IMP: Integrative Multi-species Prediction

Rattus norvegicus

311 known processes

Serpine1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

(Aliases: Pai1aa,PAI1A,Pai1,Planh,RATPAI1A)

Ensembl: ENSRNOG00000001414
Entrez: 24617
RGD: 3249
UniProtKB: P20961

Process Predictions
Disease Predictions

Serpine1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
positive regulation of cell migration	GO:0030335	96	0.907
positive regulation of locomotion	GO:0040017	102	0.885
cell motility	GO:0048870	202	0.810
apoptotic process	GO:0006915	381	0.733	Human
positive regulation of cell motility	GO:2000147	97	0.673
response to wounding	GO:0009611	254	0.663
regulation of programmed cell death	GO:0043067	341	0.661	Human
response to peptide	GO:1901652	292	0.616
negative regulation of cell death	GO:0060548	229	0.608	Human
response to corticosteroid	GO:0031960	235	0.603
response to temperature stimulus	GO:0009266	94	0.584
regulation of cellular component movement	GO:0051270	150	0.552
response to interleukin 1	GO:0070555	55	0.513
locomotion	GO:0040011	237	0.512
ovulation	GO:0030728	17	0.511
single organism reproductive process	GO:0044702	297	0.500
positive regulation of response to stimulus	GO:0048584	285	0.475	Human
cellular response to high density lipoprotein particle stimulus	GO:0071403	2	0.475
regulation of nucleic acid templated transcription	GO:1903506	380	0.468
positive regulation of cellular component movement	GO:0051272	102	0.461
regulation of cell proliferation	GO:0042127	359	0.447
regulation of signal transduction	GO:0009966	318	0.447	Human
response to estrogen	GO:0043627	232	0.424
cellular response to organic cyclic compound	GO:0071407	202	0.422
positive regulation of multicellular organismal process	GO:0051240	387	0.420
natural killer cell mediated immune response to tumor cell	GO:0002423	1	0.402
response to biotic stimulus	GO:0009607	226	0.401
regeneration	GO:0031099	163	0.400
response to inorganic substance	GO:0010035	377	0.397
cellular response to interleukin 1	GO:0071347	37	0.385
cellular response to cytokine stimulus	GO:0071345	127	0.383
programmed cell death	GO:0012501	392	0.378	Human
localization of cell	GO:0051674	202	0.374
response to lipopolysaccharide	GO:0032496	191	0.367
positive regulation of cell communication	GO:0010647	271	0.362
cellular response to endogenous stimulus	GO:0071495	377	0.357
cellular response to stress	GO:0033554	269	0.357
blood vessel development	GO:0001568	69	0.351	Human Mouse
response to bacterium	GO:0009617	200	0.339
response to estradiol	GO:0032355	164	0.337
response to acid chemical	GO:0001101	222	0.331
response to oxygen levels	GO:0070482	265	0.330
regulation of leukocyte migration	GO:0002685	24	0.325	Human
regulation of locomotion	GO:0040012	148	0.323
positive regulation of smooth muscle cell migration	GO:0014911	27	0.314
reproductive process	GO:0022414	372	0.314
response to cytokine	GO:0034097	215	0.313
response to extracellular stimulus	GO:0009991	380	0.310
response to dexamethasone	GO:0071548	49	0.309
cell chemotaxis	GO:0060326	31	0.308	Human
cellular response to hormone stimulus	GO:0032870	247	0.305
negative regulation of cell proliferation	GO:0008285	119	0.302
response to vitamin	GO:0033273	131	0.301
wound healing	GO:0042060	122	0.301
response to amino acid	GO:0043200	75	0.298
regulation of cell differentiation	GO:0045595	320	0.297	Rat
positive regulation of signaling	GO:0023056	270	0.297
cellular response to glucocorticoid stimulus	GO:0071385	68	0.283
circulatory system development	GO:0072359	134	0.282	Human Mouse
reproduction	GO:0000003	245	0.280
response to heat	GO:0009408	60	0.278
response to tumor necrosis factor	GO:0034612	56	0.276
cellular response to drug	GO:0035690	30	0.273
response to molecule of bacterial origin	GO:0002237	194	0.270
regulation of apoptotic process	GO:0042981	335	0.267	Human
positive regulation of fever generation	GO:0031622	5	0.265
anatomical structure morphogenesis	GO:0009653	298	0.259	Human Mouse
