IMP: Integrative Multi-species Prediction

Rattus norvegicus

37 known processes

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

(Aliases: Cyp2e)

RGD: 2475
Ensembl: ENSRNOG00000012458
Entrez: 25086
UniProtKB: P05182

Process Predictions
Disease Predictions

Cyp2e1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
chlorinated hydrocarbon metabolic process	GO:0042196	4	0.856	Rat
oxoacid metabolic process	GO:0043436	290	0.849	Rat
alkaloid metabolic process	GO:0009820	3	0.794	Rat
long chain fatty acid metabolic process	GO:0001676	32	0.771	Rat
carboxylic acid metabolic process	GO:0019752	289	0.698	Rat
drug metabolic process	GO:0017144	11	0.660	Human Rat
organic acid metabolic process	GO:0006082	292	0.635	Rat
response to peptide	GO:1901652	292	0.596	Rat
coenzyme metabolic process	GO:0006732	86	0.511
exogenous drug catabolic process	GO:0042738	1	0.484
halogenated hydrocarbon metabolic process	GO:0042197	4	0.476	Rat
linoleic acid metabolic process	GO:0043651	4	0.466
cellular amino acid metabolic process	GO:0006520	107	0.374
cofactor metabolic process	GO:0051186	95	0.372
cellular lipid metabolic process	GO:0044255	208	0.371
nicotine metabolic process	GO:0018933	1	0.354	Rat
cellular response to peptide hormone stimulus	GO:0071375	120	0.344
trichloroethylene metabolic process	GO:0018979	1	0.322	Rat
response to insulin	GO:0032868	133	0.321	Rat
arachidonic acid metabolic process	GO:0019369	20	0.283	Rat
drug catabolic process	GO:0042737	1	0.268
sulfur compound metabolic process	GO:0006790	70	0.267
liver development	GO:0001889	90	0.260	Rat
naphthalene containing compound metabolic process	GO:0090420	2	0.259	Rat
small molecule catabolic process	GO:0044282	59	0.244
unsaturated fatty acid metabolic process	GO:0033559	39	0.229	Rat
xenobiotic metabolic process	GO:0006805	19	0.226
response to xenobiotic stimulus	GO:0009410	23	0.225
lipid metabolic process	GO:0006629	283	0.223
response to acid chemical	GO:0001101	222	0.221
response to metal ion	GO:0010038	253	0.189	Rat
catabolic process	GO:0009056	351	0.181
response to peptide hormone	GO:0043434	278	0.174	Rat
oxidation reduction process	GO:0055114	304	0.174
alpha amino acid metabolic process	GO:1901605	71	0.162
pyridine containing compound metabolic process	GO:0072524	32	0.155	Rat
fatty acid metabolic process	GO:0006631	99	0.148	Rat
lauric acid metabolic process	GO:0048252	4	0.137
monocarboxylic acid metabolic process	GO:0032787	152	0.135	Rat
cellular response to oxygen containing compound	GO:1901701	386	0.134
gland development	GO:0048732	155	0.124	Rat
epoxygenase p450 pathway	GO:0019373	1	0.122	Rat
naphthalene metabolic process	GO:0018931	2	0.119	Rat
steroid metabolic process	GO:0008202	73	0.119	Human
cellular response to peptide	GO:1901653	133	0.116
organ regeneration	GO:0031100	101	0.114
regeneration	GO:0031099	163	0.111
response to cesium ion	GO:0010164	2	0.109	Rat
acylglycerol metabolic process	GO:0006639	21	0.109
aromatic amino acid family catabolic process	GO:0009074	7	0.106
cellular response to xenobiotic stimulus	GO:0071466	19	0.101
fatty acid derivative metabolic process	GO:1901568	38	0.100	Rat
cellular response to lipid	GO:0071396	201	0.100
hepaticobiliary system development	GO:0061008	90	0.095	Rat
neutral lipid metabolic process	GO:0006638	21	0.094
amine metabolic process	GO:0009308	38	0.091
regulation of phosphate metabolic process	GO:0019220	349	0.088
icosanoid metabolic process	GO:0006690	38	0.087	Rat
response to testosterone	GO:0033574	55	0.083	Rat
response to toxic substance	GO:0009636	133	0.080
nucleobase containing small molecule metabolic process	GO:0055086	316	0.080
small molecule biosynthetic process	GO:0044283	124	0.078
cellular catabolic process	GO:0044248	295	0.076
response to ethanol	GO:0045471	162	0.074
single organism biosynthetic process	GO:0044711	342	0.070
development of primary sexual characteristics	GO:0045137	107	0.067
response to inorganic substance	GO:0010035	377	0.063
cellular ketone metabolic process	GO:0042180	51	0.062
response to camp	GO:0051591	91	0.060
organophosphate metabolic process	GO:0019637	370	0.059
triglyceride metabolic process	GO:0006641	21	0.059
response to sulfur dioxide	GO:0010477	3	0.058	Rat
protein oligomerization	GO:0051259	191	0.058
