IMP: Integrative Multi-species Prediction

Rattus norvegicus

76 known processes

Aldh2

aldehyde dehydrogenase 2 family (mitochondrial)

Entrez: 29539
Ensembl: ENSRNOG00000001344
RGD: 69219
UniProtKB: P11884
UniProtKB: F1LN88

Process Predictions
Disease Predictions

Aldh2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
response to nutrient levels	GO:0031667	370	0.441	Rat
carboxylic acid metabolic process	GO:0019752	289	0.347	Yeast Rat
cellular response to stress	GO:0033554	269	0.222
response to metal ion	GO:0010038	253	0.218
oxidation reduction process	GO:0055114	304	0.204
response to inorganic substance	GO:0010035	377	0.185
catabolic process	GO:0009056	351	0.172	Yeast
localization of cell	GO:0051674	202	0.118
organic acid metabolic process	GO:0006082	292	0.116	Yeast Rat
cellular amino acid metabolic process	GO:0006520	107	0.097	Yeast
single organism catabolic process	GO:0044712	283	0.090
response to genistein	GO:0033595	4	0.090
response to glucocorticoid	GO:0051384	223	0.088
programmed cell death	GO:0012501	392	0.087
cellular amino acid catabolic process	GO:0009063	21	0.086
oxoacid metabolic process	GO:0043436	290	0.084	Yeast Rat
response to wounding	GO:0009611	254	0.082
regulation of neurogenesis	GO:0050767	247	0.081
positive regulation of developmental process	GO:0051094	283	0.072
cellular component movement	GO:0006928	248	0.072
gland development	GO:0048732	155	0.068
response to corticosteroid	GO:0031960	235	0.068
cell projection organization	GO:0030030	302	0.067
regulation of nervous system development	GO:0051960	264	0.066
regulation of cellular component movement	GO:0051270	150	0.061
positive regulation of nervous system development	GO:0051962	178	0.060
neuron differentiation	GO:0030182	368	0.056
response to extracellular stimulus	GO:0009991	380	0.055	Rat
cation transport	GO:0006812	382	0.053
dendrite development	GO:0016358	72	0.052
cellular response to hormone stimulus	GO:0032870	247	0.048
cell migration	GO:0016477	197	0.046
regulation of phosphorylation	GO:0042325	248	0.046
protein phosphorylation	GO:0006468	345	0.045
macromolecular complex subunit organization	GO:0043933	339	0.042	Rat
regulation of cell migration	GO:0030334	128	0.042
cellular lipid catabolic process	GO:0044242	37	0.042
response to organophosphorus	GO:0046683	102	0.041
sulfur compound metabolic process	GO:0006790	70	0.041
response to lead ion	GO:0010288	33	0.040
regulation of cell development	GO:0060284	263	0.040
response to catechin	GO:1902168	1	0.040
alpha amino acid catabolic process	GO:1901606	20	0.039
cellular catabolic process	GO:0044248	295	0.039
branched chain amino acid catabolic process	GO:0009083	4	0.038
chemical homeostasis	GO:0048878	292	0.038
organic substance catabolic process	GO:1901575	316	0.038	Yeast
cellular component biogenesis	GO:0044085	368	0.038	Rat
intracellular signal transduction	GO:0035556	314	0.037
protein complex subunit organization	GO:0071822	302	0.037	Rat
anatomical structure morphogenesis	GO:0009653	298	0.037
thioester biosynthetic process	GO:0035384	7	0.037
positive regulation of neurogenesis	GO:0050769	165	0.035
positive regulation of cell death	GO:0010942	184	0.034
neuron development	GO:0048666	286	0.034
wound healing	GO:0042060	122	0.034
chromosome segregation	GO:0007059	2	0.034
apoptotic process	GO:0006915	381	0.034
positive regulation of programmed cell death	GO:0043068	157	0.034
regulation of cell projection organization	GO:0031344	175	0.033
carboxylic acid catabolic process	GO:0046395	49	0.033
behavior	GO:0007610	205	0.033
cellular response to organic cyclic compound	GO:0071407	202	0.033
cellular homeostasis	GO:0019725	252	0.032
positive regulation of cell development	GO:0010720	176	0.032
cellular response to peptide hormone stimulus	GO:0071375	120	0.032
organonitrogen compound catabolic process	GO:1901565	179	0.031	Yeast
regulation of intracellular signal transduction	GO:1902531	218	0.031
lipid metabolic process	GO:0006629	283	0.031	Rat
