IMP: Integrative Multi-species Prediction

Rattus norvegicus

19 known processes

Twist2

twist homolog 2 (Drosophila)

(Aliases: Dermo1)

Entrez: 59327
Ensembl: ENSRNOG00000020355
RGD: 621286
UniProtKB: P97831

Process Predictions
Disease Predictions

Twist2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of multicellular organismal process	GO:0051241	203	0.542	Mouse
tissue development	GO:0009888	252	0.495	Rat Worm Fly
embryonic skeletal system morphogenesis	GO:0048704	3	0.408	Mouse
response to nutrient	GO:0007584	248	0.407
reproductive process	GO:0022414	372	0.350	Worm
cardiovascular system development	GO:0072358	134	0.342
response to extracellular stimulus	GO:0009991	380	0.332
nucleic acid templated transcription	GO:0097659	379	0.307	Mouse Rat Worm Fly
organ regeneration	GO:0031100	101	0.297
circulatory system development	GO:0072359	134	0.292
intracellular signal transduction	GO:0035556	314	0.277
response to hypoxia	GO:0001666	231	0.259
positive regulation of cell proliferation	GO:0008284	249	0.249	Mouse Rat
regulation of molecular function	GO:0065009	398	0.234	Mouse
negative regulation of metabolic process	GO:0009892	331	0.220	Mouse Fly
regulation of programmed cell death	GO:0043067	341	0.207
regulation of rna metabolic process	GO:0051252	391	0.207	Mouse Rat Worm Fly
cellular component movement	GO:0006928	248	0.202
transcription dna templated	GO:0006351	377	0.201	Mouse Rat Worm Fly
negative regulation of cell development	GO:0010721	82	0.197
regulation of cell proliferation	GO:0042127	359	0.197	Mouse Rat
response to oxygen levels	GO:0070482	265	0.183
protein localization	GO:0008104	191	0.167
response to estrogen	GO:0043627	232	0.164
ureteric bud development	GO:0001657	14	0.164
regeneration	GO:0031099	163	0.163
organelle organization	GO:0006996	266	0.161	Fly
cell motility	GO:0048870	202	0.158
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.158	Rat Worm Fly
regulation of cellular component organization	GO:0051128	368	0.156
tissue morphogenesis	GO:0048729	22	0.155	Worm Fly
negative regulation of cell differentiation	GO:0045596	99	0.148	Mouse
negative regulation of response to stimulus	GO:0048585	155	0.146
embryonic cranial skeleton morphogenesis	GO:0048701	2	0.146	Mouse
organophosphate metabolic process	GO:0019637	370	0.143
anterior posterior pattern specification	GO:0009952	1	0.143
negative regulation of developmental process	GO:0051093	125	0.139	Mouse
cellular response to endogenous stimulus	GO:0071495	377	0.136
locomotion	GO:0040011	237	0.136
mesonephros development	GO:0001823	14	0.135
positive regulation of multicellular organismal process	GO:0051240	387	0.135	Rat
organonitrogen compound biosynthetic process	GO:1901566	167	0.131
multi organism reproductive process	GO:0044703	262	0.131	Worm
blood vessel development	GO:0001568	69	0.130
regulation of anatomical structure morphogenesis	GO:0022603	141	0.128
angiogenesis	GO:0001525	53	0.127
carboxylic acid metabolic process	GO:0019752	289	0.126
negative regulation of cell proliferation	GO:0008285	119	0.123	Mouse
tube development	GO:0035295	89	0.120	Worm Fly
enzyme linked receptor protein signaling pathway	GO:0007167	116	0.120
localization of cell	GO:0051674	202	0.115
head development	GO:0060322	247	0.115	Mouse Rat
nucleobase containing small molecule metabolic process	GO:0055086	316	0.113
regulation of rna biosynthetic process	GO:2001141	381	0.112	Mouse Rat Worm Fly
rna biosynthetic process	GO:0032774	380	0.112	Mouse Rat Worm Fly
regulation of phosphorus metabolic process	GO:0051174	349	0.111
