IMP: Integrative Multi-species Prediction

Caenorhabditis elegans

114 known processes

fkh-2 (CELE_T14G12.4)

Protein FKH-2

Entrez: 180663
UniProtKB: Q95QA9
UniProtKB: Q22510

Process Predictions
Disease Predictions

fkh-2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
neuron projection guidance	GO:0097485	82	0.961	Worm
mesodermal cell fate specification	GO:0007501	13	0.948	Worm
cell fate commitment	GO:0045165	139	0.933
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	98	0.920
axonogenesis	GO:0007409	102	0.910	Worm
positive regulation of gene expression	GO:0010628	112	0.908
positive regulation of transcription dna templated	GO:0045893	102	0.905
positive regulation of rna biosynthetic process	GO:1902680	102	0.885
positive regulation of biosynthetic process	GO:0009891	109	0.864
heterocycle biosynthetic process	GO:0018130	187	0.840
neuron projection morphogenesis	GO:0048812	114	0.829	Worm
axon guidance	GO:0007411	82	0.817	Worm
transcription dna templated	GO:0006351	168	0.817
positive regulation of cellular process	GO:0048522	332	0.811
positive regulation of nucleic acid templated transcription	GO:1903508	102	0.804
regulation of transcription from rna polymerase ii promoter	GO:0006357	145	0.803
taxis	GO:0042330	128	0.794	Worm
locomotion	GO:0040011	1634	0.790	Worm
digestive tract development	GO:0048565	122	0.788	Worm
positive regulation of cellular biosynthetic process	GO:0031328	109	0.788
rna biosynthetic process	GO:0032774	169	0.784
positive regulation of macromolecule biosynthetic process	GO:0010557	109	0.782
regulation of rna biosynthetic process	GO:2001141	165	0.764
positive regulation of nucleobase containing compound metabolic process	GO:0045935	134	0.757
digestive system development	GO:0055123	122	0.754	Worm
cell projection organization	GO:0030030	231	0.754
embryo development	GO:0009790	3052	0.747
embryo development ending in birth or egg hatching	GO:0009792	2992	0.737
regulation of macromolecule biosynthetic process	GO:0010556	189	0.729
cellular component movement	GO:0006928	388	0.709	Worm
positive regulation of rna metabolic process	GO:0051254	103	0.701
cell fate commitment involved in formation of primary germ layer	GO:0060795	33	0.666	Worm
regulation of cellular biosynthetic process	GO:0031326	189	0.660
positive regulation of metabolic process	GO:0009893	187	0.655
neuron fate specification	GO:0048665	8	0.651
regulation of nitrogen compound metabolic process	GO:0051171	222	0.646
body morphogenesis	GO:0010171	620	0.645	Worm
transcription from rna polymerase ii promoter	GO:0006366	149	0.642
regulation of rna metabolic process	GO:0051252	173	0.639
positive regulation of macromolecule metabolic process	GO:0010604	149	0.630
response to chemical	GO:0042221	356	0.630	Worm
tissue morphogenesis	GO:0048729	65	0.628	Worm
mesodermal cell differentiation	GO:0048333	15	0.622	Worm
gonad development	GO:0008406	840	0.620	Worm
tube development	GO:0035295	126	0.613	Worm
regulation of nematode larval development	GO:0061062	260	0.609	Worm
rna metabolic process	GO:0016070	228	0.605
cellular nitrogen compound biosynthetic process	GO:0044271	192	0.601
mesoderm development	GO:0007498	27	0.597	Worm
regulation of cellular macromolecule biosynthetic process	GO:2000112	188	0.592
chemotaxis	GO:0006935	120	0.588	Worm
regulation of gene expression	GO:0010468	366	0.585
regulation of transcription dna templated	GO:0006355	164	0.582
cell morphogenesis involved in neuron differentiation	GO:0048667	111	0.579	Worm
gene expression	GO:0010467	412	0.578
negative regulation of vulval development	GO:0040027	206	0.574	Worm