positive regulation of cellular component organization	GO:0051130	200	0.031
cellular response to external stimulus	GO:0071496	118	0.031
homeostatic process	GO:0042592	331	0.030
response to aluminum ion	GO:0010044	10	0.030
regulation of ion transport	GO:0043269	245	0.029
negative regulation of signaling	GO:0023057	157	0.029
locomotion	GO:0040011	237	0.029
cellular response to peptide	GO:1901653	133	0.029
cellular response to lipid	GO:0071396	201	0.029
metal ion transport	GO:0030001	289	0.029
monocarboxylic acid metabolic process	GO:0032787	152	0.029	Yeast Rat
cell motility	GO:0048870	202	0.029
positive regulation of cellular biosynthetic process	GO:0031328	295	0.028
nitrogen compound transport	GO:0071705	229	0.028
rna metabolic process	GO:0016070	406	0.028
positive regulation of apoptotic process	GO:0043065	154	0.028
ion homeostasis	GO:0050801	212	0.027
response to axon injury	GO:0048678	59	0.027
response to acid chemical	GO:0001101	222	0.027
negative regulation of metabolic process	GO:0009892	331	0.027
signal transduction by phosphorylation	GO:0023014	144	0.027
regulation of cell differentiation	GO:0045595	320	0.026
cellular chemical homeostasis	GO:0055082	247	0.026
macromolecular complex assembly	GO:0065003	273	0.026	Rat
regulation of cell proliferation	GO:0042127	359	0.025
regulation of rna biosynthetic process	GO:2001141	381	0.025
positive regulation of signaling	GO:0023056	270	0.025
positive regulation of cell projection organization	GO:0031346	111	0.025
organic acid catabolic process	GO:0016054	49	0.025
negative regulation of response to stimulus	GO:0048585	155	0.025
lipid catabolic process	GO:0016042	46	0.025
negative regulation of biosynthetic process	GO:0009890	168	0.025
positive regulation of multicellular organismal process	GO:0051240	387	0.025
positive regulation of response to stimulus	GO:0048584	285	0.025
regulation of signal transduction	GO:0009966	318	0.024
cellular response to oxygen containing compound	GO:1901701	386	0.024
response to peptide	GO:1901652	292	0.024
organic acid biosynthetic process	GO:0016053	83	0.024	Yeast Rat
anion transmembrane transport	GO:0098656	77	0.024
response to toxic substance	GO:0009636	133	0.024
glycosyl compound metabolic process	GO:1901657	182	0.023
response to camp	GO:0051591	91	0.023
metal ion homeostasis	GO:0055065	186	0.023
regulation of cellular component organization	GO:0051128	368	0.023
organelle organization	GO:0006996	266	0.023
carbohydrate derivative metabolic process	GO:1901135	346	0.023
protein complex biogenesis	GO:0070271	263	0.023	Rat
negative regulation of cellular metabolic process	GO:0031324	281	0.023
multicellular organismal reproductive process	GO:0048609	233	0.023
cellular response to oxidative stress	GO:0034599	76	0.023
cellular response to organonitrogen compound	GO:0071417	197	0.022
positive regulation of cell differentiation	GO:0045597	217	0.022
cytoskeleton organization	GO:0007010	111	0.022
regulation of cellular ketone metabolic process	GO:0010565	27	0.022
regulation of cellular response to stress	GO:0080135	49	0.022
positive regulation of phosphorus metabolic process	GO:0010562	262	0.022
cellular response to endogenous stimulus	GO:0071495	377	0.022
positive regulation of cellular amine metabolic process	GO:0033240	3	0.022
transmembrane transport	GO:0055085	412	0.022
cellular ketone metabolic process	GO:0042180	51	0.021
regulation of mapk cascade	GO:0043408	116	0.021
regulation of cellular amino acid metabolic process	GO:0006521	2	0.021
positive regulation of phosphorylation	GO:0042327	177	0.021
neuron projection development	GO:0031175	273	0.021
cation homeostasis	GO:0055080	195	0.021
regulation of locomotion	GO:0040012	148	0.021
response to purine containing compound	GO:0014074	126	0.021
amine metabolic process	GO:0009308	38	0.021	Yeast
regulation of protein modification process	GO:0031399	194	0.021
cellular response to growth factor stimulus	GO:0071363	162	0.021
