Caenorhabditis elegans

39 known processes

let-2 (CELE_F01G12.5)

Protein LET-2

let-2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo developmentGO:000979030520.783
embryo development ending in birth or egg hatchingGO:000979229920.536
cell migrationGO:00164773060.502
organ developmentGO:004851311020.496
Mouse Worm Fly
response to chemicalGO:00422213560.493
Mouse
transportGO:000681010930.423
Worm
post embryonic developmentGO:000979121520.417
embryonic morphogenesisGO:00485981520.365
Human Fly
single organism reproductive processGO:004470211960.354
Fly
nucleobase containing compound metabolic processGO:00061394060.335
Mouse
establishment of localizationGO:005123411710.331
Worm
neuron projection developmentGO:00311751870.330
neuron differentiationGO:00301822170.318
localization of cellGO:00516743130.297
determination of adult lifespanGO:00083408120.296
locomotionGO:004001116340.296
reproductive system developmentGO:00614588500.290
Fly
receptor mediated endocytosisGO:00068987150.265
Worm
agingGO:00075688120.259
endocytosisGO:00068978190.255
Worm
neuron projection morphogenesisGO:00488121140.249
vesicle mediated transportGO:00161928520.248
Worm
cell developmentGO:00484686960.231
Fly
axon developmentGO:00615641630.222
single organism localizationGO:19025785180.220
Worm
regulation of locomotionGO:00400121610.213
single organism signalingGO:00447004010.197
neurogenesisGO:00220082360.190
multicellular organismal agingGO:00102598120.190
single organism organelle organizationGO:19025895010.189
cellular component movementGO:00069283880.184
nervous system developmentGO:00073992530.182
heterocycle biosynthetic processGO:00181301870.181
Mouse
tube morphogenesisGO:0035239790.170
Human Fly
regulation of multicellular organismal processGO:00512397260.168
multicellular organism reproductionGO:00325048190.163
gonad developmentGO:00084068400.163
cellular component morphogenesisGO:00329893180.160
reproductive structure developmentGO:00486088500.158
Fly
regulation of multicellular organismal developmentGO:20000263170.156
Human
development of primary sexual characteristicsGO:00451378400.156
positive regulation of multicellular organismal processGO:00512404170.152
mitotic nuclear divisionGO:0007067890.151
epithelial tube morphogenesisGO:006056210.145
Fly
striated muscle cell developmentGO:00550021570.143
Fly
single organism transportGO:00447654470.140
Worm
muscle organ morphogenesisGO:004864440.140
body morphogenesisGO:00101716200.136
cell motilityGO:00488703130.134
regulation of biological qualityGO:00650087410.133
signal transductionGO:00071653170.132
nuclear pore distributionGO:003108120.130
regulation of cell motilityGO:2000145570.130
organelle organizationGO:00069967830.127
macromolecule localizationGO:00330367710.126
Worm
catabolic processGO:00090563180.123
signalingGO:00230524010.121
inductive cell migrationGO:00400391450.118
organelle fissionGO:00482853630.117
striated muscle cell differentiationGO:00511461580.115
Fly
establishment of localization in cellGO:00516493180.114
Worm
organ morphogenesisGO:0009887670.113
Fly
protein metabolic processGO:00195384220.113
multi organism reproductive processGO:00447038670.111
ribonucleotide metabolic processGO:0009259990.109
hermaphrodite genitalia developmentGO:00400357340.108
generation of neuronsGO:00486992350.107
macromolecule biosynthetic processGO:00090592500.102
Mouse
regulation of cell morphogenesisGO:0022604400.101
post embryonic organ developmentGO:00485693360.100
maintenance of locationGO:00512355800.099
system processGO:00030081360.097
eating behaviorGO:0042755590.095
behaviorGO:00076105270.094
multicellular organismal reproductive processGO:00486098150.094
cellular response to chemical stimulusGO:00708871290.094
Mouse
embryonic body morphogenesisGO:0010172490.093
lipid localizationGO:00108765730.091
muscle cell differentiationGO:00426921710.089
Fly
regulation of organelle organizationGO:00330431640.088
regulation of cell migrationGO:0030334550.084
macromolecule catabolic processGO:00090572020.083
muscle cell developmentGO:00550011580.083
Fly
gamete generationGO:00072764610.082
programmed cell deathGO:00125015000.082
neuron recognitionGO:0008038830.082
cellular macromolecule biosynthetic processGO:00346452470.082
Mouse
regulation of cellular component organizationGO:00511282480.081
organic substance catabolic processGO:19015752940.080
neuron developmentGO:00486661990.080
molting cycle collagen and cuticulin based cuticleGO:00189962810.079
