Rattus norvegicus

153 known processes

Npr3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

(Aliases: NPRC,ANP-CR)

Npr3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
enzyme linked receptor protein signaling pathwayGO:00071671160.667
cardiovascular system developmentGO:00723581340.516
circulatory system developmentGO:00723591340.439
response to oxygen levelsGO:00704822650.404
blood vessel developmentGO:0001568690.384
regulation of programmed cell deathGO:00430673410.354
response to transforming growth factor betaGO:0071559460.315
tissue developmentGO:00098882520.313
anatomical structure morphogenesisGO:00096532980.308
cellular ion homeostasisGO:00068731840.307
response to estrogenGO:00436272320.286
cellular response to endogenous stimulusGO:00714953770.271
positive regulation of nitrogen compound metabolic processGO:00511733340.262
positive regulation of macromolecule biosynthetic processGO:00105572470.259
cation homeostasisGO:00550801950.259
cellular metal ion homeostasisGO:00068751720.255
positive regulation of programmed cell deathGO:00430681570.253
response to hypoxiaGO:00016662310.236
regulation of cell proliferationGO:00421273590.230
carboxylic acid metabolic processGO:00197522890.209
regulation of apoptotic processGO:00429813350.203
apoptotic processGO:00069153810.199
programmed cell deathGO:00125013920.199
positive regulation of apoptotic processGO:00430651540.199
regulation of multicellular organismal developmentGO:20000263760.198
cellular response to growth factor stimulusGO:00713631620.197
positive regulation of cell differentiationGO:00455972170.196
calcium ion homeostasisGO:00550741620.196
regulation of anatomical structure morphogenesisGO:00226031410.192
cellular divalent inorganic cation homeostasisGO:00725031620.189
homeostatic processGO:00425923310.185
positive regulation of developmental processGO:00510942830.185
response to decreased oxygen levelsGO:00362932370.180
positive regulation of cellular biosynthetic processGO:00313282950.179
negative regulation of cell deathGO:00605482290.179
regulation of cell developmentGO:00602842630.177
divalent inorganic cation homeostasisGO:00725071650.174
positive regulation of gene expressionGO:00106282440.174
tissue morphogenesisGO:0048729220.173
positive regulation of cell deathGO:00109421840.170
response to growth factorGO:00708481890.169
positive regulation of nucleobase containing compound metabolic processGO:00459353190.163
epithelium developmentGO:0060429960.162
response to cytokineGO:00340972150.161
positive regulation of multicellular organismal processGO:00512403870.160
regulation of signal transductionGO:00099663180.160
cellular ketone metabolic processGO:0042180510.160
rna biosynthetic processGO:00327743800.159
divalent metal ion transportGO:00708381320.152
response to extracellular stimulusGO:00099913800.148
intracellular signal transductionGO:00355563140.147
organophosphate metabolic processGO:00196373700.141
multi multicellular organism processGO:00447061380.139
vasculature developmentGO:0001944700.136
oxoacid metabolic processGO:00434362900.133
cellular homeostasisGO:00197252520.132
cation transportGO:00068123820.132
rhythmic processGO:00485111560.130
positive regulation of neurogenesisGO:00507691650.127
development of primary sexual characteristicsGO:00451371070.126
organ morphogenesisGO:0009887750.126
positive regulation of cell migrationGO:0030335960.125
positive regulation of signalingGO:00230562700.122
positive regulation of cytosolic calcium ion concentrationGO:00072041220.121
organic acid metabolic processGO:00060822920.121
response to inorganic substanceGO:00100353770.121
cellular cation homeostasisGO:00300031800.120
reproductive system developmentGO:00614581280.118
cellular calcium ion homeostasisGO:00068741600.116
gland developmentGO:00487321550.116
reproductive processGO:00224143720.114
regulation of transcription dna templatedGO:00063553740.114
blood vessel morphogenesisGO:0048514580.113
single organism organelle organizationGO:19025891800.113
protein phosphorylationGO:00064683450.113
chemical homeostasisGO:00488782920.109
ion homeostasisGO:00508012120.109
cellular lipid metabolic processGO:00442552080.109
nucleic acid templated transcriptionGO:00976593790.109