cellular response to cytokine stimulus	GO:0071345	127	0.020
cellular component assembly	GO:0022607	360	0.020	Rat
cellular calcium ion homeostasis	GO:0006874	160	0.020
positive regulation of protein metabolic process	GO:0051247	178	0.020
protein complex assembly	GO:0006461	263	0.020	Rat
fatty acid beta oxidation	GO:0006635	22	0.020
response to hydrogen peroxide	GO:0042542	89	0.020
regulation of protein metabolic process	GO:0051246	289	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.019
small molecule biosynthetic process	GO:0044283	124	0.019	Yeast Rat
regulation of cell motility	GO:2000145	131	0.019
regulation of cellular amine metabolic process	GO:0033238	8	0.019
positive regulation of cell proliferation	GO:0008284	249	0.019
monovalent inorganic cation transport	GO:0015672	172	0.019
cell projection morphogenesis	GO:0048858	123	0.019
regulation of rna metabolic process	GO:0051252	391	0.019
skeletal system development	GO:0001501	41	0.019
coenzyme metabolic process	GO:0006732	86	0.019	Yeast
cellular amide metabolic process	GO:0043603	44	0.018
response to cadmium ion	GO:0046686	35	0.018
protein heterooligomerization	GO:0051291	89	0.018
cofactor biosynthetic process	GO:0051188	28	0.018
cellular amine metabolic process	GO:0044106	38	0.018	Yeast
positive regulation of catalytic activity	GO:0043085	184	0.018
acyl coa biosynthetic process	GO:0071616	7	0.018
hair cycle process	GO:0022405	2	0.018
phospholipid metabolic process	GO:0006644	61	0.018
receptor localization to synapse	GO:0097120	2	0.018
regulation of neuron projection development	GO:0010975	161	0.018
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.018
response to antibiotic	GO:0046677	39	0.018
response to lipopolysaccharide	GO:0032496	191	0.018
response to mechanical stimulus	GO:0009612	134	0.018
muscle system process	GO:0003012	115	0.018
positive regulation of neuron projection development	GO:0010976	99	0.018
regulation of multicellular organismal development	GO:2000026	376	0.017
response to peptide hormone	GO:0043434	278	0.017
response to lithium ion	GO:0010226	28	0.017
response to cytokine	GO:0034097	215	0.017
cellular modified amino acid metabolic process	GO:0006575	61	0.017
anion transport	GO:0006820	178	0.017
cellular ion homeostasis	GO:0006873	184	0.017
response to nutrient	GO:0007584	248	0.017	Rat
head development	GO:0060322	247	0.017	Rat
sexual reproduction	GO:0019953	148	0.017
ion transmembrane transport	GO:0034220	365	0.017
purine ribonucleotide metabolic process	GO:0009150	227	0.017
positive regulation of molecular function	GO:0044093	230	0.016
positive regulation of cellular protein metabolic process	GO:0032270	167	0.016
response to bacterium	GO:0009617	200	0.016
negative regulation of cellular biosynthetic process	GO:0031327	161	0.016
carbohydrate derivative biosynthetic process	GO:1901137	124	0.016
positive regulation of gene expression	GO:0010628	244	0.016
tissue development	GO:0009888	252	0.016
renal system development	GO:0072001	67	0.016	Rat
neurological system process	GO:0050877	219	0.016
regulation of erk1 and erk2 cascade	GO:0070372	41	0.016
regulation of proteasomal protein catabolic process	GO:0061136	4	0.016
nucleic acid templated transcription	GO:0097659	379	0.016
rna biosynthetic process	GO:0032774	380	0.016
protein oligomerization	GO:0051259	191	0.016	Rat
acetyl coa metabolic process	GO:0006084	17	0.016
nucleotide biosynthetic process	GO:0009165	98	0.015
renal system process	GO:0003014	40	0.015
response to oxygen levels	GO:0070482	265	0.015
positive regulation of intracellular signal transduction	GO:1902533	138	0.015
hair follicle development	GO:0001942	2	0.015
mapk cascade	GO:0000165	140	0.015
cellular cation homeostasis	GO:0030003	180	0.015
multicellular organismal signaling	GO:0035637	44	0.015
regulation of programmed cell death	GO:0043067	341	0.015
transcription dna templated	GO:0006351	377	0.015
erk1 and erk2 cascade	GO:0070371	48	0.015
negative regulation of cell communication	GO:0010648	158	0.015
