IMP: Integrative Multi-species Prediction

Caenorhabditis elegans

140 known processes

egl-15 (CELE_F58A3.2)

Protein EGL-15

Entrez: 181291
UniProtKB: Q10656

Process Predictions
Disease Predictions

egl-15 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organ development	GO:0048513	1102	0.975
locomotion	GO:0040011	1634	0.941
cell morphogenesis	GO:0000902	163	0.914
enzyme linked receptor protein signaling pathway	GO:0007167	50	0.913
regulation of cell fate commitment	GO:0010453	22	0.910	Zebrafish Mouse
axonogenesis	GO:0007409	102	0.851
multicellular organism reproduction	GO:0032504	819	0.850
cell development	GO:0048468	696	0.849
multicellular organismal reproductive process	GO:0048609	815	0.847
regulation of macromolecule metabolic process	GO:0060255	421	0.839	Human Mouse Rat Fly
neurogenesis	GO:0022008	236	0.818
cell projection morphogenesis	GO:0048858	148	0.803
digestive tract development	GO:0048565	122	0.791
chemotaxis	GO:0006935	120	0.788
multi organism reproductive process	GO:0044703	867	0.769
tube morphogenesis	GO:0035239	79	0.762
reproductive structure development	GO:0048608	850	0.742
cell morphogenesis involved in neuron differentiation	GO:0048667	111	0.734
positive regulation of nematode larval development	GO:0061063	54	0.723
head development	GO:0060322	1	0.720	Zebrafish Mouse Rat
cell migration	GO:0016477	306	0.703
single organism signaling	GO:0044700	401	0.691
cellular component morphogenesis	GO:0032989	318	0.670
neuron development	GO:0048666	199	0.636
sexual reproduction	GO:0019953	546	0.622	Fly
taxis	GO:0042330	128	0.598
regulation of organ morphogenesis	GO:2000027	4	0.597	Mouse
sex differentiation	GO:0007548	909	0.593
transport	GO:0006810	1093	0.591
digestive tract morphogenesis	GO:0048546	76	0.582
cell part morphogenesis	GO:0032990	152	0.581
organ morphogenesis	GO:0009887	67	0.564	Human Zebrafish Mouse Fly
axon development	GO:0061564	163	0.563
behavior	GO:0007610	527	0.561
positive regulation of vulval development	GO:0040026	52	0.560
neuron projection morphogenesis	GO:0048812	114	0.559
gamete generation	GO:0007276	461	0.556	Fly
embryo development	GO:0009790	3052	0.551
regulation of transcription from rna polymerase ii promoter	GO:0006357	145	0.531	Mouse Rat
genitalia development	GO:0048806	741	0.524
muscle organ development	GO:0007517	26	0.516
regulation of signaling	GO:0023051	172	0.506	Human Mouse Fly
generation of neurons	GO:0048699	235	0.501
cell projection organization	GO:0030030	231	0.501
establishment of localization	GO:0051234	1171	0.498
embryonic morphogenesis	GO:0048598	152	0.496	Human Zebrafish Mouse Fly
positive regulation of locomotion	GO:0040017	42	0.493
embryo development ending in birth or egg hatching	GO:0009792	2992	0.484
gonad development	GO:0008406	840	0.477
ion transport	GO:0006811	113	0.477
apoptotic process	GO:0006915	478	0.474	Human Mouse
oviposition	GO:0018991	364	0.470
axon guidance	GO:0007411	82	0.465
neuron projection guidance	GO:0097485	82	0.456
hermaphrodite genitalia development	GO:0040035	734	0.452
vulval development	GO:0040025	333	0.448
directional locomotion	GO:0033058	14	0.445
cell surface receptor signaling pathway	GO:0007166	149	0.430
positive regulation of cell communication	GO:0010647	69	0.418	Human Mouse Fly
multi organism reproductive behavior	GO:0044705	387	0.413
embryonic pattern specification	GO:0009880	21	0.410	Mouse
endocytosis	GO:0006897	819	0.405
death	GO:0016265	547	0.399	Human Mouse
small molecule metabolic process	GO:0044281	186	0.398	Human Mouse
transcription from rna polymerase ii promoter	GO:0006366	149	0.398	Mouse Rat
positive regulation of cellular process	GO:0048522	332	0.390	Human Mouse Rat Fly
vesicle mediated transport	GO:0016192	852	0.384
