IMP: Integrative Multi-species Prediction

Caenorhabditis elegans

10 known processes

arl-3 (CELE_F19H8.3)

Protein ARL-3

Entrez: 175121
UniProtKB: O45379

Process Predictions
Disease Predictions

arl-3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell projection organization	GO:0030030	231	0.302	Zebrafish Mouse Worm
single organism localization	GO:1902578	518	0.251	Mouse Worm
single organism transport	GO:0044765	447	0.248	Mouse Worm
cilium organization	GO:0044782	32	0.237	Mouse Worm
establishment of localization	GO:0051234	1171	0.203	Mouse Worm
cell development	GO:0048468	696	0.182	Zebrafish Mouse
organic substance catabolic process	GO:1901575	294	0.180	Mouse
embryo development ending in birth or egg hatching	GO:0009792	2992	0.179
cilium assembly	GO:0042384	28	0.145
response to chemical	GO:0042221	356	0.144	Zebrafish
neuron projection development	GO:0031175	187	0.131	Zebrafish
cell morphogenesis	GO:0000902	163	0.130	Zebrafish Worm
behavior	GO:0007610	527	0.130	Zebrafish
multicellular organismal aging	GO:0010259	812	0.126
embryo development	GO:0009790	3052	0.122
transport	GO:0006810	1093	0.115	Mouse Worm
aging	GO:0007568	812	0.113
cilium morphogenesis	GO:0060271	33	0.112	Worm
determination of adult lifespan	GO:0008340	812	0.110
protein localization	GO:0008104	205	0.107	Worm
single organism organelle organization	GO:1902589	501	0.107	Mouse Worm
catabolic process	GO:0009056	318	0.105	Mouse
organelle organization	GO:0006996	783	0.097	Mouse Worm
purine ribonucleoside triphosphate metabolic process	GO:0009205	87	0.097	Mouse
regulation of localization	GO:0032879	194	0.095	Zebrafish
regulation of biological quality	GO:0065008	741	0.093	Zebrafish
organonitrogen compound metabolic process	GO:1901564	151	0.088	Mouse
macromolecule localization	GO:0033036	771	0.088	Worm
nucleoside triphosphate metabolic process	GO:0009141	87	0.087	Mouse
regulation of multicellular organismal process	GO:0051239	726	0.087	Zebrafish
cellular component morphogenesis	GO:0032989	318	0.087	Zebrafish Worm
multicellular organism reproduction	GO:0032504	819	0.086
locomotion	GO:0040011	1634	0.085	Zebrafish
multicellular organismal reproductive behavior	GO:0033057	384	0.085
multi organism reproductive process	GO:0044703	867	0.085
anatomical structure formation involved in morphogenesis	GO:0048646	250	0.084
cellular localization	GO:0051641	360	0.081	Mouse Worm
multicellular organismal reproductive process	GO:0048609	815	0.079
regulation of transport	GO:0051049	91	0.079
gonad development	GO:0008406	840	0.075
post embryonic development	GO:0009791	2152	0.074
axon development	GO:0061564	163	0.074	Zebrafish
generation of neurons	GO:0048699	235	0.074	Zebrafish Mouse
growth	GO:0040007	562	0.073	Zebrafish
muscle tissue development	GO:0060537	1	0.072
purine nucleoside metabolic process	GO:0042278	92	0.072	Mouse
negative regulation of biological process	GO:0048519	567	0.071
system process	GO:0003008	136	0.071	Worm
receptor mediated endocytosis	GO:0006898	715	0.070
protein metabolic process	GO:0019538	422	0.070
regulation of behavior	GO:0050795	97	0.069	Zebrafish
multi organism reproductive behavior	GO:0044705	387	0.068
purine ribonucleoside metabolic process	GO:0046128	92	0.067	Mouse
reproductive behavior	GO:0019098	387	0.067
multi organism behavior	GO:0051705	389	0.066
regulation of locomotion	GO:0040012	161	0.066	Zebrafish
neuron development	GO:0048666	199	0.065	Zebrafish Mouse
