IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

131 known processes

RAD5 (YLR032W)

Rad5p

(Aliases: REV2,SNM2)

SGD: S000004022
Entrez: 850719
UniProtKB: P32849

Process Predictions
Disease Predictions

RAD5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
dna repair	GO:0006281	236	0.999
cellular response to dna damage stimulus	GO:0006974	287	0.988
postreplication repair	GO:0006301	24	0.951
dna biosynthetic process	GO:0071897	33	0.928
error prone translesion synthesis	GO:0042276	11	0.887
dna recombination	GO:0006310	172	0.833
double strand break repair	GO:0006302	105	0.812
recombinational repair	GO:0000725	64	0.765
translesion synthesis	GO:0019985	16	0.757
double strand break repair via homologous recombination	GO:0000724	54	0.734
error free translesion synthesis	GO:0070987	9	0.693
telomere organization	GO:0032200	75	0.635
nucleotide excision repair	GO:0006289	50	0.506
homeostatic process	GO:0042592	227	0.495
lagging strand elongation	GO:0006273	10	0.470
negative regulation of biosynthetic process	GO:0009890	312	0.462
mitotic recombination	GO:0006312	55	0.442
meiotic cell cycle	GO:0051321	272	0.442
telomere maintenance via recombination	GO:0000722	32	0.441
cellular macromolecule catabolic process	GO:0044265	363	0.430
regulation of dna metabolic process	GO:0051052	100	0.413
telomere maintenance	GO:0000723	74	0.403
macromolecule catabolic process	GO:0009057	383	0.333
meiotic cell cycle process	GO:1903046	229	0.323
regulation of biological quality	GO:0065008	391	0.306
dna dependent dna replication	GO:0006261	115	0.285
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.273
maintenance of dna repeat elements	GO:0043570	20	0.265
heterocycle catabolic process	GO:0046700	494	0.261
meiotic nuclear division	GO:0007126	163	0.241
organic cyclic compound catabolic process	GO:1901361	499	0.228
mitotic sister chromatid cohesion	GO:0007064	38	0.226
anatomical structure homeostasis	GO:0060249	74	0.218
dna strand elongation involved in dna replication	GO:0006271	26	0.216
rna dependent dna replication	GO:0006278	25	0.214
meiotic cell cycle checkpoint	GO:0033313	10	0.203
cellular nitrogen compound catabolic process	GO:0044270	494	0.199
dna strand elongation	GO:0022616	29	0.190
double strand break repair via break induced replication	GO:0000727	25	0.189
negative regulation of cellular biosynthetic process	GO:0031327	312	0.178
nucleic acid phosphodiester bond hydrolysis	GO:0090305	194	0.177
reciprocal dna recombination	GO:0035825	54	0.163
nucleoside metabolic process	GO:0009116	394	0.156
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.155
reproduction of a single celled organism	GO:0032505	191	0.151
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.145
base excision repair	GO:0006284	14	0.144
sister chromatid cohesion	GO:0007062	49	0.142
negative regulation of rna metabolic process	GO:0051253	262	0.140
dna replication	GO:0006260	147	0.138
negative regulation of gene expression	GO:0010629	312	0.137
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.133
non recombinational repair	GO:0000726	33	0.133
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.132
purine nucleotide metabolic process	GO:0006163	376	0.125
nucleobase containing compound catabolic process	GO:0034655	479	0.124
positive regulation of gene expression	GO:0010628	321	0.123
purine ribonucleotide metabolic process	GO:0009150	372	0.123
purine nucleoside triphosphate catabolic process	GO:0009146	329	0.121
meiosis i	GO:0007127	92	0.120
aromatic compound catabolic process	GO:0019439	491	0.115
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.115