protein catabolic processGO:00301631620.079
digestive tract morphogenesisGO:0048546760.078
Human Fly
genitalia developmentGO:00488067410.078
organic cyclic compound biosynthetic processGO:19013621950.076
Mouse
meiotic nuclear divisionGO:00071263000.076
cytoskeleton organizationGO:00070103390.075
reproductive behaviorGO:00190983870.074
neuron projection guidanceGO:0097485820.074
anatomical structure formation involved in morphogenesisGO:00486462500.073
Human
cellular biosynthetic processGO:00442493150.072
Mouse
lipid storageGO:00199155650.072
cellular component assemblyGO:00226072930.072
regulation of nucleic acid templated transcriptionGO:19035061650.072
developmental process involved in reproductionGO:000300611650.071
Fly
nucleic acid templated transcriptionGO:00976591690.070
Mouse
muscle structure developmentGO:00610611910.070
Worm Fly
taxisGO:00423301280.070
regulation of epithelial cell proliferationGO:005067810.069
macromolecular complex subunit organizationGO:00439333200.069
cell projection organizationGO:00300302310.068
maintenance of location in cellGO:0051651120.067
negative regulation of developmental processGO:00510932270.067
Human
nucleobase containing compound biosynthetic processGO:00346541840.067
Mouse
cell cycleGO:00070495260.066
maintenance of protein location in cellGO:0032507120.066
ovulationGO:0030728330.066
cellular component biogenesisGO:00440852970.066
tube developmentGO:00352951260.065
Human Fly
single organism cellular localizationGO:1902580720.064
negative regulation of nematode larval developmentGO:00610642080.064
nucleic acid metabolic processGO:00903042990.064
Mouse
positive regulation of growthGO:00459273690.064
regulation of developmental processGO:00507936840.063
cell morphogenesisGO:00009021630.063
organic substance biosynthetic processGO:19015763230.063
Mouse
negative regulation of vulval developmentGO:00400272060.062
muscle tissue developmentGO:006053710.062
Fly
ovipositionGO:00189913640.062
regulation of response to stimulusGO:00485832430.062
cell morphogenesis involved in differentiationGO:00009041120.061
protein complex biogenesisGO:00702711860.061
microtubule based processGO:00070171820.060
regulation of nucleobase containing compound metabolic processGO:00192192220.059
protein complex assemblyGO:00064611860.059
myofibril assemblyGO:00302391540.059
maintenance of protein locationGO:0045185150.059
protein localizationGO:00081042050.059
Worm
phosphate containing compound metabolic processGO:00067962320.059
positive regulation of developmental processGO:00510944080.058
regulation of cytoskeleton organizationGO:0051493410.057
chemotaxisGO:00069351200.057
axonogenesisGO:00074091020.057
developmental growthGO:00485894120.057
cellular component assembly involved in morphogenesisGO:00109271830.056
rna metabolic processGO:00160702280.056
Mouse
cell projection morphogenesisGO:00488581480.056
tissue morphogenesisGO:0048729650.056
Fly
regulation of molecular functionGO:0065009890.055
organelle assemblyGO:00709252140.055
regulation of growthGO:00400084090.054
molting cycleGO:00423032810.054
regulation of rna metabolic processGO:00512521730.054
negative regulation of multicellular organismal processGO:00512412360.054
Human
cellular localizationGO:00516413600.054
Worm
regulation of post embryonic developmentGO:00485802600.053
apoptotic processGO:00069154780.053
skeletal muscle thin filament assemblyGO:003024030.053
positive regulation of macromolecule metabolic processGO:00106041490.053
sexual reproductionGO:00199535460.053
nucleoside phosphate metabolic processGO:00067531080.050
nucleoside metabolic processGO:0009116990.050
meiotic cell cycleGO:00513213350.050
negative regulation of post embryonic developmentGO:00485812080.050
regulation of transcription dna templatedGO:00063551640.050
regulation of anatomical structure morphogenesisGO:0022603510.049
Human
digestive tract developmentGO:00485651220.049
Human Fly
carbohydrate derivative metabolic processGO:19011351410.048
protein complex subunit organizationGO:00718222800.048
regulation of metabolic processGO:00192224780.048
cellular nitrogen compound biosynthetic processGO:00442711920.047
Mouse
uterus morphogenesisGO:006103820.047
cell part morphogenesisGO:00329901520.046
sex differentiationGO:00075489090.045
actin filament organizationGO:0007015210.045
cellular catabolic processGO:00442481990.045
cell cycle processGO:00224024820.044
deathGO:00162655470.044
axonal fasciculationGO:0007413790.044