tissue morphogenesis	GO:0048729	65	0.376	Zebrafish Mouse Fly
nucleic acid metabolic process	GO:0090304	299	0.376	Human Mouse Rat
multicellular organismal reproductive behavior	GO:0033057	384	0.366
male sex differentiation	GO:0046661	86	0.359
single organism reproductive process	GO:0044702	1196	0.353
response to chemical	GO:0042221	356	0.347
developmental process involved in reproduction	GO:0003006	1165	0.338
neuron differentiation	GO:0030182	217	0.337
multi organism behavior	GO:0051705	389	0.329
regulation of vulval development	GO:0040028	248	0.328
nucleobase containing compound metabolic process	GO:0006139	406	0.322	Human Mouse Rat
regulation of developmental growth	GO:0048638	389	0.316	Mouse Fly
single organism localization	GO:1902578	518	0.315
post embryonic development	GO:0009791	2152	0.313
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	34	0.311
single organism transport	GO:0044765	447	0.309
regulation of developmental process	GO:0050793	684	0.308	Human Zebrafish Mouse Rat Fly
signaling	GO:0023052	401	0.304
system process	GO:0003008	136	0.301	Mouse Rat
macromolecule catabolic process	GO:0009057	202	0.300
reproductive system development	GO:0061458	850	0.300
cell motility	GO:0048870	313	0.297
programmed cell death	GO:0012501	500	0.295	Human Mouse
cellular localization	GO:0051641	360	0.294
neuron projection development	GO:0031175	187	0.289
biosynthetic process	GO:0009058	323	0.287	Human Mouse Rat
regulation of organ growth	GO:0046620	5	0.280	Mouse
mesodermal cell differentiation	GO:0048333	15	0.278	Mouse Fly
cell death	GO:0008219	547	0.275	Human Mouse
establishment of localization in cell	GO:0051649	318	0.271
positive regulation of signaling	GO:0023056	66	0.271	Human Mouse Fly
negative regulation of biological process	GO:0048519	567	0.270	Zebrafish Mouse Rat Fly
regulation of cell communication	GO:0010646	176	0.268	Human Mouse Fly
muscle tissue development	GO:0060537	1	0.267	Zebrafish Mouse
rna biosynthetic process	GO:0032774	169	0.257	Mouse Rat
regulation of gene expression	GO:0010468	366	0.257	Mouse Rat
cell cell signaling	GO:0007267	118	0.256	Mouse
mesoderm development	GO:0007498	27	0.254	Zebrafish Mouse Fly
negative regulation of metabolic process	GO:0009892	240	0.250	Mouse
skeletal muscle organ development	GO:0060538	3	0.247
regulation of cellular metabolic process	GO:0031323	305	0.245	Human Mouse Rat Fly
nervous system development	GO:0007399	253	0.240
phosphate containing compound metabolic process	GO:0006796	232	0.239
regulation of cell differentiation	GO:0045595	81	0.236	Human Zebrafish Mouse Rat Fly
protein complex subunit organization	GO:0071822	280	0.234
bmp signaling pathway	GO:0030509	3	0.230
regulation of multicellular organismal process	GO:0051239	726	0.229	Human Zebrafish Mouse Rat Fly
multi multicellular organism process	GO:0044706	390	0.226
receptor mediated endocytosis	GO:0006898	715	0.225
cellular biosynthetic process	GO:0044249	315	0.224	Human Mouse Rat
reproductive behavior	GO:0019098	387	0.223
epithelium development	GO:0060429	68	0.220	Zebrafish Mouse Fly
development of primary sexual characteristics	GO:0045137	840	0.220
regulation of nematode larval development	GO:0061062	260	0.219
anatomical structure formation involved in morphogenesis	GO:0048646	250	0.218	Zebrafish Mouse Fly
organic substance biosynthetic process	GO:1901576	323	0.214	Human Mouse Rat
digestive system development	GO:0055123	122	0.213
cell fate commitment	GO:0045165	139	0.211	Zebrafish Mouse Fly
secretion by cell	GO:0032940	138	0.211
cellular component movement	GO:0006928	388	0.205
negative regulation of macromolecule metabolic process	GO:0010605	229	0.204	Mouse
response to organic substance	GO:0010033	131	0.204