asymmetric protein localization	GO:0008105	2	0.015
positive regulation of protein phosphorylation	GO:0001934	135	0.015
branched chain amino acid metabolic process	GO:0009081	4	0.015
positive regulation of cell migration	GO:0030335	96	0.015
actin cytoskeleton organization	GO:0030036	73	0.015
calcium ion homeostasis	GO:0055074	162	0.015
inorganic ion transmembrane transport	GO:0098660	229	0.014
potassium ion transport	GO:0006813	97	0.014
response to other organism	GO:0051707	220	0.014
regulation of protein phosphorylation	GO:0001932	183	0.014
carboxylic acid biosynthetic process	GO:0046394	83	0.014	Yeast Rat
cellular response to nutrient levels	GO:0031669	60	0.014
brain renin angiotensin system	GO:0002035	3	0.014
regulation of nucleic acid templated transcription	GO:1903506	380	0.014
negative regulation of signal transduction	GO:0009968	83	0.014
neuron projection morphogenesis	GO:0048812	122	0.014
cellular metal ion homeostasis	GO:0006875	172	0.014
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.014
cell communication involved in cardiac conduction	GO:0086065	2	0.014
negative regulation of innate immune response	GO:0045824	4	0.014
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.014
macromolecule localization	GO:0033036	252	0.014
response to radiation	GO:0009314	137	0.014
cellular response to extracellular stimulus	GO:0031668	73	0.014
regulation of muscle system process	GO:0090257	79	0.014
response to ketone	GO:1901654	182	0.014
positive regulation of cell motility	GO:2000147	97	0.014
benzene containing compound metabolic process	GO:0042537	22	0.014
cellular component morphogenesis	GO:0032989	155	0.013
multicellular organism reproduction	GO:0032504	233	0.013
response to estrogen	GO:0043627	232	0.013
protein homooligomerization	GO:0051260	91	0.013	Rat
brain development	GO:0007420	247	0.013	Rat
circulatory system process	GO:0003013	183	0.013
regulation of cellular catabolic process	GO:0031329	101	0.013
regulation of molecular function	GO:0065009	398	0.013
response to amino acid	GO:0043200	75	0.013
actin filament based process	GO:0030029	86	0.013
ribose phosphate metabolic process	GO:0019693	235	0.013
response to retinoic acid	GO:0032526	63	0.013	Rat
regulation of lipid metabolic process	GO:0019216	68	0.013
response to estradiol	GO:0032355	164	0.013
purine containing compound metabolic process	GO:0072521	253	0.013
negative regulation of macromolecule metabolic process	GO:0010605	260	0.013
negative regulation of programmed cell death	GO:0043069	183	0.013
positive regulation of locomotion	GO:0040017	102	0.013
ribonucleotide metabolic process	GO:0009259	231	0.013
positive regulation of biosynthetic process	GO:0009891	319	0.013
spindle organization	GO:0007051	2	0.013
inflammatory response	GO:0006954	150	0.013
sulfur compound biosynthetic process	GO:0044272	19	0.013
negative regulation of phosphorus metabolic process	GO:0010563	80	0.013
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.013
gamete generation	GO:0007276	124	0.012
cellular response to drug	GO:0035690	30	0.012	Zebrafish
single organism reproductive process	GO:0044702	297	0.012
response to oxidative stress	GO:0006979	186	0.012	Rat
purine nucleotide metabolic process	GO:0006163	229	0.012
cellular macromolecule localization	GO:0070727	122	0.012
regulation of metal ion transport	GO:0010959	118	0.012
dephosphorylation	GO:0016311	98	0.012
response to growth factor	GO:0070848	189	0.012
central nervous system development	GO:0007417	311	0.012	Rat
negative regulation of cell death	GO:0060548	229	0.012
endoplasmic reticulum to cytosol transport	GO:1903513	4	0.012
lipid storage	GO:0019915	1	0.012
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	3	0.012
divalent inorganic cation homeostasis	GO:0072507	165	0.012
cytoplasmic transport	GO:0016482	115	0.012
response to starvation	GO:0042594	59	0.012
organophosphate metabolic process	GO:0019637	370	0.012	Yeast
positive regulation of immune system process	GO:0002684	90	0.012
