Caenorhabditis elegans

92 known processes

plk-1 (CELE_C14B9.4)

Protein PLK-1

plk-1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo development ending in birth or egg hatchingGO:000979229920.845
embryo developmentGO:000979030520.650
meiotic chromosome segregationGO:00451321390.588
protein metabolic processGO:00195384220.563
Human Yeast Mouse Rat Fly
chromosome segregationGO:00070591800.526
multicellular organism reproductionGO:00325048190.516
positive regulation of catalytic activityGO:0043085590.486
Human Yeast
cell cycleGO:00070495260.460
female meiotic divisionGO:0007143170.414
apoptotic processGO:00069154780.409
endocytosisGO:00068978190.407
Fly
locomotionGO:004001116340.383
agingGO:00075688120.346
regulation of developmental processGO:00507936840.344
Fly
post embryonic developmentGO:000979121520.341
organelle fissionGO:00482853630.290
negative regulation of metabolic processGO:00098922400.283
Human
determination of adult lifespanGO:00083408120.277
cellular process involved in reproduction in multicellular organismGO:00224123510.268
multicellular organismal reproductive processGO:00486098150.256
receptor mediated endocytosisGO:00068987150.254
sexual reproductionGO:00199535460.253
meiotic cell cycle processGO:19030461700.245
cell developmentGO:00484686960.241
sister chromatid segregationGO:0000819460.236
Human
transportGO:000681010930.223
Fly
meiosis iGO:0007127190.222
Yeast Worm
oocyte developmentGO:0048599440.219
protein catabolic processGO:00301631620.218
Human
regulation of metabolic processGO:00192224780.218
Human Yeast
organ developmentGO:004851311020.216
gamete generationGO:00072764610.203
multicellular organismal agingGO:00102598120.202
regulation of mitotic cell cycleGO:0007346760.200
Human
vesicle mediated transportGO:00161928520.199
Fly
regulation of catalytic activityGO:0050790780.195
Human Yeast
post embryonic organ developmentGO:00485693360.193
phosphate containing compound metabolic processGO:00067962320.188
Human Yeast Mouse Rat Fly
negative regulation of biological processGO:00485195670.187
Human Fly
cell deathGO:00082195470.186
protein phosphorylationGO:0006468850.185
Human Yeast Mouse Rat Fly
single organism organelle organizationGO:19025895010.184
cell cycle processGO:00224024820.177
regulation of multicellular organismal processGO:00512397260.175
Fly
developmental process involved in reproductionGO:000300611650.174
reproductive structure developmentGO:00486088500.162
regulation of phosphate metabolic processGO:0019220810.151
Human
germ cell developmentGO:00072813510.150
anatomical structure formation involved in morphogenesisGO:00486462500.147
macromolecule localizationGO:00330367710.145
Human Yeast Fly
protein modification processGO:00362112070.142
Human Yeast Mouse Rat Fly
vulval developmentGO:00400253330.140
gonad developmentGO:00084068400.140
gene expressionGO:00104674120.138
Human
female gamete generationGO:00072922540.129
ovipositionGO:00189913640.127
cellular protein metabolic processGO:00442672790.127
Human Yeast Mouse Rat Fly
regulation of cell cycle processGO:00105641450.125
Human Yeast Worm
regulation of nematode larval developmentGO:00610622600.125
establishment of localizationGO:005123411710.123
Human Fly
cell divisionGO:00513012620.120
meiotic nuclear divisionGO:00071263000.120
positive regulation of molecular functionGO:0044093610.119
Human Yeast
single organism reproductive processGO:004470211960.118
neurogenesisGO:00220082360.117
Fly
cellular catabolic processGO:00442481990.112
Human
protein complex assemblyGO:00064611860.110
Yeast Fly
organelle assemblyGO:00709252140.108
Yeast Fly
developmental growthGO:00485894120.108
oogenesisGO:00484772290.105
regulation of vulval developmentGO:00400282480.105
macromolecular complex subunit organizationGO:00439333200.098
regulation of post embryonic developmentGO:00485802600.097
