IMP: Integrative Multi-species Prediction

Saccharomyces cerevisiae

38 known processes

TPK2 (YPL203W)

Tpk2p

(Aliases: YKR1,PKA2,PKA3)

Entrez: 855898
SGD: S000006124
UniProtKB: P06245

Process Predictions
Disease Predictions

TPK2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cell communication	GO:0007154	345	0.985
protein phosphorylation	GO:0006468	197	0.927
signaling	GO:0023052	208	0.900
phosphorylation	GO:0016310	291	0.889
intracellular protein transport	GO:0006886	319	0.854	Mouse
signal transduction	GO:0007165	208	0.845
regulation of phosphorylation	GO:0042325	86	0.763
single organism signaling	GO:0044700	208	0.739
regulation of response to stimulus	GO:0048583	157	0.726	Mouse Fly
single organism developmental process	GO:0044767	258	0.722	Human Mouse Worm Fly
intracellular signal transduction	GO:0035556	112	0.637
filamentous growth of a population of unicellular organisms	GO:0044182	109	0.635
filamentous growth	GO:0030447	124	0.607
regulation of signal transduction	GO:0009966	114	0.600	Mouse Fly
nuclear export	GO:0051168	124	0.518	Mouse
regulation of cell communication	GO:0010646	124	0.503	Mouse Rat Fly
negative regulation of cellular metabolic process	GO:0031324	407	0.486
proteolysis	GO:0006508	268	0.482	Human
negative regulation of cell communication	GO:0010648	33	0.454	Mouse Fly
establishment of protein localization	GO:0045184	367	0.450	Mouse
cellular response to dna damage stimulus	GO:0006974	287	0.443
growth of unicellular organism as a thread of attached cells	GO:0070783	105	0.431
organonitrogen compound biosynthetic process	GO:1901566	314	0.416
macromolecule catabolic process	GO:0009057	383	0.390	Human
ras protein signal transduction	GO:0007265	29	0.380
response to chemical	GO:0042221	390	0.365	Human Mouse Rat Fly
nuclear transport	GO:0051169	165	0.361	Mouse
developmental process	GO:0032502	261	0.350	Human Mouse Worm Fly
regulation of phosphorus metabolic process	GO:0051174	230	0.325
regulation of signaling	GO:0023051	119	0.319	Mouse Rat Fly
peptidyl amino acid modification	GO:0018193	116	0.298	Human Mouse Rat
negative regulation of macromolecule metabolic process	GO:0010605	375	0.292
regulation of phosphate metabolic process	GO:0019220	230	0.256
negative regulation of biosynthetic process	GO:0009890	312	0.255
invasive filamentous growth	GO:0036267	65	0.247
carbohydrate derivative metabolic process	GO:1901135	549	0.241
cellular response to chemical stimulus	GO:0070887	315	0.236	Human Mouse
aromatic compound catabolic process	GO:0019439	491	0.232
regulation of protein phosphorylation	GO:0001932	75	0.226
positive regulation of macromolecule metabolic process	GO:0010604	394	0.222
negative regulation of response to stimulus	GO:0048585	40	0.209	Mouse Fly
negative regulation of rna biosynthetic process	GO:1902679	260	0.208
single organism catabolic process	GO:0044712	619	0.203
organophosphate metabolic process	GO:0019637	597	0.201
nucleocytoplasmic transport	GO:0006913	163	0.200	Mouse
regulation of molecular function	GO:0065009	320	0.200	Fly
positive regulation of cellular biosynthetic process	GO:0031328	336	0.200
small gtpase mediated signal transduction	GO:0007264	36	0.198
protein complex biogenesis	GO:0070271	314	0.194
invasive growth in response to glucose limitation	GO:0001403	61	0.186
protein catabolic process	GO:0030163	221	0.182	Human
regulation of transferase activity	GO:0051338	83	0.173
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	137	0.170
regulation of cell cycle process	GO:0010564	150	0.168	Mouse
positive regulation of nucleobase containing compound metabolic process	GO:0045935	409	0.165
carbohydrate derivative biosynthetic process	GO:1901137	181	0.164
