:0031328	295	0.127	Human Mouse Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.126	Human Mouse Rat
regulation of phosphorylation	GO:0042325	248	0.125
negative regulation of phosphorus metabolic process	GO:0010563	80	0.125
regulation of smooth muscle contraction	GO:0006940	29	0.124	Rat
single organism organelle organization	GO:1902589	180	0.123
angiogenesis	GO:0001525	53	0.122	Rat
regulation of protein secretion	GO:0050708	28	0.122
response to acid chemical	GO:0001101	222	0.121
response to ketone	GO:1901654	182	0.121
regulation of defense response	GO:0031347	68	0.120	Mouse Rat
positive regulation of nervous system development	GO:0051962	178	0.120
purine containing compound biosynthetic process	GO:0072522	85	0.120	Human Mouse Rat
single organism catabolic process	GO:0044712	283	0.120	Rat
intracellular transport	GO:0046907	185	0.119	Rat
adenylate cyclase activating g protein coupled receptor signaling pathway	GO:0007189	24	0.119
calcium mediated signaling	GO:0019722	23	0.117
regulation of calcium ion transport	GO:0051924	77	0.117
positive regulation of protein modification process	GO:0031401	142	0.117	Rat
positive regulation of cyclic nucleotide biosynthetic process	GO:0030804	34	0.116	Human Mouse Rat
carbohydrate derivative catabolic process	GO:1901136	147	0.116
nucleoside catabolic process	GO:0009164	126	0.116
cellular response to cytokine stimulus	GO:0071345	127	0.115
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.115
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.113
cellular response to nitrogen compound	GO:1901699	210	0.112
response to extracellular stimulus	GO:0009991	380	0.111
reproductive process	GO:0022414	372	0.111
localization of cell	GO:0051674	202	0.109
negative regulation of cellular component organization	GO:0051129	83	0.108
ras protein signal transduction	GO:0007265	29	0.108
regulation of protein kinase activity	GO:0045859	105	0.107
positive regulation of phosphorylation	GO:0042327	177	0.107	Rat
negative regulation of cell communication	GO:0010648	158	0.107	Rat
positive regulation of stress activated mapk cascade	GO:0032874	17	0.106
regulation of cellular catabolic process	GO:0031329	101	0.106
heart contraction	GO:0060047	57	0.106	Zebrafish Rat
olfactory learning	GO:0008355	1	0.105
positive regulation of protein phosphorylation	GO:0001934	135	0.105	Rat
regulation of protein metabolic process	GO:0051246	289	0.105
myeloid leukocyte activation	GO:0002274	36	0.103
protein complex subunit organization	GO:0071822	302	0.100
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.100
catabolic process	GO:0009056	351	0.098	Rat
response to temperature stimulus	GO:0009266	94	0.098	Rat
positive regulation of programmed cell death	GO:0043068	157	0.098	Mouse
nucleotide biosynthetic process	GO:0009165	98	0.098	Human Mouse Rat
vascular process in circulatory system	GO:0003018	96	0.098
positive regulation of immune system process	GO:0002684	90	0.097
memory	GO:0007613	54	0.096
cellular catabolic process	GO:0044248	295	0.096
response to hypoxia	GO:0001666	231	0.096	Rat
response to nutrient levels	GO:0031667	370	0.095
positive regulation of biosynthetic process	GO:0009891	319	0.095	Human Mouse Rat
regulation of cell motility	GO:2000145	131	0.095
regulation of blood vessel size	GO:0050880	89	0.095
negative regulation of immune system process	GO:0002683	39	0.095	Mouse
locomotion	GO:0040011	237	0.095
response to metal ion	GO:0010038	253	0.094
renal sodium excretion	GO:0035812	20	0.093
regulation of secretion	GO:0051046	224	0.092
negative regulation of developmental process	GO:0051093	125	0.091
small gtpase mediated signal transduction	GO:0007264	36	0.091
positive regulation of protein transport	GO:0051222	41	0.091
cytokine production	GO:0001816	61	0.090
regulation of response to wounding	GO:1903034	69	0.090	Mouse Rat
negative regulation of ion transport	GO:0043271	51	0.090	Rat
purine ribonucleotide biosynthetic process	GO:0009152	81	0.090	Human Mouse Rat
regulation of stress activated mapk cascade	GO:0032872	23	0.090
positive regulation of cellular component organization	GO:0051130	200	0.089
carbohydrate derivative biosynthetic process	GO:1901137	124	0.089	Human Mouse Rat
ribonucleoside metabolic process	GO:0009119	174	0.089
