IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

50 known processes

PDS1 (YDR113C)

Pds1p

SGD: S000002520
Entrez: 851691
UniProtKB: P40316

Process Predictions
Disease Predictions

PDS1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
meiotic cell cycle	GO:0051321	272	0.832
regulation of cell cycle process	GO:0010564	150	0.793
sister chromatid segregation	GO:0000819	93	0.781
mitotic sister chromatid segregation	GO:0000070	85	0.742
meiosis i	GO:0007127	92	0.730
mitotic cell cycle process	GO:1903047	294	0.694
negative regulation of cellular metabolic process	GO:0031324	407	0.637
meiotic nuclear division	GO:0007126	163	0.620
regulation of cell cycle	GO:0051726	195	0.585
regulation of cellular component organization	GO:0051128	334	0.565
cell division	GO:0051301	205	0.558
dna replication	GO:0006260	147	0.550
negative regulation of cell cycle process	GO:0010948	86	0.523
cell cycle checkpoint	GO:0000075	82	0.513
dna dependent dna replication	GO:0006261	115	0.509
chromosome segregation	GO:0007059	159	0.506
negative regulation of cell cycle	GO:0045786	91	0.505
organelle fission	GO:0048285	272	0.483
nuclear division	GO:0000280	263	0.444
protein catabolic process	GO:0030163	221	0.442
chromosome separation	GO:0051304	33	0.441
regulation of cell division	GO:0051302	113	0.417
metaphase anaphase transition of cell cycle	GO:0044784	28	0.400
dna packaging	GO:0006323	55	0.391
regulation of mitotic metaphase anaphase transition	GO:0030071	27	0.387
regulation of mitotic cell cycle	GO:0007346	107	0.374
cellular protein catabolic process	GO:0044257	213	0.368
ubiquitin dependent protein catabolic process	GO:0006511	181	0.362
dna repair	GO:0006281	236	0.359
regulation of chromosome segregation	GO:0051983	44	0.343
macromolecule catabolic process	GO:0009057	383	0.329
metaphase anaphase transition of mitotic cell cycle	GO:0007091	28	0.327
regulation of meiotic cell cycle	GO:0051445	43	0.325
protein modification by small protein conjugation	GO:0032446	144	0.324
recombinational repair	GO:0000725	64	0.322
regulation of organelle organization	GO:0033043	243	0.319
reproductive process	GO:0022414	248	0.312
negative regulation of cell division	GO:0051782	66	0.311
cell cycle phase transition	GO:0044770	144	0.308
cellular response to dna damage stimulus	GO:0006974	287	0.307
single organism developmental process	GO:0044767	258	0.291
regulation of metaphase anaphase transition of cell cycle	GO:1902099	27	0.286
mitotic sister chromatid separation	GO:0051306	26	0.285
regulation of meiosis	GO:0040020	42	0.282
mitotic cell cycle	GO:0000278	306	0.281
regulation of cell cycle phase transition	GO:1901987	70	0.276
negative regulation of macromolecule metabolic process	GO:0010605	375	0.265
meiotic cell cycle process	GO:1903046	229	0.263
mitotic cell cycle phase transition	GO:0044772	141	0.252
negative regulation of nuclear division	GO:0051784	62	0.248
regulation of mitotic sister chromatid separation	GO:0010965	29	0.245
developmental process	GO:0032502	261	0.231
negative regulation of biosynthetic process	GO:0009890	312	0.230
regulation of mitotic cell cycle phase transition	GO:1901990	68	0.230
modification dependent macromolecule catabolic process	GO:0043632	203	0.226
single organism reproductive process	GO:0044702	159	0.223
double strand break repair	GO:0006302	105	0.212
modification dependent protein catabolic process	GO:0019941	181	0.210
proteasomal protein catabolic process	GO:0010498	141	0.209
dna replication initiation	GO:0006270	48	0.207
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.205
cellular macromolecule catabolic process	GO:0044265	363	0.193
regulation of nuclear division	GO:0051783	103	0.193
double strand break repair via homologous recombination	GO:0000724	54	0.190
sexual reproduction	GO:0019953	216	0.188
regulation of proteasomal protein catabolic process	GO:0061136	34	0.187
