IMP: Integrative Multi-species Prediction

Rattus norvegicus

11 known processes

P4hb

prolyl 4-hydroxylase, beta polypeptide

(Aliases: PDIR,PDI)

RGD: 3244
Ensembl: ENSRNOG00000036689
Entrez: 25506
UniProtKB: P04785

Process Predictions
Disease Predictions

P4hb biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
regulation of behavior	GO:0050795	61	0.388
regulation of translation	GO:0006417	27	0.287
startle response	GO:0001964	2	0.230
multicellular organism reproduction	GO:0032504	233	0.229
neuromuscular process	GO:0050905	2	0.229
organelle organization	GO:0006996	266	0.221
antigen processing and presentation of peptide antigen via mhc class i	GO:0002474	1	0.194
regulation of cellular protein metabolic process	GO:0032268	267	0.181
vesicle mediated transport	GO:0016192	181	0.168
tissue development	GO:0009888	252	0.153
macromolecular complex assembly	GO:0065003	273	0.148
negative regulation of cell death	GO:0060548	229	0.144
positive regulation of cellular component organization	GO:0051130	200	0.140
behavior	GO:0007610	205	0.136
regulation of apoptotic process	GO:0042981	335	0.122	Human
multicellular organismal reproductive process	GO:0048609	233	0.116
cellular component assembly	GO:0022607	360	0.105
regulation of protein metabolic process	GO:0051246	289	0.104
aging	GO:0007568	241	0.102
positive regulation of developmental process	GO:0051094	283	0.100
negative regulation of cell communication	GO:0010648	158	0.091
central nervous system development	GO:0007417	311	0.091
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.090
establishment of protein localization	GO:0045184	141	0.088
carbohydrate metabolic process	GO:0005975	130	0.086
secretion	GO:0046903	307	0.085
cellular component biogenesis	GO:0044085	368	0.084
posttranscriptional regulation of gene expression	GO:0010608	37	0.083
positive regulation of endocytosis	GO:0045807	28	0.082
cellular catabolic process	GO:0044248	295	0.079
positive regulation of biosynthetic process	GO:0009891	319	0.077
protein complex assembly	GO:0006461	263	0.076
cardiocyte differentiation	GO:0035051	22	0.076
regulation of neurogenesis	GO:0050767	247	0.076
reproductive process	GO:0022414	372	0.074
positive regulation of protein metabolic process	GO:0051247	178	0.073
regulation of cell development	GO:0060284	263	0.070
regulation of cell migration	GO:0030334	128	0.070
positive regulation of cell proliferation	GO:0008284	249	0.068
positive regulation of cell differentiation	GO:0045597	217	0.068
positive regulation of cellular biosynthetic process	GO:0031328	295	0.067
circulatory system development	GO:0072359	134	0.065
neuron differentiation	GO:0030182	368	0.063
positive regulation of neuron projection development	GO:0010976	99	0.062
regulation of endocytosis	GO:0030100	42	0.061
positive regulation of cell motility	GO:2000147	97	0.061
secretion by cell	GO:0032940	248	0.061
positive regulation of gene expression	GO:0010628	244	0.060
protein complex subunit organization	GO:0071822	302	0.060
cardiovascular system development	GO:0072358	134	0.059
regulation of cellular localization	GO:0060341	263	0.059
response to metal ion	GO:0010038	253	0.059
embryonic cranial skeleton morphogenesis	GO:0048701	2	0.058
skeletal system development	GO:0001501	41	0.058
cytoskeleton organization	GO:0007010	111	0.057
regulation of neuron differentiation	GO:0045664	208	0.057
regulation of programmed cell death	GO:0043067	341	0.056	Human
sexual reproduction	GO:0019953	148	0.055
tube development	GO:0035295	89	0.055
neuron projection morphogenesis	GO:0048812	122	0.054
regulation of nervous system development	GO:0051960	264	0.052
