IMP: Integrative Multi-species Prediction

Rattus norvegicus

234 known processes

Mdm2

Mdm2 p53 binding protein homolog (mouse)

Entrez: 314856
RGD: 1305332
Ensembl: ENSRNOG00000006304
UniProtKB: D3ZVH5

Process Predictions
Disease Predictions

Mdm2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
programmed cell death	GO:0012501	392	0.398
regulation of programmed cell death	GO:0043067	341	0.355
apoptotic process	GO:0006915	381	0.329
behavior	GO:0007610	205	0.310
regulation of apoptotic process	GO:0042981	335	0.276
response to inorganic substance	GO:0010035	377	0.221
response to oxygen levels	GO:0070482	265	0.218
protein complex biogenesis	GO:0070271	263	0.214
cellular response to stress	GO:0033554	269	0.210
response to decreased oxygen levels	GO:0036293	237	0.180
response to radiation	GO:0009314	137	0.171
nucleic acid templated transcription	GO:0097659	379	0.165
cell cycle	GO:0007049	101	0.164
response to reactive oxygen species	GO:0000302	120	0.157
macromolecular complex subunit organization	GO:0043933	339	0.157
protein complex assembly	GO:0006461	263	0.149
response to nutrient levels	GO:0031667	370	0.148
regulation of rna metabolic process	GO:0051252	391	0.140
proteolysis	GO:0006508	175	0.133
transcription from rna polymerase ii promoter	GO:0006366	252	0.129
rna metabolic process	GO:0016070	406	0.126
response to hypoxia	GO:0001666	231	0.123
locomotor rhythm	GO:0045475	1	0.116
organelle organization	GO:0006996	266	0.114
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.114
regulation of molecular function	GO:0065009	398	0.113
rna biosynthetic process	GO:0032774	380	0.113
cell type specific apoptotic process	GO:0097285	134	0.111
regulation of catalytic activity	GO:0050790	304	0.110
response to wounding	GO:0009611	254	0.109
regulation of hydrolase activity	GO:0051336	143	0.108
regulation of proteasomal protein catabolic process	GO:0061136	4	0.106
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.104
cellular response to oxygen containing compound	GO:1901701	386	0.102
intracellular signal transduction	GO:0035556	314	0.096
regulation of cellular component organization	GO:0051128	368	0.094
cellular component biogenesis	GO:0044085	368	0.094
protein complex subunit organization	GO:0071822	302	0.094
regulation of cell differentiation	GO:0045595	320	0.089
positive regulation of cell death	GO:0010942	184	0.088
mitotic cell cycle process	GO:1903047	35	0.087
transcription dna templated	GO:0006351	377	0.086
rhythmic process	GO:0048511	156	0.084
negative regulation of cell proliferation	GO:0008285	119	0.083
cellular response to endogenous stimulus	GO:0071495	377	0.083
response to purine containing compound	GO:0014074	126	0.083
negative regulation of cell death	GO:0060548	229	0.083
regulation of rna biosynthetic process	GO:2001141	381	0.082
response to molecule of bacterial origin	GO:0002237	194	0.081
regulation of nucleic acid templated transcription	GO:1903506	380	0.080
response to oxidative stress	GO:0006979	186	0.080
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.079
mitotic cell cycle	GO:0000278	49	0.078
cellular component assembly	GO:0022607	360	0.077
reproductive structure development	GO:0048608	128	0.077
cell cycle process	GO:0022402	57	0.076
cellular catabolic process	GO:0044248	295	0.074
cellular response to oxidative stress	GO:0034599	76	0.074
response to temperature stimulus	GO:0009266	94	0.074
macromolecular complex assembly	GO:0065003	273	0.073
positive regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032436	3	0.072
regulation of cell proliferation	GO:0042127	359	0.072
response to estrogen	GO:0043627	232	0.071
regulation of phosphorus metabolic process	GO:0051174	349	0.071
positive regulation of programmed cell death	GO:0043068	157	0.071
negative regulation of macromolecule metabolic process	GO:0010605	260	0.069
anatomical structure morphogenesis	GO:0009653	298	0.068
