Caenorhabditis elegans

49 known processes

cls-1 (CELE_C07H6.3)

Protein CLS-1

cls-1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
molting cycleGO:00423032810.364
sexual reproductionGO:00199535460.290
Fly
transportGO:000681010930.272
Worm
regulation of multicellular organismal processGO:00512397260.252
tissue developmentGO:00098881120.240
establishment of localizationGO:005123411710.232
Worm Fly
organ developmentGO:004851311020.219
Fly
organelle organizationGO:00069967830.211
cell developmentGO:00484686960.211
Fly
anatomical structure formation involved in morphogenesisGO:00486462500.210
Fly
developmental process involved in reproductionGO:000300611650.201
Fly
molting cycle collagen and cuticulin based cuticleGO:00189962810.197
muscle tissue developmentGO:006053710.192
cellular component biogenesisGO:00440852970.187
Human Fly
skeletal muscle organ developmentGO:006053830.183
establishment of localization in cellGO:00516493180.183
Worm Fly
localization of cellGO:00516743130.177
Mouse Fly
single organism reproductive processGO:004470211960.162
Fly
gamete generationGO:00072764610.158
Fly
single organism localizationGO:19025785180.157
Human Worm Fly
embryo developmentGO:000979030520.150
cell motilityGO:00488703130.148
Mouse Fly
body morphogenesisGO:00101716200.148
system processGO:00030081360.146
multicellular organismal agingGO:00102598120.140
regulation of biological qualityGO:00650087410.140
Human Worm Fly
cytoskeleton organizationGO:00070103390.137
organic substance biosynthetic processGO:19015763230.137
cellular biosynthetic processGO:00442493150.137
locomotionGO:004001116340.131
Mouse Worm Fly
macromolecule catabolic processGO:00090572020.125
cellular component morphogenesisGO:00329893180.123
Fly
organ morphogenesisGO:0009887670.116
phosphorus metabolic processGO:00067932320.115
multi organism reproductive behaviorGO:00447053870.115
behaviorGO:00076105270.110
post embryonic developmentGO:000979121520.108
Worm
regulation of transcription dna templatedGO:00063551640.106
development of primary sexual characteristicsGO:00451378400.103
nucleic acid metabolic processGO:00903042990.102
regulation of macromolecule metabolic processGO:00602554210.094
negative regulation of multicellular organismal processGO:00512412360.094
growthGO:00400075620.093
embryo development ending in birth or egg hatchingGO:000979229920.093
protein metabolic processGO:00195384220.091
single organism organelle organizationGO:19025895010.090
organic substance catabolic processGO:19015752940.089
cellular component assembly involved in morphogenesisGO:00109271830.088
reproductive behaviorGO:00190983870.088
regulation of response to stimulusGO:00485832430.087
Fly
reproductive structure developmentGO:00486088500.087
regulation of developmental processGO:00507936840.087
aromatic compound biosynthetic processGO:00194381920.087
regulation of transcription from rna polymerase ii promoterGO:00063571450.086
generation of neuronsGO:00486992350.086
Fly
sex differentiationGO:00075489090.083
agingGO:00075688120.082
reproductive system developmentGO:00614588500.082
cellular protein metabolic processGO:00442672790.082
response to external stimulusGO:00096052890.082
Fly
single organism signalingGO:00447004010.081
Fly
organelle fissionGO:00482853630.080
actin filament based processGO:00300291910.080
programmed cell deathGO:00125015000.079
regulation of cellular metabolic processGO:00313233050.077
negative regulation of metabolic processGO:00098922400.077
organic cyclic compound biosynthetic processGO:19013621950.077
matingGO:0007618340.077
biosynthetic processGO:00090583230.076
maintenance of locationGO:00512355800.076
Human Worm Fly
response to chemicalGO:00422213560.075
Fly
cell cycle processGO:00224024820.072
macromolecule localizationGO:00330367710.070
Human Worm Fly
regulation of multicellular organismal developmentGO:20000263170.070
protein catabolic processGO:00301631620.070
regulation of rna biosynthetic processGO:20011411650.068
epithelium developmentGO:0060429680.068
endocytosisGO:00068978190.067
negative regulation of cellular processGO:00485232390.066
Mouse Fly
multicellular organism reproductionGO:00325048190.065
Fly
neuron developmentGO:00486661990.064
Fly