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.089	Rat
cyclic nucleotide biosynthetic process	GO:0009190	63	0.089	Human Mouse Rat
glial cell differentiation	GO:0010001	65	0.087
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.087	Rat
nucleoside triphosphate metabolic process	GO:0009141	144	0.087
chemical homeostasis	GO:0048878	292	0.086
neuron projection development	GO:0031175	273	0.086
response to purine containing compound	GO:0014074	126	0.086
response to decreased oxygen levels	GO:0036293	237	0.085	Rat
regulation of long term neuronal synaptic plasticity	GO:0048169	15	0.085
positive regulation of adenylate cyclase activity involved in g protein coupled receptor signaling pathway	GO:0010579	2	0.084	Human
metal ion transport	GO:0030001	289	0.084
actin filament based process	GO:0030029	86	0.084
positive regulation of purine nucleotide catabolic process	GO:0033123	53	0.083
regulation of leukocyte migration	GO:0002685	24	0.082
regulation of cellular amine metabolic process	GO:0033238	8	0.082
dephosphorylation	GO:0016311	98	0.081	Rat
positive regulation of neural precursor cell proliferation	GO:2000179	10	0.081
ribonucleoside catabolic process	GO:0042454	126	0.081
regulation of purine nucleotide catabolic process	GO:0033121	65	0.081
purine nucleoside metabolic process	GO:0042278	169	0.081
regulation of respiratory system process	GO:0044065	1	0.081	Rat
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.080	Rat
organophosphate biosynthetic process	GO:0090407	143	0.080	Human Mouse Rat
regulation of ion transport	GO:0043269	245	0.080
cellular ketone metabolic process	GO:0042180	51	0.080
protein localization	GO:0008104	191	0.079
peptidyl tyrosine phosphorylation	GO:0018108	72	0.079	Rat
response to biotic stimulus	GO:0009607	226	0.079
protein phosphorylation	GO:0006468	345	0.078
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.078
locomotory exploration behavior	GO:0035641	1	0.078
regulation of neuron projection development	GO:0010975	161	0.077
taxis	GO:0042330	67	0.077
cellular component assembly	GO:0022607	360	0.076
regulation of neuron differentiation	GO:0045664	208	0.076
gtp metabolic process	GO:0046039	72	0.076
synaptic transmission glutamatergic	GO:0035249	33	0.076
neurological system process	GO:0050877	219	0.076
cellular response to peptide	GO:1901653	133	0.075
cation transport	GO:0006812	382	0.075
regulation of organic acid transport	GO:0032890	35	0.075
cell part morphogenesis	GO:0032990	123	0.075
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.075
developmental growth	GO:0048589	100	0.075
sensory perception of pain	GO:0019233	73	0.074	Rat
regulation of catalytic activity	GO:0050790	304	0.074
regulation of cell projection organization	GO:0031344	175	0.073
negative regulation of metabolic process	GO:0009892	331	0.073
regulation of cell migration	GO:0030334	128	0.073
positive regulation of neurogenesis	GO:0050769	165	0.073
positive regulation of cellular component movement	GO:0051272	102	0.072
response to oxidative stress	GO:0006979	186	0.072
regulation of neuronal synaptic plasticity	GO:0048168	31	0.072
purine nucleoside catabolic process	GO:0006152	124	0.072
positive regulation of transcription dna templated	GO:0045893	197	0.072
cellular lipid metabolic process	GO:0044255	208	0.072
cell chemotaxis	GO:0060326	31	0.071
detection of abiotic stimulus	GO:0009582	13	0.071	Rat
regulation of renal sodium excretion	GO:0035813	20	0.071
tumor necrosis factor mediated signaling pathway	GO:0033209	4	0.071
regulation of excretion	GO:0044062	21	0.071
regulation of phosphate metabolic process	GO:0019220	349	0.071
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.071
macromolecular complex subunit organization	GO:0043933	339	0.071
response to inorganic substance	GO:0010035	377	0.071
aging	GO:0007568	241	0.071
female pregnancy	GO:0007565	122	0.070
positive regulation of jnk cascade	GO:0046330	13	0.070
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.070
response to lipopolysaccharide	GO:0032496	191	0.068
regulation of cytokine production	GO:0001817	56	0.068
positive regulation of protein serine threonine kinase activity	GO:0071902	52	0.068	Rat
response to wounding	GO:0009611	254	0.068	Mouse Rat