response to hydrogen peroxide	GO:0042542	89	0.068
positive regulation of catalytic activity	GO:0043085	184	0.068
spindle organization	GO:0007051	2	0.068
neuron death	GO:0070997	127	0.067
positive regulation of apoptotic process	GO:0043065	154	0.066
negative regulation of programmed cell death	GO:0043069	183	0.065
protein phosphorylation	GO:0006468	345	0.064
negative regulation of cellular metabolic process	GO:0031324	281	0.064
positive regulation of molecular function	GO:0044093	230	0.063
response to extracellular stimulus	GO:0009991	380	0.062
regulation of cellular localization	GO:0060341	263	0.061
response to light stimulus	GO:0009416	52	0.060
response to glucocorticoid	GO:0051384	223	0.060
regulation of transcription dna templated	GO:0006355	374	0.059
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.059
cell cycle checkpoint	GO:0000075	2	0.059
regulation of phosphate metabolic process	GO:0019220	349	0.057
reproductive process	GO:0022414	372	0.057
regulation of cell cycle	GO:0051726	73	0.057
regulation of system process	GO:0044057	208	0.056
regulation of signal transduction	GO:0009966	318	0.056
regulation of nucleocytoplasmic transport	GO:0046822	28	0.056
positive regulation of cellular biosynthetic process	GO:0031328	295	0.055
growth	GO:0040007	165	0.055
negative regulation of mitotic cell cycle phase transition	GO:1901991	3	0.055
negative regulation of metabolic process	GO:0009892	331	0.054
positive regulation of rna metabolic process	GO:0051254	203	0.053
negative regulation of cell communication	GO:0010648	158	0.050
homeostatic process	GO:0042592	331	0.049
response to metal ion	GO:0010038	253	0.048
regulation of hormone secretion	GO:0046883	106	0.048
response to ammonium ion	GO:0060359	71	0.047
positive regulation of biosynthetic process	GO:0009891	319	0.047
neurological system process	GO:0050877	219	0.047
negative regulation of gene expression	GO:0010629	199	0.047
regulation of protein localization	GO:0032880	81	0.045
response to organophosphorus	GO:0046683	102	0.045
negative regulation of apoptotic process	GO:0043066	181	0.045
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.045
response to corticosteroid	GO:0031960	235	0.045
positive regulation of rna biosynthetic process	GO:1902680	197	0.044
single organism reproductive process	GO:0044702	297	0.044
reproductive system development	GO:0061458	128	0.044
nucleotide metabolic process	GO:0009117	279	0.044
single organism behavior	GO:0044708	130	0.044
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	1	0.043
cation transport	GO:0006812	382	0.042
regulation of protein metabolic process	GO:0051246	289	0.042
positive regulation of response to stimulus	GO:0048584	285	0.042
cell cell signaling	GO:0007267	335	0.041
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.041
sexual reproduction	GO:0019953	148	0.040
locomotion	GO:0040011	237	0.040
regulation of response to stress	GO:0080134	126	0.040
positive regulation of gene expression	GO:0010628	244	0.040
response to biotic stimulus	GO:0009607	226	0.040
smad protein complex assembly	GO:0007183	1	0.039
tissue development	GO:0009888	252	0.039
response to transition metal nanoparticle	GO:1990267	122	0.039
response to alkaloid	GO:0043279	132	0.039
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.039
developmental process involved in reproduction	GO:0003006	159	0.039
regulation of ion transport	GO:0043269	245	0.038
cognition	GO:0050890	92	0.038
regulation of cellular protein metabolic process	GO:0032268	267	0.038
negative regulation of molecular function	GO:0044092	133	0.037
purine ribonucleotide catabolic process	GO:0009154	136	0.036
neuron development	GO:0048666	286	0.036
response to peptide	GO:1901652	292	0.035
negative regulation of response to stimulus	GO:0048585	155	0.035
meiotic cell cycle process	GO:1903046	3	0.035
regulation of organelle organization	GO:0033043	80	0.035
negative regulation of neuron apoptotic process	GO:0043524	45	0.034