purine ribonucleoside metabolic process	GO:0046128	168	0.012
response to decreased oxygen levels	GO:0036293	237	0.012
fatty acid metabolic process	GO:0006631	99	0.012
establishment of tissue polarity	GO:0007164	2	0.012
negative regulation of gene expression	GO:0010629	199	0.012
positive regulation of protein modification process	GO:0031401	142	0.012
single organism membrane organization	GO:0044802	74	0.012
camp metabolic process	GO:0046058	63	0.012
negative regulation of multicellular organismal process	GO:0051241	203	0.012
regulation of kinase activity	GO:0043549	117	0.012
cell morphogenesis involved in differentiation	GO:0000904	119	0.012
regulation of neuron differentiation	GO:0045664	208	0.012
cellular protein localization	GO:0034613	122	0.012
cardiac conduction	GO:0061337	2	0.012
heart morphogenesis	GO:0003007	3	0.012
cell part morphogenesis	GO:0032990	123	0.011
ras protein signal transduction	GO:0007265	29	0.011
reactive nitrogen species metabolic process	GO:2001057	1	0.011
cation transmembrane transport	GO:0098655	263	0.011
regulation of membrane potential	GO:0042391	110	0.011
reproduction	GO:0000003	245	0.011
regulation of phosphate metabolic process	GO:0019220	349	0.011
glutamine family amino acid metabolic process	GO:0009064	15	0.011
cellular response to insulin stimulus	GO:0032869	81	0.011
alpha amino acid metabolic process	GO:1901605	71	0.011
small gtpase mediated signal transduction	GO:0007264	36	0.011
regulation of immune system process	GO:0002682	123	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
amide transport	GO:0042886	105	0.011
dendrite morphogenesis	GO:0048813	43	0.011
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.011
sensory organ development	GO:0007423	74	0.011
regulation of phosphorus metabolic process	GO:0051174	349	0.011
multi organism reproductive process	GO:0044703	262	0.011
molting cycle	GO:0042303	3	0.011
response to molecule of bacterial origin	GO:0002237	194	0.011
positive regulation of transferase activity	GO:0051347	81	0.011
lipid localization	GO:0010876	62	0.011
regulation of system process	GO:0044057	208	0.011
single organism intracellular transport	GO:1902582	166	0.010
response to nitrosative stress	GO:0051409	2	0.010
aging	GO:0007568	241	0.010
nucleotide metabolic process	GO:0009117	279	0.010	Yeast
neurological system process involved in regulation of systemic arterial blood pressure	GO:0001976	3	0.010
single organism carbohydrate metabolic process	GO:0044723	118	0.010
cell morphogenesis	GO:0000902	142	0.010
hair cycle	GO:0042633	3	0.010
cellular response to steroid hormone stimulus	GO:0071383	93	0.010
defense response to gram negative bacterium	GO:0050829	3	0.010
positive regulation of neuron differentiation	GO:0045666	126	0.010
ribonucleoside metabolic process	GO:0009119	174	0.010
g protein coupled receptor signaling pathway	GO:0007186	242	0.010
transmission of nerve impulse	GO:0019226	42	0.010
single organism biosynthetic process	GO:0044711	342	0.010	Yeast Rat
male gamete generation	GO:0048232	99	0.010
regeneration	GO:0031099	163	0.010
response to vitamin	GO:0033273	131	0.010	Rat
organic hydroxy compound transport	GO:0015850	77	0.010
regulation of catalytic activity	GO:0050790	304	0.010
regulation of establishment of planar polarity	GO:0090175	2	0.010

Aldh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.039
disease of metabolism	DOID:0014667	0.039
organic acidemia	DOID:0060159	0.031
amino acid metabolic disorder	DOID:9252	0.031
muscular disease	DOID:0080000	0.020
heart disease	DOID:114	0.020
cardiomyopathy	DOID:0050700	0.020
disease of anatomical entity	DOID:7	0.020
muscle tissue disease	DOID:66	0.020
myopathy	DOID:423	0.020
musculoskeletal system disease	DOID:17	0.020
intrinsic cardiomyopathy	DOID:0060036	0.020
arrhythmogenic right ventricular cardiomyopathy	DOID:0050431	0.020
cardiovascular system disease	DOID:1287	0.020

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