IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

56 known processes

PEX2 (YJL210W)

Pex2p

(Aliases: PAS5,CRT1)

Entrez: 853219
SGD: S000003746
UniProtKB: P32800

Process Predictions
Disease Predictions

PEX2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability
intracellular protein transmembrane import	GO:0044743	67	0.931
transmembrane transport	GO:0055085	349	0.927
protein transmembrane transport	GO:0071806	82	0.919
intracellular protein transmembrane transport	GO:0065002	80	0.915
establishment of protein localization	GO:0045184	367	0.903
protein localization to peroxisome	GO:0072662	22	0.874
protein targeting to peroxisome	GO:0006625	22	0.850
peroxisome organization	GO:0007031	68	0.831
peroxisomal transport	GO:0043574	22	0.795
protein targeting	GO:0006605	272	0.785
establishment of protein localization to peroxisome	GO:0072663	22	0.772
protein import	GO:0017038	122	0.766
protein import into peroxisome matrix	GO:0016558	20	0.726
protein transport	GO:0015031	345	0.700
establishment of protein localization to organelle	GO:0072594	278	0.539
intracellular protein transport	GO:0006886	319	0.516
protein localization to organelle	GO:0033365	337	0.498
single organism cellular localization	GO:1902580	375	0.481
protein ubiquitination	GO:0016567	118	0.314
protein modification by small protein conjugation or removal	GO:0070647	172	0.241
protein import into peroxisome matrix docking	GO:0016560	5	0.224
cellular macromolecule catabolic process	GO:0044265	363	0.188
histone modification	GO:0016570	119	0.153
modification dependent macromolecule catabolic process	GO:0043632	203	0.149
protein polyubiquitination	GO:0000209	20	0.143
protein modification by small protein conjugation	GO:0032446	144	0.126
dna repair	GO:0006281	236	0.120
protein localization to membrane	GO:0072657	102	0.115
microtubule cytoskeleton organization	GO:0000226	109	0.110
modification dependent protein catabolic process	GO:0019941	181	0.109
purine containing compound metabolic process	GO:0072521	400	0.100
lipid metabolic process	GO:0006629	269	0.099
protein catabolic process	GO:0030163	221	0.098
protein monoubiquitination	GO:0006513	13	0.097
proteolysis	GO:0006508	268	0.094
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.093
negative regulation of cellular metabolic process	GO:0031324	407	0.092
protein targeting to membrane	GO:0006612	52	0.091
protein import into peroxisome matrix receptor recycling	GO:0016562	5	0.089
response to chemical	GO:0042221	390	0.086
cell communication	GO:0007154	345	0.086
signaling	GO:0023052	208	0.085
cellular lipid metabolic process	GO:0044255	229	0.083
nucleoside metabolic process	GO:0009116	394	0.082
nuclear division	GO:0000280	263	0.080
organelle fission	GO:0048285	272	0.080
regulation of signaling	GO:0023051	119	0.079
proteolysis involved in cellular protein catabolic process	GO:0051603	198	0.078
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.077
negative regulation of biosynthetic process	GO:0009890	312	0.072
nucleoside monophosphate metabolic process	GO:0009123	267	0.071
macromolecule catabolic process	GO:0009057	383	0.070
nucleotide metabolic process	GO:0009117	453	0.068
vesicle mediated transport	GO:0016192	335	0.068
regulation of cell communication	GO:0010646	124	0.068
cell division	GO:0051301	205	0.065
cellular lipid catabolic process	GO:0044242	33	0.063
negative regulation of macromolecule metabolic process	GO:0010605	375	0.061
glycosyl compound metabolic process	GO:1901657	398	0.061
single organism catabolic process	GO:0044712	619	0.061
negative regulation of gene expression	GO:0010629	312	0.061
nucleic acid phosphodiester bond hydrolysis	GO:0090305	194	0.060
membrane docking	GO:0022406	22	0.060