proteolysis involved in cellular protein catabolic process	GO:0051603	198	0.185
regulation of ubiquitin protein transferase activity	GO:0051438	8	0.182
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.179
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.176
regulation of cellular protein metabolic process	GO:0032268	232	0.173
regulation of biological quality	GO:0065008	391	0.171
dna conformation change	GO:0071103	98	0.170
negative regulation of gene expression	GO:0010629	312	0.168
cell cycle g2 m phase transition	GO:0044839	39	0.167
regulation of mitotic sister chromatid segregation	GO:0033047	30	0.164
negative regulation of cellular biosynthetic process	GO:0031327	312	0.164
regulation of microtubule cytoskeleton organization	GO:0070507	32	0.162
microtubule based process	GO:0007017	117	0.153
microtubule cytoskeleton organization	GO:0000226	109	0.150
meiotic cell cycle checkpoint	GO:0033313	10	0.144
single organism catabolic process	GO:0044712	619	0.142
g2 m transition of mitotic cell cycle	GO:0000086	38	0.141
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.141
regulation of protein metabolic process	GO:0051246	237	0.137
mitotic nuclear division	GO:0007067	131	0.136
chromosome organization involved in meiosis	GO:0070192	32	0.134
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process	GO:0031145	35	0.133
synapsis	GO:0007129	19	0.130
reproduction of a single celled organism	GO:0032505	191	0.129
regulation of g2 m transition of mitotic cell cycle	GO:0010389	8	0.127
dna recombination	GO:0006310	172	0.126
proteolysis	GO:0006508	268	0.125
regulation of dna replication	GO:0006275	51	0.124
spindle organization	GO:0007051	37	0.121
negative regulation of cell cycle phase transition	GO:1901988	59	0.121
sporulation resulting in formation of a cellular spore	GO:0030435	129	0.120
negative regulation of cellular component organization	GO:0051129	109	0.118
autophagy	GO:0006914	106	0.116
mitotic cell cycle checkpoint	GO:0007093	56	0.111
protein ubiquitination	GO:0016567	118	0.108
dna damage checkpoint	GO:0000077	29	0.107
synaptonemal complex assembly	GO:0007130	12	0.105
organelle fusion	GO:0048284	85	0.104
negative regulation of mitotic cell cycle phase transition	GO:1901991	57	0.102
negative regulation of organelle organization	GO:0010639	103	0.097
regulation of dna dependent dna replication	GO:0090329	37	0.096
nucleic acid phosphodiester bond hydrolysis	GO:0090305	194	0.095
regulation of cell cycle g2 m phase transition	GO:1902749	8	0.095
positive regulation of chromosome segregation	GO:0051984	15	0.093
regulation of microtubule based process	GO:0032886	32	0.093
regulation of proteolysis involved in cellular protein catabolic process	GO:1903050	36	0.091
telomere organization	GO:0032200	75	0.091
regulation of mitosis	GO:0007088	65	0.089
regulation of chromosome organization	GO:0033044	66	0.086
regulation of sister chromatid segregation	GO:0033045	30	0.084
dephosphorylation	GO:0016311	127	0.084
cell communication	GO:0007154	345	0.083
synaptonemal complex organization	GO:0070193	16	0.083
anatomical structure development	GO:0048856	160	0.083
positive regulation of cellular component organization	GO:0051130	116	0.083
cell differentiation	GO:0030154	161	0.083
regulation of dna metabolic process	GO:0051052	100	0.077
positive regulation of cell cycle process	GO:0090068	31	0.076
cell development	GO:0048468	107	0.076
chromosome condensation	GO:0030261	19	0.075
reciprocal dna recombination	GO:0035825	54	0.073
microtubule polymerization or depolymerization	GO:0031109	36	0.069
negative regulation of dna replication	GO:0008156	15	0.068
cell wall organization or biogenesis	GO:0071554	190	0.066
regulation of protein catabolic process	GO:0042176	40	0.064
mitotic spindle assembly checkpoint	GO:0007094	23	0.064
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	137	0.063