cellular response to external stimulus	GO:0071496	118	0.057
monosaccharide metabolic process	GO:0005996	61	0.057
regulation of cellular amino acid metabolic process	GO:0006521	2	0.056
single organism catabolic process	GO:0044712	283	0.056
secondary metabolic process	GO:0019748	15	0.055	Rat
multi organism reproductive process	GO:0044703	262	0.055	Rat
aromatic amino acid family metabolic process	GO:0009072	9	0.054
glycerolipid metabolic process	GO:0046486	67	0.054
response to oxygen levels	GO:0070482	265	0.053
calcitriol biosynthetic process from calciol	GO:0036378	2	0.052
neurological system process	GO:0050877	219	0.052
response to glucocorticoid	GO:0051384	223	0.052
carbohydrate derivative metabolic process	GO:1901135	346	0.051
regulation of cellular amine metabolic process	GO:0033238	8	0.051
carboxylic acid biosynthetic process	GO:0046394	83	0.051
single organism carbohydrate metabolic process	GO:0044723	118	0.050
organic acid biosynthetic process	GO:0016053	83	0.050
response to extracellular stimulus	GO:0009991	380	0.049
protein complex biogenesis	GO:0070271	263	0.049
regulation of cellular ketone metabolic process	GO:0010565	27	0.048
response to transition metal nanoparticle	GO:1990267	122	0.048
developmental process involved in reproduction	GO:0003006	159	0.045
nitrogen compound transport	GO:0071705	229	0.045
regulation of molecular function	GO:0065009	398	0.044
organic hydroxy compound metabolic process	GO:1901615	115	0.044	Rat
cellular macromolecule localization	GO:0070727	122	0.044
response to nutrient levels	GO:0031667	370	0.043
response to corticosteroid	GO:0031960	235	0.041
regulation of hormone levels	GO:0010817	187	0.039
response to estrogen	GO:0043627	232	0.038
purine containing compound metabolic process	GO:0072521	253	0.038
cellular amine metabolic process	GO:0044106	38	0.038
protein homooligomerization	GO:0051260	91	0.038
aromatic compound catabolic process	GO:0019439	168	0.037
chemical homeostasis	GO:0048878	292	0.037
cellular response to nitrogen compound	GO:1901699	210	0.037
organic cyclic compound catabolic process	GO:1901361	175	0.035
carbohydrate metabolic process	GO:0005975	130	0.035
organonitrogen compound biosynthetic process	GO:1901566	167	0.034	Rat
pyruvate metabolic process	GO:0006090	27	0.034
hexose biosynthetic process	GO:0019319	15	0.033
positive regulation of phosphorus metabolic process	GO:0010562	262	0.032
4 chlorobiphenyl metabolic process	GO:0018880	1	0.031
response to insecticide	GO:0017085	21	0.031
defense response	GO:0006952	194	0.031
carboxylic acid catabolic process	GO:0046395	49	0.030
nicotinamide nucleotide metabolic process	GO:0046496	28	0.030
hexose metabolic process	GO:0019318	58	0.030
establishment of tissue polarity	GO:0007164	2	0.030
macromolecular complex assembly	GO:0065003	273	0.029
negative regulation of natural killer cell mediated cytotoxicity	GO:0045953	4	0.029
phenylpropanoid metabolic process	GO:0009698	5	0.029	Rat
cellular response to insulin stimulus	GO:0032869	81	0.029
cellular response to organic cyclic compound	GO:0071407	202	0.029
homeostatic process	GO:0042592	331	0.029
thioester metabolic process	GO:0035383	28	0.028
benzene containing compound metabolic process	GO:0042537	22	0.028
positive regulation of cellular amine metabolic process	GO:0033240	3	0.028
cellular response to organonitrogen compound	GO:0071417	197	0.028
gluconeogenesis	GO:0006094	15	0.028
oxidoreduction coenzyme metabolic process	GO:0006733	31	0.028
cellular hormone metabolic process	GO:0034754	49	0.028
response to growth factor	GO:0070848	189	0.028
response to starvation	GO:0042594	59	0.027
central nervous system development	GO:0007417	311	0.027
peptide transport	GO:0015833	97	0.027
serine family amino acid biosynthetic process	GO:0009070	4	0.026
regulation of phosphorylation	GO:0042325	248	0.026
protein complex assembly	GO:0006461	263	0.025
nucleotide metabolic process	GO:0009117	279	0.025
response to platinum ion	GO:0070541	4	0.025
cellular response to endogenous stimulus	GO:0071495	377	0.025
response to nutrient	GO:0007584	248	0.025
organic hydroxy compound biosynthetic process	GO:1901617	51	0.025	Rat
cell cell signaling	GO:0007267	335	0.024
reproductive process	GO:0022414	372	0.024	Rat