regulation of nucleic acid templated transcriptionGO:19035063800.108
cell cell signalingGO:00072673350.108
response to nutrient levelsGO:00316673700.108
defense responseGO:00069521940.108
regulation of catalytic activityGO:00507903040.108
response to oxidative stressGO:00069791860.107
metal ion homeostasisGO:00550651860.106
positive regulation of locomotionGO:00400171020.105
response to corticosteroidGO:00319602350.104
locomotionGO:00400112370.102
regulation of protein metabolic processGO:00512462890.102
regulation of secretion by cellGO:19035302080.100
agingGO:00075682410.100
tube developmentGO:0035295890.099
behaviorGO:00076102050.098
blood circulationGO:00080151830.098
secretion by cellGO:00329402480.098
multi organism reproductive processGO:00447032620.096
cellular response to transforming growth factor beta stimulusGO:0071560410.096
regulation of transcription from rna polymerase ii promoterGO:00063572340.096
regulation of rna metabolic processGO:00512523910.094
positive regulation of cell communicationGO:00106472710.091
heart developmentGO:0007507720.091
positive regulation of cell proliferationGO:00082842490.089
single organism reproductive processGO:00447022970.089
regulation of cellular protein metabolic processGO:00322682670.089
cellular response to stressGO:00335542690.089
developmental process involved in reproductionGO:00030061590.089
positive regulation of phosphate metabolic processGO:00459372620.087
positive regulation of biosynthetic processGO:00098913190.086
regulation of cell differentiationGO:00455953200.085
regulation of molecular functionGO:00650093980.085
regulation of rna biosynthetic processGO:20011413810.085
signal transduction by phosphorylationGO:00230141440.085
regulation of system processGO:00440572080.084
multicellular organismal reproductive processGO:00486092330.083
response to dexamethasoneGO:0071548490.083
cellular response to cytokine stimulusGO:00713451270.082
circulatory system processGO:00030131830.082
angiogenesisGO:0001525530.081
taxisGO:0042330670.081
sexual reproductionGO:00199531480.081
negative regulation of apoptotic processGO:00430661810.080
regulation of cellular component movementGO:00512701500.080
mapk cascadeGO:00001651400.079
cellular response to lipidGO:00713962010.078
positive regulation of signal transductionGO:00099671750.078
neurological system processGO:00508772190.077
positive regulation of molecular functionGO:00440932300.076
negative regulation of cell proliferationGO:00082851190.076
bmp signaling pathwayGO:003050940.075
negative regulation of programmed cell deathGO:00430691830.075
regulation of mapk cascadeGO:00434081160.075
regulation of phosphorus metabolic processGO:00511743490.074
multicellular organism reproductionGO:00325042330.074
response to lipopolysaccharideGO:00324961910.074
regulation of cell migrationGO:00303341280.073
lipid metabolic processGO:00066292830.072
reproductive structure developmentGO:00486081280.072
positive regulation of cell developmentGO:00107201760.072
cell type specific apoptotic processGO:00972851340.072
response to nutrientGO:00075842480.071
regulation of cellular ketone metabolic processGO:0010565270.070
cellular component assemblyGO:00226073600.069
single organism behaviorGO:00447081300.069
cellular component biogenesisGO:00440853680.069
cellular chemical homeostasisGO:00550822470.068
negative regulation of signalingGO:00230571570.068
carbohydrate derivative metabolic processGO:19011353460.068
secretionGO:00469033070.067
heart morphogenesisGO:000300730.067
negative regulation of metabolic processGO:00098923310.067
response to glucocorticoidGO:00513842230.066
positive regulation of cellular component organizationGO:00511302000.065
response to purine containing compoundGO:00140741260.065
positive regulation of catalytic activityGO:00430851840.064
positive regulation of rna metabolic processGO:00512542030.064
purine nucleotide metabolic processGO:00061632290.064
response to biotic stimulusGO:00096072260.063
response to acid chemicalGO:00011012220.063
regulation of phosphate metabolic processGO:00192203490.063
rna metabolic processGO:00160704060.062
reproductionGO:00000032450.062
response to interleukin 1GO:0070555550.061
organ regenerationGO:00311001010.060