catabolic process	GO:0009056	351	0.052
reproductive structure development	GO:0048608	128	0.051
regulation of anatomical structure size	GO:0090066	135	0.051
muscle tissue development	GO:0060537	58	0.050
reproduction	GO:0000003	245	0.050
response to ketone	GO:1901654	182	0.048
response to cytokine	GO:0034097	215	0.047
cell motility	GO:0048870	202	0.047
taxis	GO:0042330	67	0.047
gamete generation	GO:0007276	124	0.046
response to other organism	GO:0051707	220	0.045
hepatocyte proliferation	GO:0072574	3	0.045
positive regulation of signal transduction	GO:0009967	175	0.044
regulation of transcription dna templated	GO:0006355	374	0.044
negative regulation of signaling	GO:0023057	157	0.044
cellular response to endogenous stimulus	GO:0071495	377	0.043
response to wounding	GO:0009611	254	0.043
regulation of phagocytosis	GO:0050764	13	0.043
organ morphogenesis	GO:0009887	75	0.043
macromolecular complex subunit organization	GO:0043933	339	0.043
brain development	GO:0007420	247	0.042
dna metabolic process	GO:0006259	96	0.042
wound healing	GO:0042060	122	0.042
motor neuron axon guidance	GO:0008045	1	0.042
macromolecule glycosylation	GO:0043413	14	0.041
establishment of vesicle localization	GO:0051650	31	0.041
cell projection organization	GO:0030030	302	0.040
endocytosis	GO:0006897	84	0.040
regulation of cell differentiation	GO:0045595	320	0.039
antigen processing and presentation	GO:0019882	2	0.039
cell migration	GO:0016477	197	0.038
positive regulation of cellular protein metabolic process	GO:0032270	167	0.038
regulation of signal transduction	GO:0009966	318	0.038	Human
regulation of molecular function	GO:0065009	398	0.038
response to estradiol	GO:0032355	164	0.037
vesicle localization	GO:0051648	33	0.036
positive regulation of response to stimulus	GO:0048584	285	0.036
positive regulation of dna metabolic process	GO:0051054	39	0.036
regulation of chemotaxis	GO:0050920	29	0.036
chemosensory behavior	GO:0007635	2	0.035
cell adhesion	GO:0007155	110	0.035
cellular homeostasis	GO:0019725	252	0.035
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.035
regulation of cellular component movement	GO:0051270	150	0.034
positive regulation of cell development	GO:0010720	176	0.034
neuron projection development	GO:0031175	273	0.034
purine ribonucleoside catabolic process	GO:0046130	124	0.033
reproductive system development	GO:0061458	128	0.033
positive regulation of neurogenesis	GO:0050769	165	0.033
cellular response to oxygen containing compound	GO:1901701	386	0.033
head development	GO:0060322	247	0.033
urogenital system development	GO:0001655	78	0.032
regulation of organelle organization	GO:0033043	80	0.032
homeostatic process	GO:0042592	331	0.031
defense response	GO:0006952	194	0.030
transcription dna templated	GO:0006351	377	0.030
response to inorganic substance	GO:0010035	377	0.030
antigen processing and presentation of peptide antigen	GO:0048002	2	0.030
peptidyl lysine hydroxylation	GO:0017185	1	0.030
multi organism reproductive process	GO:0044703	262	0.029
single organism catabolic process	GO:0044712	283	0.029
camera type eye development	GO:0043010	48	0.029
regulation of nucleic acid templated transcription	GO:1903506	380	0.029
chemical homeostasis	GO:0048878	292	0.029
cellular response to vascular endothelial growth factor stimulus	GO:0035924	6	0.029
regulation of cell motility	GO:2000145	131	0.028
nucleic acid templated transcription	GO:0097659	379	0.028
response to growth factor	GO:0070848	189	0.027
exocytosis	GO:0006887	60	0.027
regulation of anatomical structure morphogenesis	GO:0022603	141	0.027
