IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

125 known processes

PEX6 (YNL329C)

Pex6p

(Aliases: PAS8)

SGD: S000005273
Entrez: 855387
UniProtKB: P33760

Process Predictions
Disease Predictions

PEX6 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
transmembrane transport	GO:0055085	349	0.974
protein transmembrane transport	GO:0071806	82	0.947
intracellular protein transmembrane transport	GO:0065002	80	0.928
protein targeting	GO:0006605	272	0.908
protein import	GO:0017038	122	0.906
peroxisome organization	GO:0007031	68	0.893
establishment of protein localization to organelle	GO:0072594	278	0.855
protein import into peroxisome matrix	GO:0016558	20	0.849
protein targeting to peroxisome	GO:0006625	22	0.824
intracellular protein transmembrane import	GO:0044743	67	0.788
protein transport	GO:0015031	345	0.786
peroxisomal transport	GO:0043574	22	0.752
establishment of protein localization	GO:0045184	367	0.750
intracellular protein transport	GO:0006886	319	0.726
protein localization to peroxisome	GO:0072662	22	0.711
establishment of protein localization to peroxisome	GO:0072663	22	0.711
single organism cellular localization	GO:1902580	375	0.646
signaling	GO:0023052	208	0.606
protein localization to organelle	GO:0033365	337	0.448
protein import into peroxisome matrix receptor recycling	GO:0016562	5	0.396
carbohydrate derivative metabolic process	GO:1901135	549	0.244
cell communication	GO:0007154	345	0.201
single organism membrane organization	GO:0044802	275	0.200
nucleotide metabolic process	GO:0009117	453	0.196
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.186
organophosphate metabolic process	GO:0019637	597	0.175
ribonucleoside monophosphate metabolic process	GO:0009161	265	0.168
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.164
purine nucleoside metabolic process	GO:0042278	380	0.163
purine ribonucleoside monophosphate metabolic process	GO:0009167	262	0.148
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.146
purine ribonucleoside triphosphate catabolic process	GO:0009207	327	0.136
organelle localization	GO:0051640	128	0.136
atp metabolic process	GO:0046034	251	0.130
organonitrogen compound biosynthetic process	GO:1901566	314	0.128
nucleobase containing compound catabolic process	GO:0034655	479	0.124
nucleoside phosphate metabolic process	GO:0006753	458	0.120
anion transport	GO:0006820	145	0.118
cellular response to dna damage stimulus	GO:0006974	287	0.115
purine ribonucleotide metabolic process	GO:0009150	372	0.114
nucleoside phosphate catabolic process	GO:1901292	331	0.114
ribonucleoside metabolic process	GO:0009119	389	0.113
lipid biosynthetic process	GO:0008610	170	0.107
nucleotide catabolic process	GO:0009166	330	0.105
vesicle mediated transport	GO:0016192	335	0.105
single organism catabolic process	GO:0044712	619	0.104
ribonucleotide metabolic process	GO:0009259	377	0.103
nucleoside triphosphate metabolic process	GO:0009141	364	0.101
regulation of cellular component organization	GO:0051128	334	0.100
aromatic compound catabolic process	GO:0019439	491	0.097
purine nucleoside triphosphate catabolic process	GO:0009146	329	0.095
purine ribonucleotide catabolic process	GO:0009154	327	0.094
signal transduction	GO:0007165	208	0.094
nucleoside monophosphate metabolic process	GO:0009123	267	0.091
ribonucleotide catabolic process	GO:0009261	327	0.090
cellular lipid metabolic process	GO:0044255	229	0.087
ribonucleoside triphosphate catabolic process	GO:0009203	327	0.085
purine nucleotide catabolic process	GO:0006195	328	0.083
organic cyclic compound catabolic process	GO:1901361	499	0.081
purine containing compound catabolic process	GO:0072523	332	0.081
glycerolipid metabolic process	GO:0046486	108	0.080
nucleobase containing small molecule metabolic process	GO:0055086	491	0.080
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.079
purine containing compound metabolic process	GO:0072521	400	0.078
intracellular signal transduction	GO:0035556	112	0.077
purine ribonucleoside catabolic process	GO:0046130	330	0.076
purine nucleoside monophosphate metabolic process	GO:0009126	262	0.075
peroxisome degradation	GO:0030242	22	0.072
nucleoside catabolic process	GO:0009164	335	0.063
negative regulation of transcription dna templated	GO:0045892	258	0.061
proteolysis	GO:0006508	268	0.060
ribonucleoside catabolic process	GO:0042454	332	0.060
organonitrogen compound catabolic process	GO:1901565	404	0.059
cellular response to external stimulus	GO:0071496	150	0.058
nucleoside metabolic process	GO:0009116	394	0.058
purine nucleoside monophosphate catabolic process	GO:0009128	224	0.056