ribonucleoside metabolic process	GO:0009119	389	0.112
regulation of dna repair	GO:0006282	14	0.110
purine ribonucleoside triphosphate catabolic process	GO:0009207	327	0.109
chromatin silencing	GO:0006342	147	0.107
positive regulation of macromolecule metabolic process	GO:0010604	394	0.105
mitochondrion organization	GO:0007005	261	0.104
organophosphate catabolic process	GO:0046434	338	0.103
chromatin silencing at telomere	GO:0006348	84	0.101
nuclear transport	GO:0051169	165	0.101
regulation of cellular component organization	GO:0051128	334	0.099
reciprocal meiotic recombination	GO:0007131	54	0.097
regulation of homeostatic process	GO:0032844	19	0.097
telomere maintenance via telomerase	GO:0007004	21	0.096
ribonucleoside triphosphate catabolic process	GO:0009203	327	0.096
regulation of chromosome organization	GO:0033044	66	0.095
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.095
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.094
dna replication okazaki fragment processing	GO:0033567	7	0.093
single organism catabolic process	GO:0044712	619	0.092
developmental process involved in reproduction	GO:0003006	159	0.090
developmental process	GO:0032502	261	0.088
negative regulation of chromosome organization	GO:2001251	39	0.088
ribonucleoside monophosphate metabolic process	GO:0009161	265	0.086
nucleotide catabolic process	GO:0009166	330	0.085
ribonucleotide metabolic process	GO:0009259	377	0.084
double strand break repair via nonhomologous end joining	GO:0006303	27	0.084
ribonucleoside catabolic process	GO:0042454	332	0.083
purine ribonucleotide catabolic process	GO:0009154	327	0.082
purine nucleoside metabolic process	GO:0042278	380	0.082
atp metabolic process	GO:0046034	251	0.081
protein import	GO:0017038	122	0.081
telomere maintenance via telomere lengthening	GO:0010833	22	0.079
regulation of organelle organization	GO:0033043	243	0.078
carbohydrate derivative catabolic process	GO:1901136	339	0.077
dna catabolic process	GO:0006308	42	0.075
protein dna complex subunit organization	GO:0071824	153	0.074
purine nucleotide catabolic process	GO:0006195	328	0.073
purine nucleoside monophosphate metabolic process	GO:0009126	262	0.072
negative regulation of cellular metabolic process	GO:0031324	407	0.071
dna geometric change	GO:0032392	43	0.071
response to chemical	GO:0042221	390	0.070
mismatch repair	GO:0006298	14	0.069
gene conversion at mating type locus	GO:0007534	11	0.068
nucleobase containing small molecule metabolic process	GO:0055086	491	0.068
negative regulation of gene expression epigenetic	GO:0045814	147	0.067
intracellular protein transport	GO:0006886	319	0.066
nuclear division	GO:0000280	263	0.065
meiotic mismatch repair	GO:0000710	9	0.064
negative regulation of macromolecule metabolic process	GO:0010605	375	0.063
monosaccharide metabolic process	GO:0005996	83	0.063
anatomical structure morphogenesis	GO:0009653	160	0.063
nucleotide metabolic process	GO:0009117	453	0.061
nucleoside catabolic process	GO:0009164	335	0.061
regulation of dna templated transcription in response to stress	GO:0043620	51	0.060
regulation of gene expression epigenetic	GO:0040029	147	0.059
cell aging	GO:0007569	70	0.058
negative regulation of dna metabolic process	GO:0051053	36	0.057
organophosphate metabolic process	GO:0019637	597	0.057
purine ribonucleoside metabolic process	GO:0046128	380	0.057
ribonucleotide catabolic process	GO:0009261	327	0.057
purine nucleoside catabolic process	GO:0006152	330	0.056
protein ubiquitination	GO:0016567	118	0.055
negative regulation of cell cycle phase transition	GO:1901988	59	0.055
negative regulation of dna replication	GO:0008156	15	0.054