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	252	0.163
negative regulation of nitrogen compound metabolic process	GO:0051172	300	0.159
regulation of cell cycle	GO:0051726	195	0.157	Mouse Rat
cellular protein catabolic process	GO:0044257	213	0.154	Human
regulation of cellular component organization	GO:0051128	334	0.153	Human Fly
response to osmotic stress	GO:0006970	83	0.152
single organism cellular localization	GO:1902580	375	0.149	Fly
positive regulation of phosphate metabolic process	GO:0045937	147	0.145
negative regulation of cell cycle process	GO:0010948	86	0.142
cell differentiation	GO:0030154	161	0.142	Human Mouse Worm Fly
cellular lipid metabolic process	GO:0044255	229	0.142
cellular response to extracellular stimulus	GO:0031668	150	0.139
regulation of biological quality	GO:0065008	391	0.132	Human
protein transport	GO:0015031	345	0.131	Mouse
pseudohyphal growth	GO:0007124	75	0.129
response to carbohydrate	GO:0009743	14	0.126	Human
purine ribonucleotide metabolic process	GO:0009150	372	0.122
negative regulation of macromolecule biosynthetic process	GO:0010558	291	0.119
regulation of protein metabolic process	GO:0051246	237	0.118	Human Mouse
negative regulation of nucleic acid templated transcription	GO:1903507	260	0.116
regulation of kinase activity	GO:0043549	71	0.113
actin cytoskeleton organization	GO:0030036	100	0.113
protein complex assembly	GO:0006461	302	0.112
regulation of ras protein signal transduction	GO:0046578	47	0.111
regulation of cellular component biogenesis	GO:0044087	112	0.110	Human Fly
negative regulation of cellular biosynthetic process	GO:0031327	312	0.107
regulation of catabolic process	GO:0009894	199	0.106	Human
energy derivation by oxidation of organic compounds	GO:0015980	125	0.106	Rat
negative regulation of signaling	GO:0023057	30	0.103	Mouse Fly
organelle fission	GO:0048285	272	0.103
nucleobase containing compound catabolic process	GO:0034655	479	0.102
response to oxygen containing compound	GO:1901700	61	0.101	Human
purine containing compound metabolic process	GO:0072521	400	0.100
developmental process involved in reproduction	GO:0003006	159	0.096	Mouse Worm Fly
lipid metabolic process	GO:0006629	269	0.094
positive regulation of phosphorus metabolic process	GO:0010562	147	0.093
negative regulation of transcription dna templated	GO:0045892	258	0.091
negative regulation of signal transduction	GO:0009968	30	0.089	Mouse Fly
glycosyl compound metabolic process	GO:1901657	398	0.089
single organism reproductive process	GO:0044702	159	0.089	Mouse Worm Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	412	0.088
positive regulation of molecular function	GO:0044093	185	0.084	Fly
purine nucleoside triphosphate metabolic process	GO:0009144	356	0.083
response to extracellular stimulus	GO:0009991	156	0.083
cellular component morphogenesis	GO:0032989	97	0.080
regulation of cellular catabolic process	GO:0031329	195	0.078	Human
regulation of catalytic activity	GO:0050790	307	0.076
negative regulation of intracellular signal transduction	GO:1902532	27	0.076
response to temperature stimulus	GO:0009266	74	0.075	Fly
purine nucleotide metabolic process	GO:0006163	376	0.075
response to monosaccharide	GO:0034284	13	0.075	Human
nucleoside catabolic process	GO:0009164	335	0.075
cellular developmental process	GO:0048869	191	0.073	Human Mouse Worm Fly
heterocycle catabolic process	GO:0046700	494	0.073
cell aging	GO:0007569	70	0.070
response to heat	GO:0009408	69	0.068
ribonucleotide metabolic process	GO:0009259	377	0.066
response to organic substance	GO:0010033	182	0.065	Human Mouse Rat
regulation of intracellular signal transduction	GO:1902531	78	0.063