epithelial tube morphogenesis	GO:0060562	1	0.203	Mouse Fly
acetylcholine transport	GO:0015870	16	0.201
response to endogenous stimulus	GO:0009719	33	0.201
regulation of cellular localization	GO:0060341	42	0.197
germ cell development	GO:0007281	351	0.196	Fly
response to fibroblast growth factor	GO:0071774	5	0.196
regulation of cell division	GO:0051302	142	0.189	Mouse
localization of cell	GO:0051674	313	0.187
mating behavior	GO:0007617	32	0.187
regulation of transcription dna templated	GO:0006355	164	0.185	Mouse Rat
regulation of synapse assembly	GO:0051963	2	0.183
regulation of locomotion	GO:0040012	161	0.178
regulation of localization	GO:0032879	194	0.176
regulation of multicellular organismal development	GO:2000026	317	0.175	Human Zebrafish Mouse Rat Fly
aromatic compound biosynthetic process	GO:0019438	192	0.172	Human Mouse Rat
regulation of behavior	GO:0050795	97	0.171
cell fate commitment involved in formation of primary germ layer	GO:0060795	33	0.168	Zebrafish Mouse Fly
cell morphogenesis involved in differentiation	GO:0000904	112	0.161
fibroblast growth factor receptor signaling pathway	GO:0008543	5	0.158
regulation of anatomical structure size	GO:0090066	46	0.157	Fly
regulation of macromolecule biosynthetic process	GO:0010556	189	0.156	Human Mouse Rat
cellular component biogenesis	GO:0044085	297	0.154	Zebrafish Fly
positive regulation of metabolic process	GO:0009893	187	0.153	Human Mouse Rat Fly
positive regulation of multicellular organismal process	GO:0051240	417	0.152	Human Mouse Rat
negative regulation of cellular metabolic process	GO:0031324	95	0.148	Mouse
cellular macromolecule biosynthetic process	GO:0034645	247	0.147	Human Mouse Rat
organelle organization	GO:0006996	783	0.144	Zebrafish Mouse
muscle structure development	GO:0061061	191	0.140
cell cycle process	GO:0022402	482	0.140	Mouse
macromolecular complex subunit organization	GO:0043933	320	0.136
heterocycle biosynthetic process	GO:0018130	187	0.136	Human Mouse Rat
regulation of development heterochronic	GO:0040034	18	0.136
secretion	GO:0046903	147	0.135
regulation of transport	GO:0051049	91	0.132
oogenesis	GO:0048477	229	0.131	Fly
metal ion transport	GO:0030001	49	0.130
multicellular organismal aging	GO:0010259	812	0.130
organic cyclic compound biosynthetic process	GO:1901362	195	0.128	Human Mouse Rat
positive regulation of cell differentiation	GO:0045597	8	0.122	Human Mouse Rat
positive regulation of nitrogen compound metabolic process	GO:0051173	134	0.122	Human Mouse Rat
positive regulation of macromolecule metabolic process	GO:0010604	149	0.121	Human Mouse Rat Fly
regulation of neurotransmitter secretion	GO:0046928	16	0.120
body morphogenesis	GO:0010171	620	0.119
cellular process involved in reproduction in multicellular organism	GO:0022412	351	0.119	Fly
regulation of phosphate metabolic process	GO:0019220	81	0.116	Human Mouse Fly
organonitrogen compound metabolic process	GO:1901564	151	0.114
regulation of biological quality	GO:0065008	741	0.113	Zebrafish Mouse Fly
determination of adult lifespan	GO:0008340	812	0.113
neuron recognition	GO:0008038	83	0.113
signal transduction	GO:0007165	317	0.112
organophosphate metabolic process	GO:0019637	125	0.112	Human
regulation of neurotransmitter levels	GO:0001505	36	0.112
cellular response to growth factor stimulus	GO:0071363	18	0.111
regulation of metabolic process	GO:0019222	478	0.110	Human Mouse Rat Fly
muscle cell differentiation	GO:0042692	171	0.108	Mouse Fly
positive regulation of catalytic activity	GO:0043085	59	0.107	Human Fly
organic substance catabolic process	GO:1901575	294	0.107
mitotic cell cycle process	GO:1903047	194	0.105	Mouse
regulation of primary metabolic process	GO:0080090	292	0.104	Human Mouse Rat Fly