macromolecule catabolic process	GO:0009057	202	0.064
maintenance of location	GO:0051235	580	0.062
multi multicellular organism process	GO:0044706	390	0.062
development of primary sexual characteristics	GO:0045137	840	0.061
organ development	GO:0048513	1102	0.058	Mouse
developmental process involved in reproduction	GO:0003006	1165	0.058
regulation of cellular component organization	GO:0051128	248	0.058	Zebrafish
regulation of developmental process	GO:0050793	684	0.058	Zebrafish
lipid localization	GO:0010876	573	0.057
lipid storage	GO:0019915	565	0.057
endocytosis	GO:0006897	819	0.056
regulation of nitrogen compound metabolic process	GO:0051171	222	0.055
cation transport	GO:0006812	78	0.055
reproductive system development	GO:0061458	850	0.054
cellular component biogenesis	GO:0044085	297	0.054
establishment of localization in cell	GO:0051649	318	0.054	Mouse Worm
cellular component assembly involved in morphogenesis	GO:0010927	183	0.053
protein catabolic process	GO:0030163	162	0.052
organelle assembly	GO:0070925	214	0.052
genitalia development	GO:0048806	741	0.051
hermaphrodite genitalia development	GO:0040035	734	0.051
neurogenesis	GO:0022008	236	0.051	Zebrafish Mouse
cell part morphogenesis	GO:0032990	152	0.051	Zebrafish Worm
organic substance transport	GO:0071702	113	0.048
body morphogenesis	GO:0010171	620	0.048
single organism behavior	GO:0044708	83	0.048
skeletal muscle organ development	GO:0060538	3	0.048
response to external stimulus	GO:0009605	289	0.048	Zebrafish
chemosensory behavior	GO:0007635	33	0.048
regulation of developmental growth	GO:0048638	389	0.048	Zebrafish
oviposition	GO:0018991	364	0.045
cellular component assembly	GO:0022607	293	0.045
phosphorus metabolic process	GO:0006793	232	0.044	Mouse
signaling	GO:0023052	401	0.044	Mouse
developmental growth	GO:0048589	412	0.044	Zebrafish
cellular component movement	GO:0006928	388	0.044	Zebrafish Mouse Worm
organophosphate metabolic process	GO:0019637	125	0.044	Mouse
localization of cell	GO:0051674	313	0.044
ribonucleoside triphosphate metabolic process	GO:0009199	87	0.044	Mouse
single organism reproductive process	GO:0044702	1196	0.043
cytoskeleton organization	GO:0007010	339	0.043
gene expression	GO:0010467	412	0.042
developmental growth involved in morphogenesis	GO:0060560	37	0.042	Zebrafish
head development	GO:0060322	1	0.041
axon extension	GO:0048675	37	0.041	Zebrafish
small molecule metabolic process	GO:0044281	186	0.041	Mouse
positive regulation of cellular metabolic process	GO:0031325	178	0.041
vesicle mediated transport	GO:0016192	852	0.041
purine ribonucleoside triphosphate catabolic process	GO:0009207	72	0.041	Mouse
regulation of multicellular organism growth	GO:0040014	373	0.039
single organism signaling	GO:0044700	401	0.039	Mouse
muscle structure development	GO:0061061	191	0.039
cellular macromolecule biosynthetic process	GO:0034645	247	0.039
sex differentiation	GO:0007548	909	0.038
reproductive structure development	GO:0048608	850	0.038
axonogenesis	GO:0007409	102	0.038	Zebrafish
multicellular organism growth	GO:0035264	385	0.038
positive regulation of nitrogen compound metabolic process	GO:0051173	134	0.038
actin filament based process	GO:0030029	191	0.037
carbohydrate derivative metabolic process	GO:1901135	141	0.037	Mouse
cell migration	GO:0016477	306	0.037
regulation of growth	GO:0040008	409	0.036	Zebrafish
neuron differentiation	GO:0030182	217	0.036	Zebrafish Mouse