positive regulation of dna metabolic process	GO:0051054	26	0.054
glycosyl compound metabolic process	GO:1901657	398	0.054
cellular developmental process	GO:0048869	191	0.053
organonitrogen compound catabolic process	GO:1901565	404	0.053
establishment of protein localization to organelle	GO:0072594	278	0.052
purine ribonucleoside catabolic process	GO:0046130	330	0.052
positive regulation of biosynthetic process	GO:0009891	336	0.051
positive regulation of cellular biosynthetic process	GO:0031328	336	0.051
nucleoside triphosphate catabolic process	GO:0009143	329	0.051
meiotic recombination checkpoint	GO:0051598	9	0.051
ribose phosphate metabolic process	GO:0019693	384	0.051
cellular protein catabolic process	GO:0044257	213	0.050
hexose metabolic process	GO:0019318	78	0.049
organelle fission	GO:0048285	272	0.049
positive regulation of rna biosynthetic process	GO:1902680	286	0.048
single organism reproductive process	GO:0044702	159	0.048
cell differentiation	GO:0030154	161	0.047
response to oxidative stress	GO:0006979	99	0.047
protein complex biogenesis	GO:0070271	314	0.047
purine nucleoside monophosphate catabolic process	GO:0009128	224	0.045
response to uv	GO:0009411	4	0.045
carbohydrate derivative metabolic process	GO:1901135	549	0.045
protein complex assembly	GO:0006461	302	0.045
purine containing compound metabolic process	GO:0072521	400	0.045
purine containing compound catabolic process	GO:0072523	332	0.045
regulation of cellular catabolic process	GO:0031329	195	0.045
glycosyl compound catabolic process	GO:1901658	335	0.044
cell cycle phase transition	GO:0044770	144	0.044
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.043
positive regulation of cellular protein metabolic process	GO:0032270	89	0.043
gene silencing	GO:0016458	151	0.042
chromatin modification	GO:0016568	200	0.042
reproductive process in single celled organism	GO:0022413	145	0.042
aging	GO:0007568	71	0.041
ribonucleoside monophosphate catabolic process	GO:0009158	224	0.040
nucleoside phosphate catabolic process	GO:1901292	331	0.040
negative regulation of transcription dna templated	GO:0045892	258	0.039
chromosome segregation	GO:0007059	159	0.038
regulation of translation	GO:0006417	89	0.037
positive regulation of rna metabolic process	GO:0051254	294	0.037
regulation of dna dependent dna replication	GO:0090329	37	0.036
rna catabolic process	GO:0006401	118	0.036
negative regulation of cellular component organization	GO:0051129	109	0.036
regulation of cell cycle process	GO:0010564	150	0.036
regulation of dna replication	GO:0006275	51	0.036
purine ribonucleoside monophosphate catabolic process	GO:0009169	224	0.036
meiotic chromosome segregation	GO:0045132	31	0.036
mating type switching	GO:0007533	28	0.036
regulation of nuclear division	GO:0051783	103	0.036
atp catabolic process	GO:0006200	224	0.035
protein localization to nucleus	GO:0034504	74	0.035
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.035
transposition rna mediated	GO:0032197	17	0.035
rna phosphodiester bond hydrolysis endonucleolytic	GO:0090502	79	0.034
regulation of cell cycle	GO:0051726	195	0.034
negative regulation of mitotic cell cycle phase transition	GO:1901991	57	0.033
regulation of mitotic cell cycle phase transition	GO:1901990	68	0.033
chromatin silencing at silent mating type cassette	GO:0030466	53	0.032
negative regulation of rna biosynthetic process	GO:1902679	260	0.032
dna double strand break processing	GO:0000729	8	0.032
single organism developmental process	GO:0044767	258	0.032
phosphorylation	GO:0016310	291	0.032
regulation of response to dna damage stimulus	GO:2001020	17	0.031