skeletal system development	GO:0001501	41	0.110	Mouse Rat
regulation of nucleic acid templated transcription	GO:1903506	380	0.108	Mouse Rat Worm Fly
apoptotic process	GO:0006915	381	0.105
carbohydrate derivative metabolic process	GO:1901135	346	0.104
cellular component morphogenesis	GO:0032989	155	0.104
oxoacid metabolic process	GO:0043436	290	0.103
response to corticosteroid	GO:0031960	235	0.101
single organism reproductive process	GO:0044702	297	0.101
transcription from rna polymerase ii promoter	GO:0006366	252	0.101	Mouse Rat Worm Fly
brain development	GO:0007420	247	0.101	Rat
axon development	GO:0061564	96	0.100
anatomical structure morphogenesis	GO:0009653	298	0.100	Mouse Rat Worm Fly
regulation of phosphorylation	GO:0042325	248	0.099
nucleotide metabolic process	GO:0009117	279	0.098
cellular response to hormone stimulus	GO:0032870	247	0.098
response to inorganic substance	GO:0010035	377	0.097
regulation of signal transduction	GO:0009966	318	0.096
embryonic skeletal system development	GO:0048706	3	0.095	Mouse
organophosphate biosynthetic process	GO:0090407	143	0.094
neuron development	GO:0048666	286	0.093
cell projection organization	GO:0030030	302	0.091
vasculature development	GO:0001944	70	0.089
reproduction	GO:0000003	245	0.088	Worm
response to estradiol	GO:0032355	164	0.088
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.086	Rat Worm Fly
regulation of phosphate metabolic process	GO:0019220	349	0.085
organ morphogenesis	GO:0009887	75	0.082	Mouse Rat Fly
positive regulation of developmental process	GO:0051094	283	0.082	Rat
negative regulation of response to external stimulus	GO:0032102	37	0.082
epithelium development	GO:0060429	96	0.081	Fly
central nervous system development	GO:0007417	311	0.080	Rat
positive regulation of phosphorus metabolic process	GO:0010562	262	0.080
response to purine containing compound	GO:0014074	126	0.079
establishment of protein localization	GO:0045184	141	0.078
negative regulation of cell death	GO:0060548	229	0.078
cellular amino acid metabolic process	GO:0006520	107	0.078
nucleoside phosphate catabolic process	GO:1901292	140	0.078
negative regulation of programmed cell death	GO:0043069	183	0.077
epithelial cell differentiation	GO:0030855	71	0.075
response to vitamin	GO:0033273	131	0.075
organic acid metabolic process	GO:0006082	292	0.074
single organism organelle organization	GO:1902589	180	0.073	Fly
gland development	GO:0048732	155	0.072	Fly
cell morphogenesis involved in differentiation	GO:0000904	119	0.072
regulation of multicellular organismal development	GO:2000026	376	0.070	Mouse Rat Fly
wound healing	GO:0042060	122	0.069
positive regulation of response to stimulus	GO:0048584	285	0.068
ovulation cycle process	GO:0022602	50	0.068
purine containing compound metabolic process	GO:0072521	253	0.068
calcium ion transport	GO:0006816	131	0.067
aging	GO:0007568	241	0.067
regulation of response to wounding	GO:1903034	69	0.067
regulation of cell motility	GO:2000145	131	0.066
regulation of cellular amino acid metabolic process	GO:0006521	2	0.065
ovulation cycle	GO:0042698	67	0.064
positive regulation of rna metabolic process	GO:0051254	203	0.064	Rat Worm Fly
multicellular organismal reproductive process	GO:0048609	233	0.064	Worm
macromolecular complex subunit organization	GO:0043933	339	0.063
blood vessel morphogenesis	GO:0048514	58	0.063
regulation of apoptotic process	GO:0042981	335	0.062
cell migration	GO:0016477	197	0.062
cellular response to lipid	GO:0071396	201	0.062
