Caenorhabditis elegans

10 known processes

top-2 (CELE_K12D12.1)

Protein TOP-2

top-2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryo developmentGO:000979030520.808
reproductive structure developmentGO:00486088500.619
cell cycle processGO:00224024820.595
Yeast Fly
mitotic cell cycle processGO:19030471940.586
Yeast Fly
gene expressionGO:00104674120.564
Mouse Worm Fly
regulation of cell cycle processGO:00105641450.526
Yeast Fly
development of primary sexual characteristicsGO:00451378400.522
embryo development ending in birth or egg hatchingGO:000979229920.506
sex differentiationGO:00075489090.431
meiotic nuclear divisionGO:00071263000.408
Yeast
gonad developmentGO:00084068400.393
hermaphrodite genitalia developmentGO:00400357340.357
nucleic acid templated transcriptionGO:00976591690.352
Mouse Fly
post embryonic developmentGO:000979121520.344
Worm
regulation of vulval developmentGO:00400282480.344
organelle organizationGO:00069967830.343
Human Yeast Mouse Fly
regulation of macromolecule metabolic processGO:00602554210.323
Human Yeast Mouse Worm Fly
negative regulation of biological processGO:00485195670.317
Yeast Worm Fly
gene silencingGO:00164581430.264
Worm Fly
locomotionGO:004001116340.243
Zebrafish Mouse
regulation of gene expression epigeneticGO:00400291630.234
Worm Fly
regulation of transcription dna templatedGO:00063551640.234
Mouse Fly
single organism reproductive processGO:004470211960.224
mitotic spindle organizationGO:0007052810.221
Fly
regulation of organelle organizationGO:00330431640.209
cell motilityGO:00488703130.208
Mouse
regulation of nematode larval developmentGO:00610622600.203
cellular localizationGO:00516413600.188
Fly
microtubule based processGO:00070171820.177
Fly
chromosome segregationGO:00070591800.173
Human Zebrafish Mouse Fly
protein localizationGO:00081042050.167
cellular response to chemical stimulusGO:00708871290.166
mitotic nuclear divisionGO:0007067890.164
Fly
genitalia developmentGO:00488067410.162
positive regulation of nucleic acid templated transcriptionGO:19035081020.161
Mouse
cellular nitrogen compound biosynthetic processGO:00442711920.161
Mouse Fly
negative regulation of macromolecule metabolic processGO:00106052290.160
Worm Fly
regulation of metabolic processGO:00192224780.160
Human Yeast Mouse Worm Fly
regulation of post embryonic developmentGO:00485802600.158
microtubule cytoskeleton organization involved in mitosisGO:1902850120.158
cytoskeleton organizationGO:00070103390.156
Fly
transcription from rna polymerase ii promoterGO:00063661490.156
Mouse
macromolecular complex subunit organizationGO:00439333200.153
Yeast Fly
meiotic cell cycleGO:00513213350.152
Yeast
organic cyclic compound biosynthetic processGO:19013621950.143
Mouse Fly
cell cycleGO:00070495260.141
Yeast Fly
positive regulation of rna metabolic processGO:00512541030.140
Human Mouse
head developmentGO:006032210.140
Mouse
negative regulation of cellular biosynthetic processGO:0031327650.139
Fly
cellular response to organic substanceGO:00713101190.136
negative regulation of vulval developmentGO:00400272060.132
negative regulation of cellular processGO:00485232390.132
Yeast Fly
dna metabolic processGO:0006259740.131
Human Yeast Mouse Fly
nucleobase containing compound biosynthetic processGO:00346541840.131
Mouse Fly
cell migrationGO:00164773060.126
Mouse
spindle organizationGO:0007051920.123
Fly
wnt signaling pathwayGO:0016055270.117
establishment of localization in cellGO:00516493180.116
Fly
organelle fissionGO:00482853630.116
Yeast Fly
regulation of gene expressionGO:00104683660.115
Mouse Worm Fly
transportGO:000681010930.115
Worm
developmental process involved in reproductionGO:000300611650.108