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	4	0.067
regulation of membrane potential	GO:0042391	110	0.067
organic acid metabolic process	GO:0006082	292	0.066
stress activated mapk cascade	GO:0051403	35	0.066
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	17	0.066
regulation of smooth muscle cell proliferation	GO:0048660	75	0.065
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.065
cellular component biogenesis	GO:0044085	368	0.064
locomotory behavior	GO:0007626	15	0.064
brain development	GO:0007420	247	0.064
carboxylic acid metabolic process	GO:0019752	289	0.064
regulation of catabolic process	GO:0009894	113	0.064	Rat
regulation of developmental growth	GO:0048638	45	0.063
oxoacid metabolic process	GO:0043436	290	0.063
positive regulation of rna metabolic process	GO:0051254	203	0.063
purine ribonucleoside catabolic process	GO:0046130	124	0.062
positive regulation of blood circulation	GO:1903524	65	0.062	Rat
negative regulation of circadian sleep wake cycle sleep	GO:0042321	5	0.061	Rat
positive regulation of adenylate cyclase activity	GO:0045762	12	0.061	Human
carboxylic acid transport	GO:0046942	115	0.061
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.061
purine ribonucleoside metabolic process	GO:0046128	168	0.061
cyclic purine nucleotide metabolic process	GO:0052652	62	0.061	Human Mouse Rat
negative regulation of g protein coupled receptor protein signaling pathway	GO:0045744	15	0.061
desensitization of g protein coupled receptor protein signaling pathway	GO:0002029	10	0.061
ribonucleotide biosynthetic process	GO:0009260	85	0.060	Human Mouse Rat
peptide transport	GO:0015833	97	0.059	Rat
central nervous system development	GO:0007417	311	0.059
regulation of anatomical structure morphogenesis	GO:0022603	141	0.059	Rat
regulation of gtpase activity	GO:0043087	57	0.059
monoamine transport	GO:0015844	43	0.059
organic cyclic compound catabolic process	GO:1901361	175	0.058
temperature homeostasis	GO:0001659	17	0.058	Rat
positive regulation of map kinase activity	GO:0043406	46	0.058	Rat
acute inflammatory response	GO:0002526	58	0.058	Rat
multi organism reproductive process	GO:0044703	262	0.058
muscle structure development	GO:0061061	87	0.057
positive regulation of protein secretion	GO:0050714	19	0.057
positive regulation of catabolic process	GO:0009896	78	0.057
purine nucleotide catabolic process	GO:0006195	136	0.057
renal system process	GO:0003014	40	0.057
response to amino acid	GO:0043200	75	0.057
cell cycle	GO:0007049	101	0.056
regulation of cellular ketone metabolic process	GO:0010565	27	0.056
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.056
synaptic transmission gabaergic	GO:0051932	22	0.056	Mouse Rat
lipid metabolic process	GO:0006629	283	0.055	Rat
purine ribonucleotide catabolic process	GO:0009154	136	0.055
cellular amine metabolic process	GO:0044106	38	0.055
positive regulation of cell motility	GO:2000147	97	0.055
positive regulation of nucleotide biosynthetic process	GO:0030810	36	0.054	Human Mouse Rat
cellular response to mechanical stimulus	GO:0071260	48	0.054
neuron neuron synaptic transmission	GO:0007270	60	0.054
organic anion transport	GO:0015711	132	0.054
response to increased oxygen levels	GO:0036296	45	0.054
positive regulation of purine nucleotide biosynthetic process	GO:1900373	36	0.054	Human Mouse Rat
regulation of growth	GO:0040008	105	0.053
single organism cellular localization	GO:1902580	102	0.053	Rat
single organism intracellular transport	GO:1902582	166	0.053	Rat
nucleoside phosphate catabolic process	GO:1901292	140	0.052
blood vessel morphogenesis	GO:0048514	58	0.052	Rat
positive regulation of cytokine production	GO:0001819	42	0.052
actin cytoskeleton organization	GO:0030036	73	0.052
regulation of establishment of protein localization	GO:0070201	69	0.052
response to estrogen	GO:0043627	232	0.052
nucleotide catabolic process	GO:0009166	139	0.051
smooth muscle cell proliferation	GO:0048659	77	0.051
positive regulation of angiogenesis	GO:0045766	28	0.051
organonitrogen compound catabolic process	GO:1901565	179	0.051
negative regulation of homeostatic process	GO:0032845	47	0.051	Rat
positive regulation of apoptotic process	GO:0043065	154	0.051	Mouse
muscle cell proliferation	GO:0033002	84	0.050