ribonucleotide metabolic process	GO:0009259	231	0.062
cell activation	GO:0001775	97	0.060
regulation of protein modification process	GO:0031399	194	0.059
negative regulation of macromolecule metabolic process	GO:0010605	260	0.059	Mouse Fly
response to wounding	GO:0009611	254	0.059
multicellular organism reproduction	GO:0032504	233	0.059	Worm
regulation of cellular protein metabolic process	GO:0032268	267	0.058
regulation of transcription from rna polymerase ii promoter	GO:0006357	234	0.057	Mouse Rat Worm Fly
rna metabolic process	GO:0016070	406	0.057	Mouse Rat Worm Fly
response to mechanical stimulus	GO:0009612	134	0.057
regulation of system process	GO:0044057	208	0.057
neuron differentiation	GO:0030182	368	0.057	Rat
cellular response to organic cyclic compound	GO:0071407	202	0.056
positive regulation of cellular amino acid metabolic process	GO:0045764	1	0.056
cation transport	GO:0006812	382	0.056
regulation of cell development	GO:0060284	263	0.055	Rat
response to metal ion	GO:0010038	253	0.055
negative regulation of neuron differentiation	GO:0045665	62	0.055
amine metabolic process	GO:0009308	38	0.054
positive regulation of transcription dna templated	GO:0045893	197	0.054	Rat Worm Fly
regulation of nervous system development	GO:0051960	264	0.054	Rat
gonad development	GO:0008406	104	0.054
kidney morphogenesis	GO:0060993	13	0.053
lymphoid progenitor cell differentiation	GO:0002320	2	0.053
regulation of transcription dna templated	GO:0006355	374	0.053	Mouse Rat Worm Fly
cation homeostasis	GO:0055080	195	0.053
purine nucleotide metabolic process	GO:0006163	229	0.053
protein transport	GO:0015031	132	0.052
regulation of neurogenesis	GO:0050767	247	0.052	Rat
negative regulation of signaling	GO:0023057	157	0.052
multicellular organism growth	GO:0035264	1	0.051
regulation of cellular component movement	GO:0051270	150	0.051
negative regulation of cellular biosynthetic process	GO:0031327	161	0.051	Mouse
neuron projection guidance	GO:0097485	24	0.051
response to radiation	GO:0009314	137	0.050
positive regulation of cellular biosynthetic process	GO:0031328	295	0.050	Rat Worm Fly
muscle cell differentiation	GO:0042692	52	0.050	Fly
mesonephric tubule development	GO:0072164	14	0.050
sensory organ development	GO:0007423	74	0.050	Mouse Rat
positive regulation of cell differentiation	GO:0045597	217	0.050	Rat
immune response	GO:0006955	104	0.049
regulation of transferase activity	GO:0051338	123	0.049
regulation of secretion by cell	GO:1903530	208	0.049
response to peptide hormone	GO:0043434	278	0.048
cellular homeostasis	GO:0019725	252	0.048	Rat
response to retinoic acid	GO:0032526	63	0.048
programmed cell death	GO:0012501	392	0.048
cellular ketone metabolic process	GO:0042180	51	0.048
purine ribonucleotide metabolic process	GO:0009150	227	0.047
protein phosphorylation	GO:0006468	345	0.047
regulation of calcium ion transport	GO:0051924	77	0.047
cellular response to oxygen containing compound	GO:1901701	386	0.047	Rat
striated muscle cell development	GO:0055002	26	0.046	Fly
neuron projection morphogenesis	GO:0048812	122	0.046
rhythmic process	GO:0048511	156	0.046
heart development	GO:0007507	72	0.046
osteoblast differentiation	GO:0001649	26	0.045	Mouse
cellular response to stress	GO:0033554	269	0.045
embryonic pattern specification	GO:0009880	1	0.045
g protein coupled receptor signaling pathway	GO:0007186	242	0.044
defense response	GO:0006952	194	0.044
regulation of cell migration	GO:0030334	128	0.044
regulation of vasculature development	GO:1901342	44	0.043