single organism signaling	GO:0044700	208	0.054
ion transport	GO:0006811	274	0.054
fungal type cell wall organization or biogenesis	GO:0071852	169	0.053
alcohol metabolic process	GO:0006066	112	0.052
oxoacid metabolic process	GO:0043436	351	0.051
phospholipid metabolic process	GO:0006644	125	0.048
cell wall organization or biogenesis	GO:0071554	190	0.048
protein complex assembly	GO:0006461	302	0.048
regulation of molecular function	GO:0065009	320	0.046
positive regulation of transcription dna templated	GO:0045893	286	0.045
regulation of catabolic process	GO:0009894	199	0.044
membrane organization	GO:0061024	276	0.044
carboxylic acid metabolic process	GO:0019752	338	0.042
sexual reproduction	GO:0019953	216	0.042
dna templated transcription elongation	GO:0006354	91	0.040
lipid metabolic process	GO:0006629	269	0.040
receptor metabolic process	GO:0043112	8	0.038
regulation of response to stimulus	GO:0048583	157	0.038
cellular response to nutrient levels	GO:0031669	144	0.037
nucleoside triphosphate catabolic process	GO:0009143	329	0.037
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.035
organic acid transport	GO:0015849	77	0.035
positive regulation of cellular biosynthetic process	GO:0031328	336	0.035
cytoskeleton dependent cytokinesis	GO:0061640	65	0.034
response to nutrient levels	GO:0031667	150	0.034
phospholipid biosynthetic process	GO:0008654	89	0.034
cell division	GO:0051301	205	0.034
nitrogen compound transport	GO:0071705	212	0.033
sexual sporulation resulting in formation of a cellular spore	GO:0043935	113	0.031
regulation of cell communication	GO:0010646	124	0.031
organic anion transport	GO:0015711	114	0.031
fatty acid catabolic process	GO:0009062	17	0.030
cation transport	GO:0006812	166	0.030
regulation of signal transduction	GO:0009966	114	0.030
cellular response to extracellular stimulus	GO:0031668	150	0.030
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	38	0.028
positive regulation of gene expression	GO:0010628	321	0.028
organic acid metabolic process	GO:0006082	352	0.027
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.027
mitotic cell cycle phase transition	GO:0044772	141	0.026
negative regulation of rna biosynthetic process	GO:1902679	260	0.026
fungal type cell wall organization	GO:0031505	145	0.026
dephosphorylation	GO:0016311	127	0.026
transcription elongation from rna polymerase ii promoter	GO:0006368	81	0.026
autophagy	GO:0006914	106	0.026
reproductive process	GO:0022414	248	0.025
carboxylic acid catabolic process	GO:0046395	71	0.025
glycerophospholipid metabolic process	GO:0006650	98	0.025
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.024
single organism reproductive process	GO:0044702	159	0.024
positive regulation of biosynthetic process	GO:0009891	336	0.024
monocarboxylic acid metabolic process	GO:0032787	122	0.024
lipid catabolic process	GO:0016042	33	0.024
protein complex biogenesis	GO:0070271	314	0.024
regulation of transport	GO:0051049	85	0.023
response to extracellular stimulus	GO:0009991	156	0.023
positive regulation of catabolic process	GO:0009896	135	0.023
carbohydrate derivative biosynthetic process	GO:1901137	181	0.023
mitotic cell cycle process	GO:1903047	294	0.022
purine nucleotide metabolic process	GO:0006163	376	0.022
positive regulation of macromolecule metabolic process	GO:0010604	394	0.022
alcohol biosynthetic process	GO:0046165	75	0.022
organic hydroxy compound biosynthetic process	GO:1901617	81	0.021
cellular homeostasis	GO:0019725	138	0.021
negative regulation of gene expression epigenetic	GO:0045814	147	0.021
endocytosis	GO:0006897	90	0.020
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.019
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.019
regulation of intracellular signal transduction	GO:1902531	78	0.019
multi organism reproductive process	GO:0044703	216	0.019
negative regulation of gene expression	GO:0010629	312	0.019
protein modification by small protein conjugation or removal	GO:0070647	172	0.019
multi organism process	GO:0051704	233	0.019
cellular ketone metabolic process	GO:0042180	63	0.018
cation transmembrane transport	GO:0098655	135	0.018
carbon catabolite regulation of transcription from rna polymerase ii promoter	GO:0000429	34	0.018
regulation of cellular catabolic process	GO:0031329	195	0.018
external encapsulating structure organization	GO:0045229	146	0.018
cellular protein complex assembly	GO:0043623	209	0.018
negative regulation of cellular metabolic process	GO:0031324	407	0.018
oxidation reduction process	GO:0055114	353	0.017
negative regulation of biosynthetic process	GO:0009890	312	0.017