negative regulation of developmental processGO:00510932270.095
Fly
growthGO:00400075620.092
regulation of protein serine threonine kinase activityGO:0071900180.092
Human
organelle organizationGO:00069967830.087
regulation of cellular component organizationGO:00511282480.087
Human Yeast Worm
regulation of cell cycleGO:00517261940.085
regulation of phosphorus metabolic processGO:0051174810.083
Human
positive regulation of nucleoside metabolic processGO:0045979280.083
protein localizationGO:00081042050.082
Human Yeast Fly
cellular component biogenesisGO:00440852970.080
Yeast Fly
maintenance of locationGO:00512355800.077
phosphorus metabolic processGO:00067932320.077
Human Yeast Mouse Rat Fly
negative regulation of macromolecule metabolic processGO:00106052290.075
Human
cellular protein localizationGO:0034613750.074
Human Fly
macromolecule modificationGO:00434122180.070
Human Yeast Mouse Rat Fly
regulation of gene expressionGO:00104683660.069
Human
protein complex subunit organizationGO:00718222800.068
meiotic cell cycleGO:00513213350.068
macromolecule catabolic processGO:00090572020.068
Human
regulation of cellular protein metabolic processGO:0032268750.068
Human
cell cycle phase transitionGO:0044770190.067
Human
phosphorylationGO:00163101160.067
Human Yeast Mouse Rat Fly
behaviorGO:00076105270.067
reproductive system developmentGO:00614588500.067
chromosome organizationGO:00512761040.065
Human Yeast
posttranscriptional regulation of gene expressionGO:00106081660.065
Human
cellular protein modification processGO:00064642070.065
Human Yeast Mouse Rat Fly
deathGO:00162655470.063
positive regulation of developmental processGO:00510944080.062
regulation of multicellular organism growthGO:00400143730.061
single organism localizationGO:19025785180.061
Fly
cytokinesisGO:0000910800.060
regulation of microtubule cytoskeleton organizationGO:0070507210.060
Yeast
negative regulation of cell cycleGO:0045786530.058
Human
catabolic processGO:00090563180.058
Human
positive regulation of multicellular organismal processGO:00512404170.058
oocyte differentiationGO:0009994450.058
Fly
membrane organizationGO:00610241350.057
regulation of biological qualityGO:00650087410.057
Human
neuron projection developmentGO:00311751870.056
lipid localizationGO:00108765730.056
regulation of developmental growthGO:00486383890.056
cellular response to stressGO:00335541620.055
Human
lipid storageGO:00199155650.055
cytoskeleton organizationGO:00070103390.054
positive regulation of developmental growthGO:00486393540.054
hermaphrodite genitalia developmentGO:00400357340.054
mitotic nuclear divisionGO:0007067890.053
programmed cell deathGO:00125015000.053
single organism cellular localizationGO:1902580720.052
cellular macromolecule localizationGO:0070727750.052
Human Fly
regulation of growthGO:00400084090.052
cellular biosynthetic processGO:00442493150.052
Human
regulation of cell divisionGO:00513021420.051
Human Worm
multi organism reproductive processGO:00447038670.051
regulation of meiosisGO:0040020940.051
Worm
development of primary sexual characteristicsGO:00451378400.051
establishment of organelle localizationGO:00516561230.050
Fly
regulation of phosphorylationGO:0042325450.050
Human
negative regulation of cellular metabolic processGO:0031324950.049
Human
cellular component assemblyGO:00226072930.048
Yeast Fly
cell fate commitmentGO:00451651390.048
Fly
single organism biosynthetic processGO:0044711910.048
synaptonemal complex assemblyGO:000713060.047
nucleobase containing compound catabolic processGO:00346551140.045
negative regulation of cellular processGO:00485232390.045
Human Fly
multicellular organismal reproductive behaviorGO:00330573840.044
genitalia developmentGO:00488067410.044
positive regulation of growthGO:00459273690.044
multicellular organism growthGO:00352643850.044
