IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Psmc4

proteasome (prosome, macropain) 26S subunit, ATPase, 4

(Aliases: Tbp7)

RGD: 621102
Entrez: 117262
Ensembl: ENSRNOG00000018994
UniProtKB: Q63570

Process Predictions
Disease Predictions

Psmc4 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
mitotic spindle organization	GO:0007052	2	0.446
proteolysis involved in cellular protein catabolic process	GO:0051603	19	0.364	Yeast
ubiquitin dependent protein catabolic process	GO:0006511	14	0.346	Yeast
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	7	0.292
spindle organization	GO:0007051	2	0.258
regulation of transcription initiation from rna polymerase ii promoter	GO:0060260	3	0.253	Yeast
cellular response to stress	GO:0033554	269	0.188	Fly
cell cycle	GO:0007049	101	0.177
modification dependent macromolecule catabolic process	GO:0043632	14	0.174	Yeast
proteasomal protein catabolic process	GO:0010498	8	0.154
cellular protein catabolic process	GO:0044257	19	0.145	Yeast
positive regulation of transcription initiation from rna polymerase ii promoter	GO:0060261	3	0.134	Yeast
macromolecule catabolic process	GO:0009057	58	0.130	Yeast
dna templated transcription initiation	GO:0006352	4	0.127	Yeast
negative regulation of translational initiation	GO:0045947	5	0.125
modification dependent protein catabolic process	GO:0019941	14	0.124	Yeast
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045899	3	0.124	Yeast
organelle organization	GO:0006996	266	0.122
proteolysis	GO:0006508	175	0.120	Yeast Fly
organic substance catabolic process	GO:1901575	316	0.109	Yeast
protein catabolic process	GO:0030163	30	0.109	Yeast
macromolecular complex assembly	GO:0065003	273	0.108	Yeast
cellular catabolic process	GO:0044248	295	0.104	Yeast
negative regulation of biosynthetic process	GO:0009890	168	0.099
macromolecule localization	GO:0033036	252	0.097
macromolecular complex subunit organization	GO:0043933	339	0.097	Yeast
negative regulation of cellular metabolic process	GO:0031324	281	0.094
centrosome organization	GO:0051297	1	0.084
ribonucleoside catabolic process	GO:0042454	126	0.082
cytoskeleton organization	GO:0007010	111	0.077
regulation of retinal cell programmed cell death	GO:0046668	1	0.075
transcription initiation from rna polymerase ii promoter	GO:0006367	3	0.075	Yeast
reproduction	GO:0000003	245	0.074	Worm
chromosome segregation	GO:0007059	2	0.071
cellular macromolecule catabolic process	GO:0044265	29	0.070	Yeast
atp catabolic process	GO:0006200	54	0.069
multicellular organism reproduction	GO:0032504	233	0.066
protein complex assembly	GO:0006461	263	0.065	Yeast
protein complex biogenesis	GO:0070271	263	0.063	Yeast
cellular component biogenesis	GO:0044085	368	0.063	Yeast
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.061
cellular protein complex assembly	GO:0043623	44	0.060	Yeast
regulation of rna polymerase ii transcriptional preinitiation complex assembly	GO:0045898	3	0.058	Yeast
microtubule organizing center organization	GO:0031023	1	0.058
nucleotide catabolic process	GO:0009166	139	0.057
organophosphate catabolic process	GO:0046434	148	0.056
purine nucleoside monophosphate catabolic process	GO:0009128	55	0.052
ribonucleotide catabolic process	GO:0009261	136	0.050
protein complex subunit organization	GO:0071822	302	0.050	Yeast
positive regulation of catalytic activity	GO:0043085	184	0.047
regulation of cell development	GO:0060284	263	0.043
rna metabolic process	GO:0016070	406	0.043	Yeast
purine nucleoside triphosphate catabolic process	GO:0009146	122	0.043
protein localization	GO:0008104	191	0.040
organonitrogen compound catabolic process	GO:1901565	179	0.040
purine nucleoside triphosphate metabolic process	GO:0009144	141	0.039
single organism organelle organization	GO:1902589	180	0.039
negative regulation of translation in response to stress	GO:0032055	5	0.039
regulation of cellular component organization	GO:0051128	368	0.038	Yeast
dna templated transcriptional preinitiation complex assembly	GO:0070897	3	0.038	Yeast
transcription from rna polymerase ii promoter	GO:0006366	252	0.038	Yeast
purine ribonucleotide metabolic process	GO:0009150	227	0.037
cellular macromolecular complex assembly	GO:0034622	58	0.037	Yeast
organelle assembly	GO:0070925	22	0.037
multicellular organismal reproductive process	GO:0048609	233	0.037
heterocycle catabolic process	GO:0046700	167	0.036
carbohydrate derivative catabolic process	GO:1901136	147	0.036
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	4	0.036
regulation of cell differentiation	GO:0045595	320	0.036
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.036	Yeast
cell cycle process	GO:0022402	57	0.035
cellular component assembly	GO:0022607	360	0.035	Yeast
regulation of cellular localization	GO:0060341	263	0.034
reproductive process	GO:0022414	372	0.033
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.033