positive regulation of cellular component organization	GO:0051130	116	0.017
ion transmembrane transport	GO:0034220	200	0.017
response to drug	GO:0042493	41	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	198	0.017
modification dependent protein catabolic process	GO:0019941	181	0.017
glycerolipid biosynthetic process	GO:0045017	71	0.017
fatty acid beta oxidation	GO:0006635	12	0.016
regulation of dna templated transcription elongation	GO:0032784	44	0.016
carboxylic acid transport	GO:0046942	74	0.016
regulation of protein complex assembly	GO:0043254	77	0.016
mitochondrial genome maintenance	GO:0000002	40	0.016
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.016
protein targeting to membrane	GO:0006612	52	0.015
mitochondrion organization	GO:0007005	261	0.015
response to chemical	GO:0042221	390	0.015
small molecule catabolic process	GO:0044282	88	0.015
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.015
regulation of cellular ketone metabolic process	GO:0010565	42	0.015
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.015
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	137	0.015
regulation of cellular component biogenesis	GO:0044087	112	0.014
cellular response to abiotic stimulus	GO:0071214	62	0.014
positive regulation of cell death	GO:0010942	3	0.014
lipid modification	GO:0030258	37	0.014
protein localization to vacuole	GO:0072665	92	0.014
cellular component disassembly	GO:0022411	86	0.014
conjugation	GO:0000746	107	0.014
single organism developmental process	GO:0044767	258	0.014
positive regulation of fatty acid oxidation	GO:0046321	3	0.014
regulation of chromatin silencing at telomere	GO:0031938	27	0.013
meiotic cell cycle process	GO:1903046	229	0.013
cellular lipid catabolic process	GO:0044242	33	0.013
cellular macromolecule catabolic process	GO:0044265	363	0.013
chromatin remodeling	GO:0006338	80	0.013
cellular response to oxidative stress	GO:0034599	94	0.013
nucleotide excision repair	GO:0006289	50	0.012
chromatin silencing at telomere	GO:0006348	84	0.012
homeostatic process	GO:0042592	227	0.012
positive regulation of apoptotic process	GO:0043065	3	0.012
regulation of phosphorus metabolic process	GO:0051174	230	0.012
organic hydroxy compound metabolic process	GO:1901615	125	0.012
carbohydrate metabolic process	GO:0005975	252	0.012
ribose phosphate metabolic process	GO:0019693	384	0.012
regulation of catalytic activity	GO:0050790	307	0.012
cell wall biogenesis	GO:0042546	93	0.012
conjugation with cellular fusion	GO:0000747	106	0.012
multi organism cellular process	GO:0044764	120	0.012
regulation of purine nucleotide metabolic process	GO:1900542	109	0.012
positive regulation of phosphorus metabolic process	GO:0010562	147	0.012
positive regulation of lipid catabolic process	GO:0050996	4	0.011
cellular amine metabolic process	GO:0044106	51	0.011
positive regulation of transcription by oleic acid	GO:0061421	4	0.011
dna recombination	GO:0006310	172	0.011
dna repair	GO:0006281	236	0.011
regulation of phosphate metabolic process	GO:0019220	230	0.011
response to uv	GO:0009411	4	0.011
regulation of response to stress	GO:0080134	57	0.011
lipid localization	GO:0010876	60	0.011
glycerophospholipid biosynthetic process	GO:0046474	68	0.011
response to oxidative stress	GO:0006979	99	0.011
late endosome to vacuole transport	GO:0045324	42	0.011
regulation of localization	GO:0032879	127	0.011
cellular response to starvation	GO:0009267	90	0.011
cellular response to chemical stimulus	GO:0070887	315	0.011
macromolecular complex disassembly	GO:0032984	80	0.011
organophosphate biosynthetic process	GO:0090407	182	0.011
carbon catabolite activation of transcription from rna polymerase ii promoter	GO:0000436	22	0.011
protein lipidation	GO:0006497	40	0.010
protein import into peroxisome matrix docking	GO:0016560	5	0.010
positive regulation of catalytic activity	GO:0043085	178	0.010
response to abiotic stimulus	GO:0009628	159	0.010
regulation of cellular response to stress	GO:0080135	50	0.010
sexual sporulation	GO:0034293	113	0.010
small molecule biosynthetic process	GO:0044283	258	0.010
developmental process involved in reproduction	GO:0003006	159	0.010
regulation of fatty acid beta oxidation	GO:0031998	3	0.010
regulation of fatty acid oxidation	GO:0046320	3	0.010
anatomical structure morphogenesis	GO:0009653	160	0.010

PEX6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.068
disease of metabolism	DOID:0014667	0.068
disease of anatomical entity	DOID:7	0.028
nervous system disease	DOID:863	0.014

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