response to organic cyclic compound	GO:0014070	1	0.031
cell cycle dna replication	GO:0044786	36	0.030
protein targeting	GO:0006605	272	0.030
protein catabolic process	GO:0030163	221	0.030
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.030
dna duplex unwinding	GO:0032508	42	0.030
dna catabolic process endonucleolytic	GO:0000737	31	0.029
nucleoside monophosphate metabolic process	GO:0009123	267	0.028
positive regulation of transcription dna templated	GO:0045893	286	0.028
dna replication removal of rna primer	GO:0043137	5	0.028
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.028	Mouse
gene conversion	GO:0035822	14	0.028
negative regulation of mitotic cell cycle	GO:0045930	63	0.028
sex determination	GO:0007530	32	0.027
regulation of dna recombination	GO:0000018	24	0.027
positive regulation of protein metabolic process	GO:0051247	93	0.027
negative regulation of cell cycle	GO:0045786	91	0.027
negative regulation of meiotic cell cycle	GO:0051447	24	0.027
regulation of response to stress	GO:0080134	57	0.026
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.026
organelle localization	GO:0051640	128	0.026
posttranscriptional regulation of gene expression	GO:0010608	115	0.025
mitotic cell cycle process	GO:1903047	294	0.025
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	51	0.025
regulation of transport	GO:0051049	85	0.025
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.025
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.025
regulation of cell cycle g2 m phase transition	GO:1902749	8	0.025
regulation of localization	GO:0032879	127	0.025
mitotic cell cycle	GO:0000278	306	0.025
response to organic substance	GO:0010033	182	0.025
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.025
regulation of molecular function	GO:0065009	320	0.024
replicative cell aging	GO:0001302	46	0.024
establishment of mitotic sister chromatid cohesion	GO:0034087	15	0.024
regulation of response to stimulus	GO:0048583	157	0.024
nucleoside phosphate metabolic process	GO:0006753	458	0.024
regulation of mitotic cell cycle	GO:0007346	107	0.024
protein dna complex assembly	GO:0065004	105	0.023
cell division	GO:0051301	205	0.023
dna conformation change	GO:0071103	98	0.023
cellular component morphogenesis	GO:0032989	97	0.023
response to oxygen containing compound	GO:1901700	61	0.023
protein transmembrane transport	GO:0071806	82	0.023
ascospore formation	GO:0030437	107	0.023
regulation of cellular response to stress	GO:0080135	50	0.023
nucleoside monophosphate catabolic process	GO:0009125	224	0.022
carboxylic acid metabolic process	GO:0019752	338	0.022
protein modification by small protein conjugation or removal	GO:0070647	172	0.022
response to abiotic stimulus	GO:0009628	159	0.022
negative regulation of homeostatic process	GO:0032845	7	0.022
mrna splicing via spliceosome	GO:0000398	108	0.022
protein import into nucleus	GO:0006606	55	0.022
modification dependent protein catabolic process	GO:0019941	181	0.022
nitrogen compound transport	GO:0071705	212	0.021
cellular protein complex assembly	GO:0043623	209	0.021
cell cycle checkpoint	GO:0000075	82	0.021
establishment of sister chromatid cohesion	GO:0034085	17	0.021
positive regulation of catabolic process	GO:0009896	135	0.021
glucose metabolic process	GO:0006006	65	0.021
regulation of cell division	GO:0051302	113	0.021
dna dependent dna replication maintenance of fidelity	GO:0045005	14	0.021
heteroduplex formation	GO:0030491	9	0.021
negative regulation of organelle organization	GO:0010639	103	0.021
protein localization to organelle	GO:0033365	337	0.021
regulation of phosphate metabolic process	GO:0019220	230	0.020