cell surface receptor signaling pathway	GO:0007166	38	0.063	Mouse Fly
carbohydrate derivative catabolic process	GO:1901136	339	0.062
proteasomal protein catabolic process	GO:0010498	141	0.062	Human
purine ribonucleoside triphosphate metabolic process	GO:0009205	354	0.062
positive regulation of response to stimulus	GO:0048584	37	0.060
cellular chemical homeostasis	GO:0055082	123	0.058	Human
aging	GO:0007568	71	0.058
glycosyl compound catabolic process	GO:1901658	335	0.057
ribonucleoside catabolic process	GO:0042454	332	0.056
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	289	0.056
protein maturation	GO:0051604	76	0.055	Mouse
regulation of small gtpase mediated signal transduction	GO:0051056	47	0.055
nucleoside triphosphate metabolic process	GO:0009141	364	0.054
negative regulation of gene expression	GO:0010629	312	0.053
multi organism reproductive process	GO:0044703	216	0.053	Mouse Worm Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	394	0.052
response to endogenous stimulus	GO:0009719	26	0.051	Mouse Rat
positive regulation of nucleocytoplasmic transport	GO:0046824	4	0.051	Mouse
nucleoside metabolic process	GO:0009116	394	0.050
response to nutrient	GO:0007584	52	0.049
ascospore formation	GO:0030437	107	0.048
regulation of cellular protein metabolic process	GO:0032268	232	0.048	Human
nuclear division	GO:0000280	263	0.047
gene silencing	GO:0016458	151	0.047
nucleotide metabolic process	GO:0009117	453	0.046
sexual sporulation	GO:0034293	113	0.046
regulation of cellular response to stress	GO:0080135	50	0.046
positive regulation of cell communication	GO:0010647	28	0.045
cellular nitrogen compound catabolic process	GO:0044270	494	0.044
generation of precursor metabolites and energy	GO:0006091	147	0.044	Rat
positive regulation of biosynthetic process	GO:0009891	336	0.042
cell wall organization or biogenesis	GO:0071554	190	0.042
positive regulation of intracellular protein transport	GO:0090316	3	0.042	Mouse
positive regulation of catalytic activity	GO:0043085	178	0.042
negative regulation of nucleobase containing compound metabolic process	GO:0045934	295	0.042
regulation of localization	GO:0032879	127	0.042	Human Mouse Fly
cellular respiration	GO:0045333	82	0.041	Rat
positive regulation of rna biosynthetic process	GO:1902680	286	0.041
cellular response to organic substance	GO:0071310	159	0.039	Human Mouse
negative regulation of meiotic cell cycle	GO:0051447	24	0.039	Rat
positive regulation of kinase activity	GO:0033674	24	0.039
g protein coupled receptor signaling pathway	GO:0007186	37	0.039
organic cyclic compound catabolic process	GO:1901361	499	0.039
regulation of growth	GO:0040008	50	0.038
ribonucleoside metabolic process	GO:0009119	389	0.037
response to organonitrogen compound	GO:0010243	18	0.037	Rat
regulation of organelle organization	GO:0033043	243	0.037
purine ribonucleotide catabolic process	GO:0009154	327	0.037
chemical homeostasis	GO:0048878	137	0.036	Human
carbohydrate metabolic process	GO:0005975	252	0.036
positive regulation of cytoplasmic transport	GO:1903651	4	0.036	Mouse
response to hexose	GO:0009746	13	0.035	Human
cellular response to heat	GO:0034605	53	0.035
regulation of protein modification process	GO:0031399	110	0.035
positive regulation of macromolecule biosynthetic process	GO:0010557	325	0.034
regulation of hydrolase activity	GO:0051336	133	0.033
sexual sporulation resulting in formation of a cellular spore	GO:0043935	113	0.033
nucleoside triphosphate catabolic process	GO:0009143	329	0.033
nuclear transcribed mrna catabolic process	GO:0000956	89	0.033
regulation of response to external stimulus	GO:0032101	20	0.032
response to organic cyclic compound	GO:0014070	1	0.032	Rat