positive regulation of nucleobase containing compound metabolic processGO:00459351340.108
Human Mouse
cellular component biogenesisGO:00440852970.106
attachment of mitotic spindle microtubules to kinetochoreGO:005131560.106
ovipositionGO:00189913640.105
regulation of cell divisionGO:00513021420.105
negative regulation of gene expressionGO:00106292170.104
Worm Fly
meiotic chromosome segregationGO:00451321390.102
regulation of nucleobase containing compound metabolic processGO:00192192220.100
Human Yeast Mouse Fly
positive regulation of gene expressionGO:00106281120.100
Mouse
posttranscriptional regulation of gene expressionGO:00106081660.099
Worm
negative regulation of nucleic acid templated transcriptionGO:1903507530.097
Fly
regulation of nucleic acid templated transcriptionGO:19035061650.095
Mouse Fly
polar body extrusion after meiotic divisionsGO:0040038140.094
dna packagingGO:000632370.094
Human Mouse Fly
posttranscriptional gene silencingGO:00164411430.093
Worm
single organism localizationGO:19025785180.093
localization of cellGO:00516743130.091
Mouse
post embryonic organ developmentGO:00485693360.091
establishment of localizationGO:005123411710.091
Worm Fly
rna biosynthetic processGO:00327741690.090
Mouse Fly
posttranscriptional gene silencing by rnaGO:00351941430.089
Worm
cell divisionGO:00513012620.089
Mouse
multicellular organism reproductionGO:00325048190.088
aromatic compound catabolic processGO:00194391160.087
Human Yeast Mouse Fly
single organism transportGO:00447654470.085
negative regulation of nematode larval developmentGO:00610642080.085
vesicle mediated transportGO:00161928520.085
Worm
gamete generationGO:00072764610.082
macromolecule localizationGO:00330367710.082
rna metabolic processGO:00160702280.079
Human Mouse Fly
regulation of macromolecule biosynthetic processGO:00105561890.079
Yeast Mouse Fly
metaphase plate congressionGO:005131050.076
Fly
regulation of meiotic cell cycleGO:00514451360.075
negative regulation of nucleobase containing compound metabolic processGO:0045934630.075
Fly
positive regulation of biosynthetic processGO:00098911090.072
Mouse
regulation of mitotic cell cycleGO:0007346760.072
Yeast Fly
negative regulation of post embryonic developmentGO:00485812080.071
negative regulation of metabolic processGO:00098922400.070
Worm Fly
sensory organ morphogenesisGO:009059620.069
Zebrafish
macromolecular complex assemblyGO:00650031930.068
negative regulation of gene expression epigeneticGO:004581420.067
Fly
reproductive system developmentGO:00614588500.067
rna interferenceGO:00162461370.067
Worm
nucleic acid metabolic processGO:00903042990.066
Human Yeast Mouse Fly
response to chemicalGO:00422213560.065
Zebrafish
vulval developmentGO:00400253330.064
negative regulation of developmental processGO:00510932270.063
determination of adult lifespanGO:00083408120.063
inductive cell migrationGO:00400391450.063
positive regulation of rna biosynthetic processGO:19026801020.061
Mouse
positive regulation of nematode larval developmentGO:0061063540.060
regulation of meiosisGO:0040020940.060
aromatic compound biosynthetic processGO:00194381920.060
Mouse Fly
single organism organelle organizationGO:19025895010.059
Human Yeast Mouse Fly
maintenance of locationGO:00512355800.059
receptor mediated endocytosisGO:00068987150.059
Worm
histone modificationGO:0016570300.057
negative regulation of cell cycleGO:0045786530.056
Yeast Fly
cellular process involved in reproduction in multicellular organismGO:00224123510.055
organelle assemblyGO:00709252140.055
cellular component movementGO:00069283880.055
Zebrafish Mouse
regulation of primary metabolic processGO:00800902920.055
