IMP: Integrative Multi-species Prediction

Rattus norvegicus

0 known processes

Wdr74

WD repeat domain 74

Ensembl: ENSRNOG00000042878
RGD: 1582881
Entrez: 690229
UniProtKB: B0BNI2
UniProtKB: D3ZMQ7

Process Predictions
Disease Predictions

Wdr74 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
negative regulation of translational initiation	GO:0045947	5	0.136
cellular component assembly	GO:0022607	360	0.130
organelle organization	GO:0006996	266	0.074
cellular component biogenesis	GO:0044085	368	0.061
regulation of programmed cell death	GO:0043067	341	0.058
negative regulation of translation in response to stress	GO:0032055	5	0.057
head development	GO:0060322	247	0.053
macromolecular complex assembly	GO:0065003	273	0.046
cellular nitrogen compound catabolic process	GO:0044270	163	0.044
apoptotic process	GO:0006915	381	0.041
response to carbohydrate	GO:0009743	183	0.039
nucleobase containing small molecule metabolic process	GO:0055086	316	0.039
ribonucleoside metabolic process	GO:0009119	174	0.038
vesicle mediated transport	GO:0016192	181	0.038
response to monosaccharide	GO:0034284	159	0.036
brain development	GO:0007420	247	0.036
sex differentiation	GO:0007548	113	0.035
development of primary sexual characteristics	GO:0045137	107	0.034
negative regulation of macromolecule metabolic process	GO:0010605	260	0.033
regulation of translation in response to stress	GO:0043555	5	0.033
response to hexose	GO:0009746	144	0.033
spindle organization	GO:0007051	2	0.033
regulation of cellular protein metabolic process	GO:0032268	267	0.032
negative regulation of cellular metabolic process	GO:0031324	281	0.032
protein complex biogenesis	GO:0070271	263	0.031
negative regulation of protein metabolic process	GO:0051248	114	0.030
response to glucose	GO:0009749	136	0.030
reproduction	GO:0000003	245	0.030
carboxylic acid metabolic process	GO:0019752	289	0.030
central nervous system development	GO:0007417	311	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	334	0.029
macromolecular complex subunit organization	GO:0043933	339	0.028
regulation of protein metabolic process	GO:0051246	289	0.028
nucleobase containing compound catabolic process	GO:0034655	152	0.027
glycosyl compound metabolic process	GO:1901657	182	0.027
hematopoietic progenitor cell differentiation	GO:0002244	2	0.027
purine nucleotide metabolic process	GO:0006163	229	0.026
rna metabolic process	GO:0016070	406	0.026
negative regulation of gene expression	GO:0010629	199	0.026
protein complex subunit organization	GO:0071822	302	0.026
synaptic transmission	GO:0007268	235	0.025
establishment or maintenance of transmembrane electrochemical gradient	GO:0010248	1	0.024
nucleoside monophosphate metabolic process	GO:0009123	93	0.024
translation	GO:0006412	35	0.024
negative regulation of programmed cell death	GO:0043069	183	0.023
embryo development	GO:0009790	49	0.023
heterocycle catabolic process	GO:0046700	167	0.023
response to peptide hormone	GO:0043434	278	0.022
multicellular organism reproduction	GO:0032504	233	0.022
regulation of phosphorus metabolic process	GO:0051174	349	0.022
positive regulation of nucleobase containing compound metabolic process	GO:0045935	319	0.022
nucleoside phosphate metabolic process	GO:0006753	283	0.021
macromolecule localization	GO:0033036	252	0.021
cellular catabolic process	GO:0044248	295	0.021
regulation of apoptotic process	GO:0042981	335	0.021
ribose phosphate metabolic process	GO:0019693	235	0.021
organic cyclic compound catabolic process	GO:1901361	175	0.021
negative regulation of biosynthetic process	GO:0009890	168	0.021
regulation of translation	GO:0006417	27	0.021
organonitrogen compound catabolic process	GO:1901565	179	0.020
nucleoside metabolic process	GO:0009116	179	0.020
organic substance catabolic process	GO:1901575	316	0.020
multi organism reproductive process	GO:0044703	262	0.020
regulation of molecular function	GO:0065009	398	0.020
reproductive system development	GO:0061458	128	0.020
purine containing compound metabolic process	GO:0072521	253	0.020
carbohydrate derivative metabolic process	GO:1901135	346	0.020
organophosphate metabolic process	GO:0019637	370	0.020
positive regulation of biosynthetic process	GO:0009891	319	0.019
protein complex assembly	GO:0006461	263	0.019
response to inorganic substance	GO:0010035	377	0.019