transmembrane transport	GO:0055085	349	0.020
sporulation resulting in formation of a cellular spore	GO:0030435	129	0.020
regulation of protein metabolic process	GO:0051246	237	0.020
transposition	GO:0032196	20	0.020
regulation of transposition rna mediated	GO:0010525	15	0.020
macromolecule methylation	GO:0043414	85	0.020
regulation of mrna splicing via spliceosome	GO:0048024	3	0.020
cellular homeostasis	GO:0019725	138	0.020
er associated ubiquitin dependent protein catabolic process	GO:0030433	46	0.020
chromatin organization	GO:0006325	242	0.020
double strand break repair via synthesis dependent strand annealing	GO:0045003	12	0.019
proteasomal protein catabolic process	GO:0010498	141	0.019
multi organism process	GO:0051704	233	0.019
nuclear export	GO:0051168	124	0.019
nucleocytoplasmic transport	GO:0006913	163	0.018
cell morphogenesis	GO:0000902	30	0.018
mating type determination	GO:0007531	32	0.018
monocarboxylic acid metabolic process	GO:0032787	122	0.018
single organism membrane fusion	GO:0044801	71	0.018
ion homeostasis	GO:0050801	118	0.017
positive regulation of cellular catabolic process	GO:0031331	128	0.017
response to drug	GO:0042493	41	0.017
carbohydrate metabolic process	GO:0005975	252	0.017
response to topologically incorrect protein	GO:0035966	38	0.017
telomere capping	GO:0016233	10	0.017
positive regulation of catalytic activity	GO:0043085	178	0.017
dna recombinase assembly	GO:0000730	9	0.017
nucleoside triphosphate metabolic process	GO:0009141	364	0.016
mitotic dna damage checkpoint	GO:0044773	11	0.016
mrna processing	GO:0006397	185	0.016
regulation of rna splicing	GO:0043484	3	0.016
cellular chemical homeostasis	GO:0055082	123	0.016
positive regulation of response to stimulus	GO:0048584	37	0.016
mitochondrion localization	GO:0051646	29	0.016
intracellular protein transmembrane transport	GO:0065002	80	0.015
g2 m transition of mitotic cell cycle	GO:0000086	38	0.015
dna integrity checkpoint	GO:0031570	41	0.015
negative regulation of cell cycle process	GO:0010948	86	0.015
chromosome organization involved in meiosis	GO:0070192	32	0.015
regulation of transposition	GO:0010528	16	0.015
cellular component assembly involved in morphogenesis	GO:0010927	73	0.015
cellular response to chemical stimulus	GO:0070887	315	0.015
cell growth	GO:0016049	89	0.015
replication fork protection	GO:0048478	6	0.015
single organism nuclear import	GO:1902593	56	0.015
mitotic cell cycle phase transition	GO:0044772	141	0.014
positive regulation of cell death	GO:0010942	3	0.014
positive regulation of cellular component organization	GO:0051130	116	0.014
response to nitrogen compound	GO:1901698	18	0.014
multi organism reproductive process	GO:0044703	216	0.014
rna phosphodiester bond hydrolysis	GO:0090501	112	0.014
macroautophagy	GO:0016236	55	0.014
positive regulation of phosphorylation	GO:0042327	33	0.014
positive regulation of protein modification process	GO:0031401	49	0.014
negative regulation of cell division	GO:0051782	66	0.014
regulation of protein localization	GO:0032880	62	0.014
growth of unicellular organism as a thread of attached cells	GO:0070783	105	0.014
positive regulation of cytoplasmic transport	GO:1903651	4	0.014
regulation of catabolic process	GO:0009894	199	0.014
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	2	0.014
positive regulation of cell cycle process	GO:0090068	31	0.014
cellular response to oxygen containing compound	GO:1901701	43	0.014
regulation of meiosis	GO:0040020	42	0.014
cellular component disassembly	GO:0022411	86	0.014
regulation of meiotic cell cycle	GO:0051445	43	0.013
sexual sporulation	GO:0034293	113	0.013