purine ribonucleotide biosynthetic process	GO:0009152	39	0.059
regulation of cellular component organization	GO:0051128	334	0.059
regulation of biological quality	GO:0065008	391	0.057
carbohydrate derivative biosynthetic process	GO:1901137	181	0.056
proton transport	GO:0015992	61	0.055
ubiquitin dependent protein catabolic process	GO:0006511	181	0.055
mitotic recombination	GO:0006312	55	0.055
ribose phosphate metabolic process	GO:0019693	384	0.055
meiotic cell cycle	GO:0051321	272	0.055
cellular nitrogen compound catabolic process	GO:0044270	494	0.053
cellular response to chemical stimulus	GO:0070887	315	0.053
negative regulation of cellular component organization	GO:0051129	109	0.052
nucleobase containing compound catabolic process	GO:0034655	479	0.050
nucleoside phosphate metabolic process	GO:0006753	458	0.049
purine nucleotide metabolic process	GO:0006163	376	0.048
organophosphate metabolic process	GO:0019637	597	0.047
regulation of phosphate metabolic process	GO:0019220	230	0.047
aromatic compound catabolic process	GO:0019439	491	0.047
microtubule based process	GO:0007017	117	0.046
purine nucleotide biosynthetic process	GO:0006164	41	0.046
covalent chromatin modification	GO:0016569	119	0.045
mitotic cell cycle process	GO:1903047	294	0.044
ribonucleoside metabolic process	GO:0009119	389	0.043
negative regulation of rna metabolic process	GO:0051253	262	0.042
single organism signaling	GO:0044700	208	0.042
negative regulation of gene expression epigenetic	GO:0045814	147	0.041
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.041
regulation of phosphorus metabolic process	GO:0051174	230	0.041
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.040
ribonucleoside monophosphate metabolic process	GO:0009161	265	0.039
regulation of cell cycle phase transition	GO:1901987	70	0.039
cellular protein catabolic process	GO:0044257	213	0.038
ion transmembrane transport	GO:0034220	200	0.038
chromatin modification	GO:0016568	200	0.038
cellular divalent inorganic cation homeostasis	GO:0072503	21	0.038
positive regulation of molecular function	GO:0044093	185	0.038
regulation of localization	GO:0032879	127	0.037
response to abiotic stimulus	GO:0009628	159	0.037
regulation of mitotic cell cycle phase transition	GO:1901990	68	0.036
organophosphate ester transport	GO:0015748	45	0.035
fungal type cell wall organization	GO:0031505	145	0.035
nucleotide biosynthetic process	GO:0009165	79	0.035
translation	GO:0006412	230	0.034
trna processing	GO:0008033	101	0.033
ribonucleotide metabolic process	GO:0009259	377	0.033
regulation of gene expression epigenetic	GO:0040029	147	0.033
nucleobase containing compound transport	GO:0015931	124	0.033
purine nucleoside metabolic process	GO:0042278	380	0.033
mitotic cell cycle	GO:0000278	306	0.032
mitotic cell cycle phase transition	GO:0044772	141	0.032
dna integrity checkpoint	GO:0031570	41	0.032
homeostatic process	GO:0042592	227	0.032
purine ribonucleotide metabolic process	GO:0009150	372	0.032
regulation of mitotic cell cycle	GO:0007346	107	0.032
carbohydrate derivative metabolic process	GO:1901135	549	0.031
posttranscriptional regulation of gene expression	GO:0010608	115	0.031
chromatin organization	GO:0006325	242	0.030
secretion by cell	GO:0032940	50	0.030
cell cycle g2 m phase transition	GO:0044839	39	0.030
ribose phosphate biosynthetic process	GO:0046390	50	0.030
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.029
purine ribonucleoside metabolic process	GO:0046128	380	0.029
single organism membrane organization	GO:0044802	275	0.029
er associated ubiquitin dependent protein catabolic process	GO:0030433	46	0.029
response to organic cyclic compound	GO:0014070	1	0.029