purine nucleotide catabolic process	GO:0006195	75	0.104
regeneration	GO:0031099	4	0.103	Zebrafish
negative regulation of cellular component organization	GO:0051129	33	0.102	Mouse Fly
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	16	0.102
tube development	GO:0035295	126	0.100
gene expression	GO:0010467	412	0.099	Mouse Rat
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	45	0.098	Mouse
response to wounding	GO:0009611	4	0.098	Zebrafish Mouse
positive regulation of neuron differentiation	GO:0045666	4	0.095	Human Mouse Rat
regulation of cell migration	GO:0030334	55	0.094
developmental growth	GO:0048589	412	0.094	Zebrafish Mouse Fly
cation transport	GO:0006812	78	0.093
establishment of protein localization to membrane	GO:0090150	3	0.093
macromolecular complex assembly	GO:0065003	193	0.093
protein phosphorylation	GO:0006468	85	0.092
growth	GO:0040007	562	0.091	Zebrafish Mouse Fly
single organism catabolic process	GO:0044712	129	0.091
defense response	GO:0006952	296	0.090	Fly
cell growth	GO:0016049	44	0.090	Fly
post embryonic organ development	GO:0048569	336	0.090	Fly
cell recognition	GO:0008037	85	0.089
cell proliferation	GO:0008283	116	0.084	Human Zebrafish Mouse Rat
regulation of anatomical structure morphogenesis	GO:0022603	51	0.084	Zebrafish Mouse Fly
posttranscriptional regulation of gene expression	GO:0010608	166	0.079
regulation of cellular macromolecule biosynthetic process	GO:2000112	188	0.078	Human Mouse Rat
regulation of nucleic acid templated transcription	GO:1903506	165	0.077	Mouse Rat
neurotransmitter secretion	GO:0007269	26	0.077
catabolic process	GO:0009056	318	0.076
backward locomotion	GO:0043057	11	0.076
aging	GO:0007568	812	0.076
single organism organelle organization	GO:1902589	501	0.075	Zebrafish Mouse
cognition	GO:0050890	27	0.075
positive regulation of developmental process	GO:0051094	408	0.075	Human Mouse Rat
regulation of response to stimulus	GO:0048583	243	0.074	Human Mouse Fly
negative regulation of developmental process	GO:0051093	227	0.074	Zebrafish Mouse Rat Fly
molting cycle collagen and cuticulin based cuticle	GO:0018996	281	0.074
positive regulation of nervous system development	GO:0051962	5	0.073	Human Mouse Rat
protein catabolic process	GO:0030163	162	0.073
neuromuscular junction development	GO:0007528	2	0.073	Mouse
regulation of bmp signaling pathway	GO:0030510	3	0.072
gastrulation	GO:0007369	58	0.072	Zebrafish Mouse Fly
regulation of cell cycle process	GO:0010564	145	0.072	Mouse
phosphorylation	GO:0016310	116	0.072
regulation of mapk cascade	GO:0043408	23	0.071	Human Mouse Fly
negative regulation of gene expression	GO:0010629	217	0.070	Mouse
erbb signaling pathway	GO:0038127	9	0.069
anterior posterior pattern specification	GO:0009952	27	0.069
protein localization	GO:0008104	205	0.068
positive regulation of epithelial cell proliferation	GO:0050679	1	0.067	Mouse
acetate ester transport	GO:1901374	16	0.067
nucleic acid templated transcription	GO:0097659	169	0.067	Mouse Rat
regulation of cellular component organization	GO:0051128	248	0.066
sensory organ morphogenesis	GO:0090596	2	0.066	Mouse
regulation of growth	GO:0040008	409	0.066	Mouse Fly
ion transmembrane transport	GO:0034220	91	0.065
regulation of phosphorus metabolic process	GO:0051174	81	0.062	Human Mouse Fly
macromolecule localization	GO:0033036	771	0.062
mesodermal cell fate specification	GO:0007501	13	0.061	Mouse
regulation of cell proliferation	GO:0042127	105	0.060	Human Mouse Rat
tissue development	GO:0009888	112	0.060	Zebrafish Mouse Fly
protein modification process	GO:0036211	207	0.060
carbohydrate derivative metabolic process	GO:1901135	141	0.058
cell division	GO:0051301	262	0.058	Mouse