response to nutrient levels	GO:0031667	370	0.043
metal ion transport	GO:0030001	289	0.043
regulation of response to external stimulus	GO:0032101	106	0.043
developmental process involved in reproduction	GO:0003006	159	0.043
gastrulation	GO:0007369	2	0.043	Worm Fly
cellular component assembly	GO:0022607	360	0.043
ribose phosphate metabolic process	GO:0019693	235	0.042
axon guidance	GO:0007411	24	0.042
regulation of intracellular signal transduction	GO:1902531	218	0.042
negative regulation of vasculature development	GO:1901343	11	0.042
response to oxidative stress	GO:0006979	186	0.042
cellular macromolecule localization	GO:0070727	122	0.042
organic substance catabolic process	GO:1901575	316	0.042
positive regulation of cellular protein metabolic process	GO:0032270	167	0.042
regulation of osteoblast differentiation	GO:0045667	14	0.042	Mouse
positive regulation of cell death	GO:0010942	184	0.042
cell growth	GO:0016049	104	0.041
response to decreased oxygen levels	GO:0036293	237	0.041
muscle system process	GO:0003012	115	0.041
renal system development	GO:0072001	67	0.041	Fly
peptidyl amino acid modification	GO:0018193	126	0.041
regulation of ossification	GO:0030278	32	0.041	Mouse
regulation of protein transport	GO:0051223	68	0.041
positive regulation of the force of heart contraction by epinephrine norepinephrine	GO:0001997	2	0.041
regulation of cell differentiation	GO:0045595	320	0.040	Mouse Rat
regulation of angiogenesis	GO:0045765	39	0.040
striated muscle tissue development	GO:0014706	58	0.040	Fly
glycosyl compound metabolic process	GO:1901657	182	0.040
regulation of cellular localization	GO:0060341	263	0.040
positive regulation of phosphorylation	GO:0042327	177	0.040
chemical homeostasis	GO:0048878	292	0.039	Rat
cytosolic calcium ion homeostasis	GO:0051480	140	0.039
gamete generation	GO:0007276	124	0.039
embryo development	GO:0009790	49	0.039	Mouse Worm Fly
sexual reproduction	GO:0019953	148	0.039
positive regulation of nervous system development	GO:0051962	178	0.039	Rat
regulation of reactive oxygen species metabolic process	GO:2000377	26	0.039
immune system process	GO:0002376	204	0.039	Mouse
negative regulation of response to wounding	GO:1903035	23	0.039
secretion	GO:0046903	307	0.039
regulation of protein localization	GO:0032880	81	0.039
anatomical structure formation involved in morphogenesis	GO:0048646	83	0.038	Worm Fly
cell projection morphogenesis	GO:0048858	123	0.038
response to peptide	GO:1901652	292	0.038
regulation of purine nucleotide catabolic process	GO:0033121	65	0.038
organophosphate catabolic process	GO:0046434	148	0.038
negative regulation of cell communication	GO:0010648	158	0.038
regulation of kinase activity	GO:0043549	117	0.037
purine nucleoside metabolic process	GO:0042278	169	0.037
bmp signaling pathway	GO:0030509	4	0.037
regulation of cellular ketone metabolic process	GO:0010565	27	0.037
response to temperature stimulus	GO:0009266	94	0.037
protein localization to organelle	GO:0033365	57	0.036
cellular component biogenesis	GO:0044085	368	0.036
tube morphogenesis	GO:0035239	23	0.036	Worm Fly
response to ionizing radiation	GO:0010212	59	0.036
development of primary sexual characteristics	GO:0045137	107	0.036
cellular amine metabolic process	GO:0044106	38	0.036
cell adhesion	GO:0007155	110	0.036
ossification	GO:0001503	70	0.036	Mouse
positive regulation of cellular amine metabolic process	GO:0033240	3	0.036
cellular catabolic process	GO:0044248	295	0.036
regulation of cell adhesion	GO:0030155	52	0.036
cellular protein localization	GO:0034613	122	0.035