Human Yeast Mouse Fly
positive regulation of neurogenesisGO:005076940.054
single organism cellular localizationGO:1902580720.054
chromatin remodelingGO:000633820.053
Yeast
covalent chromatin modificationGO:0016569300.052
agingGO:00075688120.052
cellular component assemblyGO:00226072930.052
positive regulation of cellular metabolic processGO:00313251780.052
Human Mouse
chromosome organizationGO:00512761040.052
Human Yeast Mouse Fly
positive regulation of vulval developmentGO:0040026520.052
endocytosisGO:00068978190.052
Worm
negative regulation of rna biosynthetic processGO:1902679530.051
Fly
chromatin assembly or disassemblyGO:000633310.051
Yeast
negative regulation of transcription dna templatedGO:0045892530.050
Fly
protein complex subunit organizationGO:00718222800.050
Fly
molting cycleGO:00423032810.049
regulation of biological qualityGO:00650087410.049
lipid storageGO:00199155650.049
regulation of multicellular organismal developmentGO:20000263170.048
transcription dna templatedGO:00063511680.048
Mouse Fly
positive regulation of multicellular organismal processGO:00512404170.048
organic substance catabolic processGO:19015752940.047
Human Yeast Mouse Fly
meiotic cell cycle processGO:19030461700.047
Yeast
regulation of rna biosynthetic processGO:20011411650.047
Mouse Fly
negative regulation of cellular macromolecule biosynthetic processGO:2000113650.047
Fly
germ cell developmentGO:00072813510.046
negative regulation of macromolecule biosynthetic processGO:0010558650.046
Fly
cellular response to stressGO:00335541620.045
Human Fly
positive regulation of cellular processGO:00485223320.045
Human Mouse
dna conformation changeGO:0071103110.045
Human Yeast Mouse Fly
regulation of localizationGO:00328791940.045
anatomical structure formation involved in morphogenesisGO:00486462500.043
Zebrafish
organonitrogen compound metabolic processGO:19015641510.043
Human Yeast Mouse Fly
chromatin organizationGO:0006325320.042
Yeast
regulation of cellular macromolecule biosynthetic processGO:20001121880.042
Yeast Mouse Fly
protein complex biogenesisGO:00702711860.042
cellular macromolecular complex assemblyGO:00346221840.042
nucleobase containing compound metabolic processGO:00061394060.041
Human Yeast Mouse Fly
catabolic processGO:00090563180.040
Human Yeast Mouse Fly
rna processingGO:0006396340.040
regulation of protein localizationGO:0032880500.039
lipid localizationGO:00108765730.039
negative regulation of nitrogen compound metabolic processGO:0051172630.038
Fly
cell developmentGO:00484686960.038
Zebrafish Mouse
nucleobase containing compound catabolic processGO:00346551140.038
Human Yeast Mouse Fly
regulation of cellular localizationGO:0060341420.038
negative regulation of rna metabolic processGO:0051253530.038
Fly
regulation of developmental processGO:00507936840.037
biosynthetic processGO:00090583230.037
Yeast Mouse Fly
attachment of spindle microtubules to kinetochoreGO:000860880.037
gene silencing by rnaGO:00310471430.036
Worm
organic substance biosynthetic processGO:19015763230.036
Yeast Mouse Fly
canonical wnt signaling pathwayGO:006007030.036
multicellular organismal reproductive processGO:00486098150.036
positive regulation of cellular biosynthetic processGO:00313281090.036
Mouse
ribonucleoprotein complex assemblyGO:002261840.036
mitotic sister chromatid segregationGO:0000070380.035
Fly
organelle localizationGO:00516401270.035
Fly
multicellular organismal agingGO:00102598120.035
spindle assembly involved in mitosisGO:009030760.035
multicellular organismal reproductive behaviorGO:00330573840.035
negative regulation of multicellular organismal processGO:00512412360.034
