Caenorhabditis elegans

66 known processes

top-1 (CELE_M01E5.5)

Protein TOP-1

top-1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo development ending in birth or egg hatchingGO:000979229920.863
reproductive system developmentGO:00614588500.659
embryo developmentGO:000979030520.611
post embryonic developmentGO:000979121520.607
establishment of localizationGO:005123411710.584
development of primary sexual characteristicsGO:00451378400.566
endocytosisGO:00068978190.539
single organism reproductive processGO:004470211960.505
cell motilityGO:00488703130.472
locomotionGO:004001116340.436
transportGO:000681010930.436
receptor mediated endocytosisGO:00068987150.423
developmental process involved in reproductionGO:000300611650.402
vesicle mediated transportGO:00161928520.401
reproductive structure developmentGO:00486088500.383
cell migrationGO:00164773060.348
molting cycleGO:00423032810.330
gene expressionGO:00104674120.323
Human
sex differentiationGO:00075489090.319
regulation of multicellular organismal processGO:00512397260.316
regulation of developmental processGO:00507936840.310
cellular component movementGO:00069283880.308
genitalia developmentGO:00488067410.302
hermaphrodite genitalia developmentGO:00400357340.299
multicellular organism reproductionGO:00325048190.294
multicellular organismal agingGO:00102598120.253
cell developmentGO:00484686960.244
molting cycle collagen and cuticulin based cuticleGO:00189962810.241
single organism organelle organizationGO:19025895010.235
Fly
organic substance catabolic processGO:19015752940.227
gonad developmentGO:00084068400.220
regulation of developmental growthGO:00486383890.212
positive regulation of multicellular organismal processGO:00512404170.210
positive regulation of developmental growthGO:00486393540.200
localization of cellGO:00516743130.199
cellular localizationGO:00516413600.171
body morphogenesisGO:00101716200.171
multicellular organismal reproductive behaviorGO:00330573840.171
positive regulation of growthGO:00459273690.170
transcription dna templatedGO:00063511680.165
positive regulation of multicellular organism growthGO:00400183520.162
post embryonic organ developmentGO:00485693360.151
organelle organizationGO:00069967830.150
regulation of vulval developmentGO:00400282480.150
positive regulation of developmental processGO:00510944080.141
growthGO:00400075620.139
nucleic acid metabolic processGO:00903042990.136
Human Mouse Fly
multicellular organismal reproductive processGO:00486098150.134
inductive cell migrationGO:00400391450.133
macromolecule localizationGO:00330367710.132
neurogenesisGO:00220082360.128
negative regulation of biological processGO:00485195670.127
regulation of growthGO:00400084090.126
regulation of multi organism processGO:0043900690.124
single organism transportGO:00447654470.123
regulation of cellular metabolic processGO:00313233050.121
behaviorGO:00076105270.120
developmental growthGO:00485894120.115
regulation of localizationGO:00328791940.114
agingGO:00075688120.113
catabolic processGO:00090563180.111
negative regulation of nematode larval developmentGO:00610642080.110
regulation of macromolecule metabolic processGO:00602554210.109
Human
regulation of gene expressionGO:00104683660.109
Human
ovipositionGO:00189913640.108
deathGO:00162655470.107
regulation of metabolic processGO:00192224780.105
Human
negative regulation of vulval developmentGO:00400272060.103
multicellular organism growthGO:00352643850.103
reproductive behaviorGO:00190983870.103
regulation of multicellular organism growthGO:00400143730.102
regulation of post embryonic developmentGO:00485802600.101
apoptotic processGO:00069154780.094
regulation of nematode larval developmentGO:00610622600.093
organic cyclic compound biosynthetic processGO:19013621950.093
cellular biosynthetic processGO:00442493150.092
Mouse
determination of adult lifespanGO:00083408120.092
multi organism reproductive behaviorGO:00447053870.090
gamete generationGO:00072764610.090
germ cell developmentGO:00072813510.089
regulation of biological qualityGO:00650087410.089
negative regulation of macromolecule metabolic processGO:00106052290.084
nervous system developmentGO:00073992530.084
head developmentGO:006032210.082
vulval developmentGO:00400253330.081
cell deathGO:00082195470.081
multi multicellular organism processGO:00447063900.081
organ developmentGO:004851311020.080
regulation of locomotionGO:00400121610.079
cell projection organizationGO:00300302310.079
maintenance of locationGO:00512355800.078
cytoskeleton organizationGO:00070103390.076
regulation of organelle organizationGO:00330431640.074
signalingGO:00230524010.073
regulation of cellular component organizationGO:00511282480.072
macromolecule biosynthetic processGO:00090592500.071