reproductive process in single celled organism	GO:0022413	145	0.063
protein complex assembly	GO:0006461	302	0.062
negative regulation of dna metabolic process	GO:0051053	36	0.060
positive regulation of gene expression	GO:0010628	321	0.060
regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032434	30	0.058
macroautophagy	GO:0016236	55	0.058
regulation of cellular protein catabolic process	GO:1903362	36	0.057
histone modification	GO:0016570	119	0.056
negative regulation of mitosis	GO:0045839	39	0.055
negative regulation of metaphase anaphase transition of cell cycle	GO:1902100	23	0.055
sexual sporulation	GO:0034293	113	0.055
telomere maintenance	GO:0000723	74	0.054
regulation of cellular catabolic process	GO:0031329	195	0.054
cellular response to organic substance	GO:0071310	159	0.054
negative regulation of meiotic cell cycle	GO:0051447	24	0.054
microtubule nucleation	GO:0007020	17	0.053
negative regulation of mitotic metaphase anaphase transition	GO:0045841	23	0.052
non recombinational repair	GO:0000726	33	0.052
negative regulation of mitotic cell cycle	GO:0045930	63	0.052
protein polymerization	GO:0051258	51	0.051
multi organism reproductive process	GO:0044703	216	0.051
vesicle mediated transport	GO:0016192	335	0.051
regulation of dephosphorylation	GO:0035303	18	0.050
regulation of molecular function	GO:0065009	320	0.050
dna integrity checkpoint	GO:0031570	41	0.050
positive regulation of protein metabolic process	GO:0051247	93	0.049
meiotic recombination checkpoint	GO:0051598	9	0.049
cell cycle dna replication	GO:0044786	36	0.049
cellular component disassembly	GO:0022411	86	0.049
regulation of spindle pole body separation	GO:0010695	9	0.048
negative regulation of mitotic sister chromatid separation	GO:2000816	23	0.048
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.048
multi organism process	GO:0051704	233	0.047
positive regulation of cell cycle	GO:0045787	32	0.047
negative regulation of meiosis	GO:0045835	23	0.045
protein modification by small protein conjugation or removal	GO:0070647	172	0.044
negative regulation of protein metabolic process	GO:0051248	85	0.043
microtubule polymerization	GO:0046785	30	0.042
homeostatic process	GO:0042592	227	0.042
negative regulation of rna metabolic process	GO:0051253	262	0.042
establishment of organelle localization	GO:0051656	96	0.041
positive regulation of cellular protein metabolic process	GO:0032270	89	0.041
regulation of proteolysis	GO:0030162	44	0.041
negative regulation of cellular catabolic process	GO:0031330	43	0.039
sexual sporulation resulting in formation of a cellular spore	GO:0043935	113	0.039
cytoskeleton organization	GO:0007010	230	0.039
cell wall organization	GO:0071555	146	0.038
regulation of protein modification process	GO:0031399	110	0.038
meiotic chromosome segregation	GO:0045132	31	0.037
regulation of catabolic process	GO:0009894	199	0.037
protein complex biogenesis	GO:0070271	314	0.036
protein complex disassembly	GO:0043241	70	0.036
organelle assembly	GO:0070925	118	0.034
negative regulation of mitotic sister chromatid segregation	GO:0033048	24	0.034
fungal type cell wall organization	GO:0031505	145	0.034
regulation of protein modification by small protein conjugation or removal	GO:1903320	29	0.034
regulation of ubiquitin protein ligase activity involved in mitotic cell cycle	GO:0051439	6	0.033
rna dependent dna replication	GO:0006278	25	0.033
mitotic spindle elongation	GO:0000022	14	0.032
protein dephosphorylation	GO:0006470	40	0.032
negative regulation of dna dependent dna replication	GO:2000104	8	0.030
mitotic spindle checkpoint	GO:0071174	34	0.030
cellular response to chemical stimulus	GO:0070887	315	0.030
cellular protein complex assembly	GO:0043623	209	0.030
conjugation with cellular fusion	GO:0000747	106	0.029
carbohydrate derivative metabolic process	GO:1901135	549	0.029