carbohydrate derivative metabolic process	GO:1901135	346	0.258
regulation of fever generation	GO:0031620	6	0.255
regulation of cellular component organization	GO:0051128	368	0.254
response to nutrient levels	GO:0031667	370	0.252
nucleic acid templated transcription	GO:0097659	379	0.250
tissue development	GO:0009888	252	0.250
negative regulation of programmed cell death	GO:0043069	183	0.247	Human
transcription dna templated	GO:0006351	377	0.246
cellular component biogenesis	GO:0044085	368	0.244	Rat
response to hypoxia	GO:0001666	231	0.236
response to indole 3 methanol	GO:0071680	2	0.236
leukocyte migration	GO:0050900	38	0.235	Human
response to mechanical stimulus	GO:0009612	134	0.230
cellular component movement	GO:0006928	248	0.226
positive regulation of synaptic plasticity	GO:0031915	3	0.222
multi multicellular organism process	GO:0044706	138	0.221
positive regulation of neuron projection development	GO:0010976	99	0.220	Rat
cell migration	GO:0016477	197	0.220
muscle cell migration	GO:0014812	36	0.216	Human
transformation of host cell by virus	GO:0019087	4	0.216
catabolic process	GO:0009056	351	0.209	Rat
regulation of angiogenesis	GO:0045765	39	0.204	Human Mouse
positive regulation of cell proliferation	GO:0008284	249	0.203
cellular response to oxygen containing compound	GO:1901701	386	0.201
response to other organism	GO:0051707	220	0.201
transcription from rna polymerase ii promoter	GO:0006366	252	0.199
regulation of immune system process	GO:0002682	123	0.199	Human
cellular response to lipoteichoic acid	GO:0071223	1	0.197
positive regulation of g0 to g1 transition	GO:0070318	2	0.195
positive regulation of phosphorus metabolic process	GO:0010562	262	0.195
response to high density lipoprotein particle	GO:0055099	2	0.194
multicellular organism reproduction	GO:0032504	233	0.190
response to decreased oxygen levels	GO:0036293	237	0.190
vasculature development	GO:0001944	70	0.186	Human Mouse
secretion by cell	GO:0032940	248	0.183	Rat
single organism biosynthetic process	GO:0044711	342	0.176
taxis	GO:0042330	67	0.175	Human
negative regulation of apoptotic process	GO:0043066	181	0.172	Human
regulation of cell motility	GO:2000145	131	0.172
secretion	GO:0046903	307	0.170	Rat
cellular response to low density lipoprotein particle stimulus	GO:0071404	3	0.170
response to peptide hormone	GO:0043434	278	0.168
regulation of rna metabolic process	GO:0051252	391	0.165
regulation of nervous system development	GO:0051960	264	0.164	Rat
positive regulation of biosynthetic process	GO:0009891	319	0.163
regulation of transcription dna templated	GO:0006355	374	0.163
response to external biotic stimulus	GO:0043207	221	0.162
multi organism reproductive process	GO:0044703	262	0.158
response to organophosphorus	GO:0046683	102	0.149
positive regulation of developmental process	GO:0051094	283	0.149	Human Mouse Rat
regulation of system process	GO:0044057	208	0.148
positive regulation of programmed cell death	GO:0043068	157	0.148
neuron projection development	GO:0031175	273	0.147	Rat
regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	GO:0002858	1	0.145
cellular response to iron iii ion	GO:0071283	3	0.144
regulation of cell migration	GO:0030334	128	0.143
positive regulation of gene expression	GO:0010628	244	0.142
sexual reproduction	GO:0019953	148	0.142
regulation of catalytic activity	GO:0050790	304	0.139
ossification	GO:0001503	70	0.138
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.136
biological adhesion	GO:0022610	110	0.135	Human Rat
cell adhesion	GO:0007155	110	0.134	Human Rat
blood circulation	GO:0008015	183	0.134
organ regeneration	GO:0031100	101	0.133
positive regulation of cellular biosynthetic process	GO:0031328	295	0.133
multicellular organismal reproductive process	GO:0048609	233	0.133
positive regulation of phosphorylation	GO:0042327	177	0.131
positive regulation of cellular component organization	GO:0051130	200	0.131
regulation of cell cycle	GO:0051726	73	0.130
cellular metal ion homeostasis	GO:0006875	172	0.129