nucleoside monophosphate metabolic process	GO:0009123	93	0.034
regulation of neuron death	GO:1901214	115	0.034
positive regulation of cellular catabolic process	GO:0031331	71	0.033
single organism carbohydrate metabolic process	GO:0044723	118	0.033
protein localization	GO:0008104	191	0.033
organ regeneration	GO:0031100	101	0.033
learning or memory	GO:0007611	90	0.032
meiosis i	GO:0007127	2	0.032
cellular response to hormone stimulus	GO:0032870	247	0.032
response to cytokine	GO:0034097	215	0.032
cellular carbohydrate metabolic process	GO:0044262	72	0.031
reproduction	GO:0000003	245	0.031
dephosphorylation	GO:0016311	98	0.031
regulation of phosphorylation	GO:0042325	248	0.031
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.031
circulatory system process	GO:0003013	183	0.031
regulation of protein modification process	GO:0031399	194	0.031
nucleocytoplasmic transport	GO:0006913	48	0.030
protein modification by small protein conjugation or removal	GO:0070647	35	0.030
positive regulation of cellular protein metabolic process	GO:0032270	167	0.030
response to other organism	GO:0051707	220	0.029
positive regulation of cell proliferation	GO:0008284	249	0.029
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.029
purine ribonucleotide metabolic process	GO:0009150	227	0.029
regulation of catabolic process	GO:0009894	113	0.029
cell cycle phase transition	GO:0044770	21	0.029
positive regulation of cellular component organization	GO:0051130	200	0.029
catabolic process	GO:0009056	351	0.029
regulation of protein transport	GO:0051223	68	0.028
cellular response to steroid hormone stimulus	GO:0071383	93	0.028
mitotic cell cycle phase transition	GO:0044772	20	0.028
response to camp	GO:0051591	91	0.028
cellular component movement	GO:0006928	248	0.028
oxoacid metabolic process	GO:0043436	290	0.028
negative regulation of transcription dna templated	GO:0045892	116	0.027
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	3	0.027
ubiquitin dependent protein catabolic process	GO:0006511	14	0.027
organic substance catabolic process	GO:1901575	316	0.027
regulation of hormone levels	GO:0010817	187	0.027
regulation of intracellular signal transduction	GO:1902531	218	0.027
amide transport	GO:0042886	105	0.026
response to carbohydrate	GO:0009743	183	0.026
reactive oxygen species metabolic process	GO:0072593	37	0.026
gland development	GO:0048732	155	0.026
metal ion transport	GO:0030001	289	0.026
dna metabolic process	GO:0006259	96	0.026
cellular protein localization	GO:0034613	122	0.026
negative regulation of biosynthetic process	GO:0009890	168	0.026
response to bacterium	GO:0009617	200	0.025
blood circulation	GO:0008015	183	0.025
negative regulation of rna metabolic process	GO:0051253	123	0.025
positive regulation of phosphate metabolic process	GO:0045937	262	0.025
positive regulation of proteasomal protein catabolic process	GO:1901800	3	0.025
response to lipopolysaccharide	GO:0032496	191	0.025
positive regulation of protein metabolic process	GO:0051247	178	0.025
response to external biotic stimulus	GO:0043207	221	0.025
positive regulation of hydrolase activity	GO:0051345	86	0.025
regulation of peptide transport	GO:0090087	87	0.024
positive regulation of cell communication	GO:0010647	271	0.024
positive regulation of catabolic process	GO:0009896	78	0.024
regulation of locomotion	GO:0040012	148	0.024
organic acid metabolic process	GO:0006082	292	0.024
mitotic cell cycle checkpoint	GO:0007093	1	0.023
apoptotic signaling pathway	GO:0097190	27	0.023
positive regulation of protein modification process	GO:0031401	142	0.023
rhythmic behavior	GO:0007622	24	0.023
regulation of neuron apoptotic process	GO:0043523	83	0.023
cellular response to reactive oxygen species	GO:0034614	55	0.023
purine nucleoside metabolic process	GO:0042278	169	0.023
regulation of response to external stimulus	GO:0032101	106	0.023
regulation of protein phosphorylation	GO:0001932	183	0.023