response to ketoneGO:19016541820.060
anatomical structure formation involved in morphogenesisGO:0048646830.060
cellular response to organic cyclic compoundGO:00714072020.060
negative regulation of developmental processGO:00510931250.059
regulation of blood vessel sizeGO:0050880890.059
nucleoside phosphate catabolic processGO:19012921400.058
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178270.058
transcription dna templatedGO:00063513770.057
regulation of cell motilityGO:20001451310.057
cytosolic calcium ion homeostasisGO:00514801400.057
cellular component movementGO:00069282480.057
purine containing compound catabolic processGO:00725231380.057
positive regulation of rna biosynthetic processGO:19026801970.056
positive regulation of transcription from rna polymerase ii promoterGO:00459441480.056
positive regulation of secretion by cellGO:19035321280.055
regulation of synaptic transmissionGO:00508041410.055
tissue remodelingGO:0048771400.054
male sex differentiationGO:0046661640.054
multicellular organismal homeostasisGO:0048871490.054
nucleotide metabolic processGO:00091172790.054
negative regulation of transportGO:00510511360.054
chemotaxisGO:0006935660.053
cytoskeleton organizationGO:00070101110.053
kidney developmentGO:0001822670.053
female gonad developmentGO:0008585530.052
purine nucleoside catabolic processGO:00061521240.052
response to vitaminGO:00332731310.052
response to alkaloidGO:00432791320.051
macromolecular complex assemblyGO:00650032730.051
negative regulation of molecular functionGO:00440921330.050
macromolecule localizationGO:00330362520.050
muscle structure developmentGO:0061061870.050
regulation of purine nucleotide catabolic processGO:0033121650.050
regulation of phosphorylationGO:00423252480.050
negative regulation of nitrogen compound metabolic processGO:00511721610.049
neuron deathGO:00709971270.049
regulation of locomotionGO:00400121480.049
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169850.049
positive regulation of cellular component biogenesisGO:0044089550.048
regulation of secretionGO:00510462240.048
response to peptide hormoneGO:00434342780.047
morphogenesis of an epitheliumGO:0002009200.047
purine ribonucleotide catabolic processGO:00091541360.047
nucleobase containing small molecule metabolic processGO:00550863160.047
urogenital system developmentGO:0001655780.047
regulation of immune system processGO:00026821230.047
response to estradiolGO:00323551640.046
calcium ion transportGO:00068161310.046
regulation of hydrolase activityGO:00513361430.046
response to metal ionGO:00100382530.045
positive regulation of transcription dna templatedGO:00458931970.045
response to molecule of bacterial originGO:00022371940.045
positive regulation of mapk cascadeGO:0043410920.045
neuron developmentGO:00486662860.045
immune responseGO:00069551040.045
localization of cellGO:00516742020.045
response to external biotic stimulusGO:00432072210.045
single organism catabolic processGO:00447122830.045
positive regulation of nervous system developmentGO:00519621780.044
response to reactive oxygen speciesGO:00003021200.044
response to bacteriumGO:00096172000.044
positive regulation of hydrolase activityGO:0051345860.044
organonitrogen compound catabolic processGO:19015651790.044
cellular response to hormone stimulusGO:00328702470.044
response to campGO:0051591910.044
regulation of response to external stimulusGO:00321011060.044
central nervous system developmentGO:00074173110.043
regenerationGO:00310991630.043
divalent inorganic cation transportGO:00725111340.043
response to peptideGO:19016522920.043
regulation of blood circulationGO:19035221100.043
regulation of neurogenesisGO:00507672470.043
negative regulation of multicellular organismal processGO:00512412030.043
regulation of intracellular signal transductionGO:19025312180.042
gonad developmentGO:00084061040.042
positive regulation of protein phosphorylationGO:00019341350.042
cell adhesionGO:00071551100.042
cell migrationGO:00164771970.042
head developmentGO:00603222470.042
neuron differentiationGO:00301823680.042
regulation of nervous system developmentGO:00519602640.042
cardiac muscle contractionGO:0060048270.042
negative regulation of macromolecule metabolic processGO:00106052600.041