osmosensory signaling pathway	GO:0007231	22	0.013
peroxisome organization	GO:0007031	68	0.013
cellular response to nitrogen compound	GO:1901699	14	0.013
negative regulation of protein metabolic process	GO:0051248	85	0.013
regulation of cellular protein metabolic process	GO:0032268	232	0.013
growth	GO:0040007	157	0.013
signal transduction	GO:0007165	208	0.013
cellular response to abiotic stimulus	GO:0071214	62	0.013
positive regulation of apoptotic process	GO:0043065	3	0.013
histone phosphorylation	GO:0016572	3	0.013
regulation of establishment of protein localization	GO:0070201	17	0.013
cellular response to oxidative stress	GO:0034599	94	0.013
chromatin remodeling	GO:0006338	80	0.013
positive regulation of organelle organization	GO:0010638	85	0.013
protein modification by small protein removal	GO:0070646	29	0.012
negative regulation of dna dependent dna replication	GO:2000104	8	0.012
regulation of phosphorus metabolic process	GO:0051174	230	0.012
histone methylation	GO:0016571	28	0.012
mitotic sister chromatid segregation	GO:0000070	85	0.012
anatomical structure development	GO:0048856	160	0.012
intracellular signal transduction	GO:0035556	112	0.012
macromolecular complex disassembly	GO:0032984	80	0.012
maintenance of rdna	GO:0043007	9	0.012
single organism cellular localization	GO:1902580	375	0.012
dna replication initiation	GO:0006270	48	0.012
nucleic acid transport	GO:0050657	94	0.012
regulation of protein phosphorylation	GO:0001932	75	0.012
protein complex localization	GO:0031503	32	0.012
cell fate commitment	GO:0045165	32	0.012
protein targeting to nucleus	GO:0044744	57	0.012
peroxisomal transport	GO:0043574	22	0.012
response to hypoxia	GO:0001666	4	0.012
nuclear dna replication	GO:0033260	27	0.012
protein deacylation	GO:0035601	27	0.011
rna export from nucleus	GO:0006405	88	0.011
negative regulation of cellular protein metabolic process	GO:0032269	85	0.011
cellular lipid metabolic process	GO:0044255	229	0.011
rna transport	GO:0050658	92	0.011
protein transport	GO:0015031	345	0.011
protein targeting to mitochondrion	GO:0006626	56	0.011
mitotic dna integrity checkpoint	GO:0044774	18	0.011
g1 s transition of mitotic cell cycle	GO:0000082	64	0.011
response to endogenous stimulus	GO:0009719	26	0.011
cellular response to endogenous stimulus	GO:0071495	22	0.011
cellular response to organic substance	GO:0071310	159	0.011
peptide metabolic process	GO:0006518	28	0.011
vesicle organization	GO:0016050	68	0.011
negative regulation of meiosis	GO:0045835	23	0.011
covalent chromatin modification	GO:0016569	119	0.011
programmed cell death	GO:0012501	30	0.011
regulation of chromatin silencing	GO:0031935	39	0.011
mitotic cell cycle checkpoint	GO:0007093	56	0.011
regulation of hydrolase activity	GO:0051336	133	0.010
protein polymerization	GO:0051258	51	0.010
regulation of catalytic activity	GO:0050790	307	0.010
cell cycle g1 s phase transition	GO:0044843	64	0.010
nuclear import	GO:0051170	57	0.010
histone lysine methylation	GO:0034968	26	0.010
mrna metabolic process	GO:0016071	269	0.010
budding cell bud growth	GO:0007117	29	0.010
positive regulation of molecular function	GO:0044093	185	0.010
negative regulation of phosphorus metabolic process	GO:0010563	49	0.010
regulation of histone modification	GO:0031056	18	0.010
cell budding	GO:0007114	48	0.010
regulation of cellular component biogenesis	GO:0044087	112	0.010

RAD5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability
disease of cellular proliferation	DOID:14566	0.049
cancer	DOID:162	0.027
organ system cancer	DOID:0050686	0.027
disease of anatomical entity	DOID:7	0.026

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