response to peptide hormone	GO:0043434	278	0.033
microtubule based process	GO:0007017	36	0.033
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	3	0.033
catabolic process	GO:0009056	351	0.033	Yeast
response to peptide	GO:1901652	292	0.032
nucleoside monophosphate catabolic process	GO:0009125	56	0.031
protein transport	GO:0015031	132	0.031
purine nucleoside catabolic process	GO:0006152	124	0.031
regulation of rna biosynthetic process	GO:2001141	381	0.030	Yeast
glycosyl compound catabolic process	GO:1901658	126	0.030
positive regulation of dna templated transcription initiation	GO:2000144	3	0.030	Yeast
response to inorganic substance	GO:0010035	377	0.029
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.029	Yeast
single organism catabolic process	GO:0044712	283	0.029
histone methylation	GO:0016571	3	0.029
regulation of protein metabolic process	GO:0051246	289	0.028
nucleobase containing compound catabolic process	GO:0034655	152	0.028
posttranscriptional regulation of gene expression	GO:0010608	37	0.027
purine containing compound catabolic process	GO:0072523	138	0.027
negative regulation of protein metabolic process	GO:0051248	114	0.027
secretion by cell	GO:0032940	248	0.027
rna biosynthetic process	GO:0032774	380	0.027	Yeast
chromatin modification	GO:0016568	33	0.026
eye morphogenesis	GO:0048592	4	0.026
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.026
embryo development	GO:0009790	49	0.026	Mouse Worm
purine ribonucleoside catabolic process	GO:0046130	124	0.025
purine nucleotide catabolic process	GO:0006195	136	0.025
regulation of cellular protein metabolic process	GO:0032268	267	0.024
regulation of cell proliferation	GO:0042127	359	0.024
anatomical structure morphogenesis	GO:0009653	298	0.024
purine ribonucleoside monophosphate catabolic process	GO:0009169	55	0.023
nucleoside phosphate metabolic process	GO:0006753	283	0.023
transcription dna templated	GO:0006351	377	0.023	Yeast
aromatic compound catabolic process	GO:0019439	168	0.023
establishment of protein localization	GO:0045184	141	0.023
cellular protein localization	GO:0034613	122	0.022
cytoskeleton dependent cytokinesis	GO:0061640	2	0.022
positive regulation of cellular biosynthetic process	GO:0031328	295	0.022	Yeast
neuron projection development	GO:0031175	273	0.022
transmembrane transport	GO:0055085	412	0.022
response to glucose	GO:0009749	136	0.021
apoptotic process	GO:0006915	381	0.021
mitotic cell cycle process	GO:1903047	35	0.021
organophosphate metabolic process	GO:0019637	370	0.021
secretion	GO:0046903	307	0.021
cellular nitrogen compound catabolic process	GO:0044270	163	0.021
reproductive structure development	GO:0048608	128	0.021
regulation of catabolic process	GO:0009894	113	0.021
cellular amine metabolic process	GO:0044106	38	0.021
amine metabolic process	GO:0009308	38	0.020
positive regulation of cellular component organization	GO:0051130	200	0.020	Yeast
regulation of nucleic acid templated transcription	GO:1903506	380	0.020	Yeast
membrane organization	GO:0061024	94	0.020
positive regulation of cell death	GO:0010942	184	0.020
single organism cellular localization	GO:1902580	102	0.019
regulation of translation in response to stress	GO:0043555	5	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	84	0.019
negative regulation of cellular protein metabolic process	GO:0032269	106	0.019
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.019	Yeast
regulation of translation	GO:0006417	27	0.019
cellular ketone metabolic process	GO:0042180	51	0.019
mitotic cell cycle	GO:0000278	49	0.019
positive regulation of signaling	GO:0023056	270	0.019
purine ribonucleotide catabolic process	GO:0009154	136	0.019
positive regulation of molecular function	GO:0044093	230	0.018
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.018	Yeast
negative regulation of cellular biosynthetic process	GO:0031327	161	0.018
hematopoietic progenitor cell differentiation	GO:0002244	2	0.018
vesicle mediated transport	GO:0016192	181	0.018
rna catabolic process	GO:0006401	3	0.018
biological adhesion	GO:0022610	110	0.018
programmed cell death	GO:0012501	392	0.018
regulation of proteasomal protein catabolic process	GO:0061136	4	0.018
microtubule cytoskeleton organization	GO:0000226	25	0.018
intracellular transport	GO:0046907	185	0.018
single organism reproductive process	GO:0044702	297	0.017
intracellular signal transduction	GO:0035556	314	0.017
positive regulation of cellular catabolic process	GO:0031331	71	0.017
aging	GO:0007568	241	0.017	Worm
cellular response to dna damage stimulus	GO:0006974	19	0.017	Fly
regulation of rna metabolic process	GO:0051252	391	0.017	Yeast
gonad development	GO:0008406	104	0.017
small gtpase mediated signal transduction	GO:0007264	36	0.017
sexual reproduction	GO:0019953	148	0.017
response to metal ion	GO:0010038	253	0.016
response to ethanol	GO:0045471	162	0.016