neuron projection morphogenesis	GO:0048812	114	0.036	Zebrafish
positive regulation of locomotion	GO:0040017	42	0.035
positive regulation of macromolecule metabolic process	GO:0010604	149	0.035
nucleobase containing compound catabolic process	GO:0034655	114	0.035	Mouse
positive regulation of cellular process	GO:0048522	332	0.035
nucleobase containing small molecule metabolic process	GO:0055086	115	0.035	Mouse
positive regulation of developmental growth	GO:0048639	354	0.034
synaptic transmission	GO:0007268	106	0.034
purine nucleoside triphosphate catabolic process	GO:0009146	72	0.034	Mouse
organophosphate catabolic process	GO:0046434	81	0.034	Mouse
sexual reproduction	GO:0019953	546	0.034
feeding behavior	GO:0007631	70	0.034
response to wounding	GO:0009611	4	0.033
regulation of macromolecule metabolic process	GO:0060255	421	0.033
positive regulation of growth	GO:0045927	369	0.033
protein complex subunit organization	GO:0071822	280	0.032
regulation of multi organism process	GO:0043900	69	0.032
macromolecular complex subunit organization	GO:0043933	320	0.032
negative regulation of macromolecule metabolic process	GO:0010605	229	0.032
cell motility	GO:0048870	313	0.032
regulation of gene expression	GO:0010468	366	0.031
regulation of reproductive process	GO:2000241	66	0.031
phosphate containing compound metabolic process	GO:0006796	232	0.031	Mouse
regulation of cellular component size	GO:0032535	40	0.031	Zebrafish
regulation of cell differentiation	GO:0045595	81	0.031	Zebrafish
muscle cell development	GO:0055001	158	0.030
nucleoside catabolic process	GO:0009164	78	0.030	Mouse
cellular protein metabolic process	GO:0044267	279	0.029
turning behavior involved in mating	GO:0034607	12	0.029
organic cyclic compound catabolic process	GO:1901361	119	0.029	Mouse
regulation of response to stimulus	GO:0048583	243	0.029	Zebrafish
tissue development	GO:0009888	112	0.029
purine ribonucleoside monophosphate metabolic process	GO:0009167	43	0.029
organonitrogen compound catabolic process	GO:1901565	90	0.029	Mouse
ribonucleoside catabolic process	GO:0042454	77	0.028	Mouse
nucleoside phosphate metabolic process	GO:0006753	108	0.028	Mouse
nervous system development	GO:0007399	253	0.028	Zebrafish Mouse
biosynthetic process	GO:0009058	323	0.027
positive regulation of developmental process	GO:0051094	408	0.027
purine nucleotide metabolic process	GO:0006163	95	0.027	Mouse
regulation of cellular metabolic process	GO:0031323	305	0.027
cation transmembrane transport	GO:0098655	59	0.027
cell morphogenesis involved in differentiation	GO:0000904	112	0.027	Zebrafish
positive regulation of metabolic process	GO:0009893	187	0.026
cell cell signaling	GO:0007267	118	0.026
epithelial tube morphogenesis	GO:0060562	1	0.026
regulation of feeding behavior	GO:0060259	38	0.026
regulation of neuron differentiation	GO:0045664	40	0.026	Zebrafish
ion transmembrane transport	GO:0034220	91	0.026
negative regulation of neurogenesis	GO:0050768	4	0.026
response to abiotic stimulus	GO:0009628	152	0.026
posttranscriptional regulation of gene expression	GO:0010608	166	0.025
regulation of nucleoside metabolic process	GO:0009118	37	0.025
striated muscle cell differentiation	GO:0051146	158	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	87	0.025	Mouse
organic substance biosynthetic process	GO:1901576	323	0.025
nucleotide metabolic process	GO:0009117	108	0.025	Mouse