purine ribonucleotide catabolic process	GO:0009154	75	0.058
cytoskeleton organization	GO:0007010	339	0.058
regulation of synaptic transmission	GO:0050804	34	0.058
purine ribonucleoside triphosphate metabolic process	GO:0009205	87	0.057
lipid storage	GO:0019915	565	0.057
female gamete generation	GO:0007292	254	0.057	Fly
cellular component assembly	GO:0022607	293	0.057	Zebrafish Fly
positive regulation of cellular metabolic process	GO:0031325	178	0.057	Human Mouse Rat Fly
positive regulation of post embryonic development	GO:0048582	54	0.057
regulation of secretion	GO:0051046	29	0.057
signal transduction by phosphorylation	GO:0023014	31	0.056	Human Mouse Fly
pattern specification process	GO:0007389	59	0.056	Zebrafish Mouse
feeding behavior	GO:0007631	70	0.056
macromolecule biosynthetic process	GO:0009059	250	0.055	Human Mouse Rat
cellular protein modification process	GO:0006464	207	0.055
regulation of biosynthetic process	GO:0009889	189	0.055	Human Mouse Rat
single organism cellular localization	GO:1902580	72	0.055
protein metabolic process	GO:0019538	422	0.054
regulation of multicellular organism growth	GO:0040014	373	0.054	Mouse
positive regulation of developmental growth	GO:0048639	354	0.053	Mouse
rna metabolic process	GO:0016070	228	0.052	Mouse Rat
oxidation reduction process	GO:0055114	59	0.051
positive regulation of nucleic acid templated transcription	GO:1903508	102	0.051	Mouse Rat
organic substance transport	GO:0071702	113	0.051
positive regulation of purine nucleotide metabolic process	GO:1900544	28	0.050
regulation of post embryonic development	GO:0048580	260	0.050
positive regulation of phosphorus metabolic process	GO:0010562	56	0.049	Human Mouse Fly
mesoderm morphogenesis	GO:0048332	24	0.049	Mouse Fly
maintenance of location	GO:0051235	580	0.049
regulation of nucleobase containing compound metabolic process	GO:0019219	222	0.048	Human Mouse Rat
synaptic growth at neuromuscular junction	GO:0051124	1	0.048
cellular catabolic process	GO:0044248	199	0.048
regulation of secretion by cell	GO:1903530	21	0.047
cell cycle	GO:0007049	526	0.046	Mouse
purine ribonucleotide metabolic process	GO:0009150	95	0.046
regionalization	GO:0003002	31	0.045	Zebrafish Mouse
purine containing compound metabolic process	GO:0072521	95	0.045
nucleobase containing compound biosynthetic process	GO:0034654	184	0.045	Human Mouse Rat
negative regulation of vulval development	GO:0040027	206	0.044
epithelial cell proliferation	GO:0050673	1	0.044	Mouse
regulation of nervous system development	GO:0051960	41	0.044	Human Mouse Rat Fly
positive regulation of gene expression	GO:0010628	112	0.043	Mouse Rat
regulation of cellular biosynthetic process	GO:0031326	189	0.043	Human Mouse Rat
phosphorus metabolic process	GO:0006793	232	0.043
molting cycle	GO:0042303	281	0.042	Mouse
glycosyl compound catabolic process	GO:1901658	79	0.042
detection of external stimulus	GO:0009581	4	0.042
ribonucleotide metabolic process	GO:0009259	99	0.041
regulation of cell cycle	GO:0051726	194	0.041	Mouse
organonitrogen compound catabolic process	GO:1901565	90	0.040
autophagy	GO:0006914	29	0.039
macromolecule modification	GO:0043412	218	0.039
lipid localization	GO:0010876	573	0.039
neurotransmitter transport	GO:0006836	32	0.039
negative regulation of cellular process	GO:0048523	239	0.039	Zebrafish Mouse Rat Fly
transcription dna templated	GO:0006351	168	0.038	Mouse Rat
nucleoside triphosphate metabolic process	GO:0009141	87	0.038
organic cyclic compound catabolic process	GO:1901361	119	0.038
regulation of phosphorylation	GO:0042325	45	0.038	Human Mouse Fly
axis specification	GO:0009798	23	0.037
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	4	0.037
regulation of hydrolase activity	GO:0051336	45	0.037	Human