negative regulation of biological process	GO:0048519	567	0.572	Worm Fly
positive regulation of cellular metabolic process	GO:0031325	178	0.553
nucleic acid metabolic process	GO:0090304	299	0.541
regulation of developmental process	GO:0050793	684	0.538	Worm
regulation of macromolecule metabolic process	GO:0060255	421	0.529
positive regulation of nitrogen compound metabolic process	GO:0051173	134	0.526
regulation of metabolic process	GO:0019222	478	0.525
cell fate specification involved in pattern specification	GO:0060573	4	0.518	Worm
cell migration	GO:0016477	306	0.515
reproductive structure development	GO:0048608	850	0.512	Worm
tube morphogenesis	GO:0035239	79	0.506	Worm
multicellular organism reproduction	GO:0032504	819	0.503	Worm
post embryonic development	GO:0009791	2152	0.499
regulation of multicellular organismal development	GO:2000026	317	0.498	Worm
cellular macromolecule biosynthetic process	GO:0034645	247	0.494
regulation of multicellular organismal process	GO:0051239	726	0.492	Worm
cell morphogenesis involved in differentiation	GO:0000904	112	0.475	Worm
developmental process involved in reproduction	GO:0003006	1165	0.466	Worm
organ morphogenesis	GO:0009887	67	0.460	Fly
axon development	GO:0061564	163	0.458	Worm
meiotic nuclear division	GO:0007126	300	0.447
organelle organization	GO:0006996	783	0.445
regulation of biosynthetic process	GO:0009889	189	0.445
regulation of vulval development	GO:0040028	248	0.440	Worm
oviposition	GO:0018991	364	0.434	Worm
cell motility	GO:0048870	313	0.431
aromatic compound biosynthetic process	GO:0019438	192	0.424
neuron projection development	GO:0031175	187	0.424
organ development	GO:0048513	1102	0.421	Worm Fly
tissue development	GO:0009888	112	0.417	Worm
regulation of primary metabolic process	GO:0080090	292	0.415
macromolecule biosynthetic process	GO:0009059	250	0.413
cell morphogenesis	GO:0000902	163	0.413
aging	GO:0007568	812	0.413	Worm
regulation of nucleobase containing compound metabolic process	GO:0019219	222	0.412
cell development	GO:0048468	696	0.412
biosynthetic process	GO:0009058	323	0.408
multicellular organismal reproductive process	GO:0048609	815	0.403	Worm
meiotic cell cycle	GO:0051321	335	0.400
reproductive system development	GO:0061458	850	0.400	Worm
apoptotic process	GO:0006915	478	0.399
programmed cell death	GO:0012501	500	0.392
organic substance biosynthetic process	GO:1901576	323	0.392
neuron differentiation	GO:0030182	217	0.391
cell part morphogenesis	GO:0032990	152	0.391
regulation of cell division	GO:0051302	142	0.385
vulval development	GO:0040025	333	0.384	Worm
cell projection morphogenesis	GO:0048858	148	0.378
negative regulation of cellular process	GO:0048523	239	0.378	Worm Fly
regulation of locomotion	GO:0040012	161	0.373
positive regulation of multicellular organismal process	GO:0051240	417	0.372	Worm
regulation of cell cycle process	GO:0010564	145	0.365
single organism reproductive process	GO:0044702	1196	0.353	Worm
transport	GO:0006810	1093	0.350	Worm
cell division	GO:0051301	262	0.345
multi organism reproductive process	GO:0044703	867	0.344	Worm
multi multicellular organism process	GO:0044706	390	0.336	Worm
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	45	0.332	Worm Fly
behavior	GO:0007610	527	0.330	Worm
development of primary sexual characteristics	GO:0045137	840	0.329	Worm
nervous system development	GO:0007399	253	0.328
multicellular organismal reproductive behavior	GO:0033057	384	0.321	Worm
determination of adult lifespan	GO:0008340	812	0.321	Worm