regulation of multicellular organismal processGO:00512397260.034
cell proliferationGO:00082831160.034
negative regulation of cell cycle processGO:0010948120.033
Yeast Fly
rna localizationGO:000640330.032
response to external stimulusGO:00096052890.032
Zebrafish
organic substance transportGO:00717021130.032
regulation of biosynthetic processGO:00098891890.032
Yeast Mouse Fly
regulation of cellular component organizationGO:00511282480.032
developmental growthGO:00485894120.032
body morphogenesisGO:00101716200.031
behaviorGO:00076105270.030
regulation of nuclear divisionGO:00517831150.030
neuron projection morphogenesisGO:00488121140.030
Zebrafish Mouse
heterocycle biosynthetic processGO:00181301870.030
Mouse Fly
regulation of cell cycleGO:00517261940.029
Yeast Fly
ribonucleoside monophosphate metabolic processGO:0009161450.029
Human Yeast Mouse Fly
sister chromatid segregationGO:0000819460.029
Fly
negative regulation of signal transductionGO:0009968600.029
sexual reproductionGO:00199535460.028
cellular biosynthetic processGO:00442493150.028
Yeast Mouse Fly
multi organism reproductive processGO:00447038670.028
regulation of cellular metabolic processGO:00313233050.028
Human Yeast Mouse Fly
regulation of organ morphogenesisGO:200002740.028
regulation of chromosome organizationGO:0033044200.027
regulation of rna metabolic processGO:00512521730.027
Human Mouse Fly
negative regulation of biosynthetic processGO:0009890650.027
Fly
secretion by cellGO:00329401380.027
response to organic substanceGO:00100331310.027
positive regulation of chromosome organizationGO:200125220.027
signal transductionGO:00071653170.026
multi organism behaviorGO:00517053890.026
organ developmentGO:004851311020.025
Zebrafish Mouse
regulation of growthGO:00400084090.025
cellular nitrogen compound catabolic processGO:00442701190.025
Human Yeast Mouse Fly
regulation of multicellular organism growthGO:00400143730.025
organ morphogenesisGO:0009887670.025
Zebrafish
protein dna complex subunit organizationGO:007182470.024
cell deathGO:00082195470.024
Human
multi organism reproductive behaviorGO:00447053870.024
cellular macromolecule biosynthetic processGO:00346452470.024
Yeast Mouse Fly
positive regulation of multicellular organism growthGO:00400183520.024
small molecule metabolic processGO:00442811860.023
Human Yeast Mouse Fly
regulation of response to stimulusGO:00485832430.023
intracellular transportGO:0046907770.023
reproductive behaviorGO:00190983870.023
axon guidanceGO:0007411820.023
Zebrafish
organic cyclic compound catabolic processGO:19013611190.023
Human Yeast Mouse Fly
centromere complex assemblyGO:003450850.023
regulation of mitotic spindle organizationGO:006023630.023
cellular protein complex assemblyGO:00436231780.022
cell surface receptor signaling pathwayGO:00071661490.022
purine containing compound metabolic processGO:0072521950.022
Human Yeast Mouse Fly
single organism biosynthetic processGO:0044711910.022
cuticle developmentGO:00423351000.022
nervous system developmentGO:00073992530.022
Zebrafish Mouse
positive regulation of growthGO:00459273690.021
male gamete generationGO:0048232410.021
regulation of nitrogen compound metabolic processGO:00511712220.021
Human Yeast Mouse Fly
chromatin assemblyGO:003149710.021
intracellular signal transductionGO:0035556960.021
establishment of organelle localizationGO:00516561230.021
Fly
positive regulation of transcription dna templatedGO:00458931020.020
Mouse
system processGO:00030081360.020
defense responseGO:00069522960.020
negative regulation of response to stimulusGO:0048585730.020
response to oxygen containing compoundGO:1901700440.020