aging	GO:0007568	241	0.128	Human
positive regulation of leukocyte migration	GO:0002687	21	0.128	Human
epithelial cell proliferation	GO:0050673	54	0.127
negative regulation of multicellular organismal process	GO:0051241	203	0.127	Human Mouse Rat
response to nutrient	GO:0007584	248	0.126
negative regulation of gene expression	GO:0010629	199	0.125
regulation of neurogenesis	GO:0050767	247	0.124	Rat
osteoblast differentiation	GO:0001649	26	0.120
macromolecular complex subunit organization	GO:0043933	339	0.119
cellular response to lipopolysaccharide	GO:0071222	55	0.119	Human
neuron differentiation	GO:0030182	368	0.119	Rat
regulation of cell projection organization	GO:0031344	175	0.118	Rat
homeostatic process	GO:0042592	331	0.118
cardiovascular system development	GO:0072358	134	0.116	Human Mouse
negative regulation of cellular metabolic process	GO:0031324	281	0.115
regulation of intracellular signal transduction	GO:1902531	218	0.114
positive regulation of neuron differentiation	GO:0045666	126	0.113	Rat
rna metabolic process	GO:0016070	406	0.113
natural killer cell mediated cytotoxicity directed against tumor cell target	GO:0002420	1	0.113
regulation of osteoblast differentiation	GO:0045667	14	0.112
response to tumor cell	GO:0002347	4	0.112
cellular response to growth factor stimulus	GO:0071363	162	0.110
regulation of natural killer cell mediated immune response to tumor cell	GO:0002855	1	0.110
regulation of rna biosynthetic process	GO:2001141	381	0.108
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.108
gamete generation	GO:0007276	124	0.107
cellular response to fluid shear stress	GO:0071498	4	0.106
embryo implantation	GO:0007566	15	0.105	Rat
regulation of kinase activity	GO:0043549	117	0.104
response to carbohydrate	GO:0009743	183	0.103
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.103
cellular response to ketone	GO:1901655	51	0.103
response to glucocorticoid	GO:0051384	223	0.103
response to hydrogen peroxide	GO:0042542	89	0.101
circulatory system process	GO:0003013	183	0.100
regulation of neuron differentiation	GO:0045664	208	0.100	Rat
regulation of ossification	GO:0030278	32	0.099
cellular response to molecule of bacterial origin	GO:0071219	56	0.096	Human
cell cell signaling	GO:0007267	335	0.096
negative regulation of signaling	GO:0023057	157	0.095	Human
positive regulation of muscle contraction	GO:0045933	22	0.095
growth	GO:0040007	165	0.092
immune response	GO:0006955	104	0.092
response to low density lipoprotein particle	GO:0055098	4	0.092
positive regulation of nervous system development	GO:0051962	178	0.091	Rat
cell projection organization	GO:0030030	302	0.091	Rat
positive regulation of signal transduction	GO:0009967	175	0.090
positive regulation of catalytic activity	GO:0043085	184	0.088
smooth muscle cell migration	GO:0014909	36	0.088	Human
positive regulation of leukocyte chemotaxis	GO:0002690	10	0.088	Human
response to toxic substance	GO:0009636	133	0.088
hindlimb morphogenesis	GO:0035137	2	0.086
lipid metabolic process	GO:0006629	283	0.086
cellular component morphogenesis	GO:0032989	155	0.086
cell growth	GO:0016049	104	0.085
regulation of cell adhesion	GO:0030155	52	0.084	Human Rat
cellular response to platelet derived growth factor stimulus	GO:0036120	7	0.084
cellular component assembly	GO:0022607	360	0.083
positive regulation of angiogenesis	GO:0045766	28	0.083	Human Mouse
regulation of phosphorylation	GO:0042325	248	0.083
developmental growth	GO:0048589	100	0.083
regulation of nf kappab import into nucleus	GO:0042345	5	0.083
regulation of transferase activity	GO:0051338	123	0.083
response to fatty acid	GO:0070542	65	0.082
formation of primary germ layer	GO:0001704	1	0.082
response to purine containing compound	GO:0014074	126	0.082
granulocyte chemotaxis	GO:0071621	15	0.082
positive regulation of phosphate metabolic process	GO:0045937	262	0.081
response to ketone	GO:1901654	182	0.081
fever generation	GO:0001660	9	0.081
organic substance catabolic process	GO:1901575	316	0.081	Rat