cell projection organizationGO:00300303020.041
negative regulation of osteoblast differentiationGO:004566820.041
alcohol metabolic processGO:0006066770.041
vascular process in circulatory systemGO:0003018960.041
positive regulation of cell motilityGO:2000147970.040
purine nucleotide catabolic processGO:00061951360.040
transcription from rna polymerase ii promoterGO:00063662520.040
positive regulation of phosphorus metabolic processGO:00105622620.040
regulation of cell adhesionGO:0030155520.040
organelle organizationGO:00069962660.040
amine metabolic processGO:0009308380.040
regulation of stem cell differentiationGO:200073620.039
response to tumor necrosis factorGO:0034612560.039
positive regulation of intracellular signal transductionGO:19025331380.039
response to radiationGO:00093141370.039
response to other organismGO:00517072200.038
regulation of organelle organizationGO:0033043800.038
renal system developmentGO:0072001670.038
regulation of cytoskeleton organizationGO:0051493490.038
brain developmentGO:00074202470.038
purine ribonucleoside triphosphate catabolic processGO:00092071220.038
regulation of ossificationGO:0030278320.038
purine nucleoside metabolic processGO:00422781690.038
positive regulation of cellular component movementGO:00512721020.038
wound healingGO:00420601220.038
cellular amine metabolic processGO:0044106380.038
positive regulation of protein metabolic processGO:00512471780.037
cellular response to nitrogen compoundGO:19016992100.037
immune system processGO:00023762040.037
response to mechanical stimulusGO:00096121340.037
nucleotide catabolic processGO:00091661390.036
purine containing compound metabolic processGO:00725212530.036
positive regulation of phosphorylationGO:00423271770.036
inorganic ion transmembrane transportGO:00986602290.036
heart contractionGO:0060047570.036
sex differentiationGO:00075481130.036
embryonic skeletal system developmentGO:004870630.035
cellular response to organonitrogen compoundGO:00714171970.035
inflammatory responseGO:00069541500.034
ossificationGO:0001503700.034
positive regulation of response to stimulusGO:00485842850.034
response to ethanolGO:00454711620.034
organophosphate catabolic processGO:00464341480.034
negative regulation of gene expressionGO:00106291990.034
positive regulation of bone mineralizationGO:003050140.034
response to woundingGO:00096112540.034
nucleoside triphosphate catabolic processGO:00091431230.034
regulation of cellular localizationGO:00603412630.034
proteolysisGO:00065081750.034
cell activationGO:0001775970.034
ribonucleoside triphosphate catabolic processGO:00092031220.034
cellular response to oxygen containing compoundGO:19017013860.033
cellular response to alcoholGO:0097306870.033
ribonucleotide catabolic processGO:00092611360.033
negative regulation of response to stimulusGO:00485851550.033
positive regulation of nucleic acid templated transcriptionGO:19035081970.033
actin cytoskeleton organizationGO:0030036730.033
regulation of membrane potentialGO:00423911100.032
heart processGO:0003015570.032
macromolecular complex subunit organizationGO:00439333390.032
hormone secretionGO:00468791150.032
organophosphate biosynthetic processGO:00904071430.032
monocarboxylic acid metabolic processGO:00327871520.032
response to amino acidGO:0043200750.032
muscle system processGO:00030121150.032
muscle organ developmentGO:0007517500.032
kidney epithelium developmentGO:0072073190.032
positive regulation of chemotaxisGO:0050921230.032
regulation of angiogenesisGO:0045765390.032
regulation of protein modification processGO:00313991940.032
response to low density lipoprotein particleGO:005509840.032
regulation of cell growthGO:0001558850.031
negative regulation of cellular metabolic processGO:00313242810.031
cellular nitrogen compound catabolic processGO:00442701630.031
regulation of vasculature developmentGO:1901342440.031
inorganic cation transmembrane transportGO:00986622020.031
cellular response to peptideGO:19016531330.031
aromatic compound catabolic processGO:00194391680.031
negative regulation of biosynthetic processGO:00098901680.031
positive regulation of cytoskeleton organizationGO:0051495260.031
growthGO:00400071650.030
regulation of heart contractionGO:0008016480.030