ribonucleoside metabolic process	GO:0009119	174	0.024
sulfation	GO:0051923	2	0.024
glycosyl compound metabolic process	GO:1901657	182	0.024
hormone secretion	GO:0046879	115	0.023
nucleoside metabolic process	GO:0009116	179	0.023
aging	GO:0007568	241	0.023	Rat
single organism reproductive process	GO:0044702	297	0.023
biphenyl catabolic process	GO:0070980	2	0.022
secretion	GO:0046903	307	0.022
fluorene metabolic process	GO:0018917	1	0.022
hormone transport	GO:0009914	121	0.022
cellular response to testosterone stimulus	GO:0071394	5	0.022
phenol containing compound metabolic process	GO:0018958	30	0.022	Rat
monosaccharide biosynthetic process	GO:0046364	16	0.022
choline transport	GO:0015871	4	0.022
ion homeostasis	GO:0050801	212	0.021
response to monosaccharide	GO:0034284	159	0.021
protein tetramerization	GO:0051262	38	0.021
amide transport	GO:0042886	105	0.021
cellular response to iron ion starvation	GO:0010106	1	0.021
macromolecular complex subunit organization	GO:0043933	339	0.021
biphenyl metabolic process	GO:0018879	10	0.020
cellular response to steroid hormone stimulus	GO:0071383	93	0.020
reproductive structure development	GO:0048608	128	0.020
transmission of nerve impulse	GO:0019226	42	0.020
cellular protein localization	GO:0034613	122	0.020
peptidyl amino acid modification	GO:0018193	126	0.020
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.020
t cell tolerance induction	GO:0002517	3	0.020
response to organophosphorus	GO:0046683	102	0.020
regulation of signal transduction	GO:0009966	318	0.020
hormone catabolic process	GO:0042447	2	0.019
heterocycle catabolic process	GO:0046700	167	0.019
response to mercury ion	GO:0046689	15	0.019
behavior	GO:0007610	205	0.019
4 nitrophenol metabolic process	GO:0018960	1	0.019
protein homotetramerization	GO:0051289	25	0.018
positive regulation of tolerance induction	GO:0002645	1	0.018
blood circulation	GO:0008015	183	0.018
response to external biotic stimulus	GO:0043207	221	0.018
cellular modified amino acid metabolic process	GO:0006575	61	0.018
multi multicellular organism process	GO:0044706	138	0.018	Rat
response to radiation	GO:0009314	137	0.018	Rat
cellular component biogenesis	GO:0044085	368	0.018
purine ribonucleoside metabolic process	GO:0046128	168	0.017
purine nucleoside metabolic process	GO:0042278	169	0.017
regulation of apoptotic process	GO:0042981	335	0.017
dicarboxylic acid metabolic process	GO:0043648	42	0.017
response to ionizing radiation	GO:0010212	59	0.017	Rat
positive regulation of catalytic activity	GO:0043085	184	0.017
multicellular organismal homeostasis	GO:0048871	49	0.017
regulation of transferase activity	GO:0051338	123	0.017
terpenoid metabolic process	GO:0006721	37	0.017	Human Rat
antral ovarian follicle growth	GO:0001547	3	0.017
peptidyl tyrosine modification	GO:0018212	72	0.016
response to vitamin e	GO:0033197	24	0.016
response to zinc ion	GO:0010043	39	0.016
isoprenoid metabolic process	GO:0006720	45	0.016	Human Rat
regulation of peptide transport	GO:0090087	87	0.016
glucose metabolic process	GO:0006006	52	0.016
positive regulation of secretion by cell	GO:1903532	128	0.016
regulation of programmed cell death	GO:0043067	341	0.016
rhythmic process	GO:0048511	156	0.016
insecticide metabolic process	GO:0017143	4	0.016
regulation of gluconeogenesis	GO:0006111	4	0.016
regulation of lipid metabolic process	GO:0019216	68	0.016
apoptotic process	GO:0006915	381	0.016
regulation of catalytic activity	GO:0050790	304	0.015
cellular response to growth factor stimulus	GO:0071363	162	0.015
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.015
negative regulation of metabolic process	GO:0009892	331	0.015
response to carbohydrate	GO:0009743	183	0.015
negative regulation of innate immune response	GO:0045824	4	0.015
response to purine containing compound	GO:0014074	126	0.015
secondary alcohol metabolic process	GO:1902652	2	0.015
response to lead ion	GO:0010288	33	0.015
tolerance induction dependent upon immune response	GO:0002461	2	0.015
response to biotic stimulus	GO:0009607	226	0.015
action potential	GO:0001508	54	0.015
organic substance catabolic process	GO:1901575	316	0.015
reproduction	GO:0000003	245	0.015
organonitrogen compound catabolic process	GO:1901565	179	0.015