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.029
regulation of cytoskeleton organization	GO:0051493	63	0.029
cellular response to nutrient levels	GO:0031669	144	0.028
anatomical structure homeostasis	GO:0060249	74	0.028
anatomical structure morphogenesis	GO:0009653	160	0.028
positive regulation of macromolecule metabolic process	GO:0010604	394	0.028
protein depolymerization	GO:0051261	21	0.027
developmental process involved in reproduction	GO:0003006	159	0.027
response to abiotic stimulus	GO:0009628	159	0.027
reciprocal meiotic recombination	GO:0007131	54	0.027
positive regulation of mitotic metaphase anaphase transition	GO:0045842	3	0.026
covalent chromatin modification	GO:0016569	119	0.026
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.025
response to organic cyclic compound	GO:0014070	1	0.025
cell growth	GO:0016049	89	0.024
spindle elongation	GO:0051231	14	0.024
mitotic spindle organization	GO:0007052	30	0.023
posttranscriptional regulation of gene expression	GO:0010608	115	0.023
chromatin organization	GO:0006325	242	0.023
external encapsulating structure organization	GO:0045229	146	0.023
spindle stabilization	GO:0043146	2	0.023
cell aging	GO:0007569	70	0.023
negative regulation of gene expression epigenetic	GO:0045814	147	0.022
signal transduction	GO:0007165	208	0.022
negative regulation of protein modification process	GO:0031400	37	0.022
negative regulation of transcription dna templated	GO:0045892	258	0.022
double strand break repair via nonhomologous end joining	GO:0006303	27	0.022
positive regulation of mitotic cell cycle	GO:0045931	16	0.022
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.022
cytokinesis	GO:0000910	92	0.022
double strand break repair via break induced replication	GO:0000727	25	0.021
microtubule depolymerization	GO:0007019	8	0.021
aging	GO:0007568	71	0.021
telomere maintenance via telomerase	GO:0007004	21	0.021
regulation of spindle organization	GO:0090224	8	0.020
phosphorylation	GO:0016310	291	0.020
rna localization	GO:0006403	112	0.020
positive regulation of organelle organization	GO:0010638	85	0.020
cellular response to starvation	GO:0009267	90	0.020
ascospore formation	GO:0030437	107	0.020
regulation of catalytic activity	GO:0050790	307	0.020
positive regulation of protein modification process	GO:0031401	49	0.019
nucleus organization	GO:0006997	62	0.019
nuclear migration	GO:0007097	22	0.019
growth	GO:0040007	157	0.019
cellular developmental process	GO:0048869	191	0.018
negative regulation of rna biosynthetic process	GO:1902679	260	0.018
spindle assembly checkpoint	GO:0071173	23	0.018
membrane organization	GO:0061024	276	0.018
response to chemical	GO:0042221	390	0.018
conjugation	GO:0000746	107	0.017
spindle checkpoint	GO:0031577	35	0.017
single organism signaling	GO:0044700	208	0.017
cellular component morphogenesis	GO:0032989	97	0.017
negative regulation of catabolic process	GO:0009895	43	0.017
meiotic dna double strand break formation	GO:0042138	12	0.017
regulation of translation	GO:0006417	89	0.017
sister chromatid cohesion	GO:0007062	49	0.017
glucose metabolic process	GO:0006006	65	0.017
regulation of spindle elongation	GO:0032887	3	0.016
protein phosphorylation	GO:0006468	197	0.016
positive regulation of cell death	GO:0010942	3	0.016
telomere maintenance via telomere lengthening	GO:0010833	22	0.016
positive regulation of cellular catabolic process	GO:0031331	128	0.016
negative regulation of cellular protein catabolic process	GO:1903363	27	0.016
mitotic metaphase plate congression	GO:0007080	8	0.016
positive regulation of intracellular transport	GO:0032388	4	0.016
negative regulation of chromosome segregation	GO:0051985	25	0.016
regulation of gene expression epigenetic	GO:0040029	147	0.016
signaling	GO:0023052	208	0.015
peptidyl lysine modification	GO:0018205	77	0.015
negative regulation of phosphorus metabolic process	GO:0010563	49	0.015