cell cycle	GO:0007049	526	0.321
response to external stimulus	GO:0009605	289	0.320	Worm
endocytosis	GO:0006897	819	0.319	Worm
multicellular organismal aging	GO:0010259	812	0.312	Worm
anatomical structure formation involved in morphogenesis	GO:0048646	250	0.310
regulation of cellular metabolic process	GO:0031323	305	0.304
digestive tract morphogenesis	GO:0048546	76	0.301	Worm
mesoderm morphogenesis	GO:0048332	24	0.301	Worm
growth	GO:0040007	562	0.296	Worm
post embryonic organ development	GO:0048569	336	0.294	Worm
nucleic acid templated transcription	GO:0097659	169	0.291
multi organism reproductive behavior	GO:0044705	387	0.290	Worm
organic cyclic compound biosynthetic process	GO:1901362	195	0.280
muscle tissue development	GO:0060537	1	0.278
generation of neurons	GO:0048699	235	0.277
regulation of response to stimulus	GO:0048583	243	0.271	Worm
multi organism behavior	GO:0051705	389	0.268	Worm
regulation of meiosis	GO:0040020	94	0.268
establishment of localization	GO:0051234	1171	0.261	Worm
nucleobase containing compound metabolic process	GO:0006139	406	0.258
localization of cell	GO:0051674	313	0.251
regulation of nucleic acid templated transcription	GO:1903506	165	0.235
negative regulation of gene expression	GO:0010629	217	0.232	Worm Fly
nucleobase containing compound biosynthetic process	GO:0034654	184	0.229
primary sex determination germ line	GO:0007542	3	0.229	Worm
regulation of post embryonic development	GO:0048580	260	0.226	Worm
vesicle mediated transport	GO:0016192	852	0.226	Worm
positive regulation of response to stimulus	GO:0048584	55	0.225	Worm
positive regulation of developmental process	GO:0051094	408	0.223	Worm
cell death	GO:0008219	547	0.223
cellular biosynthetic process	GO:0044249	315	0.221
inductive cell migration	GO:0040039	145	0.220
genitalia development	GO:0048806	741	0.214	Worm
neuron projection extension	GO:1990138	37	0.212	Worm
regulation of cell communication	GO:0010646	176	0.211	Worm
negative regulation of multicellular organismal process	GO:0051241	236	0.209	Worm
single organism organelle organization	GO:1902589	501	0.205
negative regulation of developmental process	GO:0051093	227	0.202	Worm
negative regulation of nematode larval development	GO:0061064	208	0.200	Worm
death	GO:0016265	547	0.198
neurogenesis	GO:0022008	236	0.196
cell cycle process	GO:0022402	482	0.196
reproductive behavior	GO:0019098	387	0.195	Worm
muscle organ morphogenesis	GO:0048644	4	0.195
pattern specification process	GO:0007389	59	0.191	Worm Fly
muscle structure development	GO:0061061	191	0.185
sex differentiation	GO:0007548	909	0.183	Worm
cell projection assembly	GO:0030031	35	0.183
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	65	0.181	Worm Fly
gastrulation	GO:0007369	58	0.179	Worm
multicellular organism growth	GO:0035264	385	0.179	Worm
negative regulation of metabolic process	GO:0009892	240	0.176	Worm Fly
phosphate containing compound metabolic process	GO:0006796	232	0.175
sexual reproduction	GO:0019953	546	0.174
organelle fission	GO:0048285	363	0.172
neuron development	GO:0048666	199	0.172
negative regulation of macromolecule biosynthetic process	GO:0010558	65	0.170	Worm Fly
cellular component morphogenesis	GO:0032989	318	0.170
regulation of meiotic cell cycle	GO:0051445	136	0.166
signaling	GO:0023052	401	0.163
negative regulation of transcription dna templated	GO:0045892	53	0.163	Worm Fly
cellular protein metabolic process	GO:0044267	279	0.162	Worm
cellular response to organic substance	GO:0071310	119	0.160
developmental growth	GO:0048589	412	0.159	Worm