regulation of coagulation	GO:0050818	11	0.027
negative regulation of multicellular organismal process	GO:0051241	203	0.027
heart development	GO:0007507	72	0.027
embryonic skeletal system morphogenesis	GO:0048704	3	0.027
cellular chemical homeostasis	GO:0055082	247	0.026
response to nutrient levels	GO:0031667	370	0.026
positive regulation of apoptotic process	GO:0043065	154	0.026
positive regulation of cell communication	GO:0010647	271	0.026
translation	GO:0006412	35	0.026
regulation of protein localization	GO:0032880	81	0.026
epithelium development	GO:0060429	96	0.026
protein complex biogenesis	GO:0070271	263	0.026
cellular response to external stimulus	GO:0071496	118	0.026
developmental process involved in reproduction	GO:0003006	159	0.025
positive regulation of cell projection organization	GO:0031346	111	0.025
response to hexose	GO:0009746	144	0.025
programmed cell death	GO:0012501	392	0.025	Human
cellular response to stress	GO:0033554	269	0.025	Human
regulation of secretion	GO:0051046	224	0.025
biological adhesion	GO:0022610	110	0.025
negative regulation of metabolic process	GO:0009892	331	0.024
cellular response to growth factor stimulus	GO:0071363	162	0.024
blood circulation	GO:0008015	183	0.024
negative regulation of cellular amide metabolic process	GO:0034249	1	0.024
regulation of locomotion	GO:0040012	148	0.024
cellular response to unfolded protein	GO:0034620	2	0.023
epithelial cell proliferation	GO:0050673	54	0.022
regulation of cell adhesion	GO:0030155	52	0.022
positive regulation of phagocytosis	GO:0050766	9	0.022
cellular protein complex assembly	GO:0043623	44	0.022
negative regulation of catalytic activity	GO:0043086	103	0.022
regulation of cell substrate adhesion	GO:0010810	18	0.022
axon extension	GO:0048675	26	0.021
regulation of multicellular organismal development	GO:2000026	376	0.021
protein oligomerization	GO:0051259	191	0.021
proteolysis	GO:0006508	175	0.021
cellular response to metal ion	GO:0071248	55	0.021
anatomical structure morphogenesis	GO:0009653	298	0.021
regulation of tube size	GO:0035150	89	0.021
rna biosynthetic process	GO:0032774	380	0.021
regulation of rna metabolic process	GO:0051252	391	0.021
formation of primary germ layer	GO:0001704	1	0.020
regulation of cellular component biogenesis	GO:0044087	86	0.020
eye development	GO:0001654	50	0.020
glucose homeostasis	GO:0042593	75	0.020
regulation of hydrolase activity	GO:0051336	143	0.020
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.020
spermatogenesis	GO:0007283	99	0.020
positive regulation of signaling	GO:0023056	270	0.019
regulation of cell proliferation	GO:0042127	359	0.019
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.019
male gamete generation	GO:0048232	99	0.019
olfactory behavior	GO:0042048	2	0.019
regulation of actin nucleation	GO:0051125	2	0.019
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	41	0.019
carbohydrate derivative metabolic process	GO:1901135	346	0.019
organic cyclic compound catabolic process	GO:1901361	175	0.019
cell substrate adhesion	GO:0031589	29	0.019
regulation of protein transport	GO:0051223	68	0.018
cellular response to cytokine stimulus	GO:0071345	127	0.018
localization of cell	GO:0051674	202	0.018
organic substance catabolic process	GO:1901575	316	0.018
single organism organelle organization	GO:1902589	180	0.018
positive regulation of phosphate metabolic process	GO:0045937	262	0.018
multicellular organism growth	GO:0035264	1	0.018
establishment of organelle localization	GO:0051656	37	0.018
positive regulation of phosphorus metabolic process	GO:0010562	262	0.018
cellular ketone metabolic process	GO:0042180	51	0.017