neuron projection development	GO:0031175	273	0.035
synaptic transmission	GO:0007268	235	0.035
positive regulation of locomotion	GO:0040017	102	0.035
vesicle mediated transport	GO:0016192	181	0.035
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure	GO:0001999	1	0.035
multi multicellular organism process	GO:0044706	138	0.035	Worm
secretion by cell	GO:0032940	248	0.034
cytoskeleton organization	GO:0007010	111	0.034	Fly
regulation of protein metabolic process	GO:0051246	289	0.034
response to glucocorticoid	GO:0051384	223	0.034
protein complex subunit organization	GO:0071822	302	0.034
limb morphogenesis	GO:0035108	4	0.033
b cell differentiation	GO:0030183	2	0.033
regulation of locomotion	GO:0040012	148	0.033
embryonic appendage morphogenesis	GO:0035113	4	0.033
growth	GO:0040007	165	0.033
hepatocyte proliferation	GO:0072574	3	0.033
divalent inorganic cation transport	GO:0072511	134	0.033
cellular response to organonitrogen compound	GO:0071417	197	0.033
nucleoside triphosphate metabolic process	GO:0009141	144	0.033
brain renin angiotensin system	GO:0002035	3	0.032
response to vitamin d	GO:0033280	34	0.032
positive regulation of protein phosphorylation	GO:0001934	135	0.032
regulation of secretion	GO:0051046	224	0.031
second messenger mediated signaling	GO:0019932	51	0.031
negative regulation of transport	GO:0051051	136	0.031
negative regulation of biosynthetic process	GO:0009890	168	0.031	Mouse
nucleoside phosphate metabolic process	GO:0006753	283	0.031
heart contraction	GO:0060047	57	0.031
positive regulation of cellular component movement	GO:0051272	102	0.031
taxis	GO:0042330	67	0.031
positive regulation of the force of heart contraction by norepinephrine	GO:0003061	1	0.030
negative regulation of neurogenesis	GO:0050768	78	0.030
female gonad development	GO:0008585	53	0.030
positive regulation of cytosolic calcium ion concentration	GO:0007204	122	0.030
response to molecule of bacterial origin	GO:0002237	194	0.030
heart morphogenesis	GO:0003007	3	0.030
regulation of protein phosphorylation	GO:0001932	183	0.030
positive regulation of programmed cell death	GO:0043068	157	0.030
regulation of homotypic cell cell adhesion	GO:0034110	4	0.030
homeostatic process	GO:0042592	331	0.030	Rat
cellular ion homeostasis	GO:0006873	184	0.029
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	85	0.029
positive regulation of nucleic acid templated transcription	GO:1903508	197	0.029	Rat Worm Fly
cell morphogenesis involved in neuron differentiation	GO:0048667	106	0.029
response to acid chemical	GO:0001101	222	0.029
signal release	GO:0023061	145	0.029
vasculogenesis	GO:0001570	3	0.029
digestive system development	GO:0055123	41	0.029	Rat Worm Fly
response to ketone	GO:1901654	182	0.029
metanephric comma shaped body morphogenesis	GO:0072278	2	0.029
cellular response to nitrogen compound	GO:1901699	210	0.029
regulation of saliva secretion	GO:0046877	3	0.029
regulation of cellular amine metabolic process	GO:0033238	8	0.029
organic hydroxy compound metabolic process	GO:1901615	115	0.029
cellular divalent inorganic cation homeostasis	GO:0072503	162	0.029
response to lipopolysaccharide	GO:0032496	191	0.029
ribonucleotide biosynthetic process	GO:0009260	85	0.028
glomerulus development	GO:0032835	10	0.028
positive regulation of phosphate metabolic process	GO:0045937	262	0.028
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	148	0.028	Rat Fly
muscle contraction	GO:0006936	88	0.028
positive regulation of signaling	GO:0023056	270	0.028