cell deathGO:00082195470.064
receptor mediated endocytosisGO:00068987150.063
cell growthGO:0016049440.063
multi organism reproductive processGO:00447038670.063
Fly
lipid storageGO:00199155650.062
lipid localizationGO:00108765730.062
cell projection organizationGO:00300302310.062
Fly
regulation of synaptic transmission dopaminergicGO:003222510.061
ras protein signal transductionGO:0007265310.061
Fly
single organism transportGO:00447654470.060
positive regulation of stem cell differentiationGO:200073810.060
cellular nitrogen compound biosynthetic processGO:00442711920.060
signal transductionGO:00071653170.060
Fly
transcription dna templatedGO:00063511680.059
gene expressionGO:00104674120.059
defense responseGO:00069522960.059
regulation of nucleic acid templated transcriptionGO:19035061650.058
deathGO:00162655470.057
vesicle mediated transportGO:00161928520.057
cellular component assemblyGO:00226072930.057
Human Fly
determination of adult lifespanGO:00083408120.057
regulation of neurogenesisGO:0050767400.057
actin cytoskeleton organizationGO:00300361840.056
striated muscle cell developmentGO:00550021570.056
mating behaviorGO:0007617320.055
secretion by cellGO:00329401380.055
protein modification processGO:00362112070.055
regulation of cellular macromolecule biosynthetic processGO:20001121880.054
muscle structure developmentGO:00610611910.052
regulation of metabolic processGO:00192224780.052
striated muscle cell differentiationGO:00511461580.051
negative regulation of biological processGO:00485195670.051
Mouse Fly
regulation of cellular component organizationGO:00511282480.051
Human Mouse Fly
negative regulation of neurogenesisGO:005076840.050
hermaphrodite genitalia developmentGO:00400357340.050
apoptotic processGO:00069154780.050
gonad developmentGO:00084068400.050
regulation of primary metabolic processGO:00800902920.049
multicellular organismal reproductive processGO:00486098150.049
Fly
positive regulation of developmental processGO:00510944080.049
nucleobase containing compound metabolic processGO:00061394060.048
cuticle developmentGO:00423351000.048
genitalia developmentGO:00488067410.048
positive regulation of multicellular organismal processGO:00512404170.048
rna metabolic processGO:00160702280.047
positive regulation of nucleobase containing compound metabolic processGO:00459351340.047
macromolecule biosynthetic processGO:00090592500.047
chromosome segregationGO:00070591800.047
Worm Fly
regulation of gene expressionGO:00104683660.047
multi organism behaviorGO:00517053890.047
axon developmentGO:00615641630.045
Fly
actomyosin structure organizationGO:00310321540.045
regulation of synaptic transmissionGO:0050804340.045
organelle assemblyGO:00709252140.045
Fly
regulation of locomotionGO:00400121610.045
establishment of nucleus localizationGO:0040023550.044
negative regulation of gene expressionGO:00106292170.044
regulation of striated muscle contractionGO:000694240.043
myofibril assemblyGO:00302391540.043
tissue morphogenesisGO:0048729650.043
adult behaviorGO:003053430.043
regulation of macromolecule biosynthetic processGO:00105561890.042
protein complex biogenesisGO:00702711860.042
Human Fly
cellular localizationGO:00516413600.042
Human Worm Fly
cell migrationGO:00164773060.042
Mouse Fly
regulation of cellular component movementGO:0051270620.041
regulation of cell migrationGO:0030334550.041
nucleic acid templated transcriptionGO:00976591690.041
cellular protein complex assemblyGO:00436231780.040
Human
muscle cell differentiationGO:00426921710.040
cell proliferationGO:00082831160.040
regulation of nucleobase containing compound metabolic processGO:00192192220.040
embryonic morphogenesisGO:00485981520.039
ovipositionGO:00189913640.039
positive regulation of developmental growthGO:00486393540.038
multicellular organismal reproductive behaviorGO:00330573840.038
catabolic processGO:00090563180.038
innate immune responseGO:00450871900.038
rna biosynthetic processGO:00327741690.037
nucleus localizationGO:0051647550.037
cellular macromolecule biosynthetic processGO:00346452470.037
phosphorylationGO:00163101160.037
meiotic nuclear divisionGO:00071263000.036
regulation of cell communicationGO:00106461760.036
Fly
response to woundingGO:000961140.036