small gtpase mediated signal transductionGO:0007264320.019
purine containing compound catabolic processGO:0072523750.019
Human Yeast Mouse Fly
regulation of chromatin modificationGO:190330820.019
positive regulation of macromolecule biosynthetic processGO:00105571090.019
Mouse
positive regulation of developmental growthGO:00486393540.019
digestive system developmentGO:00551231220.019
atp catabolic processGO:0006200270.019
Human Yeast Mouse Fly
programmed cell deathGO:00125015000.018
Human
oocyte differentiationGO:0009994450.018
chromatin modificationGO:0016568320.018
Yeast
carbohydrate derivative catabolic processGO:1901136820.018
Human Yeast Mouse Fly
engulfment of apoptotic cellGO:0043652940.018
nucleic acid transportGO:005065730.018
dna templated transcription elongationGO:000635410.018
multicellular organism growthGO:00352643850.018
mitotic g2 m transition checkpointGO:004481810.018
Fly
striated muscle cell developmentGO:00550021570.018
g1 s transition of mitotic cell cycleGO:000008220.018
regulation of protein import into nucleusGO:004230630.018
dna geometric changeGO:003239230.018
Yeast
negative regulation of signalingGO:0023057610.017
neuron differentiationGO:00301822170.017
Zebrafish Mouse
dna duplex unwindingGO:003250830.017
Yeast
negative regulation of neurogenesisGO:005076840.017
organophosphate metabolic processGO:00196371250.017
Human Yeast Mouse Fly
oocyte constructionGO:000730820.017
establishment of rna localizationGO:005123630.017
regulation of nucleocytoplasmic transportGO:004682230.017
establishment of chromosome localizationGO:0051303100.016
Fly
oogenesisGO:00484772290.016
fertilizationGO:0009566630.016
transcription elongation from rna polymerase ii promoterGO:000636810.016
organic acid metabolic processGO:0006082470.016
nucleus organizationGO:0006997380.016
regulation of transcription from rna polymerase ii promoterGO:00063571450.016
Mouse
purine ribonucleoside triphosphate catabolic processGO:0009207720.016
Human Yeast Mouse Fly
cellular response to inorganic substanceGO:007124130.016
epithelial tube morphogenesisGO:006056210.016
purine ribonucleotide metabolic processGO:0009150950.016
Human Yeast Mouse Fly
cytokinesisGO:0000910800.016
heterocycle catabolic processGO:00467001190.016
Human Yeast Mouse Fly
rna transportGO:005065830.016
positive regulation of transcription from rna polymerase ii promoterGO:0045944980.015
Mouse
apoptotic processGO:00069154780.015
Human
nitrogen compound transportGO:0071705490.015
atp metabolic processGO:0046034420.015
Human Yeast Mouse Fly
purine nucleoside metabolic processGO:0042278920.015
Human Yeast Mouse Fly
regulation of cytoplasmic transportGO:190364930.015
multi multicellular organism processGO:00447063900.015
regulation of developmental growthGO:00486383890.015
spermatogenesisGO:0007283410.015
positive regulation of response to stimulusGO:0048584550.014
purine nucleoside monophosphate catabolic processGO:0009128280.014
Human Yeast Mouse Fly
neurogenesisGO:00220082360.014
Zebrafish Mouse
ribonucleoside triphosphate catabolic processGO:0009203720.014
Human Yeast Mouse Fly
collagen and cuticulin based cuticle developmentGO:0040002990.014
spindle localizationGO:0051653510.014
actomyosin structure organizationGO:00310321540.014
tube developmentGO:00352951260.014
cell cycle phase transitionGO:0044770190.014
Yeast Fly
deoxyribonucleotide biosynthetic processGO:000926310.014
positive regulation of metabolic processGO:00098931870.014
Human Mouse
protein localization to organelleGO:0033365370.013
oocyte developmentGO:0048599440.013
purine ribonucleotide catabolic processGO:0009154750.013
Human Yeast Mouse Fly
regulation of programmed cell deathGO:0043067500.013