positive regulation of multicellular organism growthGO:00400183520.043
female gamete generationGO:00072922540.043
mesoderm developmentGO:0007498270.043
localization within membraneGO:005166820.042
positive regulation of catalytic activityGO:0043085590.042
aromatic compound catabolic processGO:00194391160.041
tissue developmentGO:00098881120.041
Human Fly
mitotic cell cycle processGO:19030471940.040
small molecule metabolic processGO:00442811860.040
cellular nitrogen compound catabolic processGO:00442701190.040
striated muscle contractionGO:0006941170.039
anatomical structure homeostasisGO:0060249110.039
cellular response to stressGO:00335541620.039
actin filament based processGO:00300291910.039
multicellular organismal reproductive behaviorGO:00330573840.039
positive regulation of metabolic processGO:00098931870.038
cellular macromolecular complex assemblyGO:00346221840.038
regulation of cellular metabolic processGO:00313233050.038
regulation of macromolecule biosynthetic processGO:00105561890.037
muscle organ developmentGO:0007517260.037
Worm Fly
membrane organizationGO:00610241350.037
positive regulation of cellular processGO:00485223320.037
Worm
myosin filament assemblyGO:00310341380.037
epithelial cell proliferationGO:005067310.036
negative regulation of biological processGO:00485195670.036
Human
gene expressionGO:00104674120.036
Mouse
cell surface receptor signaling pathwayGO:00071661490.036
heterocycle catabolic processGO:00467001190.035
regulation of cellular component sizeGO:0032535400.035
cell adhesionGO:0007155210.035
purine nucleotide metabolic processGO:0006163950.035
regulation of nitrogen compound metabolic processGO:00511712220.035
nucleoside catabolic processGO:0009164780.034
regulation of muscle contractionGO:0006937200.034
cell proliferationGO:00082831160.034
biosynthetic processGO:00090583230.034
Mouse
cuticle developmentGO:00423351000.033
cellular process involved in reproduction in multicellular organismGO:00224123510.033
regulation of vulval developmentGO:00400282480.033
regulation of developmental growthGO:00486383890.033
regulation of cellular component movementGO:0051270620.032
cell deathGO:00082195470.032
cell fate commitmentGO:00451651390.032
collagen and cuticulin based cuticle developmentGO:0040002990.032
regulation of multicellular organism growthGO:00400143730.032
rna biosynthetic processGO:00327741690.031
Mouse
regulation of primary metabolic processGO:00800902920.031
gastrulationGO:0007369580.031
Human
germ cell developmentGO:00072813510.031
er nucleus signaling pathwayGO:0006984660.031
response to acid chemicalGO:000110140.030
Mouse
regulation of localizationGO:00328791940.030
Worm
response to external stimulusGO:00096052890.030
multicellular organism growthGO:00352643850.030
regulation of actin filament based processGO:0032970220.030
regulation of nematode larval developmentGO:00610622600.030
cell morphogenesis involved in neuron differentiationGO:00486671110.029
purine nucleoside metabolic processGO:0042278920.029
cell recognitionGO:0008037850.029
purine nucleoside triphosphate metabolic processGO:0009144870.028
phosphorus metabolic processGO:00067932320.028
multi organism reproductive behaviorGO:00447053870.028
myosin filament organizationGO:00310331380.028
positive regulation of cell projection organizationGO:003134640.028
response to topologically incorrect proteinGO:0035966820.028
response to woundingGO:000961140.028
secretionGO:00469031470.028
Worm
carbohydrate derivative catabolic processGO:1901136820.028
striated muscle myosin thick filament assemblyGO:00716881380.027
vulval developmentGO:00400253330.027
purine ribonucleotide metabolic processGO:0009150950.027
positive regulation of locomotionGO:0040017420.027
defense responseGO:00069522960.027
positive regulation of neuron projection developmentGO:001097640.027
glycosyl compound metabolic processGO:19016571000.026
adult locomotory behaviorGO:000834410.026
cellular macromolecule localizationGO:0070727750.026
positive regulation of cell migrationGO:003033530.026
epithelium developmentGO:0060429680.026
Fly
positive regulation of molecular functionGO:0044093610.026
single organism behaviorGO:0044708830.025
stem cell differentiationGO:004886370.025
organic cyclic compound catabolic processGO:19013611190.025
organonitrogen compound metabolic processGO:19015641510.025
actin cytoskeleton organizationGO:00300361840.025
ribonucleoside monophosphate metabolic processGO:0009161450.025
regulation of mitotic cell cycleGO:0007346760.024