positive regulation of multicellular organism growth	GO:0040018	352	0.025
negative regulation of cellular process	GO:0048523	239	0.024
regulation of oviposition	GO:0046662	43	0.024
carbohydrate derivative catabolic process	GO:1901136	82	0.024	Mouse
mating behavior	GO:0007617	32	0.024
muscle cell differentiation	GO:0042692	171	0.024
ribose phosphate metabolic process	GO:0019693	99	0.024	Mouse
ribonucleoside metabolic process	GO:0009119	98	0.024	Mouse
regulation of endocytosis	GO:0030100	25	0.024
regulation of metabolic process	GO:0019222	478	0.024
negative regulation of multicellular organismal process	GO:0051241	236	0.024
purine ribonucleoside catabolic process	GO:0046130	75	0.023	Mouse
purine containing compound catabolic process	GO:0072523	75	0.023	Mouse
cell projection morphogenesis	GO:0048858	148	0.023	Zebrafish Worm
ion transport	GO:0006811	113	0.023
cellular biosynthetic process	GO:0044249	315	0.023
regulation of vesicle mediated transport	GO:0060627	27	0.023
nucleoside monophosphate metabolic process	GO:0009123	46	0.022
negative regulation of metabolic process	GO:0009892	240	0.022
macromolecule biosynthetic process	GO:0009059	250	0.022
regulation of nucleobase containing compound metabolic process	GO:0019219	222	0.022
cell growth	GO:0016049	44	0.022	Zebrafish
phosphorylation	GO:0016310	116	0.022
nucleic acid templated transcription	GO:0097659	169	0.022
ribonucleotide metabolic process	GO:0009259	99	0.022	Mouse
nucleotide catabolic process	GO:0009166	77	0.022	Mouse
striated muscle cell development	GO:0055002	157	0.022
cell death	GO:0008219	547	0.021
single organism catabolic process	GO:0044712	129	0.021	Mouse
ribonucleoside monophosphate metabolic process	GO:0009161	45	0.021
dauer larval development	GO:0040024	92	0.021
neuromuscular junction development	GO:0007528	2	0.021
secretion	GO:0046903	147	0.021
positive regulation of multicellular organismal process	GO:0051240	417	0.021
protein transport	GO:0015031	45	0.020
rna biosynthetic process	GO:0032774	169	0.020
male mating behavior	GO:0060179	26	0.020
regulation of pharyngeal pumping	GO:0043051	36	0.020
dorsal ventral axon guidance	GO:0033563	19	0.020
signal transduction	GO:0007165	317	0.020	Mouse
cellular catabolic process	GO:0044248	199	0.020	Mouse
nucleobase containing compound metabolic process	GO:0006139	406	0.020	Mouse
cellular nitrogen compound catabolic process	GO:0044270	119	0.020	Mouse
embryonic morphogenesis	GO:0048598	152	0.020
axon guidance	GO:0007411	82	0.020	Zebrafish
aromatic compound catabolic process	GO:0019439	116	0.019	Mouse
regulation of cell projection organization	GO:0031344	38	0.019	Zebrafish
death	GO:0016265	547	0.019
purine nucleoside monophosphate metabolic process	GO:0009126	43	0.019
nucleic acid metabolic process	GO:0090304	299	0.019
negative regulation of gene expression	GO:0010629	217	0.019
pharyngeal pumping	GO:0043050	58	0.018
protein modification process	GO:0036211	207	0.018
purine containing compound metabolic process	GO:0072521	95	0.018	Mouse
atp metabolic process	GO:0046034	42	0.018
macromolecule modification	GO:0043412	218	0.018
regulation of axonogenesis	GO:0050770	24	0.018	Zebrafish
positive regulation of nucleobase containing compound metabolic process	GO:0045935	134	0.018
cytoskeleton dependent intracellular transport	GO:0030705	19	0.018	Mouse Worm
cellular protein complex assembly	GO:0043623	178	0.018