anatomical structure homeostasis	GO:0060249	74	0.029
nucleobase containing small molecule metabolic process	GO:0055086	491	0.028
proteasomal protein catabolic process	GO:0010498	141	0.028
lipoprotein biosynthetic process	GO:0042158	40	0.028
meiotic cell cycle process	GO:1903046	229	0.028
positive regulation of apoptotic process	GO:0043065	3	0.028
rna modification	GO:0009451	99	0.028
establishment of protein localization to membrane	GO:0090150	99	0.028
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.028
atp metabolic process	GO:0046034	251	0.028
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.027
chromatin silencing at telomere	GO:0006348	84	0.027
negative regulation of cell cycle	GO:0045786	91	0.027
gene silencing	GO:0016458	151	0.027
protein homotetramerization	GO:0051289	1	0.027
nucleoside biosynthetic process	GO:0009163	38	0.027
cation transport	GO:0006812	166	0.027
organonitrogen compound catabolic process	GO:1901565	404	0.027
nucleoside triphosphate metabolic process	GO:0009141	364	0.027
purine nucleoside monophosphate biosynthetic process	GO:0009127	28	0.026
meiotic nuclear division	GO:0007126	163	0.026
negative regulation of cell cycle phase transition	GO:1901988	59	0.026
cytoskeleton dependent intracellular transport	GO:0030705	18	0.026
negative regulation of cell cycle process	GO:0010948	86	0.026
oxoacid metabolic process	GO:0043436	351	0.025
negative regulation of organelle organization	GO:0010639	103	0.025
negative regulation of transcription dna templated	GO:0045892	258	0.025
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.025
protein to membrane docking	GO:0022615	5	0.025
cytoskeleton dependent cytokinesis	GO:0061640	65	0.025
signal transduction	GO:0007165	208	0.025
maintenance of protein location in cell	GO:0032507	50	0.025
nucleoside monophosphate biosynthetic process	GO:0009124	33	0.024
meiosis i	GO:0007127	92	0.024
protein acylation	GO:0043543	66	0.024
microtubule anchoring	GO:0034453	25	0.024
glycosyl compound catabolic process	GO:1901658	335	0.024
carboxylic acid metabolic process	GO:0019752	338	0.024
organophosphate biosynthetic process	GO:0090407	182	0.024
lipid biosynthetic process	GO:0008610	170	0.024
telomere organization	GO:0032200	75	0.024
chromosome segregation	GO:0007059	159	0.024
positive regulation of phosphorus metabolic process	GO:0010562	147	0.023
sister chromatid segregation	GO:0000819	93	0.023
organophosphate catabolic process	GO:0046434	338	0.023
organic anion transport	GO:0015711	114	0.023
glycosyl compound biosynthetic process	GO:1901659	42	0.023
nitrogen compound transport	GO:0071705	212	0.023
nucleoside phosphate biosynthetic process	GO:1901293	80	0.022
cell wall organization or biogenesis	GO:0071554	190	0.022
mitotic cell cycle checkpoint	GO:0007093	56	0.022
cytoskeleton organization	GO:0007010	230	0.022
growth	GO:0040007	157	0.022
external encapsulating structure organization	GO:0045229	146	0.022
purine containing compound biosynthetic process	GO:0072522	53	0.022
anion transport	GO:0006820	145	0.022
multi organism process	GO:0051704	233	0.022
intracellular signal transduction	GO:0035556	112	0.022
secretion	GO:0046903	50	0.022
maintenance of protein location	GO:0045185	53	0.021
cytokinesis	GO:0000910	92	0.021
lipid localization	GO:0010876	60	0.021
lipoprotein metabolic process	GO:0042157	40	0.021
organic acid metabolic process	GO:0006082	352	0.021
cell cycle phase transition	GO:0044770	144	0.021
trna metabolic process	GO:0006399	151	0.021
regulation of protein modification process	GO:0031399	110	0.021
divalent inorganic cation homeostasis	GO:0072507	21	0.020
oxidoreduction coenzyme metabolic process	GO:0006733	58	0.020
ribonucleoside triphosphate catabolic process	GO:0009203	327	0.020