multi multicellular organism processGO:00447063900.024
positive regulation of developmental growthGO:00486393540.024
regulation of cytoplasmic transportGO:190364930.024
nucleobase containing compound catabolic processGO:00346551140.024
ion transportGO:00068111130.024
cellular protein complex localizationGO:003462930.024
ribonucleoside metabolic processGO:0009119980.023
nucleoside triphosphate metabolic processGO:0009141870.023
nuclear pore localizationGO:005166420.023
cellular homeostasisGO:0019725220.022
regulation of signal transductionGO:00099661350.022
positive regulation of cellular metabolic processGO:00313251780.022
adult behaviorGO:003053430.022
cell divisionGO:00513012620.022
sodium ion transportGO:0006814100.022
purine ribonucleoside catabolic processGO:0046130750.022
regulation of gene expressionGO:00104683660.022
multi organism behaviorGO:00517053890.022
regulation of cell proliferationGO:00421271050.021
purine nucleotide catabolic processGO:0006195750.021
establishment of organelle localizationGO:00516561230.021
regulation of cell communicationGO:00106461760.021
actomyosin structure organizationGO:00310321540.021
axon guidanceGO:0007411820.021
positive regulation of nucleobase containing compound metabolic processGO:00459351340.021
regulation of cell cycleGO:00517261940.020
purine ribonucleoside metabolic processGO:0046128920.020
transcription dna templatedGO:00063511680.020
Mouse
positive regulation of protein transportGO:005122240.020
Worm
nucleotide metabolic processGO:00091171080.020
regulation of macromolecule metabolic processGO:00602554210.020
purine ribonucleoside triphosphate catabolic processGO:0009207720.020
cation transportGO:0006812780.020
nucleoside monophosphate metabolic processGO:0009123460.020
posttranscriptional regulation of gene expressionGO:00106081660.020
secretion by cellGO:00329401380.019
Worm
cytokinesisGO:0000910800.019
cell substrate adhesionGO:003158910.019
growthGO:00400075620.019
regulation of cell deathGO:0010941650.019
muscle system processGO:0003012430.019
lamellipodium organizationGO:009758120.019
positive regulation of rna metabolic processGO:00512541030.019
purine ribonucleotide catabolic processGO:0009154750.018
somatic muscle developmentGO:000752510.018
purine containing compound metabolic processGO:0072521950.018
negative regulation of cellular component organizationGO:0051129330.018
negative regulation of gene expression epigeneticGO:004581420.018
ribonucleotide catabolic processGO:0009261750.018
response to organic substanceGO:00100331310.018
Mouse
macromolecular complex assemblyGO:00650031930.018
sensory organ morphogenesisGO:009059620.018
positive regulation of cell morphogenesis involved in differentiationGO:001077040.018
single organism catabolic processGO:00447121290.018
regulation of neuron projection developmentGO:0010975310.018
nucleobase containing small molecule metabolic processGO:00550861150.017
ribose phosphate metabolic processGO:0019693990.017
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169340.017
regulation of purine nucleotide catabolic processGO:0033121350.017
purine nucleoside triphosphate catabolic processGO:0009146720.017
intracellular signal transductionGO:0035556960.017
regulation of catalytic activityGO:0050790780.017
positive regulation of nitrogen compound metabolic processGO:00511731340.017
phagocytosisGO:00069091150.017
positive regulation of biosynthetic processGO:00098911090.017
regulation of cell projection organizationGO:0031344380.016
membrane invaginationGO:0010324980.016
single organism membrane organizationGO:0044802350.016
aromatic compound biosynthetic processGO:00194381920.016
Mouse
muscle contractionGO:0006936430.016
digestive system developmentGO:00551231220.016
Human Fly
regulation of protein localizationGO:0032880500.016
Worm
cellular protein localizationGO:0034613750.016
regulation of anatomical structure sizeGO:0090066460.015
establishment of nucleus localizationGO:0040023550.015
canonical wnt signaling pathwayGO:006007030.015
developmental growth involved in morphogenesisGO:0060560370.015
regulation of cellular macromolecule biosynthetic processGO:20001121880.015
purine containing compound catabolic processGO:0072523750.015
glycosyl compound catabolic processGO:1901658790.015
engulfment of apoptotic cellGO:0043652940.015
actin filament based movementGO:003004840.015
response to abiotic stimulusGO:00096281520.015
gene silencingGO:00164581430.015
sarcomere organizationGO:0045214100.015