positive regulation of neuron differentiation	GO:0045666	126	0.050
innate immune response	GO:0045087	35	0.050
growth	GO:0040007	165	0.050
amine metabolic process	GO:0009308	38	0.050
negative regulation of transcription dna templated	GO:0045892	116	0.050
regulation of respiratory gaseous exchange	GO:0043576	2	0.050	Rat
response to radiation	GO:0009314	137	0.049
apoptotic signaling pathway	GO:0097190	27	0.049	Mouse
cellular protein localization	GO:0034613	122	0.049	Rat
peptidyl amino acid modification	GO:0018193	126	0.049	Rat
positive regulation of protein kinase activity	GO:0045860	73	0.048	Rat
ribose phosphate biosynthetic process	GO:0046390	87	0.048	Human Mouse Rat
regulation of heart rate	GO:0002027	16	0.048
negative regulation of rna biosynthetic process	GO:1902679	118	0.048
negative regulation of nervous system development	GO:0051961	79	0.047
negative regulation of defense response	GO:0031348	19	0.047	Mouse Rat
camp biosynthetic process	GO:0006171	47	0.047	Human Mouse Rat
positive regulation of kinase activity	GO:0033674	77	0.047	Rat
regulation of long term synaptic potentiation	GO:1900271	5	0.047
striated muscle contraction	GO:0006941	44	0.047	Rat
kidney development	GO:0001822	67	0.047
regulation of map kinase activity	GO:0043405	53	0.047	Rat
regulation of anatomical structure size	GO:0090066	135	0.047
multicellular organism growth	GO:0035264	1	0.046
visual learning	GO:0008542	8	0.046
positive regulation of secretion by cell	GO:1903532	128	0.046
regulation of feeding behavior	GO:0060259	14	0.046
nucleoside metabolic process	GO:0009116	179	0.046
immune system development	GO:0002520	41	0.045
positive regulation of fever generation	GO:0031622	5	0.045
positive regulation of cell death	GO:0010942	184	0.045	Mouse
negative regulation of secretion by cell	GO:1903531	72	0.045	Rat
regulation of tube size	GO:0035150	89	0.045
glycosyl compound catabolic process	GO:1901658	126	0.044
regulation of cyclic nucleotide biosynthetic process	GO:0030802	45	0.044	Human Mouse Rat
neurotrophin production	GO:0032898	2	0.044	Rat
negative regulation of muscle contraction	GO:0045932	8	0.044	Rat
regulation of chemotaxis	GO:0050920	29	0.044
cellular response to lipid	GO:0071396	201	0.044
single organism biosynthetic process	GO:0044711	342	0.043	Human Mouse Rat
regulation of ion homeostasis	GO:2000021	63	0.043
negative regulation of secretion	GO:0051048	82	0.043	Rat
negative regulation of circadian rhythm	GO:0042754	5	0.043	Rat
positive regulation of cyclase activity	GO:0031281	15	0.043	Human
regulation of peptide secretion	GO:0002791	82	0.043	Rat
regulation of response to external stimulus	GO:0032101	106	0.043
regulation of synaptic transmission gabaergic	GO:0032228	17	0.043	Mouse Rat
regulation of excitatory postsynaptic membrane potential	GO:0060079	18	0.042
response to electrical stimulus	GO:0051602	56	0.042
positive regulation of organic acid transport	GO:0032892	22	0.042
regulation of respiratory gaseous exchange by neurological system process	GO:0002087	1	0.042	Rat
cytokine mediated signaling pathway	GO:0019221	43	0.042
sequestering of calcium ion	GO:0051208	8	0.042
hormone secretion	GO:0046879	115	0.042	Rat
negative regulation of biosynthetic process	GO:0009890	168	0.042	Rat
multi multicellular organism process	GO:0044706	138	0.041
muscle organ development	GO:0007517	50	0.041
negative regulation of gene expression	GO:0010629	199	0.041
negative regulation of phosphate metabolic process	GO:0045936	80	0.040
negative regulation of defecation	GO:2000293	1	0.040
regulation of cell cycle	GO:0051726	73	0.040
neuron apoptotic process	GO:0051402	88	0.040
cytoskeleton organization	GO:0007010	111	0.040
response to carbohydrate	GO:0009743	183	0.040
monovalent inorganic cation transport	GO:0015672	172	0.040	Rat
neuromuscular process	GO:0050905	2	0.039
interleukin 6 production	GO:0032635	12	0.039
heterocycle catabolic process	GO:0046700	167	0.039
reproduction	GO:0000003	245	0.039
regulation of purine nucleotide biosynthetic process	GO:1900371	46	0.039	Human Mouse Rat
myeloid cell differentiation	GO:0030099	22	0.039
cellular response to stress	GO:0033554	269	0.038

Adora2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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