rna metabolic process	GO:0016070	228	0.018
regulation of multicellular organismal development	GO:2000026	317	0.017	Zebrafish
cellular protein modification process	GO:0006464	207	0.017
transmembrane transport	GO:0055085	110	0.017
intracellular transport	GO:0046907	77	0.017	Mouse Worm
memory	GO:0007613	3	0.017
negative regulation of developmental process	GO:0051093	227	0.017
cell recognition	GO:0008037	85	0.017
cell substrate adhesion	GO:0031589	1	0.017
regulation of biosynthetic process	GO:0009889	189	0.017
detection of external stimulus	GO:0009581	4	0.017
positive regulation of rna metabolic process	GO:0051254	103	0.017
secretion by cell	GO:0032940	138	0.017
ribonucleoside triphosphate catabolic process	GO:0009203	72	0.016	Mouse
microtubule based process	GO:0007017	182	0.016	Mouse Worm
purine ribonucleotide catabolic process	GO:0009154	75	0.016	Mouse
regulation of macromolecule biosynthetic process	GO:0010556	189	0.016
myosin filament assembly	GO:0031034	138	0.016
regulation of molecular function	GO:0065009	89	0.016
adult behavior	GO:0030534	3	0.016
gamete generation	GO:0007276	461	0.016
purine nucleotide catabolic process	GO:0006195	75	0.016	Mouse
protein complex assembly	GO:0006461	186	0.015
regulation of extent of cell growth	GO:0061387	20	0.015	Zebrafish
muscle organ morphogenesis	GO:0048644	4	0.015
negative regulation of cell morphogenesis involved in differentiation	GO:0010771	2	0.015
programmed cell death	GO:0012501	500	0.015
regulation of cellular biosynthetic process	GO:0031326	189	0.015
purine nucleoside catabolic process	GO:0006152	75	0.015	Mouse
cell cycle	GO:0007049	526	0.015
positive regulation of biosynthetic process	GO:0009891	109	0.015
cellular nitrogen compound biosynthetic process	GO:0044271	192	0.015
myofibril assembly	GO:0030239	154	0.015
actin cytoskeleton organization	GO:0030036	184	0.015
regulation of signaling	GO:0023051	172	0.014
regulation of neurotransmitter levels	GO:0001505	36	0.014
regulation of cell morphogenesis involved in differentiation	GO:0010769	29	0.014	Zebrafish
positive regulation of neuron differentiation	GO:0045666	4	0.014
transcription dna templated	GO:0006351	168	0.014
protein oligomerization	GO:0051259	4	0.014
immune response	GO:0006955	192	0.014
cell projection assembly	GO:0030031	35	0.014
myosin filament organization	GO:0031033	138	0.014
locomotory behavior	GO:0007626	40	0.014
nucleoside metabolic process	GO:0009116	99	0.014	Mouse
germ cell development	GO:0007281	351	0.014
aromatic compound biosynthetic process	GO:0019438	192	0.014
intracellular receptor signaling pathway	GO:0030522	2	0.013
macromolecular complex assembly	GO:0065003	193	0.013
negative regulation of neuron differentiation	GO:0045665	4	0.013
negative regulation of cellular metabolic process	GO:0031324	95	0.013
apoptotic process	GO:0006915	478	0.013
cellular response to stress	GO:0033554	162	0.013
eating behavior	GO:0042755	59	0.013
muscle fiber development	GO:0048747	2	0.013
cell proliferation	GO:0008283	116	0.013
glycosyl compound metabolic process	GO:1901657	100	0.013	Mouse
regulation of anatomical structure size	GO:0090066	46	0.013	Zebrafish
cellular protein localization	GO:0034613	75	0.013	Worm
transcription from rna polymerase ii promoter	GO:0006366	149	0.013
regulation of cellular macromolecule biosynthetic process	GO:2000112	188	0.012
positive regulation of nucleic acid templated transcription	GO:1903508	102	0.012