response to mineralocorticoid	GO:0051385	49	0.081
limb morphogenesis	GO:0035108	4	0.080
protein complex assembly	GO:0006461	263	0.080
regulation of smooth muscle cell migration	GO:0014910	36	0.080	Human
regulation of molecular function	GO:0065009	398	0.079
cell cycle	GO:0007049	101	0.078
immune system process	GO:0002376	204	0.078
positive regulation of keratinocyte migration	GO:0051549	2	0.078
neuron death	GO:0070997	127	0.077
muscle contraction	GO:0006936	88	0.077
cation transport	GO:0006812	382	0.077
positive regulation of response to external stimulus	GO:0032103	51	0.077	Human
negative regulation of cell differentiation	GO:0045596	99	0.077
rhythmic process	GO:0048511	156	0.077
single organism catabolic process	GO:0044712	283	0.076
cellular response to peptide	GO:1901653	133	0.076
positive regulation of intracellular signal transduction	GO:1902533	138	0.076
cellular response to peptide hormone stimulus	GO:0071375	120	0.075
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.075
regulation of behavior	GO:0050795	61	0.075	Human
regulation of neuron projection development	GO:0010975	161	0.075	Rat
cellular calcium ion homeostasis	GO:0006874	160	0.074
neutrophil migration	GO:1990266	12	0.074
embryonic hindlimb morphogenesis	GO:0035116	2	0.074
skeletal muscle tissue regeneration	GO:0043403	10	0.073
negative regulation of natural killer cell mediated immunity	GO:0002716	4	0.073
reactive oxygen species metabolic process	GO:0072593	37	0.072
negative regulation of cell communication	GO:0010648	158	0.072	Human
positive regulation of transcription dna templated	GO:0045893	197	0.072
response to activity	GO:0014823	73	0.072
regulation of synaptic transmission	GO:0050804	141	0.071
response to metal ion	GO:0010038	253	0.071
mapk cascade	GO:0000165	140	0.070
response to ionizing radiation	GO:0010212	59	0.069
regulation of vasculature development	GO:1901342	44	0.068	Human Mouse
establishment of synaptic specificity at neuromuscular junction	GO:0007529	1	0.068
negative regulation of metabolic process	GO:0009892	331	0.067
response to amphetamine	GO:0001975	25	0.067
positive regulation of molecular function	GO:0044093	230	0.066
regulation of muscle system process	GO:0090257	79	0.065
response to reactive oxygen species	GO:0000302	120	0.064
carboxylic acid metabolic process	GO:0019752	289	0.064
central nervous system development	GO:0007417	311	0.064
protein phosphorylation	GO:0006468	345	0.064
positive regulation of cell development	GO:0010720	176	0.064	Rat
axon development	GO:0061564	96	0.063
regulation of response to stress	GO:0080134	126	0.063	Human Mouse Rat
response to hexose	GO:0009746	144	0.063
regulation of protein transport	GO:0051223	68	0.063
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.063
reproductive system development	GO:0061458	128	0.062
signal transduction by phosphorylation	GO:0023014	144	0.062
protein localization	GO:0008104	191	0.061
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.060
regulation of secretion	GO:0051046	224	0.060
single organism organelle organization	GO:1902589	180	0.060
cellular response to steroid hormone stimulus	GO:0071383	93	0.060
neurological system process	GO:0050877	219	0.060
cellular chemical homeostasis	GO:0055082	247	0.060
muscle system process	GO:0003012	115	0.060
eosinophil chemotaxis	GO:0048245	3	0.059
cellular response to tumor necrosis factor	GO:0071356	46	0.059
cellular response to lipid	GO:0071396	201	0.058
rna biosynthetic process	GO:0032774	380	0.058
positive regulation of protein phosphorylation	GO:0001934	135	0.058
regulation of secretion by cell	GO:1903530	208	0.058
positive regulation of apoptotic process	GO:0043065	154	0.058
neuron development	GO:0048666	286	0.058	Rat
regulation of blood circulation	GO:1903522	110	0.057
positive regulation of rna biosynthetic process	GO:1902680	197	0.057
organic acid metabolic process	GO:0006082	292	0.057
synaptic transmission	GO:0007268	235	0.056
establishment of protein localization	GO:0045184	141	0.056