cell cycleGO:00070495260.036
regulation of cell motilityGO:2000145570.035
developmental growthGO:00485894120.035
regulation of biosynthetic processGO:00098891890.035
glycosyl compound metabolic processGO:19016571000.035
neuron recognitionGO:0008038830.035
regulation of cellular biosynthetic processGO:00313261890.035
membrane organizationGO:00610241350.034
homeostatic processGO:0042592510.034
cell projection morphogenesisGO:00488581480.034
Fly
single organism catabolic processGO:00447121290.034
excretionGO:0007588490.034
cellular protein modification processGO:00064642070.034
regulation of axon extensionGO:0030516200.033
positive regulation of nucleic acid templated transcriptionGO:19035081020.033
macromolecule modificationGO:00434122180.033
small gtpase mediated signal transductionGO:0007264320.033
Fly
regulation of small gtpase mediated signal transductionGO:0051056410.033
Fly
muscle organ developmentGO:0007517260.033
digestive system developmentGO:00551231220.032
negative regulation of macromolecule metabolic processGO:00106052290.032
positive regulation of metabolic processGO:00098931870.032
regulation of nitrogen compound metabolic processGO:00511712220.032
head developmentGO:006032210.032
cellular catabolic processGO:00442481990.032
organelle localizationGO:00516401270.032
Worm Fly
secretionGO:00469031470.032
regulation of cell differentiationGO:0045595810.032
Fly
cellular macromolecular complex assemblyGO:00346221840.032
Human
transcription from rna polymerase ii promoterGO:00063661490.032
positive regulation of cellular processGO:00485223320.032
heterocycle biosynthetic processGO:00181301870.032
carbohydrate derivative metabolic processGO:19011351410.031
defense response to bacteriumGO:0042742860.031
developmental growth involved in morphogenesisGO:0060560370.031
myosin filament assemblyGO:00310341380.030
positive regulation of multicellular organism growthGO:00400183520.030
immune responseGO:00069551920.030
mitotic cell cycle processGO:19030471940.030
positive regulation of cellular metabolic processGO:00313251780.030
response to abiotic stimulusGO:00096281520.030
cellular component movementGO:00069283880.030
Mouse Fly
positive regulation of nitrogen compound metabolic processGO:00511731340.030
positive regulation of growthGO:00459273690.030
single organism behaviorGO:0044708830.030
establishment of organelle localizationGO:00516561230.029
Worm Fly
positive regulation of macromolecule metabolic processGO:00106041490.029
protein complex assemblyGO:00064611860.028
Human Fly
regulation of protein metabolic processGO:0051246810.028
regulation of growthGO:00400084090.028
protein complex subunit organizationGO:00718222800.027
multi multicellular organism processGO:00447063900.027
digestive tract morphogenesisGO:0048546760.027
signalingGO:00230524010.027
Fly
negative regulation of developmental processGO:00510932270.027
Fly
nervous system developmentGO:00073992530.027
Fly
cellular process involved in reproduction in multicellular organismGO:00224123510.026
Fly
macromolecular complex subunit organizationGO:00439333200.026
synaptic transmissionGO:00072681060.026
positive regulation of rna biosynthetic processGO:19026801020.026
transmembrane transportGO:00550851100.026
germ cell developmentGO:00072813510.026
Fly
cell recognitionGO:0008037850.026
small molecule metabolic processGO:00442811860.026
microtubule based processGO:00070171820.025
striated muscle myosin thick filament assemblyGO:00716881380.025
cell part morphogenesisGO:00329901520.025
Fly
multicellular organism growthGO:00352643850.025
regulation of extent of cell growthGO:0061387200.025
male mating behaviorGO:0060179260.024
sensory organ morphogenesisGO:009059620.024
female gamete generationGO:00072922540.024
Fly
nucleotide metabolic processGO:00091171080.024
regulation of multicellular organism growthGO:00400143730.024
positive regulation of response to stimulusGO:0048584550.024
neurological system processGO:0050877530.024
regulation of organelle organizationGO:00330431640.023
Human Mouse Fly
regulation of cellular protein metabolic processGO:0032268750.023
positive regulation of macromolecule biosynthetic processGO:00105571090.023
response to external biotic stimulusGO:00432071010.023