positive regulation of intracellular signal transduction	GO:1902533	138	0.028
cell cell signaling	GO:0007267	335	0.028
positive regulation of cell communication	GO:0010647	271	0.028
nucleoside catabolic process	GO:0009164	126	0.028
formation of primary germ layer	GO:0001704	1	0.028	Worm Fly
regulation of neuron differentiation	GO:0045664	208	0.028	Rat
positive regulation of rna biosynthetic process	GO:1902680	197	0.027	Rat Worm Fly
single organism catabolic process	GO:0044712	283	0.027
nucleoside metabolic process	GO:0009116	179	0.027
response to cold	GO:0009409	29	0.027
single organism intracellular transport	GO:1902582	166	0.027
reactive oxygen species metabolic process	GO:0072593	37	0.027
response to cytokine	GO:0034097	215	0.027
fibrinolysis	GO:0042730	2	0.027
regulation of catabolic process	GO:0009894	113	0.027
organ formation	GO:0048645	3	0.027
divalent metal ion transport	GO:0070838	132	0.027
purine ribonucleoside catabolic process	GO:0046130	124	0.027
appendage morphogenesis	GO:0035107	4	0.027
purine ribonucleoside triphosphate catabolic process	GO:0009207	122	0.027
kidney development	GO:0001822	67	0.027
positive regulation of immune system process	GO:0002684	90	0.026
cellular metal ion homeostasis	GO:0006875	172	0.026
cellular calcium ion homeostasis	GO:0006874	160	0.026
behavior	GO:0007610	205	0.026	Worm
positive regulation of cellular component organization	GO:0051130	200	0.026
endothelial cell differentiation	GO:0045446	9	0.026
mesonephric epithelium development	GO:0072163	14	0.026
forebrain development	GO:0030900	98	0.026	Rat
blood circulation	GO:0008015	183	0.026
bone development	GO:0060348	25	0.025	Rat
chemotaxis	GO:0006935	66	0.025
regulation of muscle system process	GO:0090257	79	0.025
detection of stimulus	GO:0051606	24	0.025
purine containing compound catabolic process	GO:0072523	138	0.025
positive regulation of macromolecule biosynthetic process	GO:0010557	247	0.025	Rat Worm Fly
regulation of growth	GO:0040008	105	0.025
small gtpase mediated signal transduction	GO:0007264	36	0.025
cellular nitrogen compound catabolic process	GO:0044270	163	0.025
erk1 and erk2 cascade	GO:0070371	48	0.025
regulation of metal ion transport	GO:0010959	118	0.025
carbohydrate derivative biosynthetic process	GO:1901137	124	0.025
regulation of behavior	GO:0050795	61	0.025
negative regulation of cellular metabolic process	GO:0031324	281	0.025	Mouse
regulation of catalytic activity	GO:0050790	304	0.025
embryonic organ morphogenesis	GO:0048562	5	0.025	Mouse
single organism biosynthetic process	GO:0044711	342	0.024
organonitrogen compound catabolic process	GO:1901565	179	0.024
carbohydrate derivative catabolic process	GO:1901136	147	0.024
response to hexose	GO:0009746	144	0.024	Rat
inflammatory response	GO:0006954	150	0.024
signal transduction by phosphorylation	GO:0023014	144	0.024
positive regulation of protein metabolic process	GO:0051247	178	0.024
hepaticobiliary system development	GO:0061008	90	0.024
ras protein signal transduction	GO:0007265	29	0.024
negative regulation of gene expression	GO:0010629	199	0.024	Mouse Fly
positive regulation of protein modification process	GO:0031401	142	0.024
liver development	GO:0001889	90	0.024
embryonic limb morphogenesis	GO:0030326	4	0.024
digestive tract development	GO:0048565	39	0.024	Worm Fly
kidney vasculature development	GO:0061440	6	0.024
regulation of leukocyte proliferation	GO:0070663	26	0.024
catabolic process	GO:0009056	351	0.023
detection of temperature stimulus involved in sensory perception of pain	GO:0050965	4	0.023
