IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

47 known processes

HXK1 (YFR053C)

Hxk1p

SGD: S000001949
Entrez: 850614
UniProtKB: P04806

Process Predictions
Disease Predictions

HXK1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
carbohydrate biosynthetic process	GO:0016051	82	0.873	Human Rat
cellular carbohydrate biosynthetic process	GO:0034637	49	0.834	Human Rat
cellular polysaccharide metabolic process	GO:0044264	55	0.771	Human Rat
glycogen metabolic process	GO:0005977	30	0.739	Human Rat
cellular polysaccharide biosynthetic process	GO:0033692	38	0.655	Human Rat
carbohydrate metabolic process	GO:0005975	252	0.642
glucan biosynthetic process	GO:0009250	26	0.609	Human Rat
cellular carbohydrate metabolic process	GO:0044262	135	0.606
polysaccharide metabolic process	GO:0005976	60	0.532	Human Rat
energy reserve metabolic process	GO:0006112	32	0.526	Human Rat
oligosaccharide metabolic process	GO:0009311	35	0.459
generation of precursor metabolites and energy	GO:0006091	147	0.420
energy derivation by oxidation of organic compounds	GO:0015980	125	0.392	Human Rat
polysaccharide biosynthetic process	GO:0000271	39	0.371	Human Rat
hexose biosynthetic process	GO:0019319	30	0.343	Human
single organism carbohydrate metabolic process	GO:0044723	237	0.334
monosaccharide biosynthetic process	GO:0046364	31	0.307	Human
detection of chemical stimulus	GO:0009593	3	0.288	Human Rat
monosaccharide metabolic process	GO:0005996	83	0.268
positive regulation of gene expression	GO:0010628	321	0.249
negative regulation of gluconeogenesis	GO:0045721	9	0.239	Human
positive regulation of transcription dna templated	GO:0045893	286	0.237
negative regulation of cellular metabolic process	GO:0031324	407	0.230	Human
oxidation reduction process	GO:0055114	353	0.220	Human Rat
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.218
positive regulation of rna biosynthetic process	GO:1902680	286	0.208
single organism developmental process	GO:0044767	258	0.205	Rat Fly
organophosphate biosynthetic process	GO:0090407	182	0.194
regulation of glycogen biosynthetic process	GO:0005979	9	0.192	Human
cellular glucan metabolic process	GO:0006073	44	0.189	Human Rat
developmental process	GO:0032502	261	0.188	Rat Fly
gluconeogenesis	GO:0006094	30	0.187	Human
response to chemical	GO:0042221	390	0.178	Human Rat
positive regulation of rna metabolic process	GO:0051254	294	0.177
detection of carbohydrate stimulus	GO:0009730	3	0.176	Human Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.170
negative regulation of biosynthetic process	GO:0009890	312	0.163	Human
glucan metabolic process	GO:0044042	44	0.163	Human Rat
regulation of glucose metabolic process	GO:0010906	27	0.161	Human
organophosphate metabolic process	GO:0019637	597	0.143	Human Yeast Rat
response to glucose	GO:0009749	13	0.139	Human Rat
response to organic substance	GO:0010033	182	0.137	Human Rat
single organism signaling	GO:0044700	208	0.133	Human Rat Fly
reproductive process	GO:0022414	248	0.132
pyruvate metabolic process	GO:0006090	37	0.128
multi organism process	GO:0051704	233	0.127
cellular developmental process	GO:0048869	191	0.124	Fly
sexual reproduction	GO:0019953	216	0.120
nucleoside phosphate metabolic process	GO:0006753	458	0.118
cell communication	GO:0007154	345	0.116	Human Rat Fly
response to external stimulus	GO:0009605	158	0.114	Rat
response to monosaccharide	GO:0034284	13	0.112	Human Rat
cellular ketone metabolic process	GO:0042180	63	0.111	Human
disaccharide metabolic process	GO:0005984	25	0.109
developmental process involved in reproduction	GO:0003006	159	0.105
carbohydrate catabolic process	GO:0016052	77	0.104
single organism reproductive process	GO:0044702	159	0.104
cellular carbohydrate catabolic process	GO:0044275	33	0.102	Rat
positive regulation of biosynthetic process	GO:0009891	336	0.101	Human
positive regulation of macromolecule metabolic process	GO:0010604	394	0.101	Human
signaling	GO:0023052	208	0.101	Human Rat Fly
organonitrogen compound biosynthetic process	GO:1901566	314	0.098
positive regulation of cellular biosynthetic process	GO:0031328	336	0.097	Human
regulation of glycogen metabolic process	GO:0070873	10	0.096	Human