negative regulation of macromolecule biosynthetic process	GO:0010558	148	0.019
negative regulation of cellular protein metabolic process	GO:0032269	106	0.019
aromatic compound catabolic process	GO:0019439	168	0.018
cellular response to stress	GO:0033554	269	0.018
purine ribonucleotide metabolic process	GO:0009150	227	0.018
purine ribonucleoside diphosphate metabolic process	GO:0009179	9	0.018
regulation of phosphate metabolic process	GO:0019220	349	0.017
ribonucleoside monophosphate metabolic process	GO:0009161	88	0.017
ribonucleotide catabolic process	GO:0009261	136	0.017
developmental process involved in reproduction	GO:0003006	159	0.016
positive regulation of apoptotic process	GO:0043065	154	0.016
negative regulation of cell death	GO:0060548	229	0.016
neuron differentiation	GO:0030182	368	0.016
intracellular signal transduction	GO:0035556	314	0.016
catabolic process	GO:0009056	351	0.016
nucleotide metabolic process	GO:0009117	279	0.016
negative regulation of apoptotic process	GO:0043066	181	0.016
negative regulation of metabolic process	GO:0009892	331	0.016
multicellular organismal reproductive process	GO:0048609	233	0.016
regulation of catalytic activity	GO:0050790	304	0.016
programmed cell death	GO:0012501	392	0.015
ribonucleotide metabolic process	GO:0009259	231	0.015
response to peptide	GO:1901652	292	0.015
amine metabolic process	GO:0009308	38	0.015
response to temperature stimulus	GO:0009266	94	0.015
regeneration	GO:0031099	163	0.015
cellular amine metabolic process	GO:0044106	38	0.015
endocytosis	GO:0006897	84	0.015
gonad development	GO:0008406	104	0.015
oxoacid metabolic process	GO:0043436	290	0.014
cell type specific apoptotic process	GO:0097285	134	0.014
positive regulation of catalytic activity	GO:0043085	184	0.014
response to external biotic stimulus	GO:0043207	221	0.014
purine ribonucleoside triphosphate metabolic process	GO:0009205	140	0.014
organic acid metabolic process	GO:0006082	292	0.014
reproductive process	GO:0022414	372	0.014
positive regulation of response to stimulus	GO:0048584	285	0.014
regulation of alternative mrna splicing via spliceosome	GO:0000381	2	0.014
sexual reproduction	GO:0019953	148	0.013
female gonad development	GO:0008585	53	0.013
nitrogen compound transport	GO:0071705	229	0.013
ribonucleotide biosynthetic process	GO:0009260	85	0.013
positive regulation of gene expression	GO:0010628	244	0.013
ribonucleoprotein complex biogenesis	GO:0022613	10	0.013
single organism organelle organization	GO:1902589	180	0.013
positive regulation of molecular function	GO:0044093	230	0.012
single organism reproductive process	GO:0044702	297	0.012
cellular macromolecular complex assembly	GO:0034622	58	0.012
neural crest cell development	GO:0014032	2	0.012
cellular macromolecule localization	GO:0070727	122	0.012
hepaticobiliary system development	GO:0061008	90	0.012
reproductive structure development	GO:0048608	128	0.012
regulation of membrane potential	GO:0042391	110	0.012
gtp metabolic process	GO:0046039	72	0.012
regulation of hydrolase activity	GO:0051336	143	0.012
rna localization	GO:0006403	4	0.012
nucleoside phosphate catabolic process	GO:1901292	140	0.012
positive regulation of intracellular signal transduction	GO:1902533	138	0.011
purine ribonucleoside metabolic process	GO:0046128	168	0.011
purine ribonucleoside catabolic process	GO:0046130	124	0.011
gamete generation	GO:0007276	124	0.011
response to other organism	GO:0051707	220	0.011
positive regulation of phosphorus metabolic process	GO:0010562	262	0.011
ribonucleoside catabolic process	GO:0042454	126	0.011
eye morphogenesis	GO:0048592	4	0.011
regulation of cellular catabolic process	GO:0031329	101	0.011
positive regulation of cell death	GO:0010942	184	0.011
ribonucleoside triphosphate catabolic process	GO:0009203	122	0.011
organonitrogen compound biosynthetic process	GO:1901566	167	0.011
mitotic spindle organization	GO:0007052	2	0.010
positive regulation of cellular amine metabolic process	GO:0033240	3	0.010

Wdr74 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in rat and predicted with the rat functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.013
nervous system disease	DOID:863	0.013
brain disease	DOID:936	0.010
central nervous system disease	DOID:331	0.010

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