positive regulation of cellular biosynthetic process	GO:0031328	336	0.015
sporulation	GO:0043934	132	0.015
positive regulation of protein modification by small protein conjugation or removal	GO:1903322	12	0.015
maintenance of location in cell	GO:0051651	58	0.015
macromolecular complex disassembly	GO:0032984	80	0.015
negative regulation of proteolysis involved in cellular protein catabolic process	GO:1903051	27	0.014
negative regulation of phosphate metabolic process	GO:0045936	49	0.014
peptidyl amino acid modification	GO:0018193	116	0.014
mitochondrion organization	GO:0007005	261	0.014
organelle localization	GO:0051640	128	0.014
negative regulation of cellular protein metabolic process	GO:0032269	85	0.014
cellular response to external stimulus	GO:0071496	150	0.014
fungal type cell wall organization or biogenesis	GO:0071852	169	0.014
nucleoside phosphate biosynthetic process	GO:1901293	80	0.014
response to starvation	GO:0042594	96	0.014
spindle pole body separation	GO:0000073	13	0.013
positive regulation of cytoskeleton organization	GO:0051495	39	0.013
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.013
regulation of meiosis i	GO:0060631	14	0.013
regulation of microtubule polymerization or depolymerization	GO:0031110	18	0.013
negative regulation of cytoskeleton organization	GO:0051494	24	0.013
regulation of mitotic spindle elongation	GO:0032888	3	0.013
telomere maintenance via recombination	GO:0000722	32	0.013
regulation of hydrolase activity	GO:0051336	133	0.013
carbohydrate metabolic process	GO:0005975	252	0.013
response to organic substance	GO:0010033	182	0.013
chromatin silencing	GO:0006342	147	0.012
response to oxidative stress	GO:0006979	99	0.012
cellular protein complex disassembly	GO:0043624	42	0.012
negative regulation of proteasomal ubiquitin dependent protein catabolic process	GO:0032435	24	0.012
positive regulation of chromatin modification	GO:1903310	13	0.012
nucleobase containing small molecule metabolic process	GO:0055086	491	0.012
intracellular signal transduction	GO:0035556	112	0.012
negative regulation of microtubule polymerization or depolymerization	GO:0031111	7	0.012
negative regulation of catalytic activity	GO:0043086	60	0.012
mrna metabolic process	GO:0016071	269	0.012
regulation of macroautophagy	GO:0016241	15	0.012
cellular biogenic amine metabolic process	GO:0006576	37	0.012
rdna condensation	GO:0070550	9	0.011
positive regulation of dna metabolic process	GO:0051054	26	0.011
dna biosynthetic process	GO:0071897	33	0.011
cellular response to hypoxia	GO:0071456	4	0.011
positive regulation of catabolic process	GO:0009896	135	0.011
positive regulation of biosynthetic process	GO:0009891	336	0.011
negative regulation of cell cycle g2 m phase transition	GO:1902750	5	0.011
microtubule cytoskeleton organization involved in mitosis	GO:1902850	13	0.011
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.011
regulation of response to nutrient levels	GO:0032107	20	0.011
regulation of mitotic spindle organization	GO:0060236	8	0.011
mitotic chromosome condensation	GO:0007076	11	0.011
negative regulation of molecular function	GO:0044092	68	0.011
chromosome localization	GO:0050000	20	0.011
dna dependent dna replication maintenance of fidelity	GO:0045005	14	0.010
protein localization to organelle	GO:0033365	337	0.010
positive regulation of intracellular protein transport	GO:0090316	3	0.010
positive regulation of nucleocytoplasmic transport	GO:0046824	4	0.010
pseudohyphal growth	GO:0007124	75	0.010
rna catabolic process	GO:0006401	118	0.010
positive regulation of chromosome organization	GO:2001252	20	0.010
response to uv	GO:0009411	4	0.010
cellular response to extracellular stimulus	GO:0031668	150	0.010

PDS1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.013

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