female pregnancy	GO:0007565	122	0.056
regulation of protein phosphorylation	GO:0001932	183	0.055
t helper 1 type immune response	GO:0042088	1	0.055
bmp signaling pathway	GO:0030509	4	0.055
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.055	Human Mouse
positive regulation of transcription factor import into nucleus	GO:0042993	4	0.055
angiogenesis	GO:0001525	53	0.055	Human Mouse
female gonad development	GO:0008585	53	0.055
positive regulation of transport	GO:0051050	245	0.055
granulocyte migration	GO:0097530	16	0.054
leukocyte mediated immunity	GO:0002443	28	0.054
regulation of protein kinase activity	GO:0045859	105	0.054
regulation of multicellular organismal development	GO:2000026	376	0.054	Human Mouse Rat
positive regulation of neurogenesis	GO:0050769	165	0.054	Rat
response to axon injury	GO:0048678	59	0.053
developmental process involved in reproduction	GO:0003006	159	0.053
hexose metabolic process	GO:0019318	58	0.053
keratinocyte migration	GO:0051546	2	0.052
interleukin 1 alpha biosynthetic process	GO:0050719	1	0.052
regulation of immune response to tumor cell	GO:0002837	3	0.051
chemical homeostasis	GO:0048878	292	0.051
positive regulation of immune system process	GO:0002684	90	0.050	Human
lymphocyte migration	GO:0072676	3	0.050
regulation of phosphate metabolic process	GO:0019220	349	0.049
positive regulation of cell death	GO:0010942	184	0.049
ovulation cycle	GO:0042698	67	0.049
cell matrix adhesion	GO:0007160	19	0.049	Human
negative regulation of immune response to tumor cell	GO:0002838	2	0.049
neutrophil chemotaxis	GO:0030593	11	0.048
positive regulation of cell projection organization	GO:0031346	111	0.048	Rat
regulation of smooth muscle contraction	GO:0006940	29	0.048
negative regulation of macromolecule metabolic process	GO:0010605	260	0.048
regulation of phosphorus metabolic process	GO:0051174	349	0.047
regulation of t cell chemotaxis	GO:0010819	1	0.047
positive regulation of cell differentiation	GO:0045597	217	0.047	Rat
positive regulation of behavior	GO:0048520	38	0.047	Human
protein transport	GO:0015031	132	0.047
regulation of neuron death	GO:1901214	115	0.047
positive regulation of rna metabolic process	GO:0051254	203	0.047
response to insulin	GO:0032868	133	0.047
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.047
defense response	GO:0006952	194	0.047	Human Mouse
acute inflammatory response	GO:0002526	58	0.047
regulation of tube size	GO:0035150	89	0.046
cellular catabolic process	GO:0044248	295	0.046
cellular response to organonitrogen compound	GO:0071417	197	0.046
response to growth factor	GO:0070848	189	0.046
cell morphogenesis	GO:0000902	142	0.046
myeloid leukocyte migration	GO:0097529	20	0.046	Human
regulation of muscle contraction	GO:0006937	53	0.046
regulation of leukocyte mediated immunity	GO:0002703	19	0.046
regulation of cell development	GO:0060284	263	0.046	Rat
jak stat cascade	GO:0007259	26	0.045
neuron projection regeneration	GO:0031102	35	0.045
negative regulation of transport	GO:0051051	136	0.044
heat acclimation	GO:0010286	1	0.044
cytokine production	GO:0001816	61	0.044	Human
cellular homeostasis	GO:0019725	252	0.044
innate immune response	GO:0045087	35	0.044
regulation of cellular localization	GO:0060341	263	0.043
leukocyte cell cell adhesion	GO:0007159	4	0.043
positive regulation of protein modification process	GO:0031401	142	0.043
head development	GO:0060322	247	0.043
positive regulation of lymphocyte migration	GO:2000403	1	0.042
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	141	0.042
metal ion homeostasis	GO:0055065	186	0.041
intracellular signal transduction	GO:0035556	314	0.041
amine metabolic process	GO:0009308	38	0.041
regulation of metanephros development	GO:0072215	4	0.041
gastrulation	GO:0007369	2	0.041
cellular response to external stimulus	GO:0071496	118	0.041
positive regulation of secretion	GO:0051047	140	0.040
cellular ion homeostasis	GO:0006873	184	0.040
blood vessel morphogenesis	GO:0048514	58	0.040	Human Mouse