digestive tract developmentGO:00485651220.023
regulation of cell proliferationGO:00421271050.022
myosin filament organizationGO:00310331380.022
regulation of apoptotic signaling pathwayGO:200123310.022
negative regulation of neuron differentiationGO:004566540.022
muscle cell developmentGO:00550011580.022
regulation of cellular ketone metabolic processGO:001056530.022
muscle contractionGO:0006936430.022
nucleobase containing compound biosynthetic processGO:00346541840.022
organophosphate metabolic processGO:00196371250.022
nitrogen compound transportGO:0071705490.021
cell projection assemblyGO:0030031350.021
vulval developmentGO:00400253330.021
regulation of molecular functionGO:0065009890.021
regulation of ras protein signal transductionGO:0046578410.021
Fly
collagen and cuticulin based cuticle developmentGO:0040002990.021
synaptic target recognitionGO:000803930.021
adult locomotory behaviorGO:000834410.021
cell maturationGO:0048469260.021
Fly
protein localizationGO:00081042050.021
Human Worm Fly
tube developmentGO:00352951260.021
positive regulation of molecular functionGO:0044093610.020
protein phosphorylationGO:0006468850.020
ion transmembrane transportGO:0034220910.020
phosphate containing compound metabolic processGO:00067962320.020
cell cell signalingGO:00072671180.020
negative regulation of transcription from rna polymerase ii promoterGO:0000122450.020
response to other organismGO:00517071010.019
regulation of transportGO:0051049910.019
long term memoryGO:000761620.019
ion transportGO:00068111130.019
sensory perception of tasteGO:005090940.019
striated muscle contractionGO:0006941170.018
muscle system processGO:0003012430.018
calcium ion transportGO:0006816160.018
regulation of signalingGO:00230511720.018
Fly
regulation of reproductive processGO:2000241660.018
heterocycle catabolic processGO:00467001190.017
aromatic compound catabolic processGO:00194391160.017
cell divisionGO:00513012620.017
Worm Fly
copulationGO:000762020.017
developmental cell growthGO:0048588390.017
organic cyclic compound catabolic processGO:19013611190.017
negative regulation of cellular metabolic processGO:0031324950.017
meiotic cell cycleGO:00513213350.017
macromolecular complex assemblyGO:00650031930.017
Human Fly
cilium organizationGO:0044782320.017
negative regulation of locomotionGO:0040013210.017
positive regulation of transferase activityGO:0051347210.016
regulation of developmental growthGO:00486383890.016
intracellular signal transductionGO:0035556960.016
Fly
positive regulation of gene expressionGO:00106281120.016
neuron projection developmentGO:00311751870.016
Fly
cell morphogenesisGO:00009021630.016
Fly
regulation of rna metabolic processGO:00512521730.016
positive regulation of cellular biosynthetic processGO:00313281090.016
regulation of hydrolase activityGO:0051336450.016
regulation of cell developmentGO:0060284490.016
nucleoside phosphate metabolic processGO:00067531080.016
rho protein signal transductionGO:000726620.016
positive regulation of locomotionGO:0040017420.016
detection of external stimulusGO:000958140.016
regulation of catalytic activityGO:0050790780.015
fertilizationGO:0009566630.015
positive regulation of neuron differentiationGO:004566640.015
nuclear migrationGO:0007097540.015
tube morphogenesisGO:0035239790.015
regulation of signal transductionGO:00099661350.015
Fly
oogenesisGO:00484772290.015
Fly
organonitrogen compound catabolic processGO:1901565900.015
positive regulation of catalytic activityGO:0043085590.015
modification dependent macromolecule catabolic processGO:0043632320.014
nucleobase containing compound catabolic processGO:00346551140.014
positive regulation of transcription dna templatedGO:00458931020.014
regulation of cell sizeGO:0008361300.014
cell surface receptor signaling pathwayGO:00071661490.014
proteolysisGO:0006508610.014
metal ion transportGO:0030001490.014
hermaphrodite germ line sex determinationGO:0040021480.014
regulation of cell morphogenesisGO:0022604400.014
regulation of cellular amine metabolic processGO:003323800.014
neuron projection extensionGO:1990138370.014
purine containing compound catabolic processGO:0072523750.014
regulation of nuclear divisionGO:00517831150.013