regulation of catalytic activity	GO:0050790	304	0.017
purine ribonucleoside metabolic process	GO:0046128	168	0.017
lipid storage	GO:0019915	1	0.017
regulation of cell morphogenesis involved in differentiation	GO:0010769	72	0.017
response to glucose	GO:0009749	136	0.017
epithelial cell differentiation	GO:0030855	71	0.017
growth	GO:0040007	165	0.016
single organism carbohydrate metabolic process	GO:0044723	118	0.016
single organism intracellular transport	GO:1902582	166	0.016
negative regulation of cellular protein metabolic process	GO:0032269	106	0.016
positive regulation of molecular function	GO:0044093	230	0.016
cellular component morphogenesis	GO:0032989	155	0.016
response to reactive oxygen species	GO:0000302	120	0.016
multicellular organismal catabolic process	GO:0044243	2	0.016
eye morphogenesis	GO:0048592	4	0.016
positive regulation of nervous system development	GO:0051962	178	0.016
locomotion	GO:0040011	237	0.016
circulatory system process	GO:0003013	183	0.016
axon development	GO:0061564	96	0.016
cellular amine metabolic process	GO:0044106	38	0.016
regulation of proteolysis	GO:0030162	66	0.016
response to peptide	GO:1901652	292	0.015
cellular response to hormone stimulus	GO:0032870	247	0.015
cell part morphogenesis	GO:0032990	123	0.015
regeneration	GO:0031099	163	0.015
reactive nitrogen species metabolic process	GO:2001057	1	0.015
positive regulation of chemotaxis	GO:0050921	23	0.015
neuron development	GO:0048666	286	0.015
triglyceride homeostasis	GO:0070328	2	0.015
multicellular organismal macromolecule metabolic process	GO:0044259	21	0.015
carbohydrate derivative biosynthetic process	GO:1901137	124	0.015
regulation of phosphorylation	GO:0042325	248	0.015
response to acid chemical	GO:0001101	222	0.014
cellular calcium ion homeostasis	GO:0006874	160	0.014
macromolecule localization	GO:0033036	252	0.014
protein localization	GO:0008104	191	0.014
regulation of cell size	GO:0008361	37	0.014
negative regulation of gene expression	GO:0010629	199	0.014
regulation of cellular component organization	GO:0051128	368	0.014
carbohydrate homeostasis	GO:0033500	75	0.014
cellular response to topologically incorrect protein	GO:0035967	3	0.014
regulation of rna biosynthetic process	GO:2001141	381	0.014
cellular response to organonitrogen compound	GO:0071417	197	0.014
ribose phosphate metabolic process	GO:0019693	235	0.014
negative regulation of macromolecule metabolic process	GO:0010605	260	0.014
positive regulation of catalytic activity	GO:0043085	184	0.014
gastrulation	GO:0007369	2	0.014
acylglycerol homeostasis	GO:0055090	2	0.014
cellular response to inorganic substance	GO:0071241	65	0.014
neurological system process	GO:0050877	219	0.014
intracellular transport	GO:0046907	185	0.014
cytoplasmic transport	GO:0016482	115	0.014
negative regulation of response to stimulus	GO:0048585	155	0.013
apoptotic process	GO:0006915	381	0.013	Human
regulation of cell projection organization	GO:0031344	175	0.013
positive regulation of multicellular organismal process	GO:0051240	387	0.013
amine metabolic process	GO:0009308	38	0.013
actin cytoskeleton organization	GO:0030036	73	0.013
cellular component movement	GO:0006928	248	0.013
autophagy	GO:0006914	19	0.013
ion homeostasis	GO:0050801	212	0.013
regulation of secretion by cell	GO:1903530	208	0.013
salivary gland development	GO:0007431	3	0.013
positive regulation of transport	GO:0051050	245	0.013
cellular response to nitrogen compound	GO:1901699	210	0.013
camera type eye morphogenesis	GO:0048593	2	0.013
regulation of establishment of protein localization	GO:0070201	69	0.012