negative regulation of rna metabolic process	GO:0051253	262	0.032
cellular response to endogenous stimulus	GO:0071495	22	0.031	Mouse
positive regulation of nucleic acid templated transcription	GO:1903508	286	0.030
ribose phosphate metabolic process	GO:0019693	384	0.030
purine ribonucleoside triphosphate catabolic process	GO:0009207	327	0.030
organophosphate biosynthetic process	GO:0090407	182	0.029
positive regulation of intracellular transport	GO:0032388	4	0.029	Mouse
meiotic cell cycle	GO:0051321	272	0.029	Rat
cell development	GO:0048468	107	0.029	Mouse Worm Fly
purine ribonucleoside metabolic process	GO:0046128	380	0.029
oxidation reduction process	GO:0055114	353	0.028	Rat
cellular macromolecule catabolic process	GO:0044265	363	0.028	Human
response to abiotic stimulus	GO:0009628	159	0.028	Fly
regulation of response to stress	GO:0080134	57	0.027
regulation of protein catabolic process	GO:0042176	40	0.027	Human
ribonucleoside triphosphate catabolic process	GO:0009203	327	0.027
ribonucleotide catabolic process	GO:0009261	327	0.027
regulation of translation in response to stress	GO:0043555	5	0.027
sterol metabolic process	GO:0016125	47	0.026
positive regulation of transcription dna templated	GO:0045893	286	0.026
anatomical structure formation involved in morphogenesis	GO:0048646	136	0.026	Human Mouse
response to nitrogen compound	GO:1901698	18	0.026	Rat
protein processing	GO:0016485	64	0.026	Mouse
cellular response to glucose stimulus	GO:0071333	8	0.026	Human
mitotic cell cycle	GO:0000278	306	0.026
alcohol metabolic process	GO:0006066	112	0.024
response to nutrient levels	GO:0031667	150	0.024
purine nucleoside metabolic process	GO:0042278	380	0.024
organophosphate catabolic process	GO:0046434	338	0.023
positive regulation of catabolic process	GO:0009896	135	0.023
positive regulation of cellular catabolic process	GO:0031331	128	0.023
regulation of protein serine threonine kinase activity	GO:0071900	41	0.023
protein dephosphorylation	GO:0006470	40	0.022
establishment of protein localization to organelle	GO:0072594	278	0.022
regulation of lipid metabolic process	GO:0019216	45	0.022
sporulation	GO:0043934	132	0.021
peptidyl serine phosphorylation	GO:0018105	7	0.021	Human Mouse Rat
purine containing compound biosynthetic process	GO:0072522	53	0.021
regulation of filamentous growth of a population of unicellular organisms	GO:1900428	36	0.021
endocytosis	GO:0006897	90	0.021
regulation of cell differentiation	GO:0045595	12	0.021	Human Worm Fly
purine nucleoside catabolic process	GO:0006152	330	0.020
regulation of protein kinase activity	GO:0045859	67	0.020
response to glucose	GO:0009749	13	0.020	Human
organic hydroxy compound metabolic process	GO:1901615	125	0.020
negative regulation of molecular function	GO:0044092	68	0.020
programmed cell death	GO:0012501	30	0.020	Fly
negative regulation of phosphorus metabolic process	GO:0010563	49	0.020
cell morphogenesis	GO:0000902	30	0.019
rna catabolic process	GO:0006401	118	0.019
protein localization to organelle	GO:0033365	337	0.019
actin filament based process	GO:0030029	104	0.019
reproduction of a single celled organism	GO:0032505	191	0.019
cell growth	GO:0016049	89	0.019
dephosphorylation	GO:0016311	127	0.019
regulation of developmental process	GO:0050793	30	0.019	Human Mouse Worm Fly
mrna catabolic process	GO:0006402	93	0.019
negative regulation of binding	GO:0051100	4	0.018
anatomical structure morphogenesis	GO:0009653	160	0.018	Human Mouse Fly
regulation of cellular component size	GO:0032535	50	0.018
regulation of nuclear division	GO:0051783	103	0.018
sporulation resulting in formation of a cellular spore	GO:0030435	129	0.018