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.095
meiotic cell cycle process	GO:1903046	229	0.091
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.091
purine nucleotide metabolic process	GO:0006163	376	0.088
cell differentiation	GO:0030154	161	0.086	Fly
cation homeostasis	GO:0055080	105	0.086	Rat
nucleobase containing small molecule metabolic process	GO:0055086	491	0.085
negative regulation of carbohydrate metabolic process	GO:0045912	17	0.085	Human
ribonucleoside metabolic process	GO:0009119	389	0.084
organic acid biosynthetic process	GO:0016053	152	0.084
detection of stimulus	GO:0051606	4	0.084	Human Rat
lipid biosynthetic process	GO:0008610	170	0.081
ion homeostasis	GO:0050801	118	0.081	Rat
cellular response to chemical stimulus	GO:0070887	315	0.081	Rat
detection of hexose stimulus	GO:0009732	3	0.081	Human Rat
purine ribonucleotide metabolic process	GO:0009150	372	0.080
regulation of polysaccharide metabolic process	GO:0032881	15	0.080	Human
detection of glucose	GO:0051594	3	0.079	Human Rat
chemical homeostasis	GO:0048878	137	0.076	Human Rat
nitrogen compound transport	GO:0071705	212	0.076	Human Rat
multi organism reproductive process	GO:0044703	216	0.075
reproductive process in single celled organism	GO:0022413	145	0.074
response to oxygen containing compound	GO:1901700	61	0.074	Human Rat
organic acid metabolic process	GO:0006082	352	0.073
nucleotide metabolic process	GO:0009117	453	0.073
negative regulation of cellular biosynthetic process	GO:0031327	312	0.072	Human
regulation of localization	GO:0032879	127	0.072	Human Rat
small molecule biosynthetic process	GO:0044283	258	0.071
regulation of cellular catabolic process	GO:0031329	195	0.071	Rat
cofactor metabolic process	GO:0051186	126	0.071
secretion by cell	GO:0032940	50	0.070	Human Rat
cellular ion homeostasis	GO:0006873	112	0.069	Rat
cellular response to extracellular stimulus	GO:0031668	150	0.069	Rat
purine containing compound metabolic process	GO:0072521	400	0.069
regulation of signaling	GO:0023051	119	0.067	Human Rat
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.066
ascospore formation	GO:0030437	107	0.066
single organism catabolic process	GO:0044712	619	0.065
carbohydrate derivative metabolic process	GO:1901135	549	0.064	Human Yeast Rat
purine ribonucleoside metabolic process	GO:0046128	380	0.064
cellular metal ion homeostasis	GO:0006875	78	0.063	Rat
ribose phosphate metabolic process	GO:0019693	384	0.062
anatomical structure development	GO:0048856	160	0.062	Rat
regulation of carbohydrate metabolic process	GO:0006109	43	0.061	Human Rat
nucleoside triphosphate metabolic process	GO:0009141	364	0.060
sexual sporulation	GO:0034293	113	0.060
glucose metabolic process	GO:0006006	65	0.059
positive regulation of secretion by cell	GO:1903532	2	0.059	Human Rat
single organism carbohydrate catabolic process	GO:0044724	73	0.058
regulation of catabolic process	GO:0009894	199	0.058	Rat
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.057
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.057
meiotic cell cycle	GO:0051321	272	0.057
regulation of generation of precursor metabolites and energy	GO:0043467	23	0.056	Human Rat
positive regulation of secretion	GO:0051047	2	0.056	Human Rat
sexual sporulation resulting in formation of a cellular spore	GO:0043935	113	0.055
cellular response to organic substance	GO:0071310	159	0.055	Rat
secretion	GO:0046903	50	0.054	Human Rat
positive regulation of carbohydrate metabolic process	GO:0045913	13	0.051	Human Rat
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.050
regulation of transport	GO:0051049	85	0.050	Human Rat
nucleotide biosynthetic process	GO:0009165	79	0.049
carboxylic acid biosynthetic process	GO:0046394	152	0.049
cellular response to nutrient levels	GO:0031669	144	0.049	Rat
cell fate commitment	GO:0045165	32	0.049	Fly
sporulation	GO:0043934	132	0.046
regulation of carbohydrate biosynthetic process	GO:0043255	31	0.046	Human
ribonucleoside monophosphate metabolic process	GO:0009161	265	0.046
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.044	Human
negative regulation of gene expression	GO:0010629	312	0.044