positive regulation of nucleocytoplasmic transport	GO:0046824	17	0.023
nucleoside monophosphate catabolic process	GO:0009125	56	0.023
response to nutrient	GO:0007584	248	0.023
transforming growth factor beta receptor signaling pathway	GO:0007179	18	0.022
response to ethanol	GO:0045471	162	0.022
regulation of secretion	GO:0051046	224	0.022
regulation of cell cycle process	GO:0010564	31	0.022
positive regulation of signaling	GO:0023056	270	0.022
multicellular organismal reproductive process	GO:0048609	233	0.022
regulation of multicellular organismal development	GO:2000026	376	0.022
protein oligomerization	GO:0051259	191	0.022
purine ribonucleoside catabolic process	GO:0046130	124	0.022
regulation of nervous system development	GO:0051960	264	0.022
regulation of cellular response to stress	GO:0080135	49	0.022
purine containing compound metabolic process	GO:0072521	253	0.022
multi organism reproductive process	GO:0044703	262	0.021
regulation of membrane potential	GO:0042391	110	0.021
ribonucleoside catabolic process	GO:0042454	126	0.021
wound healing	GO:0042060	122	0.021
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.021
negative regulation of signal transduction	GO:0009968	83	0.021
bmp signaling pathway	GO:0030509	4	0.021
nucleoside triphosphate catabolic process	GO:0009143	123	0.020
response to ketone	GO:1901654	182	0.020
intracellular transport	GO:0046907	185	0.020
peptide transport	GO:0015833	97	0.020
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.020
ribonucleotide metabolic process	GO:0009259	231	0.020
regulation of transforming growth factor beta3 production	GO:0032910	2	0.020
negative regulation of rna biosynthetic process	GO:1902679	118	0.020
regulation of protein kinase activity	GO:0045859	105	0.020
regulation of blood circulation	GO:1903522	110	0.020
establishment of protein localization	GO:0045184	141	0.020
response to glucose	GO:0009749	136	0.020
cellular response to molecule of bacterial origin	GO:0071219	56	0.020
positive regulation of transcription dna templated	GO:0045893	197	0.020
positive regulation of immune system process	GO:0002684	90	0.020
regulation of secretion by cell	GO:1903530	208	0.020
hormone transport	GO:0009914	121	0.020
positive regulation of multicellular organismal process	GO:0051240	387	0.020
regulation of transferase activity	GO:0051338	123	0.019
positive regulation of signal transduction	GO:0009967	175	0.019
aging	GO:0007568	241	0.019
cellular macromolecule catabolic process	GO:0044265	29	0.019
calcium ion transport	GO:0006816	131	0.019
negative regulation of cell cycle phase transition	GO:1901988	4	0.019
cellular response to organic cyclic compound	GO:0071407	202	0.019
jak stat cascade	GO:0007259	26	0.019
cell growth	GO:0016049	104	0.019
positive regulation of mitochondrion organization	GO:0010822	4	0.019
negative regulation of neuron death	GO:1901215	69	0.019
signal release	GO:0023061	145	0.019
regulation of protein targeting	GO:1903533	28	0.019
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.019
cell motility	GO:0048870	202	0.019
ribose phosphate metabolic process	GO:0019693	235	0.019
positive regulation of developmental process	GO:0051094	283	0.019
brain development	GO:0007420	247	0.019
protein maturation	GO:0051604	68	0.019
cytoplasmic transport	GO:0016482	115	0.019
cellular ketone metabolic process	GO:0042180	51	0.018
ion homeostasis	GO:0050801	212	0.018
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway	GO:2001269	1	0.018
cellular amino acid metabolic process	GO:0006520	107	0.018
negative regulation of multicellular organismal process	GO:0051241	203	0.018
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.018
response to monosaccharide	GO:0034284	159	0.018
nucleobase containing small molecule metabolic process	GO:0055086	316	0.018
action potential	GO:0001508	54	0.018
positive regulation of ion transport	GO:0043270	94	0.018