regulation of lymphocyte migration	GO:2000401	1	0.040
response to glucose	GO:0009749	136	0.040
negative regulation of rna metabolic process	GO:0051253	123	0.039
positive regulation of kinase activity	GO:0033674	77	0.039
cellular response to transforming growth factor beta stimulus	GO:0071560	41	0.039
regulation of protein metabolic process	GO:0051246	289	0.039
prostate gland epithelium morphogenesis	GO:0060740	2	0.039
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	3	0.039
protein complex biogenesis	GO:0070271	263	0.039
organonitrogen compound catabolic process	GO:1901565	179	0.038
single organism intracellular transport	GO:1902582	166	0.038
single organism cell adhesion	GO:0098602	46	0.038
negative regulation of developmental process	GO:0051093	125	0.038	Human Mouse
interleukin 1 biosynthetic process	GO:0042222	1	0.038
chemotaxis	GO:0006935	66	0.038	Human
cellular response to extracellular stimulus	GO:0031668	73	0.038
negative regulation of transcription dna templated	GO:0045892	116	0.037
calcium ion homeostasis	GO:0055074	162	0.037
organonitrogen compound biosynthetic process	GO:1901566	167	0.037
response to gamma radiation	GO:0010332	24	0.037
cell substrate adhesion	GO:0031589	29	0.036	Human
skeletal muscle tissue development	GO:0007519	31	0.036
brain renin angiotensin system	GO:0002035	3	0.036
ribonucleotide metabolic process	GO:0009259	231	0.036
regulation of anatomical structure morphogenesis	GO:0022603	141	0.036	Human Mouse
organic acid biosynthetic process	GO:0016053	83	0.035
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.035
cellular cation homeostasis	GO:0030003	180	0.035
cation homeostasis	GO:0055080	195	0.035
regulation of t cell migration	GO:2000404	1	0.035
epithelial cell migration	GO:0010631	19	0.035
epithelial cell differentiation involved in prostate gland development	GO:0060742	1	0.035
positive regulation of protein transport	GO:0051222	41	0.034
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.034
cytokine mediated signaling pathway	GO:0019221	43	0.034
regulation of neuron apoptotic process	GO:0043523	83	0.034
multicellular organismal catabolic process	GO:0044243	2	0.034
female sex differentiation	GO:0046660	59	0.034
negative regulation of secretion by cell	GO:1903531	72	0.034
negative regulation of biosynthetic process	GO:0009890	168	0.034
regulation of protein localization	GO:0032880	81	0.034
positive regulation of nf kappab import into nucleus	GO:0042346	2	0.033
regulation of protein secretion	GO:0050708	28	0.033
response to transition metal nanoparticle	GO:1990267	122	0.033
cyclic purine nucleotide metabolic process	GO:0052652	62	0.033
regulation of cellular protein metabolic process	GO:0032268	267	0.033
vesicle mediated transport	GO:0016192	181	0.033
brain development	GO:0007420	247	0.033
negative regulation of osteoblast differentiation	GO:0045668	2	0.033
regulation of cytokine production	GO:0001817	56	0.033	Human
response to radiation	GO:0009314	137	0.032	Rat
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.032
response to cold	GO:0009409	29	0.032
muscle cell proliferation	GO:0033002	84	0.032
positive regulation of blood circulation	GO:1903524	65	0.032
cellular response to corticosteroid stimulus	GO:0071384	69	0.032
positive regulation of synaptic transmission	GO:0050806	62	0.031
regulation of blood vessel size	GO:0050880	89	0.031
regulation of synaptic plasticity	GO:0048167	70	0.031
interleukin 1 alpha production	GO:0032610	1	0.031
ion homeostasis	GO:0050801	212	0.031
response to muscle stretch	GO:0035994	2	0.030
regulation of anatomical structure size	GO:0090066	135	0.030
sex differentiation	GO:0007548	113	0.030
regulation of wound healing	GO:0061041	14	0.030	Human Mouse Rat
negative regulation of cellular biosynthetic process	GO:0031327	161	0.030
muscle structure development	GO:0061061	87	0.030
cellular response to biotic stimulus	GO:0071216	59	0.030	Human
development of primary sexual characteristics	GO:0045137	107	0.030