response to amino acid	GO:0043200	75	0.014
reproductive system development	GO:0061458	128	0.014
response to hexose	GO:0009746	144	0.014
insulin secretion	GO:0030073	69	0.014
regulation of protein modification process	GO:0031399	194	0.014
lipid storage	GO:0019915	1	0.014
sex differentiation	GO:0007548	113	0.014
cellular modified amino acid catabolic process	GO:0042219	1	0.014
cellular response to hormone stimulus	GO:0032870	247	0.014
anatomical structure homeostasis	GO:0060249	29	0.014
programmed cell death	GO:0012501	392	0.014
multicellular organism reproduction	GO:0032504	233	0.014
response to ddt	GO:0046680	1	0.013
coumarin metabolic process	GO:0009804	5	0.013	Rat
androgen metabolic process	GO:0008209	14	0.013
sulfur amino acid metabolic process	GO:0000096	9	0.013
heart development	GO:0007507	72	0.013
response to glucose	GO:0009749	136	0.013
transmembrane transport	GO:0055085	412	0.013
isoquinoline alkaloid metabolic process	GO:0033076	2	0.013
catechol containing compound metabolic process	GO:0009712	19	0.013	Rat
one carbon compound transport	GO:0019755	5	0.013
anatomical structure morphogenesis	GO:0009653	298	0.012
immune system process	GO:0002376	204	0.012
glial cell differentiation	GO:0010001	65	0.012
regulation of phosphorus metabolic process	GO:0051174	349	0.012
regulation of insulin secretion	GO:0050796	65	0.012
sensory perception of smell	GO:0007608	5	0.012
phenol containing compound biosynthetic process	GO:0046189	9	0.012	Rat
cellular response to nutrient levels	GO:0031669	60	0.012
fatty acid catabolic process	GO:0009062	26	0.012
sensory perception	GO:0007600	101	0.012
response to alkaloid	GO:0043279	132	0.012
positive regulation of response to stimulus	GO:0048584	285	0.012
regulation of blood circulation	GO:1903522	110	0.012
xenobiotic catabolic process	GO:0042178	7	0.012
fructose 2 6 bisphosphate metabolic process	GO:0006003	2	0.012
circadian rhythm	GO:0007623	88	0.012
negative regulation of protein metabolic process	GO:0051248	114	0.012
peptide secretion	GO:0002790	86	0.012
negative regulation of cell differentiation	GO:0045596	99	0.011
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.011
alpha amino acid catabolic process	GO:1901606	20	0.011
neurotransmitter uptake	GO:0001504	3	0.011
intracellular protein transport	GO:0006886	79	0.011
spermatogenesis	GO:0007283	99	0.011
nucleoside phosphate metabolic process	GO:0006753	283	0.011
cellular nitrogen compound catabolic process	GO:0044270	163	0.011
pyridine nucleotide metabolic process	GO:0019362	28	0.011
oxidative demethylation	GO:0070989	2	0.011
response to genistein	GO:0033595	4	0.011
toxin catabolic process	GO:0009407	1	0.011
response to fatty acid	GO:0070542	65	0.011
male gonad development	GO:0008584	59	0.010
protein complex subunit organization	GO:0071822	302	0.010
lipid oxidation	GO:0034440	30	0.010
negative regulation of protein import into nucleus translocation	GO:0033159	1	0.010
negative regulation of cellular amino acid metabolic process	GO:0045763	0	0.010
intracellular transport	GO:0046907	185	0.010
regulation of system process	GO:0044057	208	0.010
development of primary male sexual characteristics	GO:0046546	59	0.010
catecholamine metabolic process	GO:0006584	19	0.010	Rat
regulation of tolerance induction dependent upon immune response	GO:0002652	1	0.010
catecholamine biosynthetic process	GO:0042423	9	0.010	Rat
protein transport	GO:0015031	132	0.010
response to oxidative stress	GO:0006979	186	0.010
protein targeting	GO:0006605	61	0.010
cellular alcohol biosynthetic process	GO:0044108	2	0.010
small gtpase mediated signal transduction	GO:0007264	36	0.010
regulation of protein phosphorylation	GO:0001932	183	0.010
lipid catabolic process	GO:0016042	46	0.010
protein localization	GO:0008104	191	0.010
pyrimidine nucleobase catabolic process	GO:0006208	3	0.010

Cyp2e1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of metabolism	DOID:0014667	0.040
acquired metabolic disease	DOID:0060158	0.017
nutrition disease	DOID:374	0.017
urinary system disease	DOID:18	0.015
disease of anatomical entity	DOID:7	0.015
kidney disease	DOID:557	0.015
renal tubular transport disease	DOID:447	0.015
long qt syndrome	DOID:2843	0.012

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