regulation of proteolysis	GO:0030162	66	0.018
secretion	GO:0046903	307	0.018
negative regulation of cell differentiation	GO:0045596	99	0.018
organic cyclic compound catabolic process	GO:1901361	175	0.018
negative regulation of signaling	GO:0023057	157	0.018
cellular response to corticosteroid stimulus	GO:0071384	69	0.017
positive regulation of secretion by cell	GO:1903532	128	0.017
positive regulation of transport	GO:0051050	245	0.017
response to heat	GO:0009408	60	0.017
regulation of neuron differentiation	GO:0045664	208	0.017
response to estradiol	GO:0032355	164	0.017
regulation of nucleotide catabolic process	GO:0030811	65	0.017
regulation of peptidase activity	GO:0052547	55	0.017
response to interleukin 13	GO:0035962	3	0.017
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.017
neuron apoptotic process	GO:0051402	88	0.017
regulation of neurogenesis	GO:0050767	247	0.017
negative regulation of cellular component organization	GO:0051129	83	0.017
mammary gland epithelium development	GO:0061180	1	0.017
nucleoside phosphate catabolic process	GO:1901292	140	0.017
response to peptide hormone	GO:0043434	278	0.017
response to hexose	GO:0009746	144	0.017
nitrogen compound transport	GO:0071705	229	0.017
cellular chemical homeostasis	GO:0055082	247	0.016
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.016
circadian rhythm	GO:0007623	88	0.016
cellular response to hydrogen peroxide	GO:0070301	42	0.016
organophosphate metabolic process	GO:0019637	370	0.016
negative regulation of mitotic cell cycle	GO:0045930	6	0.016
cellular response to cytokine stimulus	GO:0071345	127	0.016
response to insulin	GO:0032868	133	0.016
regulation of cell development	GO:0060284	263	0.016
chemical homeostasis	GO:0048878	292	0.016
purine nucleotide metabolic process	GO:0006163	229	0.016
purine nucleotide catabolic process	GO:0006195	136	0.016
signal transduction by phosphorylation	GO:0023014	144	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.016
dna integrity checkpoint	GO:0031570	2	0.016
cellular response to dna damage stimulus	GO:0006974	19	0.016
membrane organization	GO:0061024	94	0.016
regeneration	GO:0031099	163	0.016
neuron differentiation	GO:0030182	368	0.016
regulation of metal ion transport	GO:0010959	118	0.016
single organism catabolic process	GO:0044712	283	0.016
carbohydrate derivative metabolic process	GO:1901135	346	0.016
multicellular organism reproduction	GO:0032504	233	0.015
defense response	GO:0006952	194	0.015
central nervous system development	GO:0007417	311	0.015
cellular response to oxygen levels	GO:0071453	60	0.015
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.015
embryonic pattern specification	GO:0009880	1	0.015
negative regulation of transport	GO:0051051	136	0.015
response to vitamin	GO:0033273	131	0.015
positive regulation of organelle organization	GO:0010638	48	0.015
regulation of cellular component movement	GO:0051270	150	0.015
centrosome organization	GO:0051297	1	0.015
inflammatory response	GO:0006954	150	0.015
cytoskeleton organization	GO:0007010	111	0.015
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.015
serine family amino acid metabolic process	GO:0009069	12	0.015
response to electrical stimulus	GO:0051602	56	0.015
positive regulation of peptide secretion	GO:0002793	52	0.015
negative regulation of cellular biosynthetic process	GO:0031327	161	0.015
regulation of muscle cell apoptotic process	GO:0010660	26	0.015
cellular response to glucocorticoid stimulus	GO:0071385	68	0.015
protein dephosphorylation	GO:0006470	38	0.014
chromosome segregation	GO:0007059	2	0.014
muscle system process	GO:0003012	115	0.014
gtp catabolic process	GO:0006184	71	0.014
negative regulation of peptidase activity	GO:0010466	38	0.014
regulation of cellular catabolic process	GO:0031329	101	0.014
placenta development	GO:0001890	22	0.014
nucleoside phosphate metabolic process	GO:0006753	283	0.014