male sex differentiation	GO:0046661	86	0.158	Worm
negative regulation of macromolecule metabolic process	GO:0010605	229	0.158	Worm Fly
response to organic substance	GO:0010033	131	0.158
positive regulation of developmental growth	GO:0048639	354	0.157	Worm
regulation of developmental growth	GO:0048638	389	0.156	Worm
negative regulation of nucleobase containing compound metabolic process	GO:0045934	63	0.155	Worm Fly
embryonic morphogenesis	GO:0048598	152	0.153	Worm
hermaphrodite genitalia development	GO:0040035	734	0.149	Worm
regulation of organ morphogenesis	GO:2000027	4	0.149
gamete generation	GO:0007276	461	0.148
negative regulation of cellular metabolic process	GO:0031324	95	0.147	Worm Fly
negative regulation of rna biosynthetic process	GO:1902679	53	0.142	Worm Fly
single organism localization	GO:1902578	518	0.138
regulation of biological quality	GO:0065008	741	0.137	Worm
regulation of nuclear division	GO:0051783	115	0.135
macromolecule localization	GO:0033036	771	0.132	Worm
cilium assembly	GO:0042384	28	0.130
anterior posterior pattern specification	GO:0009952	27	0.128
regulation of signaling	GO:0023051	172	0.124
sensory organ morphogenesis	GO:0090596	2	0.124
regulation of translation	GO:0006417	19	0.123	Worm
cellular component assembly	GO:0022607	293	0.123
developmental cell growth	GO:0048588	39	0.123	Worm
negative regulation of post embryonic development	GO:0048581	208	0.123	Worm
single organism signaling	GO:0044700	401	0.122
positive regulation of multicellular organism growth	GO:0040018	352	0.121	Worm
cellular response to chemical stimulus	GO:0070887	129	0.115
protein metabolic process	GO:0019538	422	0.115	Worm
muscle organ development	GO:0007517	26	0.114
negative regulation of cellular biosynthetic process	GO:0031327	65	0.112	Worm Fly
regulation of cell cycle	GO:0051726	194	0.110
translation	GO:0006412	37	0.108	Worm
regulation of cellular component organization	GO:0051128	248	0.108
cellular component biogenesis	GO:0044085	297	0.106
muscle cell differentiation	GO:0042692	171	0.106
embryonic body morphogenesis	GO:0010172	49	0.105
regulation of cell differentiation	GO:0045595	81	0.105
female gamete generation	GO:0007292	254	0.104
positive regulation of growth	GO:0045927	369	0.102	Worm
male anatomical structure morphogenesis	GO:0090598	78	0.100	Worm
catabolic process	GO:0009056	318	0.100	Worm
collagen and cuticulin based cuticle development	GO:0040002	99	0.099	Worm
head development	GO:0060322	1	0.099	Fly
positive regulation of cell communication	GO:0010647	69	0.097	Worm
regulation of anatomical structure morphogenesis	GO:0022603	51	0.095
regulation of organelle organization	GO:0033043	164	0.093
regulation of cell death	GO:0010941	65	0.092
regulation of growth	GO:0040008	409	0.092	Worm
regulation of cell migration	GO:0030334	55	0.089
cytoskeleton organization	GO:0007010	339	0.086
development of primary male sexual characteristics	GO:0046546	4	0.085	Worm
regulation of multicellular organism growth	GO:0040014	373	0.083	Worm
neuron recognition	GO:0008038	83	0.082
regulation of neuron differentiation	GO:0045664	40	0.082
regulation of cell fate specification	GO:0042659	22	0.082
organelle assembly	GO:0070925	214	0.081
regulation of cell development	GO:0060284	49	0.081
dauer larval development	GO:0040024	92	0.080
striated muscle cell differentiation	GO:0051146	158	0.077
mitotic cell cycle process	GO:1903047	194	0.077
response to wounding	GO:0009611	4	0.077
regulation of cell fate commitment	GO:0010453	22	0.077
autophagy	GO:0006914	29	0.077	Worm
cell cell signaling	GO:0007267	118	0.075
