IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

35 known processes

SHE1 (YBL031W)

She1p

Entrez: 852249
SGD: S000000127
UniProtKB: P38200

Process Predictions
Disease Predictions

SHE1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
microtubule based process	GO:0007017	117	0.750
cytoskeleton organization	GO:0007010	230	0.549
mitotic cell cycle process	GO:1903047	294	0.519
regulation of microtubule cytoskeleton organization	GO:0070507	32	0.449
microtubule cytoskeleton organization	GO:0000226	109	0.396
regulation of microtubule based process	GO:0032886	32	0.389
mitotic cell cycle	GO:0000278	306	0.323
meiotic cell cycle	GO:0051321	272	0.295
regulation of cytoskeleton organization	GO:0051493	63	0.260
spindle organization	GO:0007051	37	0.236
mitotic nuclear division	GO:0007067	131	0.232
nuclear division	GO:0000280	263	0.217
cell division	GO:0051301	205	0.195
negative regulation of organelle organization	GO:0010639	103	0.175
regulation of cellular component organization	GO:0051128	334	0.164
organelle localization	GO:0051640	128	0.158
mitotic sister chromatid segregation	GO:0000070	85	0.143
organelle fission	GO:0048285	272	0.134
cytokinesis	GO:0000910	92	0.116
regulation of microtubule polymerization or depolymerization	GO:0031110	18	0.114
chromosome segregation	GO:0007059	159	0.113
maintenance of protein location	GO:0045185	53	0.107
regulation of biological quality	GO:0065008	391	0.107
negative regulation of cell division	GO:0051782	66	0.098
regulation of mitosis	GO:0007088	65	0.097
positive regulation of cellular biosynthetic process	GO:0031328	336	0.096
meiotic cell cycle process	GO:1903046	229	0.091
protein complex biogenesis	GO:0070271	314	0.088
secretion by cell	GO:0032940	50	0.087
regulation of organelle organization	GO:0033043	243	0.087
negative regulation of cellular component organization	GO:0051129	109	0.086
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.083
meiotic nuclear division	GO:0007126	163	0.082
microtubule anchoring	GO:0034453	25	0.082
dna replication	GO:0006260	147	0.078
negative regulation of cytoskeleton organization	GO:0051494	24	0.077
negative regulation of gene expression	GO:0010629	312	0.073
single organism catabolic process	GO:0044712	619	0.072
maintenance of protein location in cell	GO:0032507	50	0.070
mitochondrion organization	GO:0007005	261	0.069
positive regulation of macromolecule metabolic process	GO:0010604	394	0.065
attachment of spindle microtubules to kinetochore	GO:0008608	25	0.063
protein transport	GO:0015031	345	0.063
negative regulation of mitotic cell cycle phase transition	GO:1901991	57	0.062
reproduction of a single celled organism	GO:0032505	191	0.060
protein complex assembly	GO:0006461	302	0.060
maintenance of location in cell	GO:0051651	58	0.060
single organism cellular localization	GO:1902580	375	0.060
positive regulation of biosynthetic process	GO:0009891	336	0.059
regulation of cell cycle process	GO:0010564	150	0.058
positive regulation of cellular component organization	GO:0051130	116	0.057
establishment of organelle localization	GO:0051656	96	0.056
modification dependent macromolecule catabolic process	GO:0043632	203	0.056
microtubule polymerization or depolymerization	GO:0031109	36	0.053
regulation of cell division	GO:0051302	113	0.052
cellular component morphogenesis	GO:0032989	97	0.050
regulation of mitotic cell cycle	GO:0007346	107	0.049
maintenance of location	GO:0051235	66	0.049
organelle assembly	GO:0070925	118	0.048
nucleoside phosphate metabolic process	GO:0006753	458	0.048
cellular response to chemical stimulus	GO:0070887	315	0.047
rna 3 end processing	GO:0031123	88	0.047
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.045
regulation of nuclear division	GO:0051783	103	0.044
intracellular protein transport	GO:0006886	319	0.043
establishment or maintenance of cell polarity	GO:0007163	96	0.042
mitotic cell cycle checkpoint	GO:0007093	56	0.042
microtubule based movement	GO:0007018	18	0.041
mitotic spindle organization	GO:0007052	30	0.040
negative regulation of cellular metabolic process	GO:0031324	407	0.039
cellular protein catabolic process	GO:0044257	213	0.039