organelle localizationGO:00516401270.014
chromosome organizationGO:00512761040.014
ribonucleoside catabolic processGO:0042454770.014
striated muscle contraction involved in embryonic body morphogenesisGO:0061199130.014
regulation of transcription from rna polymerase ii promoterGO:00063571450.014
negative regulation of cellular processGO:00485232390.014
nuclear envelope reassemblyGO:003146840.014
nucleus localizationGO:0051647550.014
regulation of apoptotic signaling pathwayGO:200123310.014
purine nucleoside catabolic processGO:0006152750.014
ribonucleoside triphosphate catabolic processGO:0009203720.014
chromosome segregationGO:00070591800.014
regulation of cell differentiationGO:0045595810.014
endomembrane system organizationGO:0010256220.013
muscle cell cellular homeostasisGO:004671650.013
oogenesisGO:00484772290.013
regulation of hydrolase activityGO:0051336450.013
cellular response to organic substanceGO:00713101190.013
Mouse
pharyngeal pumpingGO:0043050580.013
purine ribonucleoside triphosphate metabolic processGO:0009205870.013
carboxylic acid metabolic processGO:0019752340.013
organic acid metabolic processGO:0006082470.013
macromolecule modificationGO:00434122180.013
cellular protein complex assemblyGO:00436231780.013
rna localizationGO:000640330.013
cellular macromolecule catabolic processGO:0044265730.013
spindle localizationGO:0051653510.013
organic substance transportGO:00717021130.013
Worm
positive regulation of intracellular transportGO:003238820.012
regulation of signalingGO:00230511720.012
regulation of gene expression epigeneticGO:00400291630.012
cellular response to transforming growth factor beta stimulusGO:0071560130.012
Mouse
organophosphate metabolic processGO:00196371250.012
apoptotic mitochondrial changesGO:000863720.012
negative regulation of cellular metabolic processGO:0031324950.012
posttranscriptional gene silencing by rnaGO:00351941430.012
cell type specific apoptotic processGO:009728540.011
positive regulation of stem cell differentiationGO:200073810.011
excretionGO:0007588490.011
positive regulation of kinase activityGO:0033674190.011
positive regulation of transportGO:0051050320.011
Worm
muscle attachmentGO:001620330.011
nucleoside triphosphate catabolic processGO:0009143720.011
positive regulation of cysteine type endopeptidase activityGO:200105630.011
regulation of cell divisionGO:00513021420.011
ion transmembrane transportGO:0034220910.011
regulation of cellular biosynthetic processGO:00313261890.011
response to transforming growth factor betaGO:0071559130.011
Mouse
head developmentGO:006032210.011
transcription from rna polymerase ii promoterGO:00063661490.011
positive regulation of macromolecule biosynthetic processGO:00105571090.011
cellular protein catabolic processGO:0044257370.011
chromatin remodelingGO:000633820.011
cellular protein metabolic processGO:00442672790.011
purine ribonucleoside monophosphate catabolic processGO:0009169280.011
biological adhesionGO:0022610210.010
negative regulation of signalingGO:0023057610.010
regulation of cell cycle processGO:00105641450.010
actin filament bundle assemblyGO:005101730.010
protein oligomerizationGO:005125940.010
nucleotide catabolic processGO:0009166770.010
positive regulation of phosphorus metabolic processGO:0010562560.010
multicellular organismal movementGO:005087920.010
nuclear migrationGO:0007097540.010
ribonucleoside triphosphate metabolic processGO:0009199870.010
axon extensionGO:0048675370.010

let-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
musculoskeletal system diseaseDOID:1700.330
disease of anatomical entityDOID:700.330
muscle tissue diseaseDOID:6600.330
muscular dystrophyDOID:988400.330
muscular diseaseDOID:008000000.330
congenital muscular dystrophyDOID:005055700.330
myopathyDOID:42300.330
familial partial lipodystrophyDOID:005044000.138
integumentary system diseaseDOID:1600.138
skin diseaseDOID:3700.138
lipodystrophyDOID:81100.138
cardiovascular system diseaseDOID:128700.125
heart diseaseDOID:11400.125
cardiomyopathyDOID:005070000.125
dilated cardiomyopathyDOID:1293000.074
intrinsic cardiomyopathyDOID:006003600.074
emery dreifuss muscular dystrophyDOID:1172600.034
neuromuscular diseaseDOID:44000.022
charcot marie tooth diseaseDOID:1059500.022
charcot marie tooth disease type 2DOID:005053900.022
neuropathyDOID:87000.022
nervous system diseaseDOID:86300.022
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
organ system cancerDOID:005068600.014
hypertrophic cardiomyopathyDOID:1198400.011