negative regulation of mitotic cell cycle phase transition	GO:1901991	57	0.020
negative regulation of rna biosynthetic process	GO:1902679	260	0.020
conjugation with cellular fusion	GO:0000747	106	0.020
positive regulation of macromolecule metabolic process	GO:0010604	394	0.020
organelle localization	GO:0051640	128	0.019
regulation of signal transduction	GO:0009966	114	0.019
hydrogen transport	GO:0006818	61	0.019
regulation of protein metabolic process	GO:0051246	237	0.019
ion transport	GO:0006811	274	0.019
cellular response to dna damage stimulus	GO:0006974	287	0.019
maintenance of location	GO:0051235	66	0.019
sexual reproduction	GO:0019953	216	0.018
positive regulation of phosphate metabolic process	GO:0045937	147	0.018
positive regulation of biosynthetic process	GO:0009891	336	0.018
regulation of catabolic process	GO:0009894	199	0.018
organic cyclic compound catabolic process	GO:1901361	499	0.018
protein complex assembly	GO:0006461	302	0.018
positive regulation of cell death	GO:0010942	3	0.018
aerobic respiration	GO:0009060	55	0.018
cell wall organization	GO:0071555	146	0.018
postreplication repair	GO:0006301	24	0.017
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.017
microtubule based transport	GO:0010970	18	0.017
trna modification	GO:0006400	75	0.017
dna damage checkpoint	GO:0000077	29	0.017
carbohydrate derivative catabolic process	GO:1901136	339	0.017
dna templated transcription termination	GO:0006353	42	0.017
regulation of cellular component biogenesis	GO:0044087	112	0.016
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.016
nucleoside catabolic process	GO:0009164	335	0.016
small gtpase mediated signal transduction	GO:0007264	36	0.016
protein processing	GO:0016485	64	0.016
regulation of catalytic activity	GO:0050790	307	0.016
lipid transport	GO:0006869	58	0.016
regulation of protein complex assembly	GO:0043254	77	0.016
positive regulation of catalytic activity	GO:0043085	178	0.016
ncrna processing	GO:0034470	330	0.016
response to oxidative stress	GO:0006979	99	0.015
telomere maintenance via recombination	GO:0000722	32	0.015
mitochondrial respiratory chain complex iv assembly	GO:0033617	18	0.015
cellular homeostasis	GO:0019725	138	0.015
dna replication	GO:0006260	147	0.015
positive regulation of cytoskeleton organization	GO:0051495	39	0.015
purine ribonucleotide catabolic process	GO:0009154	327	0.015
pigment biosynthetic process	GO:0046148	22	0.015
nucleoside phosphate catabolic process	GO:1901292	331	0.015
regulation of cellular localization	GO:0060341	50	0.015
negative regulation of mitotic cell cycle	GO:0045930	63	0.015
protein dna complex subunit organization	GO:0071824	153	0.015
response to external stimulus	GO:0009605	158	0.014
purine nucleoside biosynthetic process	GO:0042451	31	0.014
peptidyl amino acid modification	GO:0018193	116	0.014
regulation of cellular catabolic process	GO:0031329	195	0.014
apoptotic process	GO:0006915	30	0.014
cellular response to oxidative stress	GO:0034599	94	0.014
exocytosis	GO:0006887	42	0.014
death	GO:0016265	30	0.014
cellular ketone metabolic process	GO:0042180	63	0.014
positive regulation of cellular biosynthetic process	GO:0031328	336	0.014
regulation of cellular protein metabolic process	GO:0032268	232	0.014
positive regulation of programmed cell death	GO:0043068	3	0.014
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.014
nucleotide catabolic process	GO:0009166	330	0.014
regulation of response to stimulus	GO:0048583	157	0.013
dna dependent dna replication	GO:0006261	115	0.013
phosphorylation	GO:0016310	291	0.013
amide transport	GO:0042886	22	0.013
purine containing compound catabolic process	GO:0072523	332	0.013