vascular endothelial growth factor receptor signaling pathway	GO:0048010	8	0.030
small gtpase mediated signal transduction	GO:0007264	36	0.030
heart contraction	GO:0060047	57	0.030
response to hyperoxia	GO:0055093	45	0.029
muscle organ development	GO:0007517	50	0.029
regulation of defense response	GO:0031347	68	0.029	Human
inflammatory response	GO:0006954	150	0.029	Human
positive regulation of protein metabolic process	GO:0051247	178	0.029
protein complex subunit organization	GO:0071822	302	0.029
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	75	0.029
epiboly involved in wound healing	GO:0090505	2	0.029
vasoconstriction	GO:0042310	54	0.029
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.029
response to amine	GO:0014075	46	0.028
response to progesterone	GO:0032570	48	0.028
regulation of cell killing	GO:0031341	12	0.028
positive regulation of homeostatic process	GO:0032846	49	0.028
protein oligomerization	GO:0051259	191	0.028
regulation of mast cell chemotaxis	GO:0060753	1	0.028
interleukin 6 production	GO:0032635	12	0.028
cellular amine metabolic process	GO:0044106	38	0.028
macromolecule localization	GO:0033036	252	0.028
response to oxidative stress	GO:0006979	186	0.028
cellular response to insulin stimulus	GO:0032869	81	0.027
regulation of response to wounding	GO:1903034	69	0.027	Human Mouse Rat
response to vitamin d	GO:0033280	34	0.027
regulation of homeostatic process	GO:0032844	101	0.027
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.027
negative regulation of neuron death	GO:1901215	69	0.027
reproductive structure development	GO:0048608	128	0.027
transmission of nerve impulse	GO:0019226	42	0.027
negative regulation of rna biosynthetic process	GO:1902679	118	0.027
regulation of cell morphogenesis	GO:0022604	77	0.027
ovulation cycle process	GO:0022602	50	0.027
response to camp	GO:0051591	91	0.027
skeletal muscle organ development	GO:0060538	33	0.027
cytosolic calcium ion homeostasis	GO:0051480	140	0.026
response to electrical stimulus	GO:0051602	56	0.026
multicellular organismal macromolecule metabolic process	GO:0044259	21	0.026
response to high light intensity	GO:0009644	1	0.026
response to monosaccharide	GO:0034284	159	0.026
intracellular transport	GO:0046907	185	0.026
behavior	GO:0007610	205	0.026	Human
positive regulation of cytoskeleton organization	GO:0051495	26	0.026
cellular response to lipoprotein particle stimulus	GO:0071402	5	0.026
positive regulation of transferase activity	GO:0051347	81	0.025
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.025
cellular response to nutrient levels	GO:0031669	60	0.025
positive regulation of cardiac muscle contraction	GO:0060452	4	0.025
positive regulation of erk1 and erk2 cascade	GO:0070374	29	0.025
divalent inorganic cation homeostasis	GO:0072507	165	0.025
tissue remodeling	GO:0048771	40	0.025
carboxylic acid biosynthetic process	GO:0046394	83	0.025
regulation of neurological system process	GO:0031644	43	0.025
chemokine mediated signaling pathway	GO:0070098	5	0.025
axon regeneration	GO:0031103	28	0.025
positive regulation of interleukin 1 alpha biosynthetic process	GO:0050726	1	0.025
carbohydrate derivative biosynthetic process	GO:1901137	124	0.025
monosaccharide metabolic process	GO:0005996	61	0.025
protein homooligomerization	GO:0051260	91	0.024
cellular amino acid metabolic process	GO:0006520	107	0.024
positive regulation of organelle organization	GO:0010638	48	0.024

Serpine1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
muscle tissue disease	DOID:66	0.056
musculoskeletal system disease	DOID:17	0.056
intrinsic cardiomyopathy	DOID:0060036	0.056
cardiovascular system disease	DOID:1287	0.056
disease of anatomical entity	DOID:7	0.056
myopathy	DOID:423	0.056
dilated cardiomyopathy	DOID:12930	0.056
cardiomyopathy	DOID:0050700	0.056
muscular disease	DOID:0080000	0.056
heart disease	DOID:114	0.056
nervous system disease	DOID:863	0.036
disease of cellular proliferation	DOID:14566	0.029

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