negative regulation of multicellular organismal processGO:00512412360.044
Fly
sex differentiationGO:00075489090.043
dna duplex unwindingGO:003250830.042
positive regulation of multicellular organism growthGO:00400183520.042
regulation of gtp catabolic processGO:0033124320.041
organonitrogen compound metabolic processGO:19015641510.040
regulation of macromolecule biosynthetic processGO:00105561890.040
Human
negative regulation of cellular protein metabolic processGO:0032269270.040
Human
negative regulation of vulval developmentGO:00400272060.039
mitotic cell cycle processGO:19030471940.039
regulation of protein metabolic processGO:0051246810.039
Human
reproductive behaviorGO:00190983870.038
regulation of gene expression epigeneticGO:00400291630.038
digestive system developmentGO:00551231220.038
negative regulation of gene expressionGO:00106292170.038
Human
establishment of localization in cellGO:00516493180.038
Fly
cellular protein catabolic processGO:0044257370.037
Human
body morphogenesisGO:00101716200.037
organic substance biosynthetic processGO:19015763230.037
Human
generation of neuronsGO:00486992350.036
Fly
small molecule metabolic processGO:00442811860.036
regulation of organ morphogenesisGO:200002740.036
phagocytosisGO:00069091150.036
Fly
macromolecule biosynthetic processGO:00090592500.036
Human
negative regulation of cell cycle processGO:0010948120.035
Human
regulation of multicellular organismal developmentGO:20000263170.034
Fly
cell morphogenesisGO:00009021630.034
microtubule based processGO:00070171820.034
cell part morphogenesisGO:00329901520.033
apoptotic cell clearanceGO:00432771110.032
cellular component morphogenesisGO:00329893180.032
regulation of cell deathGO:0010941650.032
Human
nucleoside metabolic processGO:0009116990.032
tube morphogenesisGO:0035239790.031
neuron differentiationGO:00301822170.030
gene silencingGO:00164581430.030
regulation of cellular catabolic processGO:0031329510.030
Human
axonogenesisGO:00074091020.030
regulation of cellular metabolic processGO:00313233050.029
Human
multi organism reproductive behaviorGO:00447053870.029
organic substance catabolic processGO:19015752940.028
Human
negative regulation of nitrogen compound metabolic processGO:0051172630.028
Human
system processGO:00030081360.028
regulation of molecular functionGO:0065009890.028
Human Yeast
nervous system developmentGO:00073992530.028
Fly
axon developmentGO:00615641630.027
gene silencing by rnaGO:00310471430.026
positive regulation of phosphorus metabolic processGO:0010562560.025
Human
digestive tract morphogenesisGO:0048546760.025
spindle organizationGO:0007051920.025
cellular macromolecular complex assemblyGO:00346221840.025
Fly
phagocytosis engulfmentGO:0006911980.024
synapsisGO:0007129100.024
multi multicellular organism processGO:00447063900.024
cell projection morphogenesisGO:00488581480.024
posttranscriptional gene silencingGO:00164411430.024
regulation of macromolecule metabolic processGO:00602554210.023
Human
cellular component movementGO:00069283880.023
cytokinetic processGO:0032506100.023
Fly
signal transductionGO:00071653170.023
regulation of behaviorGO:0050795970.023
digestive tract developmentGO:00485651220.023
mitotic spindle organizationGO:0007052810.023
regulation of programmed cell deathGO:0043067500.023
Human
engulfment of apoptotic cellGO:0043652940.022
pronuclear migrationGO:0035046510.022
Fly
membrane invaginationGO:0010324980.022
negative regulation of nematode larval developmentGO:00610642080.022
cellular macromolecule biosynthetic processGO:00346452470.021
Human
macromolecular complex assemblyGO:00650031930.021
Yeast Fly
mitotic sister chromatid segregationGO:0000070380.021
Human
negative regulation of mitotic cell cycleGO:0045930420.021
Human
regulation of microtubule based processGO:0032886210.021
Yeast