nucleus localization	GO:0051647	22	0.038
positive regulation of organelle organization	GO:0010638	85	0.038
microtubule depolymerization	GO:0007019	8	0.038
mrna metabolic process	GO:0016071	269	0.038
negative regulation of microtubule polymerization or depolymerization	GO:0031111	7	0.038
regulation of cell cycle	GO:0051726	195	0.037
cytoskeleton dependent cytokinesis	GO:0061640	65	0.037
organonitrogen compound catabolic process	GO:1901565	404	0.036
microtubule organizing center organization	GO:0031023	33	0.036
ubiquitin dependent protein catabolic process	GO:0006511	181	0.036
phosphorylation	GO:0016310	291	0.036
cellular protein complex disassembly	GO:0043624	42	0.035
positive regulation of rna metabolic process	GO:0051254	294	0.034
negative regulation of cell cycle phase transition	GO:1901988	59	0.034
response to chemical	GO:0042221	390	0.034
spindle pole body separation	GO:0000073	13	0.034
spindle pole body organization	GO:0051300	33	0.033
negative regulation of nuclear division	GO:0051784	62	0.033
actin filament based process	GO:0030029	104	0.033
positive regulation of transcription dna templated	GO:0045893	286	0.033
asexual reproduction	GO:0019954	48	0.033
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.033
protein complex disassembly	GO:0043241	70	0.032
purine nucleoside metabolic process	GO:0042278	380	0.032
cell cycle g2 m phase transition	GO:0044839	39	0.032
microtubule based transport	GO:0010970	18	0.032
mitotic cytokinesis	GO:0000281	58	0.031
macromolecule methylation	GO:0043414	85	0.031
establishment of protein localization	GO:0045184	367	0.030
single organism developmental process	GO:0044767	258	0.029
glycosyl compound metabolic process	GO:1901657	398	0.029
regulation of protein localization	GO:0032880	62	0.029
actin cytoskeleton organization	GO:0030036	100	0.029
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.029
dna geometric change	GO:0032392	43	0.028
chromatin organization	GO:0006325	242	0.028
protein localization to organelle	GO:0033365	337	0.028
anatomical structure development	GO:0048856	160	0.027
spindle assembly	GO:0051225	9	0.027
regulation of cellular localization	GO:0060341	50	0.026
dna repair	GO:0006281	236	0.026
cellular macromolecule catabolic process	GO:0044265	363	0.026
cellular response to oxidative stress	GO:0034599	94	0.026
establishment of nucleus localization	GO:0040023	22	0.025
nuclear migration along microtubule	GO:0030473	18	0.025
protein targeting	GO:0006605	272	0.024
protein alkylation	GO:0008213	48	0.024
growth of unicellular organism as a thread of attached cells	GO:0070783	105	0.024
reproductive process	GO:0022414	248	0.024
protein processing	GO:0016485	64	0.024
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.023
multi organism process	GO:0051704	233	0.023
mitotic cytokinesis site selection	GO:1902408	35	0.023
developmental process involved in reproduction	GO:0003006	159	0.022
filamentous growth	GO:0030447	124	0.022
protein polymerization	GO:0051258	51	0.022
recombinational repair	GO:0000725	64	0.022
growth	GO:0040007	157	0.022
negative regulation of cell cycle	GO:0045786	91	0.022
cellular component disassembly	GO:0022411	86	0.022
nucleotide metabolic process	GO:0009117	453	0.021
chromosome organization involved in meiosis	GO:0070192	32	0.021
positive regulation of gene expression	GO:0010628	321	0.021
monosaccharide metabolic process	GO:0005996	83	0.020
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.020
modification dependent protein catabolic process	GO:0019941	181	0.020
cytokinetic process	GO:0032506	78	0.020
regulation of chromosome organization	GO:0033044	66	0.020
cellular response to dna damage stimulus	GO:0006974	287	0.020
regulation of cellular component biogenesis	GO:0044087	112	0.020
mitotic spindle elongation	GO:0000022	14	0.020
negative regulation of cellular biosynthetic process	GO:0031327	312	0.020
response to oxidative stress	GO:0006979	99	0.020
purine containing compound metabolic process	GO:0072521	400	0.020
sister chromatid segregation	GO:0000819	93	0.019
anatomical structure morphogenesis	GO:0009653	160	0.019
chromatin silencing at silent mating type cassette	GO:0030466	53	0.019