Mouse
regulation of cell migrationGO:0030334550.070
rna metabolic processGO:00160702280.070
regulation of transportGO:0051049910.068
lipid localizationGO:00108765730.067
regulation of multicellular organismal developmentGO:20000263170.067
response to woundingGO:000961140.067
regulation of nitrogen compound metabolic processGO:00511712220.066
programmed cell deathGO:00125015000.066
transcription from rna polymerase ii promoterGO:00063661490.066
regulation of transcription from rna polymerase ii promoterGO:00063571450.066
regulation of primary metabolic processGO:00800902920.065
multi organism behaviorGO:00517053890.065
response to external biotic stimulusGO:00432071010.064
lipid storageGO:00199155650.064
response to other organismGO:00517071010.063
regulation of transcription dna templatedGO:00063551640.063
negative regulation of developmental processGO:00510932270.062
generation of neuronsGO:00486992350.062
response to external stimulusGO:00096052890.061
negative regulation of multicellular organismal processGO:00512412360.060
positive regulation of neurogenesisGO:005076940.060
neuron differentiationGO:00301822170.059
system processGO:00030081360.059
establishment of protein localization to membraneGO:009015030.058
establishment of localization in cellGO:00516493180.058
regulation of cell motilityGO:2000145570.057
organ morphogenesisGO:0009887670.057
protein complex subunit organizationGO:00718222800.056
regulation of gene expression epigeneticGO:00400291630.056
regulation of macromolecule biosynthetic processGO:00105561890.055
protein metabolic processGO:00195384220.055
Fly
single organism localizationGO:19025785180.053
rna biosynthetic processGO:00327741690.053
embryonic morphogenesisGO:00485981520.053
cellular catabolic processGO:00442481990.051
organonitrogen compound metabolic processGO:19015641510.051
macromolecule catabolic processGO:00090572020.050
protein localizationGO:00081042050.049
negative regulation of post embryonic developmentGO:00485812080.048
ribonucleoprotein complex assemblyGO:002261840.048
female gamete generationGO:00072922540.047
cell recognitionGO:0008037850.047
negative regulation of metabolic processGO:00098922400.047
response to biotic stimulusGO:00096071010.047
muscle cell differentiationGO:00426921710.046
regulation of cellular component movementGO:0051270620.045
nucleic acid templated transcriptionGO:00976591690.045
cellular process involved in reproduction in multicellular organismGO:00224123510.044
single organism signalingGO:00447004010.044
cellular macromolecular complex assemblyGO:00346221840.043
regulation of nucleobase containing compound metabolic processGO:00192192220.043
sensory organ morphogenesisGO:009059620.042
multi organism reproductive processGO:00447038670.042
cellular macromolecule biosynthetic processGO:00346452470.041
Mouse
defense responseGO:00069522960.040
protein catabolic processGO:00301631620.039
phagocytosisGO:00069091150.038
regulation of biosynthetic processGO:00098891890.038
sexual reproductionGO:00199535460.037
cell morphogenesisGO:00009021630.037
neuron projection developmentGO:00311751870.037
neuron recognitionGO:0008038830.037
response to chemicalGO:00422213560.037
Human
cell part morphogenesisGO:00329901520.037
muscle tissue developmentGO:006053710.037
male sex differentiationGO:0046661860.036
carboxylic acid metabolic processGO:0019752340.036
cell junction organizationGO:0034330180.036
regulation of nucleic acid templated transcriptionGO:19035061650.035
actin filament based processGO:00300291910.035
cell type specific apoptotic processGO:009728540.035
neuron developmentGO:00486661990.035
actin cytoskeleton organizationGO:00300361840.034
digestive tract morphogenesisGO:0048546760.034
regulation of cellular component sizeGO:0032535400.034
apoptotic cell clearanceGO:00432771110.033
nematode male tail tip morphogenesisGO:0045138770.033
secretionGO:00469031470.033
male anatomical structure morphogenesisGO:0090598780.033
cellular component assemblyGO:00226072930.033
regulation of protein localizationGO:0032880500.032
embryonic body morphogenesisGO:0010172490.032
cell cycle processGO:00224024820.031
nucleobase containing compound metabolic processGO:00061394060.031
Human Mouse Fly
small molecule metabolic processGO:00442811860.030
aromatic compound catabolic processGO:00194391160.029
regulation of rna metabolic processGO:00512521730.029
cellular protein localizationGO:0034613750.029
collagen and cuticulin based cuticle developmentGO:0040002990.029
striated muscle cell differentiationGO:00511461580.029
regulation of cell morphogenesisGO:0022604400.028
response to bacteriumGO:0009617860.028
muscle cell developmentGO:00550011580.028
regulation of molecular functionGO:0065009890.028