Human
growthGO:00400075620.013
purine ribonucleoside monophosphate metabolic processGO:0009167430.013
Human Yeast Mouse Fly
phosphate containing compound metabolic processGO:00067962320.013
Human Yeast Mouse Fly
oocyte axis specificationGO:000730920.013
nucleobase containing small molecule metabolic processGO:00550861150.013
Human Yeast Mouse Fly
ribonucleoside catabolic processGO:0042454770.013
Human Yeast Mouse Fly
response to woundingGO:000961140.013
phosphorus metabolic processGO:00067932320.013
Human Yeast Mouse Fly
dna repairGO:0006281230.013
negative regulation of neuron differentiationGO:004566540.013
chromosome localizationGO:0050000100.013
Fly
protein complex assemblyGO:00064611860.012
phagocytosis engulfmentGO:0006911980.012
positive regulation of developmental processGO:00510944080.012
ribonucleotide catabolic processGO:0009261750.012
Human Yeast Mouse Fly
microtubule anchoringGO:003445380.012
cell part morphogenesisGO:00329901520.012
Zebrafish Mouse
regulation of cell cycle phase transitionGO:1901987130.012
Yeast Fly
stem cell divisionGO:0017145180.012
sister chromatid biorientationGO:003113420.012
regulation of microtubule based processGO:0032886210.012
neurological system processGO:0050877530.012
dna recombinationGO:0006310190.012
Yeast
mitotic metaphase plate congressionGO:000708050.012
regenerationGO:003109940.012
Zebrafish
cellular protein metabolic processGO:00442672790.012
negative regulation of cell communicationGO:0010648610.012
chemotaxisGO:00069351200.012
Zebrafish
axonogenesisGO:00074091020.011
Zebrafish Mouse
protein transportGO:0015031450.011
regulation of cell proliferationGO:00421271050.011
kinetochore organizationGO:005138370.011
regulation of canonical wnt signaling pathwayGO:006082810.011
regulation of histone modificationGO:003105610.011
cellular macromolecule catabolic processGO:0044265730.011
cell cycle g1 s phase transitionGO:004484320.011
glycoprotein metabolic processGO:0009100290.011
myosin filament organizationGO:00310331380.011
mitotic cell cycle phase transitionGO:0044772130.011
Yeast Fly
phagocytosisGO:00069091150.011
mrna processingGO:0006397130.011
protein oligomerizationGO:005125940.011
glycosyl compound catabolic processGO:1901658790.011
Human Yeast Mouse Fly
actin filament based processGO:00300291910.011
purine nucleotide metabolic processGO:0006163950.011
Human Yeast Mouse Fly
tube morphogenesisGO:0035239790.011
macromolecule modificationGO:00434122180.010
positive regulation of cellular component organizationGO:0051130340.010
glycosyl compound metabolic processGO:19016571000.010
Human Yeast Mouse Fly
regulation of microtubule cytoskeleton organizationGO:0070507210.010
axis specificationGO:0009798230.010
molting cycle collagen and cuticulin based cuticleGO:00189962810.010
regulation of chromatin organizationGO:190227520.010
positive regulation of protein transportGO:005122240.010
ribonucleoside monophosphate catabolic processGO:0009158280.010
Human Yeast Mouse Fly
ribonucleotide metabolic processGO:0009259990.010
Human Yeast Mouse Fly
ras protein signal transductionGO:0007265310.010
muscle cell developmentGO:00550011580.010
regulation of response to woundingGO:190303410.010
tissue developmentGO:00098881120.010
Zebrafish
negative regulation of cellular component organizationGO:0051129330.010
tube formationGO:003514820.010

top-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in worm and predicted with the worm functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.047
disease of cellular proliferationDOID:1456600.029
nervous system diseaseDOID:86300.019
cardiovascular system diseaseDOID:128700.016
heart diseaseDOID:11400.012