telomere maintenance	GO:0000723	74	0.019
methylation	GO:0032259	101	0.019
aromatic compound catabolic process	GO:0019439	491	0.019
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	137	0.019
heterocycle catabolic process	GO:0046700	494	0.018
negative regulation of macromolecule metabolic process	GO:0010605	375	0.018
chromatin modification	GO:0016568	200	0.018
positive regulation of cytoskeleton organization	GO:0051495	39	0.018
cytokinesis site selection	GO:0007105	40	0.018
regulation of catabolic process	GO:0009894	199	0.018
regulation of phosphorus metabolic process	GO:0051174	230	0.018
organelle inheritance	GO:0048308	51	0.018
regulation of catalytic activity	GO:0050790	307	0.018
positive regulation of rna biosynthetic process	GO:1902680	286	0.018
sporulation resulting in formation of a cellular spore	GO:0030435	129	0.018
regulation of localization	GO:0032879	127	0.018
double strand break repair via homologous recombination	GO:0000724	54	0.018
dna integrity checkpoint	GO:0031570	41	0.018
cell morphogenesis	GO:0000902	30	0.018
sexual reproduction	GO:0019953	216	0.018
purine ribonucleoside metabolic process	GO:0046128	380	0.018
chemical homeostasis	GO:0048878	137	0.017
cellular protein complex assembly	GO:0043623	209	0.017
response to organic cyclic compound	GO:0014070	1	0.017
spindle assembly involved in mitosis	GO:0090307	4	0.017
meiotic chromosome segregation	GO:0045132	31	0.017
anion transport	GO:0006820	145	0.017
meiosis i	GO:0007127	92	0.017
negative regulation of cellular catabolic process	GO:0031330	43	0.017
developmental process	GO:0032502	261	0.017
protein catabolic process	GO:0030163	221	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.016
cellular component assembly involved in morphogenesis	GO:0010927	73	0.016
purine nucleotide metabolic process	GO:0006163	376	0.016
spindle elongation	GO:0051231	14	0.016
cellular amino acid metabolic process	GO:0006520	225	0.016
cell cycle checkpoint	GO:0000075	82	0.016
cellular nitrogen compound catabolic process	GO:0044270	494	0.016
ascospore formation	GO:0030437	107	0.016
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.016
mitotic metaphase plate congression	GO:0007080	8	0.016
proteolysis involved in cellular protein catabolic process	GO:0051603	198	0.015
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	137	0.015
positive regulation of protein complex assembly	GO:0031334	39	0.015
regulation of molecular function	GO:0065009	320	0.015
negative regulation of molecular function	GO:0044092	68	0.015
regulation of mitotic cell cycle phase transition	GO:1901990	68	0.015
hexose metabolic process	GO:0019318	78	0.015
regulation of cell cycle phase transition	GO:1901987	70	0.015
regulation of dna metabolic process	GO:0051052	100	0.015
regulation of protein polymerization	GO:0032271	33	0.015
organophosphate metabolic process	GO:0019637	597	0.015
response to organic substance	GO:0010033	182	0.015
nucleobase containing compound catabolic process	GO:0034655	479	0.015
negative regulation of mitosis	GO:0045839	39	0.014
regulation of mitotic spindle organization	GO:0060236	8	0.014
establishment of cell polarity	GO:0030010	64	0.014
dna recombination	GO:0006310	172	0.014
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.014
homeostatic process	GO:0042592	227	0.014
dna conformation change	GO:0071103	98	0.014
cellular bud site selection	GO:0000282	35	0.014
cellular amide metabolic process	GO:0043603	59	0.014
cellular component movement	GO:0006928	20	0.014
regulation of phosphate metabolic process	GO:0019220	230	0.014
macromolecule catabolic process	GO:0009057	383	0.014
rna dependent dna replication	GO:0006278	25	0.014
negative regulation of biosynthetic process	GO:0009890	312	0.014
establishment of protein localization to organelle	GO:0072594	278	0.014
nucleobase containing small molecule metabolic process	GO:0055086	491	0.014
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.013
single organism reproductive process	GO:0044702	159	0.013
regulation of protein metabolic process	GO:0051246	237	0.013
mitochondrial genome maintenance	GO:0000002	40	0.013
nitrogen compound transport	GO:0071705	212	0.013