cellular amino acid metabolic processGO:00065201070.030
response to insulinGO:00328681330.030
oxidation reduction processGO:00551143040.030
regulation of neuron differentiationGO:00456642080.030
cellular catabolic processGO:00442482950.030
sensory perceptionGO:00076001010.029
muscle contractionGO:0006936880.029
g protein coupled receptor signaling pathwayGO:00071862420.029
purine ribonucleoside catabolic processGO:00461301240.029
regulation of cellular amino acid metabolic processGO:000652120.029
ribose phosphate metabolic processGO:00196932350.029
regulation of ion transportGO:00432692450.029
glycosyl compound metabolic processGO:19016571820.029
muscle tissue developmentGO:0060537580.029
regulation of organ formationGO:000315620.029
regulation of growthGO:00400081050.029
nucleoside catabolic processGO:00091641260.029
negative regulation of rna biosynthetic processGO:19026791180.029
negative regulation of cellular biosynthetic processGO:00313271610.029
erk1 and erk2 cascadeGO:0070371480.029
purine ribonucleoside metabolic processGO:00461281680.029
cellular response to tumor necrosis factorGO:0071356460.029
cellular component morphogenesisGO:00329891550.029
heterocycle catabolic processGO:00467001670.029
positive regulation of ion transportGO:0043270940.029
ribonucleoside catabolic processGO:00424541260.028
regulation of smooth muscle cell proliferationGO:0048660750.028
hepaticobiliary system developmentGO:0061008900.028
nucleoside metabolic processGO:00091161790.028
mast cell migrationGO:009753140.028
ribonucleotide metabolic processGO:00092592310.028
regulation of hormone levelsGO:00108171870.028
negative regulation of cell communicationGO:00106481580.028
organic substance catabolic processGO:19015753160.028
positive regulation of blood circulationGO:1903524650.028
vasculogenesisGO:000157030.028
organic hydroxy compound biosynthetic processGO:1901617510.027
positive regulation of behaviorGO:0048520380.027
regulation of cardiac muscle tissue developmentGO:0055024120.027
male gonad developmentGO:0008584590.027
protein complex subunit organizationGO:00718223020.027
regulation of metal ion transportGO:00109591180.027
cellular response to oxidative stressGO:0034599760.027
circadian rhythmGO:0007623880.027
positive regulation of immune system processGO:0002684900.026
response to temperature stimulusGO:0009266940.026
positive regulation of cellular amine metabolic processGO:003324030.026
coronary vasculature morphogenesisGO:006097730.026
response to starvationGO:0042594590.026
organ inductionGO:000175910.026
carbohydrate derivative catabolic processGO:19011361470.026
response to organophosphorusGO:00466831020.026
ovulation cycleGO:0042698670.026
regulation of nucleotide catabolic processGO:0030811650.026
mesenchymal cell proliferationGO:001046340.026
response to ionizing radiationGO:0010212590.026
anterior posterior pattern specificationGO:000995210.026
synaptic transmissionGO:00072682350.026
digestive tract developmentGO:0048565390.025
cell morphogenesisGO:00009021420.025
organic cyclic compound catabolic processGO:19013611750.025
regulation of body fluid levelsGO:0050878900.025
response to cocaineGO:0042220390.025
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092100.025
urinary bladder smooth muscle contractionGO:001483240.025
cation transmembrane transportGO:00986552630.025
response to carbohydrateGO:00097431830.025
regulation of tube sizeGO:0035150890.025
negative regulation of cellular macromolecule biosynthetic processGO:20001131410.025
c21 steroid hormone biosynthetic processGO:0006700100.025
catabolic processGO:00090563510.025
tonic smooth muscle contractionGO:001482040.025
mesonephric epithelium developmentGO:0072163140.024
fertilizationGO:000956630.024
muscle cell apoptotic processGO:0010657300.024
neural crest cell migrationGO:000175510.024
protein complex assemblyGO:00064612630.024
regulation of calcium ion transportGO:0051924770.024
lipid biosynthetic processGO:00086101280.024
female pregnancyGO:00075651220.024
positive regulation of purine nucleotide catabolic processGO:0033123530.024
ras protein signal transductionGO:0007265290.024
signal releaseGO:00230611450.024
response to monosaccharideGO:00342841590.023