cellular process involved in reproduction in multicellular organism	GO:0022412	351	0.073
protein localization	GO:0008104	205	0.073	Worm
germ cell development	GO:0007281	351	0.073
signal transduction	GO:0007165	317	0.071
regulation of apoptotic process	GO:0042981	36	0.071
regionalization	GO:0003002	31	0.070	Fly
lipid localization	GO:0010876	573	0.069
positive regulation of signaling	GO:0023056	66	0.069
macromolecule modification	GO:0043412	218	0.068
maintenance of location	GO:0051235	580	0.068	Worm
positive regulation of neurogenesis	GO:0050769	4	0.068
neuron fate commitment	GO:0048663	8	0.068
receptor mediated endocytosis	GO:0006898	715	0.067	Worm
molting cycle collagen and cuticulin based cuticle	GO:0018996	281	0.066
response to abiotic stimulus	GO:0009628	152	0.065
epithelium development	GO:0060429	68	0.065
organonitrogen compound metabolic process	GO:1901564	151	0.064
positive regulation of signal transduction	GO:0009967	40	0.064
system process	GO:0003008	136	0.064
posttranscriptional regulation of gene expression	GO:0010608	166	0.063	Worm
cell type specific apoptotic process	GO:0097285	4	0.063
single organism catabolic process	GO:0044712	129	0.063	Worm
dendrite development	GO:0016358	42	0.063
asymmetric cell division	GO:0008356	36	0.063
macromolecular complex subunit organization	GO:0043933	320	0.061
regulation of cellular catabolic process	GO:0031329	51	0.061	Worm
molting cycle	GO:0042303	281	0.060
lipid storage	GO:0019915	565	0.059
cellular component assembly involved in morphogenesis	GO:0010927	183	0.059
regulation of signal transduction	GO:0009966	135	0.058
phosphorylation	GO:0016310	116	0.057
response to other organism	GO:0051707	101	0.056
regulation of localization	GO:0032879	194	0.056
protein modification process	GO:0036211	207	0.055
striated muscle cell development	GO:0055002	157	0.054
oogenesis	GO:0048477	229	0.053
positive regulation of apoptotic process	GO:0043065	17	0.053
positive regulation of neuron differentiation	GO:0045666	4	0.052
defense response	GO:0006952	296	0.051
protein phosphorylation	GO:0006468	85	0.051
neuroblast fate determination	GO:0007400	1	0.050
actin filament based process	GO:0030029	191	0.050
regulation of catabolic process	GO:0009894	57	0.050	Worm
developmental growth involved in morphogenesis	GO:0060560	37	0.050	Worm
response to extracellular stimulus	GO:0009991	38	0.050	Worm
cuticle development	GO:0042335	100	0.049	Worm
regeneration	GO:0031099	4	0.049
cellular catabolic process	GO:0044248	199	0.048	Worm
cell recognition	GO:0008037	85	0.048
regulation of cell motility	GO:2000145	57	0.048
negative regulation of nitrogen compound metabolic process	GO:0051172	63	0.047	Worm Fly
cellular protein modification process	GO:0006464	207	0.047
meiotic cell cycle process	GO:1903046	170	0.047
muscle cell development	GO:0055001	158	0.047
epithelial tube morphogenesis	GO:0060562	1	0.047
regulation of molecular function	GO:0065009	89	0.046
axon extension involved in axon guidance	GO:0048846	13	0.046	Worm
negative regulation of nucleic acid templated transcription	GO:1903507	53	0.045	Worm Fly
positive regulation of catalytic activity	GO:0043085	59	0.045
actin cytoskeleton organization	GO:0030036	184	0.044
secretion by cell	GO:0032940	138	0.043
negative regulation of biosynthetic process	GO:0009890	65	0.043	Worm Fly
enzyme linked receptor protein signaling pathway	GO:0007167	50	0.042
phosphorus metabolic process	GO:0006793	232	0.042
organic substance catabolic process	GO:1901575	294	0.042
cell growth	GO:0016049	44	0.041	Worm
cell proliferation	GO:0008283	116	0.040