positive regulation of apoptotic process	GO:0043065	154	0.023
protein complex biogenesis	GO:0070271	263	0.023
cell part morphogenesis	GO:0032990	123	0.023
regulation of purine nucleotide metabolic process	GO:1900542	115	0.023
regulation of body fluid levels	GO:0050878	90	0.023
artery smooth muscle contraction	GO:0014824	4	0.023
s shaped body morphogenesis	GO:0072050	2	0.023
regulation of bmp signaling pathway	GO:0030510	2	0.023
smooth muscle contraction	GO:0006939	37	0.022
negative regulation of phosphate metabolic process	GO:0045936	80	0.022
purine nucleotide catabolic process	GO:0006195	136	0.022
purine ribonucleotide biosynthetic process	GO:0009152	81	0.022
female sex differentiation	GO:0046660	59	0.022
positive regulation of transferase activity	GO:0051347	81	0.022
mapk cascade	GO:0000165	140	0.022
cellular carbohydrate metabolic process	GO:0044262	72	0.022
glomerular mesangium development	GO:0072109	4	0.022
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.022
response to insulin	GO:0032868	133	0.022
regulation of anatomical structure size	GO:0090066	135	0.022
positive regulation of molecular function	GO:0044093	230	0.022
motor neuron axon guidance	GO:0008045	1	0.022
biological adhesion	GO:0022610	110	0.021
negative regulation of growth	GO:0045926	37	0.021
calcium ion homeostasis	GO:0055074	162	0.021
cellular response to steroid hormone stimulus	GO:0071383	93	0.021
axis specification	GO:0009798	4	0.021
regulation of organ formation	GO:0003156	2	0.021
actin cytoskeleton organization	GO:0030036	73	0.021	Fly
positive regulation of cell motility	GO:2000147	97	0.021
protein complex assembly	GO:0006461	263	0.021
neurological system process	GO:0050877	219	0.021
regulation of immune system process	GO:0002682	123	0.021	Mouse
positive regulation of the force of heart contraction by epinephrine	GO:0003059	1	0.021
adenylate cyclase modulating g protein coupled receptor signaling pathway	GO:0007188	51	0.021
negative regulation of molecular function	GO:0044092	133	0.021	Mouse
negative regulation of nervous system development	GO:0051961	79	0.021
kidney epithelium development	GO:0072073	19	0.021
purine nucleoside catabolic process	GO:0006152	124	0.021
macromolecule localization	GO:0033036	252	0.020
glycosyl compound catabolic process	GO:1901658	126	0.020
tissue regeneration	GO:0042246	36	0.020
divalent inorganic cation homeostasis	GO:0072507	165	0.020
urogenital system development	GO:0001655	78	0.020	Fly
intracellular protein transport	GO:0006886	79	0.020
renin secretion into blood stream	GO:0002001	1	0.020
nucleotide catabolic process	GO:0009166	139	0.020
response to bacterium	GO:0009617	200	0.020
ribonucleoside catabolic process	GO:0042454	126	0.020
morphogenesis of an epithelium	GO:0002009	20	0.020	Fly
sensory perception	GO:0007600	101	0.020
regulation of organ morphogenesis	GO:2000027	22	0.020
ribonucleoside metabolic process	GO:0009119	174	0.020
parasympathetic nervous system development	GO:0048486	1	0.020
hematopoietic progenitor cell differentiation	GO:0002244	2	0.020
response to ethanol	GO:0045471	162	0.020
negative regulation of rna biosynthetic process	GO:1902679	118	0.019	Mouse
cyclic nucleotide metabolic process	GO:0009187	80	0.019
negative regulation of nitrogen compound metabolic process	GO:0051172	161	0.019	Mouse
reproductive structure development	GO:0048608	128	0.019
neural crest cell differentiation	GO:0014033	2	0.019
cellular response to external stimulus	GO:0071496	118	0.019
metal ion homeostasis	GO:0055065	186	0.019