response to extracellular stimulus	GO:0009991	156	0.044	Rat
regulation of gene expression epigenetic	GO:0040029	147	0.043
anion transport	GO:0006820	145	0.043
cellular response to external stimulus	GO:0071496	150	0.041	Rat
positive regulation of catabolic process	GO:0009896	135	0.041	Rat
negative regulation of cellular component organization	GO:0051129	109	0.041
purine nucleoside monophosphate metabolic process	GO:0009126	262	0.041
homeostatic process	GO:0042592	227	0.041	Human Rat
macromolecule catabolic process	GO:0009057	383	0.041
mitotic cell cycle	GO:0000278	306	0.041
negative regulation of macromolecule metabolic process	GO:0010605	375	0.040
regulation of gluconeogenesis	GO:0006111	16	0.040	Human
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.039
cell aging	GO:0007569	70	0.038
response to carbohydrate	GO:0009743	14	0.038	Human Rat
cellular cation homeostasis	GO:0030003	100	0.038	Rat
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.038
negative regulation of rna metabolic process	GO:0051253	262	0.037
nucleoside monophosphate metabolic process	GO:0009123	267	0.035
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.035
regulation of glucan biosynthetic process	GO:0010962	11	0.034	Human
regulation of cellular component organization	GO:0051128	334	0.033
cellular chemical homeostasis	GO:0055082	123	0.032	Rat
negative regulation of rna biosynthetic process	GO:1902679	260	0.032
glycosyl compound metabolic process	GO:1901657	398	0.032
dna recombination	GO:0006310	172	0.031
oxoacid metabolic process	GO:0043436	351	0.031
monocarboxylic acid metabolic process	GO:0032787	122	0.031
replicative cell aging	GO:0001302	46	0.030
regulation of cellular localization	GO:0060341	50	0.030	Human Rat
coenzyme metabolic process	GO:0006732	104	0.030
detection of monosaccharide stimulus	GO:0034287	3	0.029	Human Rat
response to nutrient levels	GO:0031667	150	0.029	Rat
negative regulation of transcription dna templated	GO:0045892	258	0.028
positive regulation of cellular catabolic process	GO:0031331	128	0.028	Rat
response to inorganic substance	GO:0010035	47	0.028
hormone transport	GO:0009914	1	0.028	Human Rat
ribonucleotide metabolic process	GO:0009259	377	0.027
atp metabolic process	GO:0046034	251	0.027
intracellular signal transduction	GO:0035556	112	0.026	Rat
coenzyme biosynthetic process	GO:0009108	66	0.026
negative regulation of cell communication	GO:0010648	33	0.026	Rat
regulation of cell communication	GO:0010646	124	0.026	Human Rat
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.026
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.026
growth	GO:0040007	157	0.025
carboxylic acid metabolic process	GO:0019752	338	0.025
regulation of organelle organization	GO:0033043	243	0.025
phosphorylation	GO:0016310	291	0.025
nuclear export	GO:0051168	124	0.024
anatomical structure morphogenesis	GO:0009653	160	0.024
reproduction of a single celled organism	GO:0032505	191	0.024
negative regulation of cellular carbohydrate metabolic process	GO:0010677	17	0.023	Human
single organism membrane organization	GO:0044802	275	0.023
nucleoside metabolic process	GO:0009116	394	0.022
response to temperature stimulus	GO:0009266	74	0.022
nuclear division	GO:0000280	263	0.022
peptide transport	GO:0015833	14	0.021	Human Rat
single organism cellular localization	GO:1902580	375	0.021
ncrna processing	GO:0034470	330	0.021
glycolytic process	GO:0006096	21	0.020
regulation of biological quality	GO:0065008	391	0.020	Human Rat
regulation of anatomical structure size	GO:0090066	50	0.020
cellular homeostasis	GO:0019725	138	0.020	Rat
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.019
regulation of dna metabolic process	GO:0051052	100	0.019
regulation of phosphorus metabolic process	GO:0051174	230	0.019	Rat
lipid metabolic process	GO:0006629	269	0.019
regulation of phosphate metabolic process	GO:0019220	230	0.019	Rat
regulation of cell division	GO:0051302	113	0.019
gene silencing	GO:0016458	151	0.019
oligosaccharide catabolic process	GO:0009313	18	0.019
negative regulation of response to stimulus	GO:0048585	40	0.019
carbohydrate transport	GO:0008643	33	0.019
mitochondrial atp synthesis coupled electron transport	GO:0042775	25	0.019