response to ketone	GO:1901654	182	0.016
nucleoside triphosphate catabolic process	GO:0009143	123	0.016
centrosome cycle	GO:0007098	1	0.016
regulation of signal transduction	GO:0009966	318	0.016
regulation of nucleotide catabolic process	GO:0030811	65	0.016
ribonucleoside triphosphate metabolic process	GO:0009199	141	0.015
purine containing compound metabolic process	GO:0072521	253	0.015
male gamete generation	GO:0048232	99	0.015
nucleocytoplasmic transport	GO:0006913	48	0.015
oxoacid metabolic process	GO:0043436	290	0.015
chromosome organization	GO:0051276	36	0.015
tube development	GO:0035295	89	0.015
translation	GO:0006412	35	0.015
positive regulation of neuron death	GO:1901216	43	0.015
positive regulation of response to stimulus	GO:0048584	285	0.015
nucleoside phosphate catabolic process	GO:1901292	140	0.015
peptidyl amino acid modification	GO:0018193	126	0.015
regulation of cellular amino acid metabolic process	GO:0006521	2	0.014
positive regulation of hydrolase activity	GO:0051345	86	0.014
neuron differentiation	GO:0030182	368	0.014
positive regulation of cell communication	GO:0010647	271	0.014
cell projection organization	GO:0030030	302	0.014
purine nucleotide metabolic process	GO:0006163	229	0.014
double strand break repair	GO:0006302	1	0.014
multi organism reproductive process	GO:0044703	262	0.014
positive regulation of rna metabolic process	GO:0051254	203	0.014	Yeast
ribonucleotide metabolic process	GO:0009259	231	0.014
spermatogenesis	GO:0007283	99	0.014
cellular response to unfolded protein	GO:0034620	2	0.013
positive regulation of transcription dna templated	GO:0045893	197	0.013	Yeast
negative regulation of rna biosynthetic process	GO:1902679	118	0.013
positive regulation of gene expression	GO:0010628	244	0.013	Yeast
positive regulation of apoptotic process	GO:0043065	154	0.013
rna polymerase ii transcriptional preinitiation complex assembly	GO:0051123	3	0.013	Yeast
organelle fission	GO:0048285	25	0.013
organic cyclic compound catabolic process	GO:1901361	175	0.013
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.013
cell adhesion	GO:0007155	110	0.013
response to endoplasmic reticulum stress	GO:0034976	10	0.013
maintenance of location	GO:0051235	17	0.013
negative regulation of metabolic process	GO:0009892	331	0.013
cytoplasmic transport	GO:0016482	115	0.013
sex differentiation	GO:0007548	113	0.013
carbohydrate derivative metabolic process	GO:1901135	346	0.013
positive regulation of biosynthetic process	GO:0009891	319	0.013	Yeast
growth	GO:0040007	165	0.013
regulation of organelle organization	GO:0033043	80	0.013
regulation of multicellular organismal development	GO:2000026	376	0.013
nucleic acid templated transcription	GO:0097659	379	0.013	Yeast
negative regulation of multicellular organismal process	GO:0051241	203	0.013
regulation of purine nucleotide metabolic process	GO:1900542	115	0.013
cellular response to oxygen levels	GO:0071453	60	0.013
tissue development	GO:0009888	252	0.012
development of primary sexual characteristics	GO:0045137	107	0.012
ovulation cycle	GO:0042698	67	0.012
regulation of cellular amine metabolic process	GO:0033238	8	0.012
er nucleus signaling pathway	GO:0006984	3	0.012
positive regulation of cellular component biogenesis	GO:0044089	55	0.012	Yeast
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.012
negative regulation of transport	GO:0051051	136	0.012
regulation of cell growth	GO:0001558	85	0.012
nucleoside catabolic process	GO:0009164	126	0.012
ras protein signal transduction	GO:0007265	29	0.011
cellular macromolecule localization	GO:0070727	122	0.011
regulation of neurogenesis	GO:0050767	247	0.011
response to calcium ion	GO:0051592	59	0.011
amino acid activation	GO:0043038	3	0.011
regulation of molecular function	GO:0065009	398	0.011
nucleobase containing small molecule metabolic process	GO:0055086	316	0.011
cell projection morphogenesis	GO:0048858	123	0.011
negative regulation of nucleic acid templated transcription	GO:1903507	117	0.011
regulation of catalytic activity	GO:0050790	304	0.011
protein polymerization	GO:0051258	22	0.011
response to starvation	GO:0042594	59	0.011
embryo development ending in birth or egg hatching	GO:0009792	22	0.011	Mouse Worm
regulation of cellular ketone metabolic process	GO:0010565	27	0.010
respiratory system development	GO:0060541	45	0.010
regulation of hydrolase activity	GO:0051336	143	0.010
regulation of neuron projection development	GO:0010975	161	0.010
positive regulation of protein modification process	GO:0031401	142	0.010
cellular response to topologically incorrect protein	GO:0035967	3	0.010
neuron development	GO:0048666	286	0.010
positive regulation of catabolic process	GO:0009896	78	0.010

Psmc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.015
	nervous system disease	DOID:863	0	0.015

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