response to interferon gammaGO:0034341200.023
small molecule biosynthetic processGO:00442831240.023
cell motilityGO:00488702020.023
nucleoside triphosphate metabolic processGO:00091411440.023
regulation of transferase activityGO:00513381230.023
fatty acid metabolic processGO:0006631990.023
positive regulation of cell projection organizationGO:00313461110.023
cellular response to interleukin 1GO:0071347370.023
eye developmentGO:0001654500.023
developmental inductionGO:003112820.023
actin filament based processGO:0030029860.023
ovulation cycle processGO:0022602500.022
myeloid cell differentiationGO:0030099220.022
mast cell chemotaxisGO:000255140.022
ion transmembrane transportGO:00342203650.022
erythrocyte differentiationGO:003021810.022
cellular response to external stimulusGO:00714961180.022
ribonucleoside metabolic processGO:00091191740.022
positive regulation of purine nucleotide metabolic processGO:1900544910.022
small gtpase mediated signal transductionGO:0007264360.022
forebrain developmentGO:0030900980.022
purine ribonucleotide metabolic processGO:00091502270.022
purine nucleoside triphosphate catabolic processGO:00091461220.022
ribonucleoside triphosphate metabolic processGO:00091991410.021
female sex differentiationGO:0046660590.021
negative regulation of protein metabolic processGO:00512481140.021
mesonephric tubule developmentGO:0072164140.021
protein maturationGO:0051604680.021
protein localizationGO:00081041910.021
regulation of cellular amine metabolic processGO:003323880.021
prostate gland epithelium morphogenesisGO:006074020.021
negative regulation of nucleobase containing compound metabolic processGO:00459341530.021
ureteric bud developmentGO:0001657140.021
regulation of cellular component organizationGO:00511283680.021
regulation of cellular component biogenesisGO:0044087860.021
nitrogen compound transportGO:00717052290.021
regulation of protein phosphorylationGO:00019321830.021
regulation of protein kinase activityGO:00458591050.021
single organism biosynthetic processGO:00447113420.021
smooth muscle cell proliferationGO:0048659770.021
negative regulation of secretionGO:0051048820.021
positive regulation of biomineral tissue developmentGO:007016940.021
saliva secretionGO:004654130.020
regulation of homeostatic processGO:00328441010.020
negative regulation of macromolecule biosynthetic processGO:00105581480.020
lymphocyte migrationGO:007267630.020
muscle cell differentiationGO:0042692520.020
transmission of nerve impulseGO:0019226420.020
organic hydroxy compound metabolic processGO:19016151150.020
neural crest cell differentiationGO:001403320.020
second messenger mediated signalingGO:0019932510.020
angiogenesis involved in coronary vascular morphogenesisGO:006097830.020
response to retinoic acidGO:0032526630.020
cellular response to insulin stimulusGO:0032869810.020
regulation of homotypic cell cell adhesionGO:003411040.020
cyclic purine nucleotide metabolic processGO:0052652620.020
monovalent inorganic cation transportGO:00156721720.020
nucleoside phosphate metabolic processGO:00067532830.020
cellular response to campGO:0071320260.019
glycosyl compound catabolic processGO:19016581260.019
metal ion transportGO:00300012890.019
regulation of leukocyte migrationGO:0002685240.019
neuron projection developmentGO:00311752730.019
positive regulation of erk1 and erk2 cascadeGO:0070374290.019
gliogenesisGO:0042063930.019
purine nucleoside triphosphate metabolic processGO:00091441410.019
response to hydrogen peroxideGO:0042542890.019
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:009010120.019
osteoblast differentiationGO:0001649260.019
regulation of cellular catabolic processGO:00313291010.019
single organism intracellular transportGO:19025821660.019
striated muscle contractionGO:0006941440.019
cellular response to ketoneGO:1901655510.019
skeletal muscle tissue developmentGO:0007519310.018
formation of primary germ layerGO:000170410.018
regulation of neuron deathGO:19012141150.018

Npr3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.146
disease of anatomical entityDOID:700.146
sensory system diseaseDOID:005015500.035
eye and adnexa diseaseDOID:149200.035
central nervous system diseaseDOID:33100.031
eye diseaseDOID:561400.021