response to nutrient	GO:0007584	52	0.018
establishment of protein localization	GO:0045184	367	0.018
trehalose metabolic process	GO:0005991	11	0.018
transmembrane transport	GO:0055085	349	0.018
response to pheromone	GO:0019236	92	0.018
positive regulation of transport	GO:0051050	32	0.017	Human Rat
monocarboxylic acid biosynthetic process	GO:0072330	35	0.017
positive regulation of cellular carbohydrate metabolic process	GO:0010676	13	0.017	Human Rat
aging	GO:0007568	71	0.017
regulation of dna replication	GO:0006275	51	0.017
cell development	GO:0048468	107	0.017
cellular response to oxidative stress	GO:0034599	94	0.016
membrane organization	GO:0061024	276	0.016
protein complex biogenesis	GO:0070271	314	0.016
organelle assembly	GO:0070925	118	0.016
cellular response to heat	GO:0034605	53	0.016
response to starvation	GO:0042594	96	0.016	Rat
cofactor biosynthetic process	GO:0051188	80	0.016
amide transport	GO:0042886	22	0.016	Human Rat
metal ion homeostasis	GO:0055065	79	0.015	Rat
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.015
purine nucleoside metabolic process	GO:0042278	380	0.015
cellular response to dna damage stimulus	GO:0006974	287	0.015
establishment of organelle localization	GO:0051656	96	0.014
alpha amino acid biosynthetic process	GO:1901607	91	0.014
dna dependent dna replication	GO:0006261	115	0.014
negative regulation of signaling	GO:0023057	30	0.014	Rat
cellular lipid metabolic process	GO:0044255	229	0.014
mitotic cell cycle process	GO:1903047	294	0.014
chromatin silencing at telomere	GO:0006348	84	0.014
divalent inorganic cation homeostasis	GO:0072507	21	0.013	Rat
regulation of cellular component biogenesis	GO:0044087	112	0.013
nucleoside phosphate biosynthetic process	GO:1901293	80	0.013
acyl coa metabolic process	GO:0006637	13	0.013
cytoskeleton organization	GO:0007010	230	0.013
oxidoreduction coenzyme metabolic process	GO:0006733	58	0.013
chromatin silencing	GO:0006342	147	0.013
positive regulation of phosphorus metabolic process	GO:0010562	147	0.013	Rat
regulation of cellular component size	GO:0032535	50	0.013
regulation of molecular function	GO:0065009	320	0.013
carbohydrate derivative catabolic process	GO:1901136	339	0.013
phospholipid biosynthetic process	GO:0008654	89	0.012
cellular protein complex assembly	GO:0043623	209	0.012
filamentous growth of a population of unicellular organisms	GO:0044182	109	0.012
proteolysis	GO:0006508	268	0.012
response to heat	GO:0009408	69	0.012
nucleobase containing compound catabolic process	GO:0034655	479	0.012
hexose metabolic process	GO:0019318	78	0.012
glycosyl compound catabolic process	GO:1901658	335	0.012
regulation of response to stimulus	GO:0048583	157	0.012
cell division	GO:0051301	205	0.011
fructose transport	GO:0015755	13	0.011
glycerolipid metabolic process	GO:0046486	108	0.011
response to oxidative stress	GO:0006979	99	0.011
conjugation with cellular fusion	GO:0000747	106	0.011
transition metal ion transport	GO:0000041	45	0.011
regulation of response to nutrient levels	GO:0032107	20	0.011
response to abiotic stimulus	GO:0009628	159	0.011
protein localization to organelle	GO:0033365	337	0.011
dna repair	GO:0006281	236	0.011
intracellular protein transport	GO:0006886	319	0.011
regulation of growth	GO:0040008	50	0.011
nad metabolic process	GO:0019674	25	0.011
response to hexose	GO:0009746	13	0.010	Human Rat
protein modification by small protein conjugation or removal	GO:0070647	172	0.010
alcohol metabolic process	GO:0006066	112	0.010
cell cycle phase transition	GO:0044770	144	0.010
regulation of protein metabolic process	GO:0051246	237	0.010
carbohydrate derivative biosynthetic process	GO:1901137	181	0.010

HXK1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability	Func Analog Org
inherited metabolic disorder	DOID:655	0.022	Human
disease of metabolism	DOID:0014667	0.022	Human
diabetes mellitus	DOID:9351	0.011	Human
type 2 diabetes mellitus	DOID:9352	0.011	Human
carbohydrate metabolism disease	DOID:0050013	0.011	Human
acquired metabolic disease	DOID:0060158	0.011	Human
glucose metabolism disease	DOID:4194	0.011	Human

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network