glomerulus vasculature development	GO:0072012	6	0.019
negative regulation of nucleobase containing compound metabolic process	GO:0045934	153	0.019	Mouse
regulation of tube size	GO:0035150	89	0.019
muscle structure development	GO:0061061	87	0.019	Fly
spermatogenesis	GO:0007283	99	0.018
rho protein signal transduction	GO:0007266	11	0.018
positive regulation of signal transduction	GO:0009967	175	0.018
cellular response to peptide	GO:1901653	133	0.018
developmental growth	GO:0048589	100	0.018
protein localization to nucleus	GO:0034504	39	0.018
positive regulation of transport	GO:0051050	245	0.018
carbohydrate metabolic process	GO:0005975	130	0.018
cell type specific apoptotic process	GO:0097285	134	0.018
regulation of organelle organization	GO:0033043	80	0.018
mesoderm development	GO:0007498	2	0.018	Worm Fly
cellular response to growth factor stimulus	GO:0071363	162	0.018	Rat
nucleobase containing compound catabolic process	GO:0034655	152	0.018
regulation of defense response	GO:0031347	68	0.018
cellular response to peptide hormone stimulus	GO:0071375	120	0.018
response to dexamethasone	GO:0071548	49	0.018
cellular response to acid chemical	GO:0071229	75	0.018
purine ribonucleoside metabolic process	GO:0046128	168	0.018
single organism carbohydrate metabolic process	GO:0044723	118	0.018
regulation of nucleotide catabolic process	GO:0030811	65	0.018
axonogenesis	GO:0007409	71	0.018
cellular response to corticosteroid stimulus	GO:0071384	69	0.017
muscle tissue development	GO:0060537	58	0.017	Fly
nuclear import	GO:0051170	35	0.017
cellular response to abiotic stimulus	GO:0071214	85	0.017
aromatic compound catabolic process	GO:0019439	168	0.017
negative regulation of wound healing	GO:0061045	8	0.017
response to light stimulus	GO:0009416	52	0.017
negative regulation of synaptic transmission glutamatergic	GO:0051967	8	0.017
maintenance of location	GO:0051235	17	0.017
regulation of blood circulation	GO:1903522	110	0.017
monocarboxylic acid metabolic process	GO:0032787	152	0.017
lipid metabolic process	GO:0006629	283	0.017
regulation of response to stress	GO:0080134	126	0.017
cell morphogenesis	GO:0000902	142	0.017
complement receptor mediated signaling pathway	GO:0002430	2	0.017
regulation of epithelial cell differentiation	GO:0030856	12	0.017
single organism nuclear import	GO:1902593	35	0.017
response to monosaccharide	GO:0034284	159	0.017	Rat
hindlimb morphogenesis	GO:0035137	2	0.017
protein import	GO:0017038	37	0.017
positive regulation of immunoglobulin production	GO:0002639	4	0.017
negative regulation of apoptotic process	GO:0043066	181	0.017
regulation of sodium ion transmembrane transporter activity	GO:2000649	4	0.017
dendrite morphogenesis	GO:0048813	43	0.016
purine ribonucleoside monophosphate metabolic process	GO:0009167	84	0.016
muscle cell proliferation	GO:0033002	84	0.016
single organism cellular localization	GO:1902580	102	0.016
hair cycle	GO:0042633	3	0.016
phospholipid metabolic process	GO:0006644	61	0.016
organic cyclic compound catabolic process	GO:1901361	175	0.016
purine ribonucleotide catabolic process	GO:0009154	136	0.016
positive regulation of hydrolase activity	GO:0051345	86	0.016
gtp metabolic process	GO:0046039	72	0.016
regulation of canonical wnt signaling pathway	GO:0060828	4	0.016
dendrite development	GO:0016358	72	0.016
positive regulation of epithelial cell proliferation	GO:0050679	32	0.016	Mouse Rat

Twist2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org

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