response to nutrient levels	GO:0031667	35	0.039	Worm
regulation of protein metabolic process	GO:0051246	81	0.039	Worm
pharynx development	GO:0060465	51	0.039	Worm
positive regulation of protein metabolic process	GO:0051247	45	0.039	Worm
epidermal cell fate specification	GO:0009957	5	0.039
response to oxygen containing compound	GO:1901700	44	0.039
positive regulation of transcription from rna polymerase ii promoter in response to osmotic stress	GO:0061393	1	0.038
establishment of localization in cell	GO:0051649	318	0.038
immune response	GO:0006955	192	0.038
regulation of sequence specific dna binding transcription factor activity	GO:0051090	3	0.038
lipid metabolic process	GO:0006629	77	0.037	Worm
axonal fasciculation	GO:0007413	79	0.037
small molecule metabolic process	GO:0044281	186	0.036
regulation of programmed cell death	GO:0043067	50	0.035
male germ line sex determination	GO:0019100	2	0.035	Worm
nematode male tail tip morphogenesis	GO:0045138	77	0.035	Worm
regulation of cell proliferation	GO:0042127	105	0.035
secretion	GO:0046903	147	0.035
regulation of stem cell differentiation	GO:2000736	1	0.034
regulation of cellular protein metabolic process	GO:0032268	75	0.034	Worm
cilium morphogenesis	GO:0060271	33	0.034
skeletal muscle organ development	GO:0060538	3	0.034
intracellular signal transduction	GO:0035556	96	0.034
striated muscle myosin thick filament assembly	GO:0071688	138	0.032
cellular response to inorganic substance	GO:0071241	3	0.031
neurological system process	GO:0050877	53	0.031
positive regulation of transcription from rna polymerase ii promoter in response to stress	GO:0036003	2	0.031
regulation of intracellular signal transduction	GO:1902531	77	0.031
tube formation	GO:0035148	2	0.031
regulation of cellular component movement	GO:0051270	62	0.031
macromolecular complex assembly	GO:0065003	193	0.030
cellular localization	GO:0051641	360	0.030
single organism behavior	GO:0044708	83	0.030
organic substance transport	GO:0071702	113	0.030
cellular protein complex assembly	GO:0043623	178	0.030
membrane organization	GO:0061024	135	0.030
single organism transport	GO:0044765	447	0.029
negative regulation of rna metabolic process	GO:0051253	53	0.029	Worm Fly
cell surface receptor signaling pathway	GO:0007166	149	0.029
myofibril assembly	GO:0030239	154	0.028
regulation of transcription from rna polymerase ii promoter in response to osmotic stress	GO:0061392	1	0.028
cellular response to starvation	GO:0009267	13	0.027	Worm
negative regulation of neurogenesis	GO:0050768	4	0.027
negative regulation of cell communication	GO:0010648	61	0.027
cell fate commitment involved in pattern specification	GO:0060581	7	0.027	Worm
positive regulation of cell cycle	GO:0045787	55	0.027
regulation of cell projection organization	GO:0031344	38	0.027
defense response to other organism	GO:0098542	100	0.027
stem cell proliferation	GO:0072089	9	0.027
bmp signaling pathway	GO:0030509	3	0.026
hormone transport	GO:0009914	2	0.026
protein complex biogenesis	GO:0070271	186	0.026
organophosphate metabolic process	GO:0019637	125	0.026
positive regulation of cell death	GO:0010942	38	0.026
positive regulation of transcription from rna polymerase ii promoter in response to salt stress	GO:0036251	1	0.025
regulation of gastrulation	GO:0010470	4	0.025
regulation of bmp signaling pathway	GO:0030510	3	0.025
cellular macromolecular complex assembly	GO:0034622	184	0.025
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	2	0.025
cellular response to stress	GO:0033554	162	0.025	Worm