cellular response to lipid	GO:0071396	201	0.014
nucleoside triphosphate metabolic process	GO:0009141	144	0.014
developmental growth	GO:0048589	100	0.014
neuron projection development	GO:0031175	273	0.014
regulation of cell motility	GO:2000145	131	0.014
regulation of protein import into nucleus	GO:0042306	24	0.014
nuclear import	GO:0051170	35	0.014
regulation of p38mapk cascade	GO:1900744	1	0.014
multicellular organism growth	GO:0035264	1	0.014
positive regulation of secretion	GO:0051047	140	0.014
muscle cell apoptotic process	GO:0010657	30	0.014
negative regulation of muscle cell apoptotic process	GO:0010656	21	0.014
regulation of kinase activity	GO:0043549	117	0.014
neuronal action potential	GO:0019228	35	0.014
regulation of smooth muscle cell proliferation	GO:0048660	75	0.014
response to antibiotic	GO:0046677	39	0.013
gamete generation	GO:0007276	124	0.013
purine containing compound catabolic process	GO:0072523	138	0.013
nucleoside metabolic process	GO:0009116	179	0.013
protein processing	GO:0016485	68	0.013
metaphase anaphase transition of cell cycle	GO:0044784	1	0.013
cellular response to alcohol	GO:0097306	87	0.013
positive regulation of cell differentiation	GO:0045597	217	0.013
positive regulation of nervous system development	GO:0051962	178	0.013
cellular component morphogenesis	GO:0032989	155	0.013
cellular response to nitrogen compound	GO:1901699	210	0.013
cellular response to organonitrogen compound	GO:0071417	197	0.013
carbohydrate derivative catabolic process	GO:1901136	147	0.013
carbohydrate metabolic process	GO:0005975	130	0.013
small gtpase mediated signal transduction	GO:0007264	36	0.013
atp catabolic process	GO:0006200	54	0.013
carboxylic acid metabolic process	GO:0019752	289	0.013
macromolecule catabolic process	GO:0009057	58	0.013
regulation of protein serine threonine kinase activity	GO:0071900	64	0.013
regulation of neuron projection development	GO:0010975	161	0.013
cell migration	GO:0016477	197	0.013
organonitrogen compound catabolic process	GO:1901565	179	0.013
g protein coupled receptor signaling pathway	GO:0007186	242	0.013
negative regulation of intracellular signal transduction	GO:1902532	38	0.013
positive regulation of phosphorus metabolic process	GO:0010562	262	0.013
cellular response to growth factor stimulus	GO:0071363	162	0.013
activation of cysteine type endopeptidase activity	GO:0097202	4	0.013
single organism intracellular transport	GO:1902582	166	0.013
cellular homeostasis	GO:0019725	252	0.013
response to dexamethasone	GO:0071548	49	0.013
response to acid chemical	GO:0001101	222	0.012
protein catabolic process	GO:0030163	30	0.012
mitotic dna damage checkpoint	GO:0044773	1	0.012
cellular cation homeostasis	GO:0030003	180	0.012
regulation of cytoskeleton organization	GO:0051493	49	0.012
single organism cellular localization	GO:1902580	102	0.012
chromosome separation	GO:0051304	1	0.012
nucleotide catabolic process	GO:0009166	139	0.012
regulation of apoptotic signaling pathway	GO:2001233	13	0.012
gastrulation	GO:0007369	2	0.012
glycosyl compound metabolic process	GO:1901657	182	0.012
protein import	GO:0017038	37	0.012
protein targeting to nucleus	GO:0044744	35	0.012
cellular macromolecule localization	GO:0070727	122	0.012
intrinsic apoptotic signaling pathway in response to dna damage	GO:0008630	1	0.012
metaphase anaphase transition of mitotic cell cycle	GO:0007091	1	0.012
positive regulation of phosphorylation	GO:0042327	177	0.012
transmission of nerve impulse	GO:0019226	42	0.012
protein modification by small protein conjugation	GO:0032446	31	0.012
protein localization to nucleus	GO:0034504	39	0.012
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.012
modification dependent macromolecule catabolic process	GO:0043632	14	0.012
response to axon injury	GO:0048678	59	0.012
regulation of nucleoside metabolic process	GO:0009118	66	0.012
heart process	GO:0003015	57	0.012
modification dependent protein catabolic process	GO:0019941	14	0.012