positive regulation of sequence specific dna binding transcription factor activity	GO:0051091	2	0.018	Fly
growth	GO:0040007	157	0.018
regulation of nucleoside metabolic process	GO:0009118	106	0.017
negative regulation of cellular protein metabolic process	GO:0032269	85	0.017
regulation of nucleotide metabolic process	GO:0006140	110	0.017
protein targeting	GO:0006605	272	0.017
mitotic cell cycle phase transition	GO:0044772	141	0.017
mitochondrion organization	GO:0007005	261	0.017	Yeast
positive regulation of protein modification process	GO:0031401	49	0.017
cell cycle phase transition	GO:0044770	144	0.017
proteolysis involved in cellular protein catabolic process	GO:0051603	198	0.016	Human
mrna metabolic process	GO:0016071	269	0.016
vacuolar transport	GO:0007034	145	0.015
negative regulation of protein metabolic process	GO:0051248	85	0.015
cell fate commitment	GO:0045165	32	0.015
negative regulation of dna binding	GO:0043392	3	0.015
small molecule catabolic process	GO:0044282	88	0.015
ribonucleoside triphosphate metabolic process	GO:0009199	356	0.015
external encapsulating structure organization	GO:0045229	146	0.014
protein export from nucleus	GO:0006611	17	0.014	Mouse
mitotic cell cycle process	GO:1903047	294	0.014
purine containing compound catabolic process	GO:0072523	332	0.014
regulation of anatomical structure size	GO:0090066	50	0.014
regulation of dna metabolic process	GO:0051052	100	0.014
membrane organization	GO:0061024	276	0.014
anatomical structure development	GO:0048856	160	0.013	Human Mouse Worm Fly
positive regulation of gene expression	GO:0010628	321	0.013
organonitrogen compound catabolic process	GO:1901565	404	0.013
positive regulation of rna metabolic process	GO:0051254	294	0.013
negative regulation of phosphate metabolic process	GO:0045936	49	0.013
purine nucleoside triphosphate catabolic process	GO:0009146	329	0.013
positive regulation of signaling	GO:0023056	20	0.013
lipid biosynthetic process	GO:0008610	170	0.012
cellular response to external stimulus	GO:0071496	150	0.012
reproductive process	GO:0022414	248	0.012	Mouse Worm Fly
cytoskeleton organization	GO:0007010	230	0.012	Fly
cellular homeostasis	GO:0019725	138	0.012	Human
positive regulation of nucleotide metabolic process	GO:0045981	101	0.012
positive regulation of secretion	GO:0051047	2	0.012
cellular response to abiotic stimulus	GO:0071214	62	0.012
single organism membrane organization	GO:0044802	275	0.012
cell death	GO:0008219	30	0.012	Fly
regulation of purine nucleotide metabolic process	GO:1900542	109	0.011
nucleoside phosphate metabolic process	GO:0006753	458	0.011
cellular response to osmotic stress	GO:0071470	50	0.011
organic acid metabolic process	GO:0006082	352	0.011
nucleobase containing small molecule metabolic process	GO:0055086	491	0.011
positive regulation of adenylate cyclase activity	GO:0045762	3	0.011
positive regulation of cell cycle process	GO:0090068	31	0.011	Mouse
regulation of protein localization	GO:0032880	62	0.011	Mouse
positive regulation of g1 s transition of mitotic cell cycle	GO:1900087	7	0.011
homeostatic process	GO:0042592	227	0.011	Human
organelle assembly	GO:0070925	118	0.010
dna integrity checkpoint	GO:0031570	41	0.010
regulation of cell growth	GO:0001558	29	0.010
fatty acid metabolic process	GO:0006631	51	0.010
positive regulation of phosphorylation	GO:0042327	33	0.010
rna localization	GO:0006403	112	0.010	Fly

TPK2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in yeast and predicted with the yeast functional network.

Disease	DO term ID	Probability
nervous system disease	DOID:863	0.011
disease of anatomical entity	DOID:7	0.011
neuropathy	DOID:870	0.011

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