regulation of transport	GO:0051049	91	0.025
regulation of cell morphogenesis involved in differentiation	GO:0010769	29	0.024
positive regulation of transcription from rna polymerase ii promoter involved in defense response to gram negative bacterium	GO:1902097	4	0.024
locomotory behavior	GO:0007626	40	0.024
positive regulation of transcription from rna polymerase ii promoter in response to increased salt	GO:0061404	1	0.024
synaptic transmission	GO:0007268	106	0.024
response to biotic stimulus	GO:0009607	101	0.024
positive regulation of transcription from rna polymerase ii promoter involved in defense response to fungus	GO:1901244	1	0.024
oxoacid metabolic process	GO:0043436	47	0.023
positive regulation of catabolic process	GO:0009896	38	0.023	Worm
positive regulation of programmed cell death	GO:0043068	27	0.023
organic acid metabolic process	GO:0006082	47	0.023
regulation of neurogenesis	GO:0050767	40	0.022
response to bacterium	GO:0009617	86	0.022
nitrogen compound transport	GO:0071705	49	0.022
regulation of response to wounding	GO:1903034	1	0.022
negative regulation of neuron differentiation	GO:0045665	4	0.022
positive regulation of cell development	GO:0010720	6	0.022
cellular response to hormone stimulus	GO:0032870	14	0.021
regulation of muscle cell differentiation	GO:0051147	1	0.021
muscle fiber development	GO:0048747	2	0.021
sex determination	GO:0007530	60	0.021	Worm
myosin filament assembly	GO:0031034	138	0.021
defense response to bacterium	GO:0042742	86	0.021
response to temperature stimulus	GO:0009266	66	0.021
regulation of epithelial cell differentiation	GO:0030856	4	0.020
chromosome segregation	GO:0007059	180	0.020
cellular response to oxygen containing compound	GO:1901701	21	0.020
positive regulation of cell differentiation	GO:0045597	8	0.020
regulation of transcription from rna polymerase ii promoter in response to salt stress	GO:0061416	1	0.019
organonitrogen compound biosynthetic process	GO:1901566	44	0.019
cellular response to endogenous stimulus	GO:0071495	32	0.019
cellular response to extracellular stimulus	GO:0031668	16	0.019	Worm
regulation of epithelial cell proliferation	GO:0050678	1	0.019
regulation of gene expression epigenetic	GO:0040029	163	0.019
gabaergic neuron differentiation	GO:0097154	1	0.018
positive regulation of locomotion	GO:0040017	42	0.018
germ line sex determination	GO:0018992	51	0.018	Worm
cellular amine metabolic process	GO:0044106	15	0.018
regulation of cellular ketone metabolic process	GO:0010565	3	0.018
regulation of lipid metabolic process	GO:0019216	4	0.018
positive regulation of cell migration	GO:0030335	3	0.018
regulation of nervous system development	GO:0051960	41	0.018
cellular response to dna damage stimulus	GO:0006974	41	0.018
stem cell differentiation	GO:0048863	7	0.018
epidermis development	GO:0008544	24	0.018
carboxylic acid metabolic process	GO:0019752	34	0.018
purine ribonucleotide catabolic process	GO:0009154	75	0.018
cellular response to abiotic stimulus	GO:0071214	4	0.018
cilium organization	GO:0044782	32	0.018
posttranscriptional gene silencing	GO:0016441	143	0.017
regulation of synaptic transmission	GO:0050804	34	0.017
chromosome organization	GO:0051276	104	0.017
glycosyl compound metabolic process	GO:1901657	100	0.017
nucleobase containing small molecule metabolic process	GO:0055086	115	0.017
regulation of cellular amine metabolic process	GO:0033238	0	0.017
canonical wnt signaling pathway	GO:0060070	3	0.017
endodermal cell differentiation	GO:0035987	18	0.017
proteolysis	GO:0006508	61	0.017