cellular nitrogen compound biosynthetic process	GO:0044271	192	0.037	Human Mouse Rat
ribonucleoside metabolic process	GO:0009119	98	0.037
cellular macromolecule localization	GO:0070727	75	0.036
pharyngeal pumping	GO:0043050	58	0.035
glycosyl compound metabolic process	GO:1901657	100	0.035
organelle fission	GO:0048285	363	0.033	Mouse
regulation of programmed cell death	GO:0043067	50	0.033	Mouse
male anatomical structure morphogenesis	GO:0090598	78	0.033
regulation of meiotic cell cycle	GO:0051445	136	0.033
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090100	5	0.032
signal release	GO:0023061	28	0.032
regulation of mitotic cell cycle	GO:0007346	76	0.032	Mouse
dna metabolic process	GO:0006259	74	0.032	Human
positive regulation of synapse assembly	GO:0051965	1	0.032
regulation of cellular component size	GO:0032535	40	0.032	Fly
regulation of nitrogen compound metabolic process	GO:0051171	222	0.032	Human Mouse Rat
learning	GO:0007612	21	0.032
positive regulation of cell migration	GO:0030335	3	0.032
monovalent inorganic cation transport	GO:0015672	33	0.031
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	65	0.031	Mouse
regulation of cell fate specification	GO:0042659	22	0.031	Zebrafish Mouse
negative regulation of multicellular organismal process	GO:0051241	236	0.030	Zebrafish Mouse Rat Fly
regulation of apoptotic process	GO:0042981	36	0.030	Mouse
regulation of rna biosynthetic process	GO:2001141	165	0.030	Mouse Rat
organelle assembly	GO:0070925	214	0.030	Zebrafish
nucleoside metabolic process	GO:0009116	99	0.030
regulation of organelle organization	GO:0033043	164	0.029	Mouse
regulation of neurotransmitter transport	GO:0051588	16	0.029
negative regulation of apoptotic process	GO:0043066	17	0.029	Mouse
positive regulation of growth	GO:0045927	369	0.029	Mouse
regulation of stem cell differentiation	GO:2000736	1	0.029
inductive cell migration	GO:0040039	145	0.029
response to abiotic stimulus	GO:0009628	152	0.029
regulation of neuron differentiation	GO:0045664	40	0.028	Human Mouse Rat Fly
cellular response to organic substance	GO:0071310	119	0.028
regulation of nuclear division	GO:0051783	115	0.028	Mouse
synapse organization	GO:0050808	24	0.028	Mouse
regulation of cytoplasmic transport	GO:1903649	3	0.028
cellular amine metabolic process	GO:0044106	15	0.028
purine ribonucleoside catabolic process	GO:0046130	75	0.028
muscle contraction	GO:0006936	43	0.028
purine containing compound catabolic process	GO:0072523	75	0.028
positive regulation of molecular function	GO:0044093	61	0.028	Human Fly
regulation of ion transport	GO:0043269	39	0.027
single organism behavior	GO:0044708	83	0.027
cellular protein metabolic process	GO:0044267	279	0.027
response to external stimulus	GO:0009605	289	0.027
positive regulation of amine transport	GO:0051954	8	0.027
negative regulation of response to stimulus	GO:0048585	73	0.027	Mouse
negative regulation of neurogenesis	GO:0050768	4	0.027	Mouse Fly
regulation of cellular response to growth factor stimulus	GO:0090287	11	0.026	Mouse
positive regulation of catabolic process	GO:0009896	38	0.026
cellular component assembly involved in morphogenesis	GO:0010927	183	0.026	Zebrafish
positive regulation of mapk cascade	GO:0043410	14	0.026	Human Mouse Fly
dauer larval development	GO:0040024	92	0.026
negative regulation of post embryonic development	GO:0048581	208	0.025
response to acid chemical	GO:0001101	4	0.025
organophosphate catabolic process	GO:0046434	81	0.025
regulation of signal transduction	GO:0009966	135	0.025	Human Mouse Fly
regulation of cell motility	GO:2000145	57	0.025
regulation of epithelial cell proliferation	GO:0050678	1	0.025	Mouse
positive regulation of cell cycle	GO:0045787	55	0.025	Mouse