guanosine containing compound metabolic process	GO:1901068	49	0.012	Mouse
nucleoside triphosphate catabolic process	GO:0009143	72	0.012	Mouse
protein complex biogenesis	GO:0070271	186	0.012
cellular macromolecular complex assembly	GO:0034622	184	0.012
acetylcholine metabolic process	GO:0008291	4	0.012
axonal fasciculation	GO:0007413	79	0.012
positive regulation of intracellular transport	GO:0032388	2	0.012
regulation of protein targeting	GO:1903533	3	0.012
regulation of post embryonic development	GO:0048580	260	0.012
collagen and cuticulin based cuticle development	GO:0040002	99	0.012
neurotransmitter transport	GO:0006836	32	0.012
sensory perception of chemical stimulus	GO:0007606	15	0.012	Worm
negative regulation of biosynthetic process	GO:0009890	65	0.012
positive regulation of phosphorus metabolic process	GO:0010562	56	0.012
regulation of gtp catabolic process	GO:0033124	32	0.012
heterocycle catabolic process	GO:0046700	119	0.012	Mouse
gtp catabolic process	GO:0006184	46	0.012	Mouse
synaptic target recognition	GO:0008039	3	0.012
regulation of phosphate metabolic process	GO:0019220	81	0.012
intracellular signal transduction	GO:0035556	96	0.012
carbohydrate metabolic process	GO:0005975	34	0.011
regulation of primary metabolic process	GO:0080090	292	0.011
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	4	0.011
regeneration	GO:0031099	4	0.011
chemotaxis	GO:0006935	120	0.011	Zebrafish
single organism intracellular transport	GO:1902582	70	0.011	Mouse Worm
regulation of cell proliferation	GO:0042127	105	0.011
positive regulation of cell migration	GO:0030335	3	0.011
positive regulation of gtpase activity	GO:0043547	28	0.011
regulation of phosphorus metabolic process	GO:0051174	81	0.011
inductive cell migration	GO:0040039	145	0.011
acetylcholine catabolic process	GO:0006581	4	0.011
glycosyl compound catabolic process	GO:1901658	79	0.011	Mouse
organic cyclic compound biosynthetic process	GO:1901362	195	0.011
regulation of protein metabolic process	GO:0051246	81	0.011
cell type specific apoptotic process	GO:0097285	4	0.011
taxis	GO:0042330	128	0.011	Zebrafish
regulation of rna metabolic process	GO:0051252	173	0.011
cellular macromolecule localization	GO:0070727	75	0.011	Worm
nonmotile primary cilium assembly	GO:0035058	18	0.011
neurotransmitter catabolic process	GO:0042135	4	0.011
ribonucleotide catabolic process	GO:0009261	75	0.011	Mouse
positive regulation of phosphate metabolic process	GO:0045937	56	0.011
amine metabolic process	GO:0009308	15	0.011
negative regulation of cellular component organization	GO:0051129	33	0.011
somatic muscle development	GO:0007525	1	0.011
establishment of protein localization	GO:0045184	50	0.011
sensory perception of taste	GO:0050909	4	0.011
regulation of purine nucleotide metabolic process	GO:1900542	37	0.010
positive regulation of catabolic process	GO:0009896	38	0.010
negative regulation of axonogenesis	GO:0050771	2	0.010
regulation of apoptotic signaling pathway	GO:2001233	1	0.010
response to organic substance	GO:0010033	131	0.010
regulation of gtpase activity	GO:0043087	30	0.010
positive regulation of cell projection organization	GO:0031346	4	0.010
negative regulation of axon extension	GO:0030517	2	0.010
turning behavior	GO:0035178	12	0.010

arl-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.032
	nervous system disease	DOID:863	0	0.018

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