multi multicellular organism process	GO:0044706	138	0.012
mitotic spindle organization	GO:0007052	2	0.012
positive regulation of nucleotide metabolic process	GO:0045981	91	0.012
cellular protein complex assembly	GO:0043623	44	0.012
regulation of cell projection organization	GO:0031344	175	0.011
response to ionizing radiation	GO:0010212	59	0.011
nuclear transport	GO:0051169	49	0.011
regulation of heart contraction	GO:0008016	48	0.011
calcium ion homeostasis	GO:0055074	162	0.011
regulation of defense response	GO:0031347	68	0.011
cellular response to ketone	GO:1901655	51	0.011
myelination	GO:0042552	39	0.011
regulation of body fluid levels	GO:0050878	90	0.011
cellular response to dexamethasone stimulus	GO:0071549	36	0.011
cellular response to external stimulus	GO:0071496	118	0.011
positive regulation of proteolysis involved in cellular protein catabolic process	GO:1903052	6	0.011
insulin secretion	GO:0030073	69	0.011
ncrna processing	GO:0034470	3	0.011
immune system process	GO:0002376	204	0.011
p38mapk cascade	GO:0038066	1	0.011
divalent inorganic cation transport	GO:0072511	134	0.011
single organism organelle organization	GO:1902589	180	0.011
regulation of growth	GO:0040008	105	0.011
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.011
reactive oxygen species biosynthetic process	GO:1903409	8	0.011
cellular response to peptide	GO:1901653	133	0.011
divalent metal ion transport	GO:0070838	132	0.011
purine nucleoside catabolic process	GO:0006152	124	0.011
positive regulation of protein localization to nucleus	GO:1900182	15	0.011
positive regulation of biomineral tissue development	GO:0070169	4	0.011
cell projection organization	GO:0030030	302	0.011
response to luteinizing hormone	GO:0034699	5	0.011
activation of mapkk activity	GO:0000186	18	0.011
metal ion homeostasis	GO:0055065	186	0.011
neuronal ion channel clustering	GO:0045161	3	0.011
positive regulation of protein phosphorylation	GO:0001934	135	0.011
regulation of mitotic sister chromatid segregation	GO:0033047	1	0.011
single fertilization	GO:0007338	3	0.011
protein autophosphorylation	GO:0046777	66	0.011
positive regulation of cell projection organization	GO:0031346	111	0.011
positive regulation of peptide hormone secretion	GO:0090277	50	0.011
protein ubiquitination	GO:0016567	28	0.011
regulation of calcium ion transport	GO:0051924	77	0.011
microtubule organizing center organization	GO:0031023	1	0.011
regulation of cellular ketone metabolic process	GO:0010565	27	0.011
nucleoside catabolic process	GO:0009164	126	0.011
positive regulation of cytokine production	GO:0001819	42	0.011
positive regulation of nucleotide catabolic process	GO:0030813	53	0.011
single organism nuclear import	GO:1902593	35	0.010
response to uv c	GO:0010225	2	0.010
axis specification	GO:0009798	4	0.010
cation homeostasis	GO:0055080	195	0.010
multicellular organismal signaling	GO:0035637	44	0.010
response to growth factor	GO:0070848	189	0.010
cellular protein catabolic process	GO:0044257	19	0.010
response to toxic substance	GO:0009636	133	0.010
regulation of establishment of protein localization	GO:0070201	69	0.010
response to cocaine	GO:0042220	39	0.010
regulation of cellular amino acid metabolic process	GO:0006521	2	0.010
cellular response to lipopolysaccharide	GO:0071222	55	0.010
tissue morphogenesis	GO:0048729	22	0.010
cellular amide metabolic process	GO:0043603	44	0.010
secretion by cell	GO:0032940	248	0.010
positive regulation of hormone secretion	GO:0046887	65	0.010
negative regulation of cellular protein metabolic process	GO:0032269	106	0.010
regulation of synaptic transmission	GO:0050804	141	0.010

Mdm2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.046
cancer	DOID:162	0.046
disease of anatomical entity	DOID:7	0.017
musculoskeletal system disease	DOID:17	0.017
organ system cancer	DOID:0050686	0.015

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