negative regulation of cellular catabolic process	GO:0031330	9	0.025
cellular protein complex assembly	GO:0043623	178	0.025
regulation of hormone secretion	GO:0046883	2	0.025
protein complex assembly	GO:0006461	186	0.024
positive regulation of neurogenesis	GO:0050769	4	0.024	Human Mouse Rat
regulation of nucleoside metabolic process	GO:0009118	37	0.024
regulation of lipid metabolic process	GO:0019216	4	0.024	Human Mouse
regulation of cellular ketone metabolic process	GO:0010565	3	0.024	Human Mouse
oocyte construction	GO:0007308	2	0.024
positive regulation of protein kinase activity	GO:0045860	18	0.023	Human Fly
epithelial cell differentiation	GO:0030855	17	0.023	Mouse Fly
regulation of nucleotide catabolic process	GO:0030811	35	0.023
positive regulation of transport	GO:0051050	32	0.023
cuticle development	GO:0042335	100	0.023
negative regulation of bmp signaling pathway	GO:0030514	1	0.023
wnt signaling pathway	GO:0016055	27	0.023	Mouse
cellular macromolecular complex assembly	GO:0034622	184	0.023
g protein coupled receptor signaling pathway	GO:0007186	46	0.023
regulation of protein metabolic process	GO:0051246	81	0.023	Human Mouse Fly
adult behavior	GO:0030534	3	0.023
cellular protein localization	GO:0034613	75	0.022
regulation of protein localization	GO:0032880	50	0.022
positive regulation of biosynthetic process	GO:0009891	109	0.022	Human Mouse Rat
regulation of epithelial cell differentiation	GO:0030856	4	0.022
learning or memory	GO:0007611	27	0.022
regulation of cellular component biogenesis	GO:0044087	26	0.022
regulation of meiosis	GO:0040020	94	0.022
purine nucleoside catabolic process	GO:0006152	75	0.021
negative regulation of macromolecule biosynthetic process	GO:0010558	65	0.021	Mouse
regulation of protein import into nucleus	GO:0042306	3	0.021
nucleoside phosphate metabolic process	GO:0006753	108	0.021
negative regulation of catabolic process	GO:0009895	9	0.021
cellular ketone metabolic process	GO:0042180	14	0.021	Human Mouse
regulation of rna metabolic process	GO:0051252	173	0.021	Mouse Rat
negative regulation of cell death	GO:0060548	21	0.021	Mouse
nucleobase containing compound catabolic process	GO:0034655	114	0.021
ribonucleotide catabolic process	GO:0009261	75	0.021
negative regulation of cell communication	GO:0010648	61	0.021	Mouse
regulation of apoptotic signaling pathway	GO:2001233	1	0.021	Mouse
regulation of transferase activity	GO:0051338	31	0.020	Human Fly
protein complex biogenesis	GO:0070271	186	0.020
transmembrane transport	GO:0055085	110	0.020
regulation of cell projection organization	GO:0031344	38	0.020
establishment or maintenance of cell polarity	GO:0007163	63	0.020
muscle system process	GO:0003012	43	0.020
regulation of embryonic development	GO:0045995	16	0.020	Zebrafish Mouse
positive regulation of protein modification process	GO:0031401	29	0.020	Human Mouse Fly
positive regulation of bmp signaling pathway	GO:0030513	2	0.020
homeostatic process	GO:0042592	51	0.020	Zebrafish Mouse
nucleoside catabolic process	GO:0009164	78	0.019
positive regulation of cellular component organization	GO:0051130	34	0.019	Mouse Rat
single organism membrane organization	GO:0044802	35	0.019
organic hydroxy compound metabolic process	GO:1901615	25	0.019	Human Mouse
axonal fasciculation	GO:0007413	79	0.019
carbohydrate derivative catabolic process	GO:1901136	82	0.019
potassium ion transport	GO:0006813	21	0.019
epidermal growth factor receptor signaling pathway	GO:0007173	9	0.019
positive regulation of gtp catabolic process	GO:0033126	28	0.019
purine ribonucleoside metabolic process	GO:0046128	92	0.018
heterocycle catabolic process	GO:0046700	119	0.018
defense response to gram negative bacterium	GO:0050829	64	0.018	Fly