negative regulation of gene expressionGO:00106292170.028
cellular protein metabolic processGO:00442672790.027
Fly
cellular component biogenesisGO:00440852970.027
regulation of cellular amino acid metabolic processGO:000652100.027
actomyosin structure organizationGO:00310321540.027
cell cell signalingGO:00072671180.027
cellular response to chemical stimulusGO:00708871290.027
peptidyl tyrosine phosphorylationGO:001810820.027
neuron projection morphogenesisGO:00488121140.027
axonal fasciculationGO:0007413790.026
membrane organizationGO:00610241350.026
gene silencingGO:00164581430.026
cellular amino acid metabolic processGO:0006520150.025
macromolecular complex assemblyGO:00650031930.025
myofibril assemblyGO:00302391540.025
tissue morphogenesisGO:0048729650.025
organic substance biosynthetic processGO:19015763230.025
Mouse
posttranscriptional gene silencingGO:00164411430.025
positive regulation of cellular metabolic processGO:00313251780.025
protein complex assemblyGO:00064611860.025
regulation of anatomical structure morphogenesisGO:0022603510.024
regulation of cellular biosynthetic processGO:00313261890.024
regulation of axonogenesisGO:0050770240.024
nucleotide metabolic processGO:00091171080.024
taxisGO:00423301280.024
nucleobase containing compound biosynthetic processGO:00346541840.024
positive regulation of transcription from rna polymerase ii promoterGO:0045944980.024
regulation of phosphorus metabolic processGO:0051174810.024
negative regulation of cellular processGO:00485232390.024
regulation of anatomical structure sizeGO:0090066460.023
regulation of behaviorGO:0050795970.023
cellular protein complex assemblyGO:00436231780.023
organic substance transportGO:00717021130.023
positive regulation of nucleic acid templated transcriptionGO:19035081020.023
cation transportGO:0006812780.023
mrna metabolic processGO:0016071310.023
immune responseGO:00069551920.022
intracellular signal transductionGO:0035556960.022
cell cycleGO:00070495260.022
cellular macromolecule localizationGO:0070727750.022
cellular response to organic substanceGO:00713101190.022
regulation of cellular amine metabolic processGO:003323800.022
signal transduction by phosphorylationGO:0023014310.022
organelle assemblyGO:00709252140.022
biosynthetic processGO:00090583230.022
Mouse
cellular component assembly involved in morphogenesisGO:00109271830.022
gene silencing by rnaGO:00310471430.022
striated muscle myosin thick filament assemblyGO:00716881380.021
posttranscriptional regulation of gene expressionGO:00106081660.021
regulation of signal transductionGO:00099661350.021
cellular amine metabolic processGO:0044106150.021
positive regulation of molecular functionGO:0044093610.021
axon developmentGO:00615641630.021
epithelium developmentGO:0060429680.021
secretion by cellGO:00329401380.020
rna interferenceGO:00162461370.020
positive regulation of cell migrationGO:003033530.020
cellular nitrogen compound catabolic processGO:00442701190.020
cellular nitrogen compound biosynthetic processGO:00442711920.020
regulation of cellular macromolecule biosynthetic processGO:20001121880.020
posttranscriptional gene silencing by rnaGO:00351941430.020
positive regulation of cellular processGO:00485223320.020
axonogenesisGO:00074091020.020
anatomical structure formation involved in morphogenesisGO:00486462500.020
regulation of meiotic cell cycleGO:00514451360.020
muscle structure developmentGO:00610611910.019
cellular component morphogenesisGO:00329893180.019
cellular protein modification processGO:00064642070.019
Fly
cuticle developmentGO:00423351000.019
striated muscle cell developmentGO:00550021570.019
positive regulation of nitrogen compound metabolic processGO:00511731340.019
dauer larval developmentGO:0040024920.019
intracellular receptor signaling pathwayGO:003052220.018
myosin filament organizationGO:00310331380.018
negative regulation of biosynthetic processGO:0009890650.018
defense response to bacteriumGO:0042742860.018
response to abiotic stimulusGO:00096281520.018
nucleobase containing compound catabolic processGO:00346551140.018
biological adhesionGO:0022610210.018
heterocycle biosynthetic processGO:00181301870.018
mapk cascadeGO:0000165310.017
regulation of cellular ketone metabolic processGO:001056530.017
amine metabolic processGO:0009308150.017
positive regulation of catalytic activityGO:0043085590.017
cell morphogenesis involved in neuron differentiationGO:00486671110.017
aromatic compound biosynthetic processGO:00194381920.017
positive regulation of signalingGO:0023056660.017
oxoacid metabolic processGO:0043436470.017
oogenesisGO:00484772290.017
neuron projection guidanceGO:0097485820.017
organic cyclic compound catabolic processGO:19013611190.017