chromosome segregation	GO:0007059	2	0.012
negative regulation of protein modification by small protein conjugation or removal	GO:1903321	4	0.012
regulation of hormone levels	GO:0010817	187	0.012
collagen catabolic process	GO:0030574	2	0.012
collagen metabolic process	GO:0032963	21	0.012
liver morphogenesis	GO:0072576	3	0.012
negative regulation of synaptic transmission	GO:0050805	29	0.012
single organism behavior	GO:0044708	130	0.012
neural crest cell differentiation	GO:0014033	2	0.012
protein secretion	GO:0009306	34	0.012
dendrite development	GO:0016358	72	0.012
carbohydrate derivative catabolic process	GO:1901136	147	0.012
regulation of kinase activity	GO:0043549	117	0.012
synaptic vesicle endocytosis	GO:0048488	4	0.012
regulation of angiotensin levels in blood	GO:0002002	2	0.012
ribonucleotide metabolic process	GO:0009259	231	0.012
mapk cascade	GO:0000165	140	0.012
glycoprotein biosynthetic process	GO:0009101	19	0.012
regulation of immune system process	GO:0002682	123	0.012
response to lead ion	GO:0010288	33	0.011
protein transport	GO:0015031	132	0.011
response to nutrient	GO:0007584	248	0.011
endoplasmic reticulum unfolded protein response	GO:0030968	2	0.011
defense response to gram negative bacterium	GO:0050829	3	0.011
cell morphogenesis	GO:0000902	142	0.011
nucleobase containing small molecule metabolic process	GO:0055086	316	0.011
regulation of proteasomal protein catabolic process	GO:0061136	4	0.011
regulation of cellular amine metabolic process	GO:0033238	8	0.011
intracellular signal transduction	GO:0035556	314	0.011	Human
macromolecule catabolic process	GO:0009057	58	0.011
oxidation reduction process	GO:0055114	304	0.011	Human Yeast
reactive oxygen species biosynthetic process	GO:1903409	8	0.011
regulation of neuron projection development	GO:0010975	161	0.011
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.011
macroautophagy	GO:0016236	4	0.011
cell cell signaling	GO:0007267	335	0.011
regulation of cellular component size	GO:0032535	51	0.011
purine nucleotide metabolic process	GO:0006163	229	0.011
positive regulation of cell death	GO:0010942	184	0.011
regulation of cellular amino acid metabolic process	GO:0006521	2	0.011
positive regulation of cell growth	GO:0030307	44	0.011
developmental growth	GO:0048589	100	0.011
liver development	GO:0001889	90	0.011
regulation of developmental growth	GO:0048638	45	0.011
protein phosphorylation	GO:0006468	345	0.010
regulation of transferase activity	GO:0051338	123	0.010
negative regulation of developmental process	GO:0051093	125	0.010
cellular metal ion homeostasis	GO:0006875	172	0.010
positive regulation of neuron differentiation	GO:0045666	126	0.010
respiratory system development	GO:0060541	45	0.010
positive regulation of cellular component biogenesis	GO:0044089	55	0.010
response to monosaccharide	GO:0034284	159	0.010
positive regulation of kinase activity	GO:0033674	77	0.010
negative regulation of cell development	GO:0010721	82	0.010
positive regulation of transcription dna templated	GO:0045893	197	0.010
cell matrix adhesion	GO:0007160	19	0.010

P4hb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
connective tissue disease	DOID:65	0.291
musculoskeletal system disease	DOID:17	0.291
disease of anatomical entity	DOID:7	0.291
bone disease	DOID:0080001	0.058
bone development disease	DOID:0080006	0.058
osteochondrodysplasia	DOID:2256	0.048
osteogenesis imperfecta	DOID:12347	0.048
nervous system disease	DOID:863	0.029
disease of cellular proliferation	DOID:14566	0.016
cancer	DOID:162	0.016
organ system cancer	DOID:0050686	0.014

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