Fly
regulation of localizationGO:00328791940.013
ectoderm developmentGO:000739830.013
apoptotic mitochondrial changesGO:000863720.013
negative regulation of cellular macromolecule biosynthetic processGO:2000113650.013
regulation of cell cycleGO:00517261940.013
Fly
peptidyl tyrosine modificationGO:001821230.013
regulation of neurotransmitter secretionGO:0046928160.013
calcium mediated signalingGO:001972230.013
negative regulation of nitrogen compound metabolic processGO:0051172630.013
positive regulation of striated muscle contractionGO:004598920.013
single organism cellular localizationGO:1902580720.013
Fly
neuromuscular junction developmentGO:000752820.013
purine ribonucleoside catabolic processGO:0046130750.012
negative regulation of macromolecule biosynthetic processGO:0010558650.012
positive regulation of neurotransmitter transportGO:0051590110.012
positive regulation of hydrolase activityGO:0051345380.012
positive regulation of phosphorus metabolic processGO:0010562560.012
regulation of cellular component sizeGO:0032535400.012
negative regulation of programmed cell deathGO:0043069190.012
negative regulation of response to stimulusGO:0048585730.012
Fly
microtubule based movementGO:0007018330.012
negative regulation of rna biosynthetic processGO:1902679530.012
turning behavior involved in matingGO:0034607120.012
cilium morphogenesisGO:0060271330.012
positive regulation of intracellular transportGO:003238820.012
defecationGO:0030421470.012
positive regulation of ion transportGO:0043270100.012
rna localizationGO:000640330.012
organic substance transportGO:00717021130.012
positive regulation of neurogenesisGO:005076940.012
regulation of vulval developmentGO:00400282480.012
single organism membrane organizationGO:0044802350.012
regulation of phosphate metabolic processGO:0019220810.011
epithelial tube morphogenesisGO:006056210.011
regulation of intracellular signal transductionGO:1902531770.011
Fly
response to bacteriumGO:0009617860.011
purine nucleotide metabolic processGO:0006163950.011
regulation of organ morphogenesisGO:200002740.011
gene silencingGO:00164581430.011
regulation of nematode larval developmentGO:00610622600.011
regulation of multi organism processGO:0043900690.011
embryonic body morphogenesisGO:0010172490.011
cilium assemblyGO:0042384280.011
regulation of programmed cell deathGO:0043067500.011
response to biotic stimulusGO:00096071010.011
nucleoside metabolic processGO:0009116990.011
regenerationGO:003109940.011
protein modification by small protein conjugation or removalGO:0070647400.011
neurogenesisGO:00220082360.011
Fly
turning behaviorGO:0035178120.011
ribonucleoside triphosphate catabolic processGO:0009203720.011
muscle fiber developmentGO:004874720.011
cation transmembrane transportGO:0098655590.011
positive regulation of synaptic transmissionGO:0050806240.010
regulation of protein localizationGO:0032880500.010
regulation of cytoplasmic transportGO:190364930.010
cellular amine metabolic processGO:0044106150.010
positive regulation of rna metabolic processGO:00512541030.010
regulation of neuron differentiationGO:0045664400.010
amine metabolic processGO:0009308150.010
positive regulation of neuron projection developmentGO:001097640.010
regulation of anatomical structure morphogenesisGO:0022603510.010
nucleoside triphosphate metabolic processGO:0009141870.010
chromosome organizationGO:00512761040.010
Worm Fly
response to growth factorGO:0070848180.010
nucleobase containing small molecule metabolic processGO:00550861150.010

cls-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.169
musculoskeletal system diseaseDOID:1700.169
myopathyDOID:42300.169
muscle tissue diseaseDOID:6600.169
muscular diseaseDOID:008000000.169
cardiomyopathyDOID:005070000.169
cardiovascular system diseaseDOID:128700.169
heart diseaseDOID:11400.169
nervous system diseaseDOID:86300.029
disease of cellular proliferationDOID:1456600.016
cancerDOID:16200.016
charcot marie tooth diseaseDOID:1059500.016
neuropathyDOID:87000.016
neuromuscular diseaseDOID:44000.016
charcot marie tooth disease type 2DOID:005053900.016
integumentary system diseaseDOID:1600.014
skin diseaseDOID:3700.014
lipodystrophyDOID:81100.014
organ system cancerDOID:005068600.012