nucleoside monophosphate metabolic processGO:0009123460.017
positive regulation of gene expressionGO:00106281120.017
defense response to other organismGO:00985421000.016
positive regulation of cellular biosynthetic processGO:00313281090.016
protein phosphorylationGO:0006468850.016
Fly
purine nucleotide metabolic processGO:0006163950.016
rna splicingGO:000838080.016
phagocytosis engulfmentGO:0006911980.016
tube morphogenesisGO:0035239790.016
regulation of cell proliferationGO:00421271050.016
meiotic cell cycleGO:00513213350.016
negative regulation of cellular macromolecule biosynthetic processGO:2000113650.016
chromosome segregationGO:00070591800.015
neuron projection extensionGO:1990138370.015
regulation of intracellular signal transductionGO:1902531770.015
digestive tract developmentGO:00485651220.015
cell divisionGO:00513012620.015
Mouse
purine ribonucleoside metabolic processGO:0046128920.015
establishment or maintenance of cell polarityGO:0007163630.015
phosphorylationGO:00163101160.015
Fly
macromolecular complex subunit organizationGO:00439333200.015
Human
positive regulation of cell projection organizationGO:003134640.014
positive regulation of locomotionGO:0040017420.014
synaptic transmissionGO:00072681060.014
chemotaxisGO:00069351200.014
regulation of response to stimulusGO:00485832430.014
cell substrate adhesionGO:003158910.014
single organism intracellular transportGO:1902582700.014
neuromuscular junction developmentGO:000752820.014
positive regulation of metabolic processGO:00098931870.014
nucleoside phosphate metabolic processGO:00067531080.014
positive regulation of phosphorus metabolic processGO:0010562560.014
rna localizationGO:000640330.014
organic acid metabolic processGO:0006082470.014
regulation of cell developmentGO:0060284490.014
cell proliferationGO:00082831160.013
Fly
skeletal muscle organ developmentGO:006053830.013
regulation of nuclear divisionGO:00517831150.013
nucleotide catabolic processGO:0009166770.013
positive regulation of neuron differentiationGO:004566640.013
engulfment of apoptotic cellGO:0043652940.013
regulation of response to woundingGO:190303410.013
excretionGO:0007588490.013
tube developmentGO:00352951260.013
regulation of cell differentiationGO:0045595810.013
regulation of cell sizeGO:0008361300.013
chromosome organizationGO:00512761040.013
Human Fly
regulation of cell communicationGO:00106461760.012
regulation of cell divisionGO:00513021420.012
protein complex biogenesisGO:00702711860.012
regulation of purine nucleotide catabolic processGO:0033121350.012
cell fate commitmentGO:00451651390.012
muscle contractionGO:0006936430.012
protein modification processGO:00362112070.012
Fly
regulation of epithelial cell differentiationGO:003085640.012
developmental growth involved in morphogenesisGO:0060560370.012
negative regulation of nitrogen compound metabolic processGO:0051172630.012
carbohydrate derivative metabolic processGO:19011351410.012
nucleobase containing small molecule metabolic processGO:00550861150.012
regulation of cell cycleGO:00517261940.011
microtubule based processGO:00070171820.011
ribonucleotide catabolic processGO:0009261750.011
purine containing compound catabolic processGO:0072523750.011
regulation of lipid metabolic processGO:001921640.011
macromolecule modificationGO:00434122180.011
Fly
regulation of meiosisGO:0040020940.011
cellular response to abiotic stimulusGO:007121440.011
cellular response to endogenous stimulusGO:0071495320.011
negative regulation of cellular metabolic processGO:0031324950.011
digestive system developmentGO:00551231220.011
peptidyl tyrosine modificationGO:001821230.011
establishment of protein localizationGO:0045184500.011
negative regulation of nucleic acid templated transcriptionGO:1903507530.011
regulation of reproductive processGO:2000241660.011
cell growthGO:0016049440.011
defecationGO:0030421470.011
axon guidanceGO:0007411820.010
ribonucleoside metabolic processGO:0009119980.010
regulation of secretionGO:0051046290.010
mesoderm developmentGO:0007498270.010
cellular response to stressGO:00335541620.010
regulation of nervous system developmentGO:0051960410.010
secondary metabolic processGO:001974830.010
feeding behaviorGO:0007631700.010
regulation of neuron differentiationGO:0045664400.010
negative regulation of neurogenesisGO:005076840.010
regulation of cellular protein metabolic processGO:0032268750.010
regulation of nucleocytoplasmic transportGO:004682230.010
regulation of protein metabolic processGO:0051246810.010
positive regulation of biosynthetic processGO:00098911090.010

top-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.022
organ system cancerDOID:005068600.011
disease of cellular proliferationDOID:1456600.011
cancerDOID:16200.011
nervous system diseaseDOID:86300.010