reproductive process in single celled organism	GO:0022413	145	0.013
nucleoside transport	GO:0015858	14	0.013
response to temperature stimulus	GO:0009266	74	0.013
hydrogen ion transmembrane transport	GO:1902600	49	0.013
protein complex biogenesis	GO:0070271	314	0.013
cofactor transport	GO:0051181	16	0.012
regulation of dna replication	GO:0006275	51	0.012
regulation of intracellular signal transduction	GO:1902531	78	0.012
positive regulation of rna biosynthetic process	GO:1902680	286	0.012
regulation of translation	GO:0006417	89	0.012
protein ubiquitination involved in ubiquitin dependent protein catabolic process	GO:0042787	26	0.012
respiratory chain complex iv assembly	GO:0008535	18	0.012
negative regulation of cellular biosynthetic process	GO:0031327	312	0.012
purine nucleoside monophosphate metabolic process	GO:0009126	262	0.012
carboxylic acid transport	GO:0046942	74	0.012
small molecule biosynthetic process	GO:0044283	258	0.012
phospholipid biosynthetic process	GO:0008654	89	0.012
late endosome to vacuole transport	GO:0045324	42	0.012
lipid catabolic process	GO:0016042	33	0.012
purine ribonucleoside monophosphate biosynthetic process	GO:0009168	28	0.011
cellular component disassembly	GO:0022411	86	0.011
purine nucleotide catabolic process	GO:0006195	328	0.011
cellular amide metabolic process	GO:0043603	59	0.011
positive regulation of catabolic process	GO:0009896	135	0.011
histone ubiquitination	GO:0016574	17	0.011
single organism developmental process	GO:0044767	258	0.011
dna recombination	GO:0006310	172	0.011
ribonucleotide biosynthetic process	GO:0009260	44	0.011
anion transmembrane transport	GO:0098656	79	0.011
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.011
cell aging	GO:0007569	70	0.011
purine ribonucleoside triphosphate catabolic process	GO:0009207	327	0.011
heme metabolic process	GO:0042168	15	0.011
organic acid catabolic process	GO:0016054	71	0.011
endocytosis	GO:0006897	90	0.011
cellular amine metabolic process	GO:0044106	51	0.011
mitotic sister chromatid segregation	GO:0000070	85	0.011
spindle organization	GO:0007051	37	0.011
rna localization	GO:0006403	112	0.011
response to extracellular stimulus	GO:0009991	156	0.011
nad metabolic process	GO:0019674	25	0.011
regulation of organelle organization	GO:0033043	243	0.011
negative regulation of catabolic process	GO:0009895	43	0.011
double strand break repair	GO:0006302	105	0.011
regulation of mitochondrion organization	GO:0010821	20	0.011
mitotic dna integrity checkpoint	GO:0044774	18	0.011
g protein coupled receptor signaling pathway	GO:0007186	37	0.010
hexose metabolic process	GO:0019318	78	0.010
organic acid transport	GO:0015849	77	0.010
vacuolar transport	GO:0007034	145	0.010
nucleoside triphosphate catabolic process	GO:0009143	329	0.010
monocarboxylic acid transport	GO:0015718	24	0.010
maintenance of location in cell	GO:0051651	58	0.010
nucleus organization	GO:0006997	62	0.010
translesion synthesis	GO:0019985	16	0.010
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.010
amino acid import	GO:0043090	2	0.010
rrna metabolic process	GO:0016072	244	0.010
positive regulation of protein metabolic process	GO:0051247	93	0.010
conjugation	GO:0000746	107	0.010
dephosphorylation	GO:0016311	127	0.010
regulation of molecular function	GO:0065009	320	0.010
inorganic ion transmembrane transport	GO:0098660	109	0.010

PEX2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.016
disease of metabolism	DOID:0014667	0.014
inherited metabolic disorder	DOID:655	0.014
nervous system disease	DOID:863	0.013
organ system cancer	DOID:0050686	0.010
disease of cellular proliferation	DOID:14566	0.010
cancer	DOID:162	0.010

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network