actin filament based process	GO:0030029	191	0.018
regulation of system process	GO:0044057	27	0.018	Rat
regulation of kinase activity	GO:0043549	29	0.018	Human Fly
negative regulation of protein metabolic process	GO:0051248	27	0.018
regulation of synaptic growth at neuromuscular junction	GO:0008582	1	0.018
endoderm development	GO:0007492	20	0.018	Zebrafish Fly
regulation of cellular catabolic process	GO:0031329	51	0.018
cellular response to abiotic stimulus	GO:0071214	4	0.018
muscle cell development	GO:0055001	158	0.018	Fly
nematode male tail tip morphogenesis	GO:0045138	77	0.018
regulation of muscle contraction	GO:0006937	20	0.018
regulation of protein targeting	GO:1903533	3	0.017
negative regulation of nematode larval development	GO:0061064	208	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	72	0.017
immune response	GO:0006955	192	0.017	Fly
positive regulation of phosphorylation	GO:0042327	27	0.017	Human Mouse Fly
positive regulation of synaptic transmission	GO:0050806	24	0.017
nucleotide catabolic process	GO:0009166	77	0.017
regulation of acetylcholine secretion neurotransmission	GO:0014056	9	0.017
regulation of synaptic plasticity	GO:0048167	1	0.017
stem cell proliferation	GO:0072089	9	0.017	Mouse Rat
regulation of backward locomotion	GO:0043058	8	0.017
ribonucleoside catabolic process	GO:0042454	77	0.017
regulation of cell size	GO:0008361	30	0.017	Fly
regulation of cellular component movement	GO:0051270	62	0.017
establishment of protein localization	GO:0045184	50	0.016
positive regulation of multicellular organism growth	GO:0040018	352	0.016
cellular response to chemical stimulus	GO:0070887	129	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	63	0.016	Mouse
protein modification by small protein conjugation or removal	GO:0070647	40	0.016	Mouse
striated muscle cell development	GO:0055002	157	0.016	Fly
purine ribonucleoside triphosphate catabolic process	GO:0009207	72	0.016
purine nucleotide metabolic process	GO:0006163	95	0.016
regulation of protein stability	GO:0031647	3	0.016
intracellular signal transduction	GO:0035556	96	0.016	Human Mouse Fly
acetylcholine secretion	GO:0061526	11	0.016
cellular response to endogenous stimulus	GO:0071495	32	0.016
detection of abiotic stimulus	GO:0009582	4	0.016
regulation of purine nucleotide metabolic process	GO:1900542	37	0.016
actin cytoskeleton organization	GO:0030036	184	0.016
oocyte axis specification	GO:0007309	2	0.016
synaptic transmission	GO:0007268	106	0.016	Mouse
cell type specific apoptotic process	GO:0097285	4	0.015	Mouse
positive regulation of nucleotide catabolic process	GO:0030813	28	0.015
multicellular organism growth	GO:0035264	385	0.015	Mouse
negative regulation of biosynthetic process	GO:0009890	65	0.015	Mouse
cell maturation	GO:0048469	26	0.015	Mouse
embryonic axis specification	GO:0000578	9	0.015
regulation of dna replication	GO:0006275	5	0.015
sex determination	GO:0007530	60	0.015
positive regulation of cellular catabolic process	GO:0031331	35	0.015
negative regulation of organelle organization	GO:0010639	20	0.015	Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	12	0.015
gtp metabolic process	GO:0046039	46	0.014

egl-15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease	DO term ID	Probability	Func Analog Org
disease of anatomical entity	DOID:7	0.159	Human
gastrointestinal system cancer	DOID:3119	0.041	Human
disease of cellular proliferation	DOID:14566	0.041	Human
organ system cancer	DOID:0050686	0.041	Human
cancer	DOID:162	0.041	Human
large intestine cancer	DOID:5672	0.041	Human
intestinal cancer	DOID:10155	0.041	Human
nervous system disease	DOID:863	0.015

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