negative regulation of protein processing	GO:0010955	33	0.013
negative regulation of cell cycle process	GO:0010948	86	0.013
organelle transport along microtubule	GO:0072384	18	0.013
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.013
purine containing compound catabolic process	GO:0072523	332	0.013
regulation of exit from mitosis	GO:0007096	29	0.013
vesicle mediated transport	GO:0016192	335	0.012
microtubule polymerization	GO:0046785	30	0.012
signal transduction	GO:0007165	208	0.012
nuclear migration	GO:0007097	22	0.012
macromolecular complex disassembly	GO:0032984	80	0.012
mitotic cell cycle phase transition	GO:0044772	141	0.012
gtp catabolic process	GO:0006184	107	0.012
negative regulation of transcription dna templated	GO:0045892	258	0.012
cell differentiation	GO:0030154	161	0.012
carboxylic acid biosynthetic process	GO:0046394	152	0.012
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.012
telomere organization	GO:0032200	75	0.012
protein import	GO:0017038	122	0.012
regulation of hydrolase activity	GO:0051336	133	0.012
protein localization to membrane	GO:0072657	102	0.012
negative regulation of phosphorus metabolic process	GO:0010563	49	0.012
cellular response to organic substance	GO:0071310	159	0.012
cellular developmental process	GO:0048869	191	0.012
regulation of cellular catabolic process	GO:0031329	195	0.012
gtp metabolic process	GO:0046039	107	0.012
positive regulation of cellular protein metabolic process	GO:0032270	89	0.012
protein depolymerization	GO:0051261	21	0.011
positive regulation of chromosome segregation	GO:0051984	15	0.011
nuclear transport	GO:0051169	165	0.011
telomere maintenance via telomerase	GO:0007004	21	0.011
mitotic spindle checkpoint	GO:0071174	34	0.011
cellular chemical homeostasis	GO:0055082	123	0.011
multi organism reproductive process	GO:0044703	216	0.011
protein dephosphorylation	GO:0006470	40	0.011
endonucleolytic cleavage involved in rrna processing	GO:0000478	47	0.011
protein maturation	GO:0051604	76	0.011
microtubule cytoskeleton organization involved in mitosis	GO:1902850	13	0.011
positive regulation of purine nucleotide metabolic process	GO:1900544	100	0.011
filamentous growth of a population of unicellular organisms	GO:0044182	109	0.011
regulation of dna templated transcription elongation	GO:0032784	44	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.011
negative regulation of protein metabolic process	GO:0051248	85	0.011
nucleoside phosphate biosynthetic process	GO:1901293	80	0.011
rna phosphodiester bond hydrolysis	GO:0090501	112	0.011
protein ubiquitination	GO:0016567	118	0.011
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.011
carbohydrate metabolic process	GO:0005975	252	0.011
ribonucleoside metabolic process	GO:0009119	389	0.011
organic acid biosynthetic process	GO:0016053	152	0.011
ribonucleoside catabolic process	GO:0042454	332	0.011
negative regulation of phosphate metabolic process	GO:0045936	49	0.011
sexual sporulation	GO:0034293	113	0.011
multi organism cellular process	GO:0044764	120	0.011
purine nucleotide catabolic process	GO:0006195	328	0.011
reciprocal meiotic recombination	GO:0007131	54	0.011
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.011
carboxylic acid metabolic process	GO:0019752	338	0.011
telomere maintenance via telomere lengthening	GO:0010833	22	0.010
carbohydrate derivative metabolic process	GO:1901135	549	0.010
nucleotide biosynthetic process	GO:0009165	79	0.010
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.010
organic acid metabolic process	GO:0006082	352	0.010
nucleoside triphosphate catabolic process	GO:0009143	329	0.010
positive regulation of cellular catabolic process	GO:0031331	128	0.010
organic cyclic compound catabolic process	GO:1901361	499	0.010
negative regulation of catabolic process	GO:0009895	43	0.010
mrna 3 end processing	GO:0031124	54	0.010
ribose phosphate metabolic process	GO:0019693	384	0.010
nucleic acid transport	GO:0050657	94	0.010

SHE1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

	Disease	DO term ID	Size	Probability	Func Analog Org
	disease of anatomical entity	DOID:7	0	0.014

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network