wnt signaling pathway	GO:0016055	27	0.016
positive regulation of vulval development	GO:0040026	52	0.016
nucleoside phosphate metabolic process	GO:0006753	108	0.016
cellular response to metal ion	GO:0071248	3	0.016
actomyosin structure organization	GO:0031032	154	0.016
regulation of phosphate metabolic process	GO:0019220	81	0.016
ribonucleotide metabolic process	GO:0009259	99	0.016
regulation of cellular amino acid metabolic process	GO:0006521	0	0.016
carbohydrate derivative metabolic process	GO:1901135	141	0.016
endodermal cell fate determination	GO:0007493	2	0.016
cell substrate adhesion	GO:0031589	1	0.015
neuron projection extension involved in neuron projection guidance	GO:1902284	13	0.015	Worm
cellular ketone metabolic process	GO:0042180	14	0.015
small gtpase mediated signal transduction	GO:0007264	32	0.015
positive regulation of molecular function	GO:0044093	61	0.015
myosin filament organization	GO:0031033	138	0.015
amine metabolic process	GO:0009308	15	0.015
positive regulation of translation	GO:0045727	6	0.015	Worm
cellular response to nutrient levels	GO:0031669	13	0.015	Worm
adult behavior	GO:0030534	3	0.015
negative regulation of cell cycle	GO:0045786	53	0.015
negative regulation of response to stimulus	GO:0048585	73	0.015
heterocycle catabolic process	GO:0046700	119	0.015
cellular amino acid metabolic process	GO:0006520	15	0.015
posttranscriptional gene silencing by rna	GO:0035194	143	0.015
epithelial cell differentiation	GO:0030855	17	0.015
nucleotide metabolic process	GO:0009117	108	0.014
purine ribonucleotide metabolic process	GO:0009150	95	0.014
organic hydroxy compound metabolic process	GO:1901615	25	0.014
response to external biotic stimulus	GO:0043207	101	0.014
positive regulation of epithelial cell proliferation	GO:0050679	1	0.014
epithelial cell proliferation	GO:0050673	1	0.014
phenol containing compound biosynthetic process	GO:0046189	8	0.014
chemosensory behavior	GO:0007635	33	0.014
regulation of behavior	GO:0050795	97	0.014
gene silencing	GO:0016458	143	0.014
specification of symmetry	GO:0009799	9	0.014
rna interference	GO:0016246	137	0.014
protein complex subunit organization	GO:0071822	280	0.014
pigment metabolic process	GO:0042440	2	0.014
regulation of response to stress	GO:0080134	28	0.014	Worm
negative regulation of cellular component organization	GO:0051129	33	0.014
pigmentation	GO:0043473	2	0.014
protein complex assembly	GO:0006461	186	0.013
male sex determination	GO:0030238	6	0.013	Worm
gene silencing by rna	GO:0031047	143	0.013
ribonucleoside metabolic process	GO:0009119	98	0.013
establishment of organelle localization	GO:0051656	123	0.013
defense response to fungus	GO:0050832	19	0.013
regulation of catalytic activity	GO:0050790	78	0.013
protein catabolic process	GO:0030163	162	0.013
response to endogenous stimulus	GO:0009719	33	0.013
regulation of phosphorus metabolic process	GO:0051174	81	0.013
neuroblast fate specification	GO:0014018	4	0.013
intracellular receptor signaling pathway	GO:0030522	2	0.013
regulation of phosphorylation	GO:0042325	45	0.013
chromatin modification	GO:0016568	32	0.013
regulation of canonical wnt signaling pathway	GO:0060828	1	0.013
regulation of protein stability	GO:0031647	3	0.013
embryonic pattern specification	GO:0009880	21	0.012	Fly
negative regulation of signaling	GO:0023057	61	0.012

fkh-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.050
musculoskeletal system disease	DOID:17	0.015
cardiovascular system disease	DOID:1287	0.014
nervous system disease	DOID:863	0.013

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