positive regulation of protein metabolic processGO:0051247450.021
Human
endomembrane system organizationGO:0010256220.020
rna interferenceGO:00162461370.020
multi organism behaviorGO:00517053890.020
dna metabolic processGO:0006259740.020
Yeast
spindle localizationGO:0051653510.020
response to chemicalGO:00422213560.020
Rat
aromatic compound catabolic processGO:00194391160.020
muscle structure developmentGO:00610611910.020
response to abiotic stimulusGO:00096281520.020
epithelium developmentGO:0060429680.019
Fly
biosynthetic processGO:00090583230.019
Human
ribonucleoside triphosphate metabolic processGO:0009199870.019
cellular macromolecule catabolic processGO:0044265730.019
Human
dna conformation changeGO:0071103110.019
positive regulation of transferase activityGO:0051347210.018
Human
cellular nitrogen compound catabolic processGO:00442701190.018
signalingGO:00230524010.018
purine nucleoside metabolic processGO:0042278920.018
regulation of meiotic cell cycleGO:00514451360.018
Worm
negative regulation of gene expression epigeneticGO:004581420.018
cytoskeleton dependent cytokinesisGO:0061640350.018
regulation of hydrolase activityGO:0051336450.018
carbohydrate derivative catabolic processGO:1901136820.017
regulation of protein kinase activityGO:0045859280.017
Human
regulation of transferase activityGO:0051338310.017
Human
protein complex biogenesisGO:00702711860.017
Yeast Fly
cell migrationGO:00164773060.017
regulation of catabolic processGO:0009894570.017
Human
heterocycle catabolic processGO:00467001190.017
single organism transportGO:00447654470.017
Fly
organism emergence from protective structureGO:0071684480.017
ribose phosphate metabolic processGO:0019693990.016
regulation of protein localizationGO:0032880500.016
single organism catabolic processGO:00447121290.016
Human
response to heatGO:0009408500.016
cell projection organizationGO:00300302310.016
g1 s transition of mitotic cell cycleGO:000008220.016
nucleoside triphosphate metabolic processGO:0009141870.016
organonitrogen compound catabolic processGO:1901565900.016
dna geometric changeGO:003239230.016
dauer larval developmentGO:0040024920.016
transcription from rna polymerase ii promoterGO:00063661490.016
Human
positive regulation of cell cycleGO:0045787550.015
Human Yeast
carbohydrate derivative metabolic processGO:19011351410.015
regulation of cytoskeleton organizationGO:0051493410.015
Yeast
ribosome biogenesisGO:004225440.015
organophosphate metabolic processGO:00196371250.015
mitotic g2 m transition checkpointGO:004481810.015
nucleobase containing small molecule metabolic processGO:00550861150.015
regulation of nucleoside metabolic processGO:0009118370.015
cellular component assembly involved in morphogenesisGO:00109271830.015
localization of cellGO:00516743130.015
glycosyl compound catabolic processGO:1901658790.015
purine nucleoside triphosphate metabolic processGO:0009144870.015
sensory organ morphogenesisGO:009059620.015
regulation of apoptotic signaling pathwayGO:200123310.014
modification dependent macromolecule catabolic processGO:0043632320.014
Human
purine ribonucleoside catabolic processGO:0046130750.014
single organism signalingGO:00447004010.014
myosin filament organizationGO:00310331380.014
nucleoside catabolic processGO:0009164780.014
purine ribonucleoside triphosphate catabolic processGO:0009207720.014
cell cycle dna replicationGO:004478630.014
mitotic cell cycle phase transitionGO:0044772130.014
Human
posttranscriptional gene silencing by rnaGO:00351941430.014
embryonic morphogenesisGO:00485981520.014
negative regulation of signal transductionGO:0009968600.014
regulation of nuclear divisionGO:00517831150.013
Human Worm
chromosome condensationGO:003026160.013
ubiquitin dependent protein catabolic processGO:0006511320.013
Human
organophosphate catabolic processGO:0046434810.013
cell cycle g1 s phase transitionGO:004484320.013
chromatin remodelingGO:000633820.013
head developmentGO:006032210.013
regulation of purine nucleotide catabolic processGO:0033121350.013
regulation of dna catabolic processGO:190362410.013
positive regulation of protein kinase activityGO:0045860180.013
nucleoside phosphate catabolic processGO:1901292770.013
purine ribonucleoside metabolic processGO:0046128920.013
glycosyl compound metabolic processGO:19016571000.013
regulation of organelle organizationGO:00330431640.013
Human Yeast Worm
protein localization to organelleGO:0033365370.012
Human
neuron projection morphogenesisGO:00488121140.012
nucleoside triphosphate catabolic processGO:0009143720.012
fertilizationGO:0009566630.012
Fly
nematode male tail tip morphogenesisGO:0045138770.012
positive regulation of cellular metabolic processGO:00313251780.012
Human
pattern specification processGO:0007389590.012
negative regulation of cellular macromolecule biosynthetic processGO:2000113650.012
Human
single organism membrane organizationGO:0044802350.012
protein oligomerizationGO:005125940.012
neuron developmentGO:00486661990.012
peptidyl amino acid modificationGO:0018193580.012
Human
positive regulation of phosphate metabolic processGO:0045937560.012
Human
negative regulation of post embryonic developmentGO:00485812080.012
actin filament based processGO:00300291910.012
Fly
organ morphogenesisGO:0009887670.012
cellular localizationGO:00516413600.012
Human Fly
negative regulation of macromolecule biosynthetic processGO:0010558650.012
Human
muscle cell developmentGO:00550011580.012
nucleus localizationGO:0051647550.012
Fly
regulation of cellular amino acid metabolic processGO:000652100.012
positive regulation of gtpase activityGO:0043547280.011
negative regulation of mitotic cell cycle phase transitionGO:190199150.011
Human
purine nucleoside catabolic processGO:0006152750.011
nucleotide metabolic processGO:00091171080.011
actomyosin structure organizationGO:00310321540.011
Fly
negative regulation of chromosome segregationGO:005198540.011
Human
ribonucleoside catabolic processGO:0042454770.011
regulation of localizationGO:00328791940.011
purine ribonucleoside triphosphate metabolic processGO:0009205870.011
chromosome organization involved in meiosisGO:0070192250.011
cell cycle g2 m phase transitionGO:004483910.011
Human
male gamete generationGO:0048232410.011
Fly
cellular ketone metabolic processGO:0042180140.011
translationGO:0006412370.011
establishment of protein localizationGO:0045184500.011
Human
positive regulation of post embryonic developmentGO:0048582540.011
protein transportGO:0015031450.011
regulation of cellular amine metabolic processGO:003323800.011
guanosine containing compound metabolic processGO:1901068490.010
cell cycle switching mitotic to meiotic cell cycleGO:0051728350.010
tube developmentGO:00352951260.010
Fly
negative regulation of cell cycle phase transitionGO:190198860.010
Human
chromatin assemblyGO:003149710.010
spindle checkpointGO:003157740.010
Human
regulation of nucleotide catabolic processGO:0030811350.010
purine ribonucleotide metabolic processGO:0009150950.010
purine containing compound metabolic processGO:0072521950.010
positive regulation of mitotic sister chromatid separationGO:190197010.010
Human
organic acid metabolic processGO:0006082470.010
myosin filament assemblyGO:00310341380.010
regulation of purine nucleotide metabolic processGO:1900542370.010
actin cytoskeleton organizationGO:00300361840.010
Fly
regulation of epithelial cell differentiationGO:003085640.010

plk-1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
head and neck squamous cell carcinomaDOID:552000.010
head and neck carcinomaDOID:154200.010
cancerDOID:16200.010
disease of cellular proliferationDOID:1456600.010
organ system cancerDOID